108 Matching Annotations
  1. Last 7 days
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    Disrupting the interaction between androgen receptor and its coregulator WDR77 delays the growth of treatment-resistant prostate cancer
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    sciencedirect.com/science/article/pii/S221112472501006X
  3. Sep 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ablating UNG activity in a mouse model inhibits colorectal cancer growth by increasing tumor immunogenicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12406714/
  5. Aug 2025
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    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70112
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multi-selective RAS(ON) Inhibition Targets Oncogenic RAS Mutations and Overcomes RAS/MAPK-Mediated Resistance to FLT3 and BCL2 Inhibitors in Acute Myeloid Leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12259086/
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    PALB2 and 53BP1 govern post-resection homologous recombination DNA repair
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    sciencedirect.com/science/article/pii/S1097276525006045
  9. Jul 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Advanced viral genome in vitro Cas9 editing (AdVICE): an overnight method for traceless and limitless manipulation of adenoviral and vector genomes with large transgenes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12172474/
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    Adipocyte-specific Zeb1 downregulation remodels the tumor-associated adipose microenvironment to facilitate female breast cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219764/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural Repetition Detector for multi-scale quantitative mapping of molecular complexes through microscopy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219329/
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    The copper chaperone ATOX1 exhibits differential protein-protein interactions and contributes to skeletal myoblast differentiation
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    biorxiv.org/content/10.1101/2025.07.08.663731v1
  14. Jun 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A monomeric envelope glycoprotein cytoplasmic tail is sufficient for HIV-1 Gag lattice trapping and incorporation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12090761/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphatase activity is dispensable for PRL-3-mediated oncogenesis and tumor progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132575/
  17. May 2025
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    Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates
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    sciencedirect.com/science/article/pii/S0092867425005094
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel STAT3 Y360C Gain-of-function Variant Underlies Immune Dysregulation and Aberrancy in Mitochondrial Dynamics
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    pmc.ncbi.nlm.nih.gov/articles/PMC12056293/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11982463/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppression of Ovarian Cancer Cell Proliferation Is Associated with Upregulation of Cell-Matrix Adhesion Programs and Integrin-β4-Induced Cell Protection from Cisplatin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12070841/
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    LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046326/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Epstein-Barr virus deubiquitinase BPLF1 regulates stress-induced ribosome UFMylation and reticulophagy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12013442/
  24. Apr 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolic constraint of human telomere length by nucleotide salvage efficiency
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    Saturation mapping of MUTYH variant effects using DNA repair reporters
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908140/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Colorectal cancer hot spot mutations attenuate the ASXL-MLL4 interaction
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    pmc.ncbi.nlm.nih.gov/articles/PMC11957774/
  28. www.biorxiv.org www.biorxiv.org
    Inhibition of cytosolic DNA sensing and transposon activity safeguards pluripotency
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    biorxiv.org/content/10.1101/2025.03.26.645264v1
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    SWI/SNF complex-mediated ZNF410 cooperative binding maintains chromatin accessibility and enhancer activity
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    cell.com/cell-reports/fulltext/S2211-1247(25)00247-5
  30. Mar 2025
  31. www.biorxiv.org www.biorxiv.org
    In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer
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    biorxiv.org/content/10.1101/2025.03.20.644389v1
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    De novo design of Ras isoform selective binders
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838417/
  33. Feb 2025
  34. www.sciencedirect.com www.sciencedirect.com
    Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation
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    sciencedirect.com/science/article/pii/S1097276525000577
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Extracellular Histones as Exosome Membrane Proteins Regulated by Cell Stress
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  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations
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    pmc.ncbi.nlm.nih.gov/articles/PMC11811908/
  37. Jan 2025
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    Cytoplasmic mRNA decay controlling inflammatory gene expression is determined by pre-mRNA fate decision
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    The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
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    sciencedirect.com/science/article/pii/S2451945624004896
  40. Dec 2024
  41. elifesciences.org elifesciences.org
    Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment
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    elifesciences.org/articles/95106
  42. 52.53.155.43 52.53.155.43
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  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2
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    pmc.ncbi.nlm.nih.gov/articles/PMC10760916/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A fully human IgG1 antibody targeting connexin 32 extracellular domain blocks CMTX1 hemichannel dysfunction in an in vitro model
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    pmc.ncbi.nlm.nih.gov/articles/PMC11619691/
  45. Oct 2024
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    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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  47. Sep 2024
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Grb2 SH3 Domains with Affimer Proteins Provides Novel Insights into Ras Signalling Modulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11352564/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade
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    ncbi.nlm.nih.gov/pmc/articles/PMC11364849/
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    Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations
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    ncbi.nlm.nih.gov/pmc/articles/PMC11370454/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic Effect of Ubiquitin-Specific Protease 14 and Poly(ADP-Ribose) Glycohydrolase Co-Inhibition in BRCA1-Mutant, Poly(ADP-Ribose) Polymerase Inhibitor-Resistant Triple-Negative Breast Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11385694/
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    Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11383994/
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    The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization
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    sciencedirect.com/science/article/pii/S2211124724010404
  54. Aug 2024
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumoral Interferon Beta Induces an Immune-Stimulatory Phenotype in Tumor-Associated Macrophages in Melanoma Brain Metastases
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    ncbi.nlm.nih.gov/pmc/articles/PMC11337092/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human stem cell–derived neurons and astrocytes to detect novel auto-reactive IgG response in immune-mediated neurological diseases
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    ncbi.nlm.nih.gov/pmc/articles/PMC11303155/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks
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    ncbi.nlm.nih.gov/pmc/articles/PMC11310344/
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    Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation
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    sciencedirect.com/science/article/pii/S1097276524005896
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    A High-Throughput Screening Identifies MCM Chromatin loading Inhibitors Targeting Cells with increased Replication Origins
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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cyclin F–EXO1 axis controls cell cycle–dependent execution of double-strand break repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC11313846/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth
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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10265649/
  63. Jul 2024
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Highlights from MBoC Selection: A methodology for specific disruption of microtubule polymerization into dendritic spines
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    ncbi.nlm.nih.gov/pmc/articles/PMC11238079/
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    Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease
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    elifesciences.org/articles/98649
  66. Jun 2024
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers
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    ncbi.nlm.nih.gov/pmc/articles/PMC11161652/
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeted sequencing for hereditary breast and ovarian cancer in BRCA1/2-negative families from the Lynch Memorial Biobank reveals complex genetic architecture and phenocopies
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    ncbi.nlm.nih.gov/pmc/articles/PMC11166883/
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11148166/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TCF7L1 regulates colorectal cancer cell migration by repressing GAS1 expression
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  72. May 2024
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Herpes simplex encephalitis due to a mutation in an E3 ubiquitin ligase
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    ncbi.nlm.nih.gov/pmc/articles/PMC11087577/
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Downregulation of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase response
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    ncbi.nlm.nih.gov/pmc/articles/PMC11099168/
  75. www.biorxiv.org www.biorxiv.org
    Context dependent activity of p63-bound gene regulatory elements
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    biorxiv.org/content/10.1101/2024.05.09.593326v1
  76. www.science.org www.science.org
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
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    science.org/doi/10.1126/sciadv.adl6082
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
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  78. Apr 2024
  79. www.pnas.org www.pnas.org
    NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells
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    pnas.org/doi/abs/10.1073/pnas.2314695121
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor Cell-Associated IL-1α Affects Breast Cancer Progression and Metastasis in Mice through Manipulation of the Tumor Immune Microenvironment
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    ncbi.nlm.nih.gov/pmc/articles/PMC11011794/
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    SHIP inhibition mediates select TREM2-induced microglial functions
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    sciencedirect.com/science/article/pii/S0161589024000725
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thymidine nucleotide metabolism controls human telomere length
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    ncbi.nlm.nih.gov/pmc/articles/PMC11000509/
  83. Mar 2024
  84. link.springer.com link.springer.com
    Altered vacuole membrane protein 1 (VMP1) expression is associated with increased NLRP3 inflammasome activation and mitochondrial dysfunction
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    link.springer.com/article/10.1007/s00011-024-01856-x
  85. www.biorxiv.org www.biorxiv.org
    A Methodology for Specific Disruption of Microtubules in Dendritic Spines
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    biorxiv.org/content/10.1101/2024.03.04.583370v1
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protein supersaturation powers innate immune signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10055258/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A model of human neural networks reveals NPTX2 pathology in ALS and FTLD
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    ncbi.nlm.nih.gov/pmc/articles/PMC10901740/
  88. Feb 2024
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10879500/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DUX4-r exerts a neomorphic activity that depends on GTF2I in acute lymphoblastic leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10881058/
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses
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    ncbi.nlm.nih.gov/pmc/articles/PMC10781586/
  92. Jan 2024
  93. www.sciencedirect.com www.sciencedirect.com
    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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    sciencedirect.com/science/article/pii/S1097276523010857
  94. www.sciencedirect.com www.sciencedirect.com
    The male pachynema-specific protein MAPS drives phase separation in vitro and regulates sex body formation and chromatin behaviors in vivo
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    sciencedirect.com/science/article/pii/S2211124723016625
  95. Nov 2023
  96. www.sciencedirect.com www.sciencedirect.com
    Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
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    sciencedirect.com/science/article/pii/S2666379123004846
  97. Sep 2023
  98. www.sciencedirect.com www.sciencedirect.com
    CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax
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    sciencedirect.com/science/article/pii/S2211124723010951
  99. May 2023
  100. elifesciences.org elifesciences.org
    Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction
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    elifesciences.org/articles/82057
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    Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin
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    sciencedirect.com/science/article/pii/S2211124723004837
  102. Mar 2023
  103. 52.53.155.43 52.53.155.43
    Remodeling of the Ribosomal Quality Control and Protein Translation by a Viral Ubiquitin Deconjugase
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    52.53.155.43/56dd9657520d89efd227b99f30a1871711d5fdb7/2023.01.31.526464v1.full-html.html
  104. www.biorxiv.org www.biorxiv.org
    The Dietary Supplement Taurine Suppresses Ovarian Cancer Growth
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    biorxiv.org/content/10.1101/2023.02.24.529893v1
  105. Feb 2023
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9357213/
  107. Sep 2022
  108. www.sciencedirect.com www.sciencedirect.com
    A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation
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    sciencedirect.com/science/article/pii/S2211124722012530
  109. Aug 2022
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9398446/
  111. Jul 2022
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Quantitative Assay for Ca2+ Uptake through Normal and Pathological Hemichannels
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    ncbi.nlm.nih.gov/pmc/articles/PMC9266989/
  113. Apr 2022
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Data-driven learning how oncogenic gene expression locally alters heterocellular networks
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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
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    Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis
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  119. Mar 2022
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  121. Feb 2022
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  123. Oct 2021
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    Exocyst complex mediates recycling of internal cilia
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    CLIP-170S is a microtubule +TIP variant that confers resistance to taxanes by impairing drug-target engagement
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  126. Sep 2021
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    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
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  128. Aug 2021
  129. elifesciences.org elifesciences.org
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  130. Jul 2021
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    Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization
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  132. www.frontiersin.org www.frontiersin.org
    BHLHE40 Regulates IL-10 and IFN-γ Production in T Cells but Does Not Interfere With Human Type 1 Regulatory T Cell Differentiation
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  133. May 2021
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    RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness
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    HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis
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  136. Apr 2021
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    Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1
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    The white matter is a pro-differentiative niche for glioblastoma
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  139. Jan 2021
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    Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer
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  141. Sep 2020
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    Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation
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    Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
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    Codon optimization is an essential parameter for the efficient allotopic expression of mtDNA genes
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    KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage
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