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Integrative multiomic analysis links TDP-43-driven splicing defects to cascading proteomic disruption of ALS/FTD pathways

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1. scibot 14 Oct 2025
  
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  Addgene_43860
  
  DOI: 10.1101/2025.09.29.679403
  
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biorxiv.org/content/10.1101/2025.09.29.679403v1
Sep 2025
link.springer.com link.springer.com

Cohesin regulation of genome organization in mature granule neurons in the mouse cerebellum

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1. scibot 30 Sep 2025
  
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  Addgene_43860
  
  DOI: 10.1186/s13072-025-00625-2
  
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link.springer.com/article/10.1186/s13072-025-00625-2
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A streamlined base editor engineering strategy to reduce bystander editing

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1. scibot 03 Sep 2025
  
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  RRID:Addgene_43860
  
  DOI: 10.1038/s41467-025-63609-6
  
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nature.com/articles/s41467-025-63609-6
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Epigenetic editing and epi-drugs: a combination strategy to simultaneously target KDM4 as a novel anticancer approach

1
1. scibot 20 Jul 2025
  
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  plasmid_43860
  
  DOI: 10.1186/s13148-025-01913-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12177974/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abundance

1
1. scibot 14 Jun 2025
  
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  plasmid_43860
  
  DOI: 10.1371/journal.pgen.1011677
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12148233/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The antibacterial factor APOL3 couples lysosomal damage to mitochondrial DNA efflux and type I IFN induction

1
1. scibot 14 Jun 2025
  
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  Addgene_43860
  
  DOI: 10.1101/2025.05.16.654477
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12139963/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

MSH2 is not required for either maintenance of DNA methylation or repeat contraction at the FMR1 locus in fragile X syndrome or the FXN locus in Friedreich’s ataxia

1
1. scibot 21 May 2025
  
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  plasmid_43860
  
  DOI: 10.1186/s13072-025-00588-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12036138/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Utility of the Base Editing System for Introducing Drug-Resistant Gene Mutations Into Human Leukemia Cellular Models

1
1. scibot 17 May 2025
  
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  43860
  
  DOI: 10.7759/cureus.81889
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12060998/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SOX9 haploinsufficiency reveals SOX9-Noggin interaction in BMP-SMAD signaling pathway in chondrogenesis

1
1. scibot 11 Mar 2025
  
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  Addgene_43860
  
  DOI: 10.1007/s00018-025-05622-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11872873/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

β-catenin mediates endodermal commitment of human ES cells via distinct transactivation functions

1
1. scibot 18 Aug 2024
  
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  Addgene_43860
  
  DOI: 10.1186/s13578-024-01279-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11267888/
Jul 2024
www.biorxiv.org www.biorxiv.org

Reduced SH3RF3 may protect against Alzheimer’s disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling

1
1. scibot 03 Jul 2024
  
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  RRID:Addgene_43860
  
  DOI: 10.1101/2024.06.23.600281
  
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biorxiv.org/content/10.1101/2024.06.23.600281v1
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning

1
1. scibot 30 Jun 2024
  
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  43860
  
  DOI: 10.7554/eLife.85560
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11189632/
May 2024
www.sciencedirect.com www.sciencedirect.com

Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization

1
1. scibot 03 May 2024
  
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  AddgeneCat #43860
  
  DOI: 10.1016/j.devcel.2024.04.012
  
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sciencedirect.com/science/article/pii/S1534580724002375
Apr 2024
www.sciencedirect.com www.sciencedirect.com

Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons

1
1. scibot 16 Apr 2024
  
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  AddgeneCat#43860; http://n2t.net/addgene:43860; RRID:Addgene_43860
  
  DOI: 10.1016/j.stem.2024.03.013
  
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sciencedirect.com/science/article/pii/S1934590924000948
Mar 2024
www.sciencedirect.com www.sciencedirect.com

The Y49H cytochrome c variant enhances megakaryocytic maturation of K-562 cells

1
1. scibot 29 Mar 2024
  
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  RRID:Addgene_43860
  
  DOI: 10.1016/j.bbadis.2024.167134
  
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sciencedirect.com/science/article/pii/S0925443924001236
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of β-catenin stability

1
1. scibot 17 Mar 2024
  
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  plasmid_43860
  
  DOI: 10.1101/2024.02.02.578552
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10896346/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RTF2 controls replication repriming and ribonucleotide excision at the replisome

1
1. scibot 06 Mar 2024
  
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  RRID:Addgene_43860
  
  DOI: 10.1038/s41467-024-45947-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10908796/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cellular Targets and Lysine Selectivity of the HERC5 ISG15 Ligase

1
1. scibot 03 Feb 2024
  
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  RRID:Addgene_43860
  
  DOI: 10.1016/j.isci.2024.108820
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10831901/
May 2023
www.biorxiv.org www.biorxiv.org

Identification of B56alpha, B56gamma; and BAP1 as PRR14L binding partners

2
1. scibot 18 May 2023
  
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  plasmid MLM3636
  
  DOI: 10.1101/2023.04.29.538809
  
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  Curator: @anisehay
  
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2. scibot 18 May 2023
  
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  RRID:Addgene_43860
  
  DOI: 10.1101/2023.04.29.538809
  
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biorxiv.org/content/10.1101/2023.04.29.538809v1
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease

1
1. scibot 13 May 2023
  
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  plasmid_43860
  
  DOI: 10.1096/fj.202300223R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202300223R
Apr 2023
www.sciencedirect.com www.sciencedirect.com

Generation of two induced pluripotent stem cell lines with heterozygous and homozygous amyotrophic lateral sclerosis-causing mutation P525L (c.1574 C>T) in FUS gene

1
1. scibot 26 Apr 2023
  
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  Addgene_43860
  
  DOI: 10.1016/j.scr.2023.103103
  
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sciencedirect.com/science/article/pii/S1873506123000892
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RTF2 controls replication repriming and ribonucleotide excision at the replisome

1
1. scibot 12 Apr 2023
  
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  RRID:Addgene_43860
  
  DOI: 10.1101/2023.03.13.532415
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10054921/
Mar 2023
www.sciencedirect.com www.sciencedirect.com

Generation of two induced pluripotent stem cell lines with heterozygous and homozygous amyotrophic lateral sclerosis-causing mutation R521G (c.1561C > G) in FUS gene

1
1. scibot 28 Mar 2023
  
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  Addgene_43860
  
  DOI: 10.1016/j.scr.2023.103078
  
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sciencedirect.com/science/article/pii/S1873506123000648
Feb 2023
www.sciencedirect.com www.sciencedirect.com

The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia

1
1. scibot 09 Feb 2023
  
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  Plasmid_43860
  
  DOI: 10.1016/j.isci.2023.105993
  
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sciencedirect.com/science/article/pii/S2589004223000706
Oct 2022
www.sciencedirect.com www.sciencedirect.com

Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex

1
1. scibot 07 Oct 2022
  
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  Addgene Cat#43860
  
  DOI: 10.1016/j.molcel.2022.09.006
  
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sciencedirect.com/science/article/pii/S1097276522008954
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways

1
1. scibot 17 Aug 2022
  
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  RRID:Addgene_43860
  
  DOI: 10.1016/j.celrep.2022.111181
  
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sciencedirect.com/science/article/pii/S2211124722009949
Jan 2022
www.embopress.org www.embopress.org

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency

1
1. scibot 13 Jan 2022
  
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  RRID:Addgene_43860
  
  DOI: 10.15252/embj.2021109108
  
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embopress.org/doi/abs/10.15252/embj.2021109108
Nov 2021
mct.aacrjournals.org mct.aacrjournals.org

SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents

1
1. scibot 24 Nov 2021
  
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  plasmid_43860
  
  DOI: 10.1158/1535-7163.MCT-21-0089
  
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mct.aacrjournals.org/content/20/11/2151
Sep 2021
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Generation of two induced pluripotent stem cell lines with heterozygous and homozygous GAG deletion in TOR1A gene from a healthy hiPSC line

1
1. scibot 14 Sep 2021
  
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  Addgene_43860
  
  DOI: 10.1016/j.scr.2021.102536
  
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sciencedirect.com/science/article/pii/S1873506121003834
Aug 2021
www.sciencedirect.com www.sciencedirect.com

CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons

1
1. scibot 04 Aug 2021
  
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  Plasmid_43860
  
  DOI: 10.1016/j.molcel.2017.08.008
  
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sciencedirect.com/science/article/pii/S1097276517306056
Jun 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer

1
1. scibot 02 Jun 2021
  
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  plasmid_43860
  
  DOI: 10.1002/ctm2.454
  
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onlinelibrary.wiley.com/doi/10.1002/ctm2.454
May 2021
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Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk

1
1. scibot 09 May 2021
  
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  Addgene_43860
  
  DOI: 10.1016/j.stem.2020.12.001
  
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sciencedirect.com/science/article/pii/S1934590920305853
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Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance

1
1. scibot 07 May 2021
  
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  plasmid_43860
  
  DOI: 10.1016/j.molcel.2020.06.037
  
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sciencedirect.com/science/article/pii/S1097276520304664
Apr 2021
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STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma

1
1. scibot 30 Apr 2021
  
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  RRID:Addgene_43860
  
  DOI: 10.1016/j.ccell.2021.04.001
  
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sciencedirect.com/science/article/pii/S1535610821002087
Mar 2021
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SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration

1
1. scibot 22 Mar 2021
  
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  plasmid_43860
  
  DOI: 10.1016/j.expneurol.2021.113636
  
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sciencedirect.com/science/article/pii/S0014488621000418
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish

1
1. scibot 09 Mar 2021
  
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  Addgene_43860
  
  DOI: 10.15252/embr.202050287
  
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URL

ncbi.nlm.nih.gov/pmc/articles/PMC7332985/
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion

1
1. scibot 23 Sep 2020
  
  in Public
  
  RRID:Addgene_43860
  
  DOI: 10.1016/j.celrep.2019.12.037
  
  Resource: RRID:Addgene_43860
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_43860
  
  What is this?
  
  RRID:Addgene_43860 RRIDCUR:Validated
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RRID:Addgene_43860

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S2211124719316948
academic.oup.com academic.oup.com

A point mutation in the nuclease domain of MLH3 eliminates repeat expansions in a mouse stem cell model of the Fragile X-related disorders

1
1. scibot 09 Sep 2020
  
  in Public
  
  RRID:Addgene_43860
  
  DOI: 10.1093/nar/gkaa573
  
  Resource: RRID:Addgene_43860
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_43860
  
  What is this?
  
  RRIDCUR:Validated RRID:Addgene_43860
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RRID:Addgene_43860

RRIDCUR:Validated

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scibot

URL

academic.oup.com/nar/article/doi/10.1093/nar/gkaa573/5867105
www.sciencedirect.com www.sciencedirect.com

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase

1
1. scibot 06 Sep 2020
  
  in Public
  
  Addgene_43860
  
  DOI: 10.1016/j.celrep.2020.107922
  
  Resource: RRID:Addgene_43860
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_43860
  
  What is this?
  
  RRIDCUR:Validated RRID:Addgene_43860
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RRID:Addgene_43860

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720309037
Jan 2020
www.sciencedirect.com www.sciencedirect.com

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

1
1. scibot 13 Jan 2020
  
  in Public
  
  Addgene_43860
  
  DOI: 10.1016/j.neuron.2019.07.010
  
  Resource: RRID:Addgene_43860
  
  Curator: @ethanbadger
  
  SciCrunch record: Addgene_43860
  
  What is this?
  
  RRID:Addgene_43860 RRIDCUR:Validated
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RRID:Addgene_43860

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S0896627319306361
www.nature.com www.nature.com

Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_43860
  
  DOI: 10.1038/s41598-019-52543-5
  
  Resource: RRID:Addgene_43860
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_43860
  
  What is this?
  
  RRID:Addgene_43860 RRIDCUR:Validated
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RRID:Addgene_43860

RRIDCUR:Validated

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scibot

URL

nature.com/articles/s41598-019-52543-5