459 Matching Annotations
  1. Apr 2025
  2. www.mdpi.com www.mdpi.com
    Disruption of Man-6-P-Dependent Sorting to Lysosomes Confers IGF1R-Mediated Apoptosis Resistance
    1
    1. scibot 13 Apr 2025
      RRID:Addgene_42230

      DOI: 10.3390/ijms26083586

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    mdpi.com/1422-0067/26/8/3586
  3. academic.oup.com academic.oup.com
    Structure of the nucleosome-bound human BCL7A
    1
    1. scibot 13 Apr 2025
      RRID:Addgene_42230

      DOI: 10.1093/nar/gkaf273

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    academic.oup.com/nar/article/53/7/gkaf273/8109940
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Replication-dependent histone labeling dissects the physical properties of euchromatin/heterochromatin in living human cells
    1
    1. scibot 07 Apr 2025
      42230

      DOI: 10.1126/sciadv.adu8400

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    pmc.ncbi.nlm.nih.gov/articles/PMC11952110/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic high-throughput evaluation reveals FrCas9’s superior specificity and efficiency for therapeutic genome editing
    1
    1. scibot 07 Apr 2025
      pX330-U6-Chimeric_BB-CBh-hSpCas9

      DOI: 10.1126/sciadv.adu7334

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    pmc.ncbi.nlm.nih.gov/articles/PMC11939069/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans
    1
    1. scibot 05 Apr 2025
      pX330

      DOI: 10.1016/j.xgen.2025.100782

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    pmc.ncbi.nlm.nih.gov/articles/PMC11960549/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular basis for the calcium-dependent activation of the ribonuclease EndoU
    1
    1. scibot 05 Apr 2025
      Addgene_42230

      DOI: 10.1038/s41467-025-58462-6

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    pmc.ncbi.nlm.nih.gov/articles/PMC11961692/
  8. www.science.org www.science.org
    Retinal gene therapy for Stargardt disease with dual AAV intein vectors is both safe and effective in large animal models
    1
    1. scibot 02 Apr 2025
      RRID:Addgene_42230

      DOI: 10.1126/sciadv.adt9354

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    science.org/doi/10.1126/sciadv.adt9354
  9. Mar 2025
  10. www.sciencedirect.com www.sciencedirect.com
    Noncanonical phagocytosis-like SEAL establishes mammalian fertilization
    1
    1. scibot 29 Mar 2025
      Plasmid_42230

      DOI: 10.1016/j.celrep.2025.115463

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    sciencedirect.com/science/article/pii/S2211124725002347
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Retinal gene therapy for Stargardt disease with dual AAV intein vectors is both safe and effective in large animal models
    1
    1. scibot 28 Mar 2025
      RRID:Addgene_42230

      DOI: 10.1126/sciadv.adt9354

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    pmc.ncbi.nlm.nih.gov/articles/PMC11939046/
  12. 52.53.155.43 52.53.155.43
    PDF-html.html
    1
    1. scibot 23 Mar 2025
      Addgene 42230

      DOI: 10.1101/2025.03.19.643339

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    52.53.155.43/62d1ab468ae2105585e292a77643013ab01db943/PDF-html.html
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice
    1
    1. scibot 23 Mar 2025
      pX330

      DOI: 10.1101/2024.01.05.574442

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    pmc.ncbi.nlm.nih.gov/articles/PMC11312463/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells
    1
    1. scibot 21 Mar 2025
      Addgene_42230

      DOI: 10.1101/2025.02.20.639352

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    pmc.ncbi.nlm.nih.gov/articles/PMC11888184/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proteogenomic analysis reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer
    1
    1. scibot 20 Mar 2025
      Addgene_42230

      DOI: 10.1038/s44318-025-00372-w

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    pmc.ncbi.nlm.nih.gov/articles/PMC11914506/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutations in the kinesin KIF12 promote MASH in humans and mice by disrupting lipogenic enzyme turnover
    1
    1. scibot 20 Mar 2025
      plasmid_42230

      DOI: 10.1038/s44318-025-00366-8

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    pmc.ncbi.nlm.nih.gov/articles/PMC11914266/
  17. www.sciencedirect.com www.sciencedirect.com
    SRBD1, a highly conserved gene required for chromosome individualization
    1
    1. scibot 20 Mar 2025
      plasmid_42230

      DOI: 10.1016/j.celrep.2025.115443

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    sciencedirect.com/science/article/pii/S2211124725002141
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Betacoronaviruses Differentially Activate the Integrated Stress Response to Optimize Viral Replication in Lung-Derived Cell Lines
    1
    1. scibot 11 Mar 2025
      42230

      DOI: 10.3390/v17010120

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    pmc.ncbi.nlm.nih.gov/articles/PMC11769277/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HDAC6 Facilitates PRV and VSV Infection by Inhibiting Type I Interferon Production
    1
    1. scibot 11 Mar 2025
      42230

      DOI: 10.3390/v17010090

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    pmc.ncbi.nlm.nih.gov/articles/PMC11768819/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutations in Filamin C Associated with Both Alleles Do Not Affect the Functioning of Mice Cardiac Muscles
    1
    1. scibot 11 Mar 2025
      px330

      DOI: 10.3390/ijms26041409

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    pmc.ncbi.nlm.nih.gov/articles/PMC11855563/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation
    1
    1. scibot 11 Mar 2025
      pX330

      DOI: 10.1186/s12915-025-02137-7

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    pmc.ncbi.nlm.nih.gov/articles/PMC11874400/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The PST repeat region of MDC1 is a tunable multivalent chromatin tethering domain
    1
    1. scibot 11 Mar 2025
      42230

      DOI: 10.1101/2025.01.10.632395

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    pmc.ncbi.nlm.nih.gov/articles/PMC11761366/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting of retrovirus-derived Rtl8a/8b causes late-onset obesity, reduced social response and increased apathy-like behaviour
    1
    1. scibot 11 Mar 2025
      42230

      DOI: 10.1098/rsob.240279

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    pmc.ncbi.nlm.nih.gov/articles/PMC11774587/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rapid human oogonia-like cell specification via transcription factor-directed differentiation
    1
    1. scibot 11 Mar 2025
      42230

      DOI: 10.1038/s44319-025-00371-2

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    pmc.ncbi.nlm.nih.gov/articles/PMC11850904/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model
    1
    1. scibot 11 Mar 2025
      42230

      DOI: 10.1038/s41420-025-02299-x

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    pmc.ncbi.nlm.nih.gov/articles/PMC11763003/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineering Base Changes and Epitope‐Tagged Alleles in Mice Using Cas9 RNA‐Guided Nuclease
    1
    1. scibot 11 Mar 2025
      42230

      DOI: 10.1002/cpz1.70109

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    pmc.ncbi.nlm.nih.gov/articles/PMC11856344/
  27. Feb 2025
  28. www.nature.com www.nature.com
    Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation
    1
    1. scibot 27 Feb 2025
      RRID:Addgene_42230

      DOI: 10.1038/s41467-025-56711-2

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    nature.com/articles/s41467-025-56711-2
  29. www.sciencedirect.com www.sciencedirect.com
    Functional rescue of F508del-CFTR through revertant mutations introduced by CRISPR base editing
    1
    1. scibot 27 Feb 2025
      RRID:Addgene_42230

      DOI: 10.1016/j.ymthe.2025.01.011

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    sciencedirect.com/science/article/pii/S1525001625000152
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pioneer factor GATA6 promotes colorectal cancer through 3D genome regulation
    1
    1. scibot 18 Feb 2025
      42230

      DOI: 10.1126/sciadv.ads4985

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    pmc.ncbi.nlm.nih.gov/articles/PMC11804904/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3
    1
    1. scibot 18 Feb 2025
      42230

      DOI: 10.1038/s41467-025-56444-2

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    pmc.ncbi.nlm.nih.gov/articles/PMC11802746/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma
    1
    1. scibot 18 Feb 2025
      plasmid_42230

      DOI: 10.1038/s41467-025-56632-0

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    pmc.ncbi.nlm.nih.gov/articles/PMC11788431/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Construction of a TAT-Cas9-EGFP Site-Specific Integration Eukaryotic Cell Line Using Efficient PEG10 Modification
    1
    1. scibot 16 Feb 2025
      42230

      DOI: 10.3390/ijms26031331

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    pmc.ncbi.nlm.nih.gov/articles/PMC11818622/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transdermal microneedle-assisted ultrasound-enhanced CRISPRa system to enable sono-gene therapy for obesity
    1
    1. scibot 16 Feb 2025
      PX330

      DOI: 10.1038/s41467-025-56755-4

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    pmc.ncbi.nlm.nih.gov/articles/PMC11811159/
  35. onlinelibrary.wiley.com onlinelibrary.wiley.com
    MCAM Expression Facilitates Melanoma–Endothelial Interactions and Promotes Metastatic Disease Progression
    1
    1. scibot 14 Feb 2025
      Plasmid_42230

      DOI: 10.1111/exd.70059

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    onlinelibrary.wiley.com/doi/10.1111/exd.70059
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PICH impacts the spindle assembly checkpoint via its DNA translocase and SUMO-interaction activities
    1
    1. scibot 11 Feb 2025
      RRID:Addgene_42230

      DOI: 10.26508/lsa.202403140

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    pmc.ncbi.nlm.nih.gov/articles/PMC11806350/
  37. www.biorxiv.org www.biorxiv.org
    Elevated Ubiquitin Phosphorylation by PINK1 Contributes to Proteasomal Impairment and Promotes Neurodegeneration
    1
    1. scibot 07 Feb 2025
      RRID: Addgene 42230

      DOI: 10.1101/2024.10.18.619025

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    biorxiv.org/content/10.1101/2024.10.18.619025v1
  38. Jan 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Recombinant Marek’s disease virus expressing VP1 and VP2 proteins provides robust immune protection against chicken infectious anemia virus
    1
    1. scibot 27 Jan 2025
      pX330

      DOI: 10.3389/fmicb.2024.1515415

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    pmc.ncbi.nlm.nih.gov/articles/PMC11743625/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease
    1
    1. scibot 27 Jan 2025
      42230

      DOI: 10.14814/phy2.70191

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    pmc.ncbi.nlm.nih.gov/articles/PMC11738646/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pol II degradation activates cell death independently from the loss of transcription
    1
    1. scibot 27 Jan 2025
      Addgene

      DOI: 10.1101/2024.12.09.627542

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    pmc.ncbi.nlm.nih.gov/articles/PMC11661175/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The role of KLF4 in human primordial germ cell development
    1
    1. scibot 27 Jan 2025
      42230

      DOI: 10.1098/rsob.240214

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    pmc.ncbi.nlm.nih.gov/articles/PMC11750398/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell cycle progression of under-replicated cells
    1
    1. scibot 27 Jan 2025
      42230

      DOI: 10.1093/nar/gkae1311

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    pmc.ncbi.nlm.nih.gov/articles/PMC11707533/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pervasive RNA-binding protein enrichment on TAD boundaries regulates TAD organization
    1
    1. scibot 27 Jan 2025
      42230

      DOI: 10.1093/nar/gkae1271

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    pmc.ncbi.nlm.nih.gov/articles/PMC11705077/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Generation and propagation of high fecundity gene edited fine wool sheep by CRISPR/Cas9
    1
    1. scibot 27 Jan 2025
      42230

      DOI: 10.1038/s41598-025-86592-w

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    pmc.ncbi.nlm.nih.gov/articles/PMC11747170/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations
    1
    1. scibot 27 Jan 2025
      42230

      DOI: 10.1038/s41588-024-02039-4

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    pmc.ncbi.nlm.nih.gov/articles/PMC11735402/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol for generating splice isoform-specific mouse mutants using CRISPR-Cas9 and a minigene splicing reporter
    1
    1. scibot 27 Jan 2025
      42230

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  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Exocyst complex component 1 (Exoc1) loss in dormant oocyte disrupts c-KIT and growth differentiation factor (GDF9) subcellular localization and causes female infertility in mice
    1
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  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optimizing approaches for targeted integration of transgenic cassettes by integrase-mediated cassette exchange in mouse and human stem cells
    1
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  50. www.sciencedirect.com www.sciencedirect.com
    Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell function
    2
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      Addgene #42230

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  51. elifesciences.org elifesciences.org
    Elevated Ubiquitin Phosphorylation by PINK1 Contributes to Proteasomal Impairment and Promotes Neurodegeneration
    1
    1. scibot 09 Jan 2025
      plasmid_42230

      DOI: 10.7554/eLife.103945.1

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  52. Dec 2024
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor Intrinsic Immunogenicity Suppressor SETDB1 Worsens the Prognosis of Patients with Hepatocellular Carcinoma
    1
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  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cas12f1 gene drives propagate efficiently in herpesviruses and induce minimal resistance
    1
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  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A temperature-sensitive and less immunogenic Sendai virus for efficient gene editing
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  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The prolyl isomerase FKBP11 is a secretory translocon accessory factor
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  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Adaptor protein 3BP2 regulates gene expression in addition to the ubiquitination and proteolytic activity of MALT1 in dectin-1–stimulated cells
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  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The glucocorticoid receptor potentiates aldosterone-induced transcription by the mineralocorticoid receptor
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  59. www.sciencedirect.com www.sciencedirect.com
    PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress
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    sciencedirect.com/science/article/pii/S2211124724014177
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular details and phospho-regulation of the CENP-T-Mis12 complex interaction during mitosis in DT40 cells
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      plasmid_42230

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  61. www.sciencedirect.com www.sciencedirect.com
    OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase
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    sciencedirect.com/science/article/pii/S2211124724013895
  62. Nov 2024
  63. www.sciencedirect.com www.sciencedirect.com
    Impaired pheromone detection and abnormal sexual behavior in female mice deficient for ancV1R
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    sciencedirect.com/science/article/pii/S0960982224015045
  64. www.sciencedirect.com www.sciencedirect.com
    Endogenous oncogenic KRAS expression increases cell proliferation and motility in near-diploid hTERT RPE-1 cells
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    sciencedirect.com/science/article/pii/S0021925824019100
  65. 52.53.155.43 52.53.155.43
    Ghazizadeh et al-100319-html.html
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    1. scibot 19 Nov 2024
      plasmid_42230

      DOI: 10.1161/circulationaha.119.044268

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  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chromatin protein complexes involved in gene repression in lamina-associated domains
    2
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  67. Oct 2024
  68. www.sciencedirect.com www.sciencedirect.com
    CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neoteny
    2
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  69. Sep 2024
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins
    1
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      Addgene

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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis
    1
    1. scibot 29 Sep 2024
      PX330

      DOI: 10.7554/eLife.92195

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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fatty acid–binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2
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      pX-330

      DOI: 10.1016/j.ebiom.2024.105281

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  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct functions of PAXX and MRI during chromosomal end joining
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of the ITGB1 gene attenuates crystalline silica-induced pulmonary fibrosis via epithelial-mesenchymal transformation
    1
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      pX330-U6-Chimeric_BB-CBh-hSpCas9

      DOI: 10.1590/1414-431X2024e13486

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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CyCoNP lncRNA establishes cis and trans RNA–RNA interactions to supervise neuron physiology
    1
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      PX330

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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual-specificity phosphatases 13 and 27 as key switches in muscle stem cell transition from proliferation to differentiation
    1
    1. scibot 28 Sep 2024
      px330-U6-Chimeric_BB-CBh-hSpCas9

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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyper-recombination in ribosomal DNA is driven by long-range resection-independent RAD51 accumulation
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      plasmid_42230

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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    When less is more – a fast TurboID knock-in approach for high-sensitivity endogenous interactome mapping
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      plasmid_42230

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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HSF1 is required for cellular adaptation to daily temperature fluctuations
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      42230

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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tuberculosis in otherwise healthy adults with inherited TNF deficiency
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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Electrophysiology of Human iPSC-derived Vascular Smooth Muscle Cells and Cell-autonomous Consequences of Cantú Syndrome Mutations
    1
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      Addgene_42230

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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A suite of genome-engineered hepatic cells provides novel insights into the spatiotemporal metabolism of apolipoprotein B and apolipoprotein B–containing lipoprotein secretion
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Senataxin RNA/DNA helicase promotes replication restart at co-transcriptional R-loops to prevent MUS81-dependent fork degradation
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      plasmid_42

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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterising replisome disassembly in human cells
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      42230

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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator
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  87. www.sciencedirect.com www.sciencedirect.com
    Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation
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      Cat# 42230

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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPRi with barcoded expression reporters dissects regulatory networks in human cells
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      42230

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  89. www.nature.com www.nature.com
    Activation of the NLRP1B inflammasome by caspase-8
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      plasmid_42230

      DOI: 10.1038/s42003-024-06882-3

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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alternative splicing coupled to nonsense-mediated decay coordinates downregulation of non-neuronal genes in developing mouse neurons
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      plasmid_42

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  91. www.sciencedirect.com www.sciencedirect.com
    The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization
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      RRID:Addgene_42230

      DOI: 10.1016/j.celrep.2024.114689

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  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation
    1
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      Addgene, #42230

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  93. Aug 2024
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blockage of BCL-XL overcomes venetoclax resistance across BCL2+ lymphoid malignancies irrespective of BIM status
    1
    1. scibot 26 Aug 2024
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  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions
    1
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      42230

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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-nucleosome imaging unveils that condensins and nucleosome–nucleosome interactions differentially constrain chromatin to organize mitotic chromosomes
    1
    1. scibot 26 Aug 2024
      42230

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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular Basis for the Calcium-Dependent Activation of the Ribonuclease EndoU
    1
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      Addgene_42230

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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RECON gene disruption enhances host resistance to enable genome-wide evaluation of intracellular pathogen fitness during infection
    1
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  99. www.sciencedirect.com www.sciencedirect.com
    BEAM: A combinatorial recombinase toolbox for binary gene expression and mosaic genetic analysis
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  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer
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      Addgene_42230

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  101. www.sciencedirect.com www.sciencedirect.com
    Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes
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  102. www.sciencedirect.com www.sciencedirect.com
    Generation of a fluorescent hESC reporter line (Kle033-A-1) for the isolation of distinct midbrain progenitor cell types
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    1. scibot 21 Aug 2024
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Axo-axonic synaptic input drives homeostatic plasticity by tuning the axon initial segment structurally and functionally
    1
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  104. onlinelibrary.wiley.com onlinelibrary.wiley.com
    SNX32 Regulates Sorting and Trafficking of Activated EGFR to the Lysosomal Degradation Pathway
    1
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      plasmid_42230

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  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis
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  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A mechanistic study on the tolerance of PAM distal end mismatch by SpCas9
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      plasmid_42230

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  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel chemical genetic approach reveals paralog-specific role of ERK1/2 in mouse embryonic stem cell fate control
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      plasmid_42230

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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinesins regulate the heterogeneity in centrosome clustering after whole-genome duplication
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      plasmid_42230

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  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Golgi pH homeostasis stabilizes the lysosomal membrane through N-glycosylation of membrane proteins
    1
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      42230

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  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ki-67 is necessary during DNA replication for fork protection and genome stability
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      42230

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  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity
    2
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      42230

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  112. 52.53.155.43 52.53.155.43
    Method of Monitoring 26S Proteasome in the Cells Revealed the Crucial Role of PSMA3 C-terminus in 26S Integrity
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      RRID:  Addgene_42230

      DOI: 10.20944/preprints202305.1610.v1

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  113. Jul 2024
  114. www.sciencedirect.com www.sciencedirect.com
    Generation of MBP-tdTomato reporter human induced pluripotent stem cell line for live myelin visualization
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      RRID:Addgene_42230

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  115. www.sciencedirect.com www.sciencedirect.com
    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
    2
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      AddgeneCat# 42230

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    sciencedirect.com/science/article/pii/S2211124724007939
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9
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      RRID:Addgene_42230

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  117. Jun 2024
  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery and gene editing in primary human cells
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      42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC11092779/
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells
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      plasmid_42230

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  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of DNA-binding domains of CLOCK–BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells
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      42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC11161756/
  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mode of SUV420H2 heterochromatin localization through multiple HP1 binding motifs in the heterochromatic targeting module
    1
    1. scibot 15 Jun 2024
      42,230

      DOI: 10.1111/gtc.13109

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  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An antifouling membrane-fusogenic liposome for effective intracellular delivery in vivo
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      42230

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  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ciliary tip actin dynamics regulate photoreceptor outer segment integrity
    1
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  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A global gene regulatory program and its region-specific regulator partition neurons into commissural and ipsilateral projection types
    1
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pseudopregnant mice generated from Piwil1 deficiency sterile mice
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      Plasmid_42230

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  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FokI-RYdCas9 Mediates Nearly PAM-Less and High-Precise Gene Editing in Human Cells
    1
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      plasmid_42230

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  128. 52.53.155.43 52.53.155.43
    2024.05.31.596483v1.full-html.html
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  129. www.sciencedirect.com www.sciencedirect.com
    Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression
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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic movement of the Golgi unit and its glycosylation enzyme zones
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  131. May 2024
  132. www.biorxiv.org www.biorxiv.org
    Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer
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      plasmid_42230

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  133. www.sciencedirect.com www.sciencedirect.com
    Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion
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      plasmid_42230

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      RRID:Addgene_4223031

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  134. www.biorxiv.org www.biorxiv.org
    Mammalian RNAi represses pericentromeric lncRNAs to maintain genome stability
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      RRID:Addgene_42230

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    biorxiv.org/content/10.1101/2024.05.09.593425v1
  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD74 supports accumulation and function of regulatory T cells in tumors
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      42230

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  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HIF-1α participates in the regulation of S100A16-HRD1-GSK3β/CK1α pathway in renal hypoxia injury
    1
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  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy
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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Coregulation of NDC80 Complex Subunits Determines the Fidelity of the Spindle-Assembly Checkpoint and Mitosis
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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    WNT5B drives osteosarcoma stemness, chemoresistance and metastasis
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  140. Apr 2024
  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Linear interaction between replication and transcription shapes DNA break dynamics at recurrent DNA break Clusters
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  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria
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  143. rupress.org rupress.org
    Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization
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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptomic profiling across human serotonin neuron differentiation via the FEV reporter system
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  145. www.nature.com www.nature.com
    Luciferase- and HaloTag-based reporter assays to measure small-molecule-induced degradation pathway in living cells
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  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IntAct: A nondisruptive internal tagging strategy to study the organization and function of actin isoforms
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  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma
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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular basis promoting centriole triplet microtubule assembly
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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oligomerization mediated by the D2 domain of DTX3L is critical for DTX3L‐PARP9 reading function of mono‐ADP‐ribosylated androgen receptor
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  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication
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  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons
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  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport
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  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells
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  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The impact of canonical Wnt transcriptional repressors TLE3 and TLE4 on postsynaptic transcription at the neuromuscular junction
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  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer’s Disease
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  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
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  158. www.sciencedirect.com www.sciencedirect.com
    Generation of human cerebral organoids with a structured outer subventricular zone
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  159. Mar 2024
  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure and function of Semaphorin-5A glycosaminoglycan interactions
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  161. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mycobacterium tuberculosis inhibits METTL14-mediated m6A methylation of Nox2 mRNA and suppresses anti-TB immunity
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  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The genetically modified human foreskin fibroblast cell line (YhFF#8) stably expressing Cas9 gene: A lab resource report
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  163. onlinelibrary.wiley.com onlinelibrary.wiley.com
    An oocyte-specific Cas9-expressing mouse for germline CRISPR/Cas9-mediated genome editing
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  164. link.springer.com link.springer.com
    Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
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  165. www.nature.com www.nature.com
    Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species
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  166. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous ALX1 knockout human embryonic stem cell line (WAe001-A-060) by a CRISPR/Cas9 system
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation
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  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of Fel d 1 chain 2 genome-edited cats by CRISPR-Cas9 system
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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
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  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prediction and validation of circulating G-quadruplexes as a novel biomarker in colorectal cancer
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  171. www.nature.com www.nature.com
    Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis
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  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DJ-1 protects proteins from acylation by catalyzing the hydrolysis of highly reactive cyclic 3-phosphoglyceric anhydride
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  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells
    1
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  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of protein kinase C increases Prdm14 level to promote self-renewal of embryonic stem cells through reducing Suv39h-induced H3K9 methylation
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      pX330-U6-Chimeric_BB-CBh-hSpCas9

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  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism
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  176. www.sciencedirect.com www.sciencedirect.com
    SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A humanized mouse model for adeno-associated viral gene therapy
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  178. www.sciencedirect.com www.sciencedirect.com
    LncRNA Litchi is a Regulator for Harmonizing Maturity and Resilient Functionality in Spinal Motor Neurons
    2
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
    1
    1. scibot 06 Mar 2024
      RRID:Addgene_42230

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  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis
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      DOI: 10.1016/j.celrep.2023.113637

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    ncbi.nlm.nih.gov/pmc/articles/PMC10883656/
  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10899107/
  182. Feb 2024
  183. www.biorxiv.org www.biorxiv.org
    Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes
    1
    1. scibot 29 Feb 2024
      pX330-U6-Chimeric_BB-CBh-hSpCas9

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    biorxiv.org/content/10.1101/2024.02.05.578969v1
  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Undetectable off-target effects induced by FokI catalytic domain in mouse embryos
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      plasmid_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC10877887/
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence
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    1. scibot 21 Feb 2024
      pX330-U6-Chimeric_BB-CBh-hSpCas9

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873425/
  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA m6A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo
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    1. scibot 21 Feb 2024
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  187. www.sciencedirect.com www.sciencedirect.com
    Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
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    sciencedirect.com/science/article/pii/S1097276524000893
  188. www.biorxiv.org www.biorxiv.org
    Post-synaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles
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    1. scibot 15 Feb 2024
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  189. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin
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      DOI: 10.1101/2024.02.06.579191

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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BCL-XL regulates the timing of mitotic apoptosis independently of BCL2 and MCL1 compensation
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  191. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An ovalbumin fusion strategy to increase recombinant protein secretion in chicken eggs
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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
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    ncbi.nlm.nih.gov/pmc/articles/PMC10784283/
  193. www.sciencedirect.com www.sciencedirect.com
    CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs
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    sciencedirect.com/science/article/pii/S1097276524000078
  194. Jan 2024
  195. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Methodology to Create Auxin-Inducible Degron Tagging System to Control Expression of a Target Protein in Mammalian Cell Lines
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      https://www.addgene.org/42230/

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    ncbi.nlm.nih.gov/pmc/articles/PMC10804242/
  196. www.sciencedirect.com www.sciencedirect.com
    Generation of a patient-specific iPSC cell line with cardiac arrhythmias and dilated cardiomyopathy (CBRCULi016-A), an isogenic control (CBRCULi016-A-1), and a paternal control (CBRCULi017-A)
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    sciencedirect.com/science/article/pii/S1873506124000060
  197. Dec 2023
  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Altered Phenotypes of Breast Epithelial × Breast Cancer Hybrids after ZEB1 Knock-Out
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    1. scibot 28 Dec 2023
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      DOI: 10.3390/ijms242417310

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    ncbi.nlm.nih.gov/pmc/articles/PMC10744253/
  199. www.sciencedirect.com www.sciencedirect.com
    Highly cooperative chimeric super-SOX induces naive pluripotency across species
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    sciencedirect.com/science/article/pii/S1934590923004022
  200. link.springer.com link.springer.com
    Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation
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      RRID:Addgene_42230

      DOI: 10.1038/s41467-023-43896-7

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  201. Nov 2023
  202. www.sciencedirect.com www.sciencedirect.com
    Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth
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    1. scibot 22 Nov 2023
      plasmid_42230

      DOI: 10.1016/j.cell.2023.10.026

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    sciencedirect.com/science/article/pii/S0092867423011777
  203. Oct 2023
  204. www.sciencedirect.com www.sciencedirect.com
    The intrinsically disordered region of eIF5B stimulates IRES usage and nucleates biological granule formation
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      plasmid_42230

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    sciencedirect.com/science/article/pii/S2211124723012950
  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for auxin-inducible depletion of the RNA-binding protein PTBP1 in mouse embryonic stem cells
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    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.xpro.2023.102644

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  206. dx.doi.org dx.doi.org
    Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction
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      RRID:Addgene_42230

      DOI: 10.1093/nar/gkad863

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  207. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LINE-1 activation in the cerebellum drives ataxia
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    1. scibot 20 Oct 2023
      Addgene #42230

      DOI: 10.1016/j.neuron.2022.08.011

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      DOI: 10.1016/j.neuron.2022.08.011

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    ncbi.nlm.nih.gov/pmc/articles/PMC9588660/
  208. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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    1. scibot 06 Oct 2023
      plasmid_42230

      DOI: 10.1016/j.celrep.2023.112845

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    ncbi.nlm.nih.gov/pmc/articles/PMC10521973/
  209. www.sciencedirect.com www.sciencedirect.com
    ZEB2 and MEIS1 independently contribute to hematopoiesis via early hematopoietic enhancer activation
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      DOI: 10.1016/j.isci.2023.107893

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    sciencedirect.com/science/article/pii/S2589004223019703