29 Matching Annotations
  1. Nov 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rotenone accelerates endogenous α-synuclein spreading and enhances neurodegeneration in an intra-striatal α-synuclein preformed fibril injected mouse model of Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12531225/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proteolytic activities of extracellular vesicles attenuate A-synuclein aggregation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12480265/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thermodynamic stability modulates chaperone-mediated disaggregation of α-synuclein fibrils
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    pmc.ncbi.nlm.nih.gov/articles/PMC12622358/
  5. Sep 2025
  6. molecularneurodegeneration.biomedcentral.com molecularneurodegeneration.biomedcentral.com
    Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology
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    molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-025-00886-1
  7. Jul 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Photochemically synthesized gold nanoparticles conjugated with Boswellic acid inhibit alpha synuclein aggregation and delay fibrillation kinetics
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    pmc.ncbi.nlm.nih.gov/articles/PMC12267561/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12258067/
  10. May 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12019160/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of cytotoxic fibril formation of α-synuclein and human insulin by Silymarin from the Silybum marianum
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12047757/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Live-cell quantification reveals viscoelastic regulation of synapsin condensates by α-synuclein
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12007584/
  14. Apr 2025
  15. www.sciencedirect.com www.sciencedirect.com
    The basolateral amygdala and striatum propagate alpha-synuclein pathology causing increased fear response in a Parkinson’s disease model
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    sciencedirect.com/science/article/pii/S088915912500162X
  16. Feb 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular Rotors Detect the Formation and Conversion of α-Synuclein Oligomers
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    pmc.ncbi.nlm.nih.gov/articles/PMC11843532/
  18. Jan 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11749544/
  20. Sep 2024
  21. www.sciencedirect.com www.sciencedirect.com
    Astroglia proliferate upon biogenesis of tunneling nanotubes via α-synuclein dependent transient nuclear translocation of focal adhesion kinase
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    sciencedirect.com/science/article/pii/S2589004224017905
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson’s disease
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11384021/
  23. Aug 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interplay between Copper, Phosphatidylserine, and α-Synuclein Suggests a Link between Copper Homeostasis and Synaptic Vesicle Cycling
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11311125/
  25. Jul 2024
  26. www.biorxiv.org www.biorxiv.org
    1.94 Å structure of synthetic α-synuclein fibrils seeding MSA neuropathology
    1
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    biorxiv.org/content/10.1101/2024.07.01.601498v1
  27. May 2024
  28. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Activation and Purification of ß-Glucocerebrosidase by Exploiting its Transporter LIMP-2 – Implications for Novel Treatment Strategies in Gaucher's and Parkinson's Disease
    1
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    onlinelibrary.wiley.com/doi/10.1002/advs.202401641
  29. Feb 2024
  30. www.sciencedirect.com www.sciencedirect.com
    Thermodynamic characterization of amyloid polymorphism by microfluidic transient incomplete separation
    1
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    sciencedirect.com/org/science/article/abs/pii/S2041652024001792
  31. Dec 2023
  32. 52.53.155.43 52.53.155.43
    Thermodynamic characterization of amyloid polymorphism by Taylor dispersion analysis
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    52.53.155.43/de782f30423bb1d94eb106c996580349f21fc73a/thermodynamic-characterization-of-amyloid-polymorphism-by-taylor-dispersion-analysis-html.html
  33. Jan 2023
  34. academic.oup.com academic.oup.com
    Differential interactions of α-synuclein conformers affect refolding and activity of proteins
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    academic.oup.com/jb/advance-article/doi/10.1093/jb/mvac095/6824396
  35. Aug 2022
  36. pubs-acs-org.ezproxy2.utwente.nl pubs-acs-org.ezproxy2.utwente.nl
    Modulation of α-Synuclein Aggregation In Vitro by a DNA Aptamer
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    pubs-acs-org.ezproxy2.utwente.nl/doi/10.1021/acs.biochem.2c00207
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9406079/
  38. Jun 2022
  39. academic.oup.com academic.oup.com
    Detection of neuron-derived pathological α-synuclein in blood
    2
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    academic.oup.com/brain/advance-article/doi/10.1093/brain/awac115/6608621
  40. Dec 2021
  41. www.mdpi.com www.mdpi.com
    Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy
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    mdpi.com/1422-0067/22/24/13398/htm
  42. May 2021
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ architecture of neuronal α-Synuclein inclusions
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    ncbi.nlm.nih.gov/pmc/articles/PMC8046968/
  44. Feb 2021
  45. pubs.acs.org pubs.acs.org
    Toxic metamorphosis – how changes from lysosomal to cytosolic pH modify alpha-synuclein aggregation pattern
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    pubs.acs.org/doi/full/10.1021/acs.biomac.0c00629
  46. www.sciencedirect.com www.sciencedirect.com
    DIBMA nanodiscs keep α-synuclein folded
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    sciencedirect.com/science/article/pii/S0005273620301450
  47. Sep 2020
  48. pubs.acs.org pubs.acs.org
    Self- and Cross-Seeding on α-Synuclein Fibril Growth Kinetics and Structure Observed by High-Speed Atomic Force Microscopy
    1
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    pubs.acs.org/doi/10.1021/acsnano.0c03074