204 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Wnt10b signaling regulates replication stress–induced chromosomal instability in human cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12373720/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12373916/
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    Generation of a PHF19 knockout human embryonic stem cell line by CRISPR/Cas9 system
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    sciencedirect.com/science/article/pii/S1873506125001746
  5. Aug 2025
  6. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225016529-main-html.html
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    52.53.155.43/4f4fe074a3a34390503819ded993b7919366019b/1-s2.0-S2589004225016529-main-html.html
  7. www.biorxiv.org www.biorxiv.org
    Structural basis of an EMC:Spf1 insertase-dislocase complex in the eukaryotic endoplasmic reticulum
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    biorxiv.org/content/10.1101/2025.08.07.669073v1
  8. Jul 2025
  9. www.sciencedirect.com www.sciencedirect.com
    Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects
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    sciencedirect.com/science/article/pii/S0896627325004751
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural insights into the human HRD1 ubiquitin ligase complex
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    pmc.ncbi.nlm.nih.gov/articles/PMC12217079/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcription Factor-Wide Association Studies to Identify Functional SNPs in Alzheimer's Disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11714347/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phase separated condensates of ATRX regulate neural progenitor identity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12259971/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    β-catenin safeguards cell survival via a transcription-independent mechanism during the induction of primitive streak from hESCs
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    pmc.ncbi.nlm.nih.gov/articles/PMC12222672/
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    Liver CYP4A autophagic-lysosomal degradation (ALD): A major role for the autophagic receptor SQSTM1/p62 through an uncommon target interaction site
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    sciencedirect.com/science/article/pii/S0026895X25153212
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural and Functional Characterization of N-Glycanase-1 Pathogenic Variants
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    pmc.ncbi.nlm.nih.gov/articles/PMC12248763/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility
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    pmc.ncbi.nlm.nih.gov/articles/PMC6389287/
  17. www.nature.com www.nature.com
    Generating and characterizing human telencephalic brain organoids from stem cell-derived single neural rosettes
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    nature.com/articles/s41596-025-01197-x
  18. Jun 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LYSET facilitates integration of both the N- and C-terminal transmembrane helices/cytoplasmic domains of GlcNAc-1-phosphotransferase
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    pmc.ncbi.nlm.nih.gov/articles/PMC12005095/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nonreceptor tyrosine kinase ABL1 regulates lysosomal acidification by phosphorylating the ATP6V1B2 subunit of the vacuolar-type H+-ATPase
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    pmc.ncbi.nlm.nih.gov/articles/PMC12087662/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub
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    pmc.ncbi.nlm.nih.gov/articles/PMC12081701/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Pregnane-X receptor regulates steroid synthesis in mouse Leydig cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12088964/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S2589004225009605-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12164204/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Generation of a Mouse Model of Fuchs Endothelial Corneal Dystrophy by Knock-in of CTG Trinucleotide Repeat Expansion in the TCF4 Gene
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    pmc.ncbi.nlm.nih.gov/articles/PMC12151262/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12240685/
  26. May 2025
  27. www.sciencedirect.com www.sciencedirect.com
    Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity
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    sciencedirect.com/science/article/pii/S2211124725005376
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    Multigenerational cell tracking of DNA replication and heritable DNA damage
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    nature.com/articles/s41586-025-08986-0
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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    pmc.ncbi.nlm.nih.gov/articles/PMC12164204/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Med12 cooperates with multiple differentiation signals to facilitate efficient lineage transitions in embryonic stem cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12079664/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AUP1 and UBE2G2 complex targets STING signaling and regulates virus-induced innate immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077101/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213
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    pmc.ncbi.nlm.nih.gov/articles/PMC12075652/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lipid flippases ATP9A and ATP9B form a complex and contribute to the exocytic pathway from the Golgi
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    pmc.ncbi.nlm.nih.gov/articles/PMC12000689/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CLCa mediates a novel cross-talk between Wnt secretion and actin organization
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    pmc.ncbi.nlm.nih.gov/articles/PMC12050421/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CARM1/PRMT4 facilitates XPF–ERCC1 heterodimer assembly and maintains nucleotide excision repair activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12041854/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Emergence of CpG-cluster blanket methylation in aged tissues: a novel signature of epigenomic aging
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    pmc.ncbi.nlm.nih.gov/articles/PMC12065108/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Extracellular vesicles adhere to cells primarily by interactions of integrins and GM1 with laminin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12042775/
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    A specific role for endothelial EPLIN-isoform-regulated actin dynamics in neutrophil transmigration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12053001/
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    UFMylation safeguards human hepatocyte differentiation and liver homeostasis by regulating ribosome dissociation
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    sciencedirect.com/science/article/pii/S2211124725004577
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    Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis
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    sciencedirect.com/science/article/pii/S2211124725004280
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    SLC7A11 is an unconventional H+ transporter in lysosomes
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    sciencedirect.com/science/article/pii/S0092867425004064
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD
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    pmc.ncbi.nlm.nih.gov/articles/PMC12005767/
  43. Apr 2025
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Upregulation of RIG‐I is Critical for Responsiveness to IFN‐α Plus Anti‐PD‐1 in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11926914/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Siglec-15 is a putative receptor for porcine epidemic diarrhea virus infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC11965083/
  46. Mar 2025
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges
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    pmc.ncbi.nlm.nih.gov/articles/PMC11894219/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850942/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions
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    pmc.ncbi.nlm.nih.gov/articles/PMC11844454/
  50. Feb 2025
  51. www.sciencedirect.com www.sciencedirect.com
    Effect of MisMatch repair deficiency on metastasis occurrence in a syngeneic mouse model
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    sciencedirect.com/science/article/pii/S1476558625000247
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MCTS2 and distinct eIF2D roles in uORF-dependent translation regulation revealed by in vitro re-initiation assays
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    pmc.ncbi.nlm.nih.gov/articles/PMC11790910/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss-of-function mutations in the dystonia gene THAP1 impair proteasome function by inhibiting PSMB5 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11811203/
  54. Jan 2025
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cholesterol restriction primes antiviral innate immunity via SREBP1-driven noncanonical type I IFNs
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    pmc.ncbi.nlm.nih.gov/articles/PMC11772592/
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    Ciliopathy-associated missense mutations in IFT140 are tolerated by the inherent resilience of the IFT machinery
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    sciencedirect.com/science/article/pii/S1535947625000143
  57. www.cell.com www.cell.com
    The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A
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    cell.com/cell-reports/fulltext/S2211-1247(24)01438-4
  58. Dec 2024
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular Insights into the Regulation of GNPTAB by TMEM251
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    pmc.ncbi.nlm.nih.gov/articles/PMC11643035/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dissecting the Kaiso binding profile in clear renal cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11657142/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pancreatic agenesis and altered m6A methylation in the pancreas of PDX1-mutant cynomolgus macaques
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    pmc.ncbi.nlm.nih.gov/articles/PMC11668947/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Contributing factors to the oxidation-induced mutational landscape in human cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11666792/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Gradient-Elution Nanoflow Liquid Chromatography Without a Binary Pump: Smoothed Step Gradients Enable Reproducible, Sensitive, and Low-Cost Separations for Single-Cell Proteomics
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    pmc.ncbi.nlm.nih.gov/articles/PMC11667035/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Control of cell proliferation by memories of mitosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11621110/
  65. Nov 2024
  66. www.sciencedirect.com www.sciencedirect.com
    PP2A licenses the FANCD2/FANCI complex for chromosome loading
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    sciencedirect.com/science/article/pii/S2211124724013226
  67. Oct 2024
  68. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Constitutive Androstane Receptor Regulates Germ Cell Homeostasis, Sperm Quality, and Male Fertility via Akt-Foxo1 Pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/advs.202402082
  69. aacrjournals.org aacrjournals.org
    H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
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    aacrjournals.org/cancerdiscovery/article/10/12/1968/2414/H3-3-G34W-Promotes-Growth-and-Impedes
  70. Sep 2024
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unexpected roles for AMPK in the suppression of autophagy and the reactivation of MTORC1 signaling during prolonged amino acid deprivation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11346535/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    One-Step Genetic Modification by Embryonic Doral Aorta Injection of Adenoviral CRISPR/Cas9 Vector in Chicken
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    ncbi.nlm.nih.gov/pmc/articles/PMC11354862/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prostatic lineage differentiation from human embryonic stem cells through inducible expression of NKX3-1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11367998/
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Missense variants in CMS22 patients reveal that PREPL has both enzymatic and nonenzymatic functions
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    ncbi.nlm.nih.gov/pmc/articles/PMC11385081/
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Paxillin phase separation promotes focal adhesion assembly and integrin signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10926639/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell cycle arrest combined with CDK1 inhibition suppresses genome-wide mutations by activating alternative DNA repair genes during genome editing
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    ncbi.nlm.nih.gov/pmc/articles/PMC11416245/
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PGC-based cryobanking, regeneration through germline chimera mating, and CRISPR/Cas9-mediated TYRP1 modification in indigenous Chinese chickens
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    ncbi.nlm.nih.gov/pmc/articles/PMC11399235/
  78. elifesciences.org elifesciences.org
    Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas
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    elifesciences.org/articles/92774
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UBQLN1 links proteostasis and mitochondria function to telomere maintenance in human embryonic stem cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11191273/
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11364545/
  81. Aug 2024
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rit1-TBC1D10B signaling modulates FcγR-mediated phagosome formation in RAW264 macrophages
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    ncbi.nlm.nih.gov/pmc/articles/PMC11291910/
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetalax (Oxyphenisatin acetate, NSC 59687) and bisacodyl Cause Oncosis in Triple Negative Breast Cancer Cell lines by Poisoning Ion Exchange Membrane Protein TRPM4
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    ncbi.nlm.nih.gov/pmc/articles/PMC11322923/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of IRP2-dependent reprogramming of iron metabolism suppresses tumor growth in colorectal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11342626/
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IER3IP1-mutations cause microcephaly by selective inhibition of ER-Golgi transport
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    ncbi.nlm.nih.gov/pmc/articles/PMC11335259/
  86. www.sciencedirect.com www.sciencedirect.com
    Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins
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    sciencedirect.com/science/article/pii/S1097276524006592
  87. www.sciencedirect.com www.sciencedirect.com
    The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network
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    sciencedirect.com/science/article/pii/S2211124724009677
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Using deep learning to decipher the impact of telomerase promoter mutations on the dynamic metastatic morpholome
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    ncbi.nlm.nih.gov/pmc/articles/PMC11288469/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex
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    ncbi.nlm.nih.gov/pmc/articles/PMC10818064/
  90. Jul 2024
  91. www.sciencedirect.com www.sciencedirect.com
    Engineering single-cycle MeV vector for CRISPR-Cas9 gene editing
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    sciencedirect.com/science/article/pii/S2329050124001062
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition
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    ncbi.nlm.nih.gov/pmc/articles/PMC7116740/
  93. Jun 2024
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysfunction of Complementarity Determining Region 1 Encoded by T Cell Receptor Beta Variable Gene Is Potentially Associated with African Swine Fever Virus Infection in Pigs
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    ncbi.nlm.nih.gov/pmc/articles/PMC11205859/
  95. link.springer.com link.springer.com
    CDK5 Deficiency Does not Impair Neuronal Differentiation of Human Induced Pluripotent Stem Cells but Affects Neurite Outgrowth
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    link.springer.com/article/10.1007/s12035-024-04325-y
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interactomic exploration of LRRC8A in volume-regulated anion channels
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    ncbi.nlm.nih.gov/pmc/articles/PMC11193767/
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tissue-intrinsic beta-catenin signals antagonize Nodal-driven anterior visceral endoderm differentiation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11176336/
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FUS reads histone H3K36me3 to regulate alternative polyadenylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11162772/
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pre-hypertrophic chondrogenic enhancer landscape of limb and axial skeleton development
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    ncbi.nlm.nih.gov/pmc/articles/PMC11156918/
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A dynamic in vitro model of Down syndrome neurogenesis with trisomy 21 gene dosage correction
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  221. Apr 2021
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  238. Sep 2020
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  246. Jan 2020
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