123 Matching Annotations
  1. Aug 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cyanine-modified ssODNs enhance CRISPR-Cas9 HDR in stem cell embryo models via chromatin and chemical modulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13392270/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A cargo receptor entrapment complex is a therapeutic node for genetically and clinically distinct proteinopathies
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13404660/
  4. Jul 2026
  5. www.sciencedirect.com www.sciencedirect.com
    FGF21 synergizes with leptin to counteract obesity-related metabolic comorbidities by reversing hepatic leptin resistance
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    sciencedirect.com/science/article/pii/S1550413126002470
  6. www.science.org www.science.org
    Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion
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    science.org/doi/10.1126/science.aec6299
  7. Jun 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oxidative DNA lesions destabilize centromeres and drive chromosome instability
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    pmc.ncbi.nlm.nih.gov/articles/PMC13142297/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies a cytokine-enhancer circuit driving HIF-2α activation in renal cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13178659/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13134964/
  11. Apr 2026
  12. www.sciencedirect.com www.sciencedirect.com
    Unbiased niche labeling maps immune-excluded niche in bone metastasis
    1
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    sciencedirect.com/science/article/pii/S0092867426003983
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RB loss modulates chromatin organization by regulating cohesin-dependent loops and enhancer-promoter interactions
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13103356/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of USP7 destabilizes the noncanonical PRC1.1 complex and induces neuroblastoma differentiation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13082235/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A CRISPR-Cas9 screen Reveals STEEP1 as a Key Host Dependency Factor for Epstein-Barr Virus Latent Membrane Protein 1 Trafficking and Signaling
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13015697/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dissection of Gαs and Hedgehog Signaling Cross-talk Reveals Therapeutic Opportunities to Target Hedgehog-Dependent Tumors
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13055637/
  17. www.nature.com www.nature.com
    X-linked cancer-associated polypeptide (XCP) from lncRNA1456 modulates PHF8 histone demethylase activity to regulate the epigenome, gene expression, and cellular pathways in breast cancer
    1
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    nature.com/articles/s41388-026-03740-w
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reprogramming mRNA localization by targeted RNA-protein interference
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    pmc.ncbi.nlm.nih.gov/articles/PMC12991119/
  19. Mar 2026
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12917913/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CELF2 Promotes Tau Exon 10 Inclusion via Hinge Domain-Mediated Nuclear Condensation, Driving Cognitive Dysfunction in Tauopathy Models
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12869637/
  22. Feb 2026
  23. www.sciencedirect.com www.sciencedirect.com
    NAD+ sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis
    1
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    sciencedirect.com/science/article/pii/S2211124726000070
  24. Jan 2026
  25. www.sciencedirect.com www.sciencedirect.com
    Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML
    1
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    sciencedirect.com/science/article/pii/S155041312600001X
  26. Dec 2025
  27. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    The TIM22 carrier translocase supports cell proliferation by facilitating mitochondrial iron uptake for Fe-S biogenesis
    1
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    sciencedirect.com:5037/science/article/pii/S1097276525009396
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting KRAS Inhibitor–Resistant Pancreatic Cancer with an MUC1-C Antibody–Drug Conjugate
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12703357/
  29. Nov 2025
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    APPswe mutation causes functional deficits in endothelial cells generated by transient ETV2 overexpression in human iPSCs
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12639930/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Conserved mode of nuclear lamina distortion by primate cytomegaloviruses: importance of the pSer22 motif, viral kinase and cis/trans isomerase Pin1 activity
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12578131/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12639036/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Activation of a FOXO3-induced cell cycle arrest regulates ferroptosis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12533257/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lysosome-dependent nutrient scavenging underlies stress adaptation during epithelial-to-mesenchymal transition
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12485954/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12631751/
  36. Sep 2025
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CA-125 as a Biomarker in Renal Medullary Carcinoma: Integrated Molecular Profiling, Functional Characterization, and Prospective Clinical Validation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11913570/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intron retention regulates STAT2 function and predicts immunotherapy response in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12393442/
  39. Aug 2025
  40. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70112
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Drug tolerance and persistence to EGFR inhibitor treatment are mediated by an ILK-SFK-YAP signaling axis in lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12318776/
  42. Jun 2025
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12141477/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutation of SMARCA4 Induces Cancer Cell–Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12127800/
  45. May 2025
  46. dx.doi.org dx.doi.org
    RFX6 regulates human intestinal patterning and function upstream of PDX1
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    dx.doi.org/10.1242/dev.202529
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity in cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11986510/
  48. www.sciencedirect.com www.sciencedirect.com
    Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity
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    sciencedirect.com/science/article/pii/S1074761325001839
  49. Apr 2025
  50. www.sciencedirect.com www.sciencedirect.com
    MLKL activity requires a splicing-regulated, druggable intramolecular interaction
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    sciencedirect.com/science/article/pii/S109727652500259X
  51. Mar 2025
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lethal co-expression intolerance underlies the mutually exclusive expression of ASCL1 and NEUROD1 in SCLC cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11906894/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dissection of Gαs and Hedgehog signaling crosstalk reveals therapeutic opportunities to target adenosine receptor 2b in Hedgehog-dependent tumors
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11888225/
  54. www.nature.com www.nature.com
    Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations
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    nature.com/articles/s41586-024-08533-3
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11882444/
  56. Feb 2025
  57. dx.doi.org dx.doi.org
    Relaxin Modulates the Genomic Actions and Biological Effects of Estrogen in the Myometrium
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    dx.doi.org/10.1210/endocr/bqae123
  58. Jan 2025
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11735390/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RACK1 MARylation regulates translation and stress granules in ovarian cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11702359/
  61. Dec 2024
  62. www.jbc.org www.jbc.org
    Chikungunya virus nonstructural protein 1 is a versatile RNA capping and decapping enzyme
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    jbc.org/article/S0021-9258(23)02443-2/fulltext
  63. Sep 2024
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11411125/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11007937/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RBN-2397, a PARP7 Inhibitor, Synergizes with Paclitaxel to Inhibit Proliferation and Migration of Ovarian Cancer Cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11370341/
  67. Aug 2024
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11300780/
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oncogenic transcription factors instruct promoter-enhancer hubs in individual triple negative breast cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11305386/
  70. Jul 2024
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MUC1-C Dependence for the Progression of Pancreatic Neuroendocrine Tumors Identifies a Druggable Target for the Treatment of This Rare Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11274714/
  72. www.sciencedirect.com www.sciencedirect.com
    Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton
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    sciencedirect.com/science/article/pii/S2211124724008398
  73. Jun 2024
  74. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13672
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pure estrogen receptor antagonists potentiate capecitabine activity in ESR1-mutant breast cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11162492/
  76. May 2024
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11091074/
  78. www.sciencedirect.com www.sciencedirect.com
    Metabolic regulator ERRγ governs gastric stem cell differentiation into acid-secreting parietal cells
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    sciencedirect.com/science/article/pii/S1934590924001437
  79. Apr 2024
  80. www.sciencedirect.com www.sciencedirect.com
    Unprocessed genomic uracil as a source of DNA replication stress in cancer cells
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    sciencedirect.com/science/article/pii/S109727652400282X
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased frequency of CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression without inducing homologous recombination deficiency
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11030533/
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11009390/
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quaking isoforms cooperate to promote the mesenchymal phenotype
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    ncbi.nlm.nih.gov/pmc/articles/PMC10881146/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The DNA Damage Response (DDR) landscape of endometrial cancer defines discrete disease subtypes and reveals therapeutic opportunities
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    ncbi.nlm.nih.gov/pmc/articles/PMC11000323/
  85. Mar 2024
  86. www.sciencedirect.com www.sciencedirect.com
    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
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    sciencedirect.com/science/article/pii/S1097276524001758
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Passenger Gene Coamplifications Create Collateral Therapeutic Vulnerabilities in Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10911929/
  88. Feb 2024
  89. www.biorxiv.org www.biorxiv.org
    KDM6A Regulates Immune Response Genes in Multiple Myeloma
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    biorxiv.org/content/10.1101/2024.02.12.579179v1
  90. www.sciencedirect.com www.sciencedirect.com
    Specialized replication mechanisms maintain genome stability at human centromeres
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    sciencedirect.com/science/article/pii/S1097276524000546
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Somatic estrogen receptor α mutations that induce dimerization promote receptor activity and breast cancer proliferation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10760953/
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10770371/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic proximity interaction profiling suggests that YPEL2 is involved in cellular stress surveillance
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    ncbi.nlm.nih.gov/pmc/articles/PMC10804680/
  94. Jan 2024
  95. www.sciencedirect.com www.sciencedirect.com
    BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution
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    sciencedirect.com/science/article/pii/S1097276523010869
  96. Dec 2023
  97. journals.plos.org journals.plos.org
    Functional regulation of the structure-specific endonuclease FEN1 by the human cytomegalovirus protein IE1 suggests a role for the re-initiation of stalled viral replication forks
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    journals.plos.org/plospathogens/article
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF524 directly interacts with telomeric DNA and supports telomere integrity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10716145/
  99. Nov 2023
  100. www.sciencedirect.com www.sciencedirect.com
    Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas
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    sciencedirect.com/science/article/pii/S2211124723014821
  101. www.sciencedirect.com www.sciencedirect.com
    Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
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    sciencedirect.com/science/article/pii/S2211124723014900
  102. www.biorxiv.org www.biorxiv.org
    APC/C prevents non-canonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor-induced arrest
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    biorxiv.org/content/10.1101/2023.11.09.566394v1
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MUC1-C INTEGRATES AEROBIC GLYCOLYSIS WITH SUPPRESSION OF OXIDATIVE PHOSPHORYLATION IN TRIPLE-NEGATIVE BREAST CANCER STEM CELLS
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    ncbi.nlm.nih.gov/pmc/articles/PMC10616323/
  104. Oct 2023
  105. www.sciencedirect.com www.sciencedirect.com
    Lactate activates the mitochondrial electron transport chain independently of its metabolism
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    sciencedirect.com/science/article/pii/S1097276523008006
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Global role of IGF2BP1 in controlling the expression of Wnt/β-catenin-regulated genes in colorectal cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10565211/
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP
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    ncbi.nlm.nih.gov/pmc/articles/PMC10541173/
  108. Sep 2023
  109. dx.doi.org dx.doi.org
    RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells
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    dx.doi.org/10.1093/nar/gkad733
  110. Jun 2023
  111. www.sciencedirect.com www.sciencedirect.com
    An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets
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    sciencedirect.com/science/article/pii/S1535610823002088
  112. May 2023
  113. www.mdpi.com www.mdpi.com
    TGF-β Type I Receptor Signaling in Melanoma Liver Metastases Increases Metastatic Outgrowth
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    mdpi.com/1422-0067/24/10/8676
  114. Mar 2023
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosomal trafficking of the glucose transporter GLUT1 requires sequential regulation by TXNIP and ubiquitin
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    ncbi.nlm.nih.gov/pmc/articles/PMC9986520/
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9975292/
  117. Feb 2023
  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combinatorial Treatment with Poly(ADP-ribose) Polymerase-1 Inhibitors and Cisplatin Attenuates Cervical Cancer Growth Through Fos-Driven Changes in Gene Expression
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  120. Jan 2023
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  122. Nov 2022
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  124. Oct 2022
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  144. Aug 2021
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  147. Jul 2021
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  154. Apr 2021
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  157. Mar 2021
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  160. Feb 2021
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  162. Jan 2021
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  165. Dec 2020
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  167. Sep 2020
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  170. Jan 2020
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