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Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Treatment of Huntington’s disease with a pan-HTT-targeting CRISPR nuclease

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1. scibot 26 Jan 2026
  
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  Addgene_41815
  
  DOI: 10.64898/2025.12.20.695720
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12776121/
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The Chimeric Nuclease SpRYc Exhibits Highly Variable Performance Across Biological Systems

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1. scibot 26 Jan 2026
  
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  DOI: 10.3390/ijms27010488
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12787127/
Nov 2025
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Cytosine methylase and hydroxymethylase activity in mammalian mitochondria

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1. scibot 24 Nov 2025
  
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  41815
  
  DOI: 10.3389/fcell.2025.1677402
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12568578/
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CRISPR/Cas9 generated DSB clusters mimic complex lesions induced by high-LET radiation and shift repair from c-NHEJ to mutagenic repair pathways

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1. scibot 24 Nov 2025
  
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  DOI: 10.1038/s41598-025-22945-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12537819/
Sep 2025
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The p400 complex promotes HIV-1 latency by suppressing viral transcription and altering the host cell state

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1. scibot 07 Sep 2025
  
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  plasmid_41815
  
  DOI: 10.1093/nar/gkaf764
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12370628/
Jul 2025
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BRAFV600E maintains the CpG island methylator phenotype, and DNA methylation of PRC2 targets genes in colon cancer

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1. scibot 20 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.112905
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12269043/
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BRAFV600E augments WNT signaling in colorectal cancer via aberrant DNA methylation

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1. scibot 20 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.112708
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12272824/
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Targeted in vivo gene integration of a secretion-enabled GLP-1 receptor agonist reverses diet-induced non-genetic obesity and pre-diabetes

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1. scibot 20 Jul 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12241343/
Jun 2025
www.cell.com www.cell.com

Phase separation of TTBK2 and CEP164 is necessary for ciliogenesis

1
1. scibot 18 Jun 2025
  
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  RRID:Addgene_41815
  
  DOI: 10.1016/j.celrep.2025.115810
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00581-9
Apr 2025
www.sciencedirect.com www.sciencedirect.com

RabGAP1L modulates Rab7A and Rab10 to orchestrate cell-autonomous immunity

1
1. scibot 19 Apr 2025
  
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  AddgeneCat# 41815
  
  DOI: 10.1016/j.celrep.2025.115599
  
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sciencedirect.com/science/article/pii/S2211124725003705
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

GATA4 binding to the Sox9 enhancer mXYSRa/Enh13 is critical for testis differentiation in mouse

1
1. scibot 27 Jan 2025
  
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  41815
  
  DOI: 10.1038/s42003-025-07504-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11743149/
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DNA-damage orchestrates self-renewal and differentiation via reciprocal p53 family and Hippo/Wnt/TGF-β pathway activation in embryonic stem cells

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1. scibot 27 Jan 2025
  
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  Addgene_41815
  
  DOI: 10.1007/s00018-024-05561-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11704118/
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A Flexible Hybrid Site‐Specific Integration‐Based Expression System in CHO Cells for Higher‐Throughput Evaluation of Monoclonal Antibody Expression Cassettes

1
1. scibot 27 Jan 2025
  
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  plasmid_41815
  
  DOI: 10.1002/biot.202400520
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11747262/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Lipid Nanoparticles Enable Efficient In Vivo DNA Knock-In via HITI-Mediated Genome Editing

1
1. scibot 29 Dec 2024
  
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  DOI: 10.3390/biom14121558
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11673532/
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Perinuclear assembly of vimentin intermediate filaments induces cancer cell nuclear dysmorphia

1
1. scibot 27 Dec 2024
  
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  plasmid_41815
  
  DOI: 10.1016/j.jbc.2024.107981
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11647624/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation

1
1. scibot 29 Sep 2024
  
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  plasmid_41815
  
  DOI: 10.1038/s41467-024-52049-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11374810/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Furin Egress from the TGN is Regulated by Membrane‐Associated RING‐CH Finger (MARCHF) Proteins and Ubiquitin‐Specific Protease 32 (USP32) via Nondegradable K33‐Polyubiquitination

1
1. scibot 28 Sep 2024
  
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  plasmid_41815
  
  DOI: 10.1002/advs.202403732
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11425283/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RNA-mediated double-strand break repair by end-joining mechanisms

1
1. scibot 27 Sep 2024
  
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  Plasmid_41815
  
  DOI: 10.1038/s41467-024-51457-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11390984/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

β-catenin mediates endodermal commitment of human ES cells via distinct transactivation functions

1
1. scibot 18 Aug 2024
  
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  Addgene_41815
  
  DOI: 10.1186/s13578-024-01279-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11267888/
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Identification and Validation of New DNA-PKcs Inhibitors through High-Throughput Virtual Screening and Experimental Verification

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1. scibot 18 Aug 2024
  
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  DOI: 10.3390/ijms25147982
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11277333/
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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

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1. scibot 02 Aug 2024
  
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  Addgene 41815
  
  DOI: 10.1016/j.molcel.2021.01.004
  
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sciencedirect.com/science/article/pii/S1097276521000046
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons

1
1. scibot 19 Jul 2024
  
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  plasmid_41815
  
  DOI: 10.3390/cells12081143
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10136645/
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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

1
1. scibot 18 Jul 2024
  
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  Addgene Cat# 41815
  
  DOI: 10.1038/s41422-024-00985-6
  
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  RRID:Addgene_41815 DOI:10.1038/s41422-024-00985-6
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pmc.ncbi.nlm.nih.gov/articles/PMC11442470/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Exonuclease editor promotes precision of gene editing in mammalian cells

1
1. scibot 07 Jun 2024
  
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  41815
  
  DOI: 10.1186/s12915-024-01918-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11107001/
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Assessing cell lines with inducible depletion of cohesin and condensins components through analysis of metaphase chromosome morphology

1
1. scibot 05 May 2024
  
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  41815
  
  DOI: 10.18699/vjgb-24-16
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11057366/
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Conditional chemoconnectomics (cCCTomics) as a strategy for efficient and conditional targeting of chemical transmission

1
1. scibot 02 May 2024
  
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  DOI: 10.7554/eLife.91927
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11060718/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Lysosomal membrane proteins LAMP1 and LIMP2 are segregated in the Golgi apparatus independently of their clathrin adaptor binding motif

1
1. scibot 23 Apr 2024
  
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  RRID:Addgene_41815
  
  DOI: 10.1091/mbc.E23-06-0251
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10916873/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Evolution of a novel regulatory mechanism of hypoxia inducible factor in hypoxia-tolerant electric fishes

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1. scibot 15 Apr 2024
  
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  DOI: 10.1016/j.jbc.2024.105727
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10958119/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation

1
1. scibot 22 Mar 2024
  
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  RRID:Addgene_41815
  
  DOI: 10.1016/j.isci.2024.109357
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10951985/
www.molbiolcell.org www.molbiolcell.org

Lysosomal membrane proteins LAMP1 and LIMP2 are segregated in the Golgi apparatus independently of their clathrin adaptor binding motif

1
1. scibot 21 Mar 2024
  
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  RRID:Addgene_41815
  
  DOI: 10.1091/mbc.E23-06-0251
  
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molbiolcell.org/doi/10.1091/mbc.E23-06-0251
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SpCas9-HF1 enhances accuracy of cell cycle-dependent genome editing by increasing HDR efficiency, and by reducing off-target effects and indel rates

1
1. scibot 13 Feb 2024
  
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  41815
  
  DOI: 10.1016/j.omtn.2024.102124
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10848011/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Tumor Pigmentation Does Not Affect Light-Activated Belzupacap Sarotalocan Treatment but Influences Macrophage Polarization in a Murine Melanoma Model

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1. scibot 05 Feb 2024
  
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  41815
  
  DOI: 10.1167/iovs.65.1.42
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10829805/
Dec 2023
www.sciencedirect.com www.sciencedirect.com

Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling

1
1. scibot 19 Dec 2023
  
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  plasmid_41815
  
  DOI: 10.1016/j.devcel.2023.11.023
  
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sciencedirect.com/science/article/pii/S1534580723006214
Nov 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CatSper mediates not only chemotactic behavior but also the motility of ascidian sperm

1
1. scibot 18 Nov 2023
  
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  RRID:Addgene_41815
  
  DOI: 10.3389/fcell.2023.1136537
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10652287/
Jun 2023
www.embopress.org www.embopress.org

PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems

1
1. scibot 23 Jun 2023
  
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  RRID:Addgene_41815
  
  DOI: 10.15252/embr.202256399
  
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embopress.org/doi/full/10.15252/embr.202256399
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

In vivo18F-DOPA PET imaging identifies a dopaminergic deficit in a rat model with a G51D α-synuclein mutation

1
1. scibot 10 Jun 2023
  
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  RRID:Addgene_41815
  
  DOI: 10.3389/fnins.2023.1095761
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10244711/
May 2023
www.biorxiv.org www.biorxiv.org

Identification of B56alpha, B56gamma; and BAP1 as PRR14L binding partners

1
1. scibot 18 May 2023
  
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  RRID:Addgene_41815
  
  DOI: 10.1101/2023.04.29.538809
  
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biorxiv.org/content/10.1101/2023.04.29.538809v1
Nov 2022
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Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization

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Sep 2022
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A genetically modified minipig model for Alzheimer’s disease with SORL1 haploinsufficiency

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  plasmid_41815
  
  DOI: 10.1016/j.xcrm.2022.100740
  
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sciencedirect.com/science/article/pii/S2666379122002890
Aug 2022
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Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways

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  RRID:Addgene_41815
  
  DOI: 10.1016/j.celrep.2022.111181
  
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sciencedirect.com/science/article/pii/S2211124722009949
May 2022
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XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation

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  Plasmid_41815
  
  DOI: 10.1016/j.cell.2022.04.034
  
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Apr 2022
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CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming

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sciencedirect.com/science/article/pii/S2211124722003746
Mar 2022
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BMI-1 regulates DNA end resection and homologous recombination repair

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  DOI: 10.1016/j.celrep.2022.110536
  
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sciencedirect.com/science/article/pii/S2211124722002777
Feb 2022
rupress.org rupress.org

Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo

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  RRID:Addgene_41815
  
  DOI: 10.1083/jcb.202104044
  
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rupress.org/jcb/article/221/2/e202104044/212919/Efficient-progranulin-exit-from-the-ER-requires
Nov 2021
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A stem cell marker KLF5 regulates CCAT1 via three-dimensional genome structure in colorectal cancer cells

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  DOI: 10.1038/s41416-021-01579-4
  
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nature.com/articles/s41416-021-01579-4
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RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

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1. scibot 05 Nov 2021
  
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  RRID:Addgene_41815
  
  DOI: 10.7554/eLife.65759
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8550759/
Oct 2021
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Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy

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  plasmid_41815
  
  DOI: 10.1016/j.molcel.2021.10.001
  
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Aug 2021
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Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo

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sciencedirect.com/science/article/pii/S1931312817305450
Jul 2021
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Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction

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  DOI: 10.1038/s41422-019-0213-0
  
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Neuroplastin and Basigin Are Essential Auxiliary Subunits of Plasma Membrane Ca2+-ATPases and Key Regulators of Ca2+ Clearance

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  Plasmid_41815
  
  DOI: 10.1016/j.neuron.2017.09.038
  
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The BTB-domain transcription factor ZBTB2 recruits chromatin remodelers and a histone chaperone during the exit from pluripotency

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  plasmid_41815
  
  DOI: 10.1016/j.jbc.2021.100947
  
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sciencedirect.com/science/article/pii/S002192582100747X
May 2021
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SAA1/TLR2 axis directs chemotactic migration of hepatic stellate cells responding to injury

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  Cat#41815
  
  DOI: 10.1016/j.isci.2021.102483
  
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sciencedirect.com/science/article/pii/S258900422100451X
Feb 2021
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Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling

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  plasmid_41815
  
  DOI: 10.1016/j.molcel.2019.11.013
  
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sciencedirect.com/science/article/pii/S1097276519308421
Jan 2021
www.embopress.org www.embopress.org

Transcriptionally active enhancers in human cancer cells

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1. scibot 30 Jan 2021
  
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  Plasmid_41815
  
  DOI: 10.15252/msb.20209873
  
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embopress.org/doi/abs/10.15252/msb.20209873
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Maternal Anti-Dengue IgG Fucosylation Predicts Susceptibility to Dengue Disease in Infants

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  Plasmid_41815
  
  DOI: 10.1016/j.celrep.2020.107642
  
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sciencedirect.com/science/article/pii/S2211124720305957
Nov 2020
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Generation of PAX7 Reporter Cells to Investigate Skeletal Myogenesis from Human Pluripotent Stem Cells

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1. scibot 11 Nov 2020
  
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  RRID: Addgene_41815
  
  DOI: 10.1016/j.xpro.2020.100158
  
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sciencedirect.com/science/article/pii/S2666166720301453
Sep 2020
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Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion

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  RRID:Addgene_41815
  
  DOI: 10.1016/j.celrep.2019.12.037
  
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Transcriptional landscape of myogenesis from human pluripotent stem cells reveals a key role of TWIST1 in maintenance of skeletal muscle progenitors

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1. scibot 08 Sep 2020
  
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  plasmid_41815
  
  DOI: 10.7554/eLife.46981
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6996923/
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A fly model establishes distinct mechanisms for synthetic CRISPR/Cas9 sex distorters

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  RRID:Addgene_41815
  
  DOI: 10.1371/journal.pgen.1008647
  
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A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells

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  RRID: Addgene_41815
  
  DOI: 10.1016/j.stem.2020.04.017
  
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sciencedirect.com/science/article/pii/S1934590920301569
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Maternal Anti-Dengue IgG Fucosylation Predicts Susceptibility to Dengue Disease in Infants

1
1. scibot 03 Sep 2020
  
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  Plasmid #41815
  
  DOI: 10.1016/j.celrep.2020.107642
  
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sciencedirect.com/science/article/pii/S2211124720305957
Jan 2020
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Intra-Vκ Cluster Recombination Shapes the Ig Kappa Locus Repertoire

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  RRID:Addgene_41815
  
  DOI: 10.1016/j.celrep.2019.11.088
  
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sciencedirect.com/science/article/pii/S2211124719315864
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Untitled document

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  DOI: 10.1186/s12915-018-0616-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6310992/
bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com

Untitled document

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bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0616-2

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