69 Matching Annotations
  1. Jun 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic analysis of hippo pathway signaling identifies TEAD1 as a transcriptional regulator of neuroendocrine prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13241777/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting TYRO3 attenuates apoptotic cell–driven cancer stemness in triple negative breast cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13237900/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DPP-Mediated Interaction of TAZ/β-Catenin Promotes the Differentiation of DPSCs into Odontoblasts
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    pmc.ncbi.nlm.nih.gov/articles/PMC13207296/
  5. Apr 2026
  6. dx.doi.org dx.doi.org
    Regulation of YAP activity by nuclear G-actin binding
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    dx.doi.org/10.1093/nar/gkag248
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dissection of Gαs and Hedgehog Signaling Cross-talk Reveals Therapeutic Opportunities to Target Hedgehog-Dependent Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC13055637/
  8. Jan 2026
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP
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    pmc.ncbi.nlm.nih.gov/articles/PMC8897400/
  10. Nov 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12456957/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cytoplasmic TRIM24 promotes colorectal cancer cell proliferation by activating Wnt/β-catenin signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12480548/
  13. Sep 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A feedforward loop between STAT1 and YAP1 stimulates lipid biosynthesis, accelerates tumor growth, and promotes chemotherapy resistance in mutant KRAS colorectal cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12378792/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting YAP/TAZ-TEAD signaling as a therapeutic approach in head and neck squamous cell carcinoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12044704/
  16. Aug 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SON-dependent nuclear speckle rehabilitation alleviates proteinopathies
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12325801/
  18. www.biorxiv.org www.biorxiv.org
    Regulation of YAP activity by nuclear G-actin binding
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    biorxiv.org/content/10.1101/2025.07.30.667612v1
  19. Jul 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Restriction of YWHAB-mediated YAP cytoplasmic retention is a novel mechanism underlying stemness maintenance and chemoresistance in ovarian cancer peritoneal metastasis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12221726/
  21. May 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VGLL2 and TEAD1 fusion proteins identified in human sarcoma drive YAP/TAZ-independent tumorigenesis by engaging EP300
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12061476/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP24 promotes hepatocellular carcinoma progression by deubiquitinating and stabilizing YAP1
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12034148/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRB2 Depletion Induces YAP Signaling and Disrupts Mechanosensing in Podocytes
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12076484/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The guanine nucleotide exchange factor Ric-8A regulates the sensitivity of constitutively active Gαq to the inhibitor YM-254890
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12033907/
  26. link.springer.com link.springer.com
    Microtubule associated serine/threonine kinase-3 inhibits the malignant phenotype of breast cancer by promoting phosphorylation-mediated ubiquitination degradation of yes-associated protein
    1
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    link.springer.com/article/10.1186/s13058-025-02028-3
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Disrupting bile acid metabolism by suppressing Fxr causes hepatocellular carcinoma induced by YAP activation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12000370/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of Rho GEFs attenuates pulmonary fibrosis through suppressing myofibroblast activation and reprogramming profibrotic macrophages
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11992128/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetically engineered secretory horseradish peroxidase is a sensitive, stable, and affordable non-lytic reporter gene system for real-time promoter activity management
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12012966/
  30. Apr 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Vertical inhibition of p110α/AKT and N‐cadherin enhances treatment efficacy in PIK3CA‐aberrated ovarian cancer cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11977650/
  32. Mar 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HDAC inhibitors modulate Hippo pathway signaling in hormone positive breast cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11863526/
  34. Feb 2025
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of ER stress-induced apoptotic and inflammatory responses via YAP/TAZ-mediated control of the TRAIL-R2/DR5 signaling pathway
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11794427/
  36. Jan 2025
  37. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    CDK5 interacts with MST2 and modulates the Hippo signalling pathway
    1
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    febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13962
  38. Dec 2024
  39. biosignaling.biomedcentral.com biosignaling.biomedcentral.com
    Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP/Hippo signalling pathway and cell proliferation
    1
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    biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01981-4
  40. pubs.acs.org pubs.acs.org
    YAP/TAZ Inhibitor-Based Drug Delivery System for Selective Tumor Accumulation and Cancer Combination Therapy
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    pubs.acs.org/doi/full/10.1021/acs.biomac.4c01076
  41. Sep 2024
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of zinc finger MIZ-type containing 2 as an oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1 deacetylase activity to regulate Wnt and Hippo pathways in non-small-cell lung cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11391738/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Retinoic acid-induced protein 14 links mechanical forces to Hippo signaling
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387738/
  44. Aug 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEDD8 enhances Hippo signaling by mediating YAP1 neddylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11327456/
  46. Jun 2024
  47. link.springer.com link.springer.com
    Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E–deficient mice
    1
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    link.springer.com/article/10.1038/s41401-024-01317-5
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent transcription and tumorigenesis by engaging p300
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11092657/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    O-GlcNAcylation controls pro-fibrotic transcriptional regulatory signaling in myofibroblasts
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    ncbi.nlm.nih.gov/pmc/articles/PMC11148087/
  50. May 2024
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRIM21 is critical in regulating hepatocellular carcinoma growth and response to therapy by altering the MST1/YAP pathway
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11093211/
  52. Apr 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11043391/
  54. www.sciencedirect.com www.sciencedirect.com
    TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis
    1
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    sciencedirect.com/science/article/pii/S1550413124001232
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CSN6‐SPOP‐HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11005689/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting CD73 with flavonoids inhibits cancer stem cells and increases lymphocyte infiltration in a triple-negative breast cancer mouse model
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11004431/
  57. Mar 2024
  58. www.sciencedirect.com www.sciencedirect.com
    Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway
    1
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    sciencedirect.com/science/article/pii/S2211383524001230
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10937711/
  60. Feb 2024
  61. aacrjournals.org aacrjournals.org
    A novel irreversible TEAD inhibitor, SWTX-143, blocks Hippo pathway transcriptional output and causes tumor regression in preclinical mesothelioma models
    1
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    aacrjournals.org/mct/article/23/1/3/732154/A-Novel-Irreversible-TEAD-Inhibitor-SWTX-143
  62. Dec 2023
  63. link.springer.com link.springer.com
    The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells
    1
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    link.springer.com/article/10.1038/s41467-023-43775-1
  64. Oct 2023
  65. www.mdpi.com www.mdpi.com
    Role of the YAP/TAZ-TEAD Transcriptional Complex in the Metabolic Control of TRAIL Sensitivity by the Mevalonate Pathway in Cancer Cells
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    mdpi.com/2073-4409/12/19/2370
  66. 52.53.155.43 52.53.155.43
    mct-22-0681-html.html
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    52.53.155.43/d35db28aa1e833dc8bdcaa7cf7e7e23e3392038d/mct-22-0681-html.html
  67. Sep 2023
  68. dx.doi.org dx.doi.org
    Loss of CDKN2A Cooperates with WWTR1(TAZ)–CAMTA1 Gene Fusion to Promote Tumor Progression in Epithelioid Hemangioendothelioma
    1
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    dx.doi.org/10.1158/1078-0432.CCR-22-2497
  69. Jun 2023
  70. aacrjournals.org aacrjournals.org
    Interdependence of SS18-SSX-driven YAP1 and β-catenin activation in synovial sarcoma
    1
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    aacrjournals.org/mcr/article/21/6/535/726509/Interdependence-of-SS18-SSX-driven-YAP1-and
  71. Mar 2023
  72. www.sciencedirect.com www.sciencedirect.com
    Prolyl isomerase Pin1 promotes extracellular matrix production in hepatic stellate cells through regulating formation of the Smad3-TAZ complex
    1
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    sciencedirect.com/science/article/pii/S0014482723000915
  73. Jan 2023
  74. www.biorxiv.org www.biorxiv.org
    YAP-dependent autophagy is controlled by AMPK, SIRT1 and flow intensity in kidney epithelial cells
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    biorxiv.org/content/10.1101/2023.01.09.523237v1
  75. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16007
  76. Sep 2022
  77. www.sciencedirect.com www.sciencedirect.com
    Virtual screening for small-molecule pathway regulators by image-profile matching
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    sciencedirect.com/science/article/pii/S2405471222003301
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett’s-associated esophageal adenocarcinomas
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9434868/
  79. Nov 2021
  80. pubs.acs.org pubs.acs.org
    Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia
    1
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    pubs.acs.org/doi/abs/10.1021/acs.jmedchem.1c00804
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Involvement of the TGF-β Signaling Pathway in the Development of YAP-Driven Osteosarcoma Lung Metastasis
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8576330/
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states
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    ncbi.nlm.nih.gov/pmc/articles/PMC8555985/
  83. Aug 2021
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8313754/
  85. elifesciences.org elifesciences.org
    Systematic morphological profiling of human gene and allele function via Cell Painting
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    elifesciences.org/articles/24060
  86. Jul 2021
  87. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1535610819300431
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6231326/
  89. academic.oup.com academic.oup.com
    Loss of Yap/taz in cardiac fibroblasts attenuates adverse remodeling and improves cardiac function
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    academic.oup.com/cardiovascres/advance-article-abstract/doi/10.1093/cvr/cvab205/6300518
  90. May 2021
  91. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    YAP1 Mediates Trametinib Resistance in Head and Neck Squamous Cell Carcinomas
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    clincancerres.aacrjournals.org/content/27/8/2326
  92. Mar 2021
  93. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15378
  94. Feb 2021
  95. www.mdpi.com www.mdpi.com
    The YAP/TEAD Axis as a New Therapeutic Target in Osteosarcoma: Effect of Verteporfin and CA3 on Primary Tumor Growth
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    mdpi.com/2072-6694/12/12/3847/htm
  96. www.oncotarget.com www.oncotarget.com
    A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells
    1
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    oncotarget.com/article/27871/text/
  97. Jan 2021
  98. www.sciencedirect.com www.sciencedirect.com
    Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription
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    sciencedirect.com/science/article/pii/S1934590920300941
  99. www.mdpi.com www.mdpi.com
    The YAP/TEAD Axis as a New Therapeutic Target in Osteosarcoma: Effect of Verteporfin and CA3 on Primary Tumor Growth
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    mdpi.com/2072-6694/12/12/3847/htm
  100. Dec 2020
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PNPLA3 I148M Up-Regulates Hedgehog and Yap Signaling in Human Hepatic Stellate Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC7698885/
  102. Oct 2020
  103. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Chondroitin synthase‐3 regulates nucleus pulposus degeneration through actin‐induced YAP signaling
    1
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001021R
  104. Sep 2020
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC7112954/
  106. Jan 2020
  107. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1535610819300431