126 Matching Annotations
  1. Jul 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition
    1
    1. scibot 15 Jul 2024
      Addgene_48139

      DOI: 10.1038/s41556-020-00626-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC7116740/
  3. Jun 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysfunction of Complementarity Determining Region 1 Encoded by T Cell Receptor Beta Variable Gene Is Potentially Associated with African Swine Fever Virus Infection in Pigs
    1
    1. scibot 30 Jun 2024
      pSpCas9(BB)-2A-Puro

      DOI: 10.3390/microorganisms12061113

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    ncbi.nlm.nih.gov/pmc/articles/PMC11205859/
  5. link.springer.com link.springer.com
    CDK5 Deficiency Does not Impair Neuronal Differentiation of Human Induced Pluripotent Stem Cells but Affects Neurite Outgrowth
    1
    1. scibot 30 Jun 2024
      RRID:Addgene_48139

      DOI: 10.1007/s12035-024-04325-y

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    link.springer.com/article/10.1007/s12035-024-04325-y
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interactomic exploration of LRRC8A in volume-regulated anion channels
    1
    1. scibot 30 Jun 2024
      Plasmid_48139

      DOI: 10.1038/s41420-024-02032-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11193767/
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tissue-intrinsic beta-catenin signals antagonize Nodal-driven anterior visceral endoderm differentiation
    1
    1. scibot 20 Jun 2024
      48139

      DOI: 10.1038/s41467-024-49380-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11176336/
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FUS reads histone H3K36me3 to regulate alternative polyadenylation
    1
    1. scibot 15 Jun 2024
      plasmid_48139

      DOI: 10.1093/nar/gkae184

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    ncbi.nlm.nih.gov/pmc/articles/PMC11162772/
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pre-hypertrophic chondrogenic enhancer landscape of limb and axial skeleton development
    1
    1. scibot 09 Jun 2024
      48139

      DOI: 10.1038/s41467-024-49203-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11156918/
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A dynamic in vitro model of Down syndrome neurogenesis with trisomy 21 gene dosage correction
    1
    1. scibot 09 Jun 2024
      plasmid_48139

      DOI: 10.1126/sciadv.adj0385

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    ncbi.nlm.nih.gov/pmc/articles/PMC11160455/
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Characterization of a Spectrum of Genetic Variants in a Family with Succinic Semialdehyde Dehydrogenase Deficiency
    1
    1. scibot 07 Jun 2024
      48139

      DOI: 10.3390/ijms25105237

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    ncbi.nlm.nih.gov/pmc/articles/PMC11121183/
  12. www.sciencedirect.com www.sciencedirect.com
    DNA-based ForceChrono probes for deciphering single-molecule force dynamics in living cells
    1
    1. scibot 05 Jun 2024
      Addgene48139

      DOI: 10.1016/j.cell.2024.05.008

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      RRID:Addgene_48139 DOI:10.1016/j.cell.2024.05.008
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    sciencedirect.com/science/article/pii/S0092867424005178
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mapping SCA1 regional vulnerabilities reveals neural and skeletal muscle contributions to disease
    1
    1. scibot 03 Jun 2024
      48139

      DOI: 10.1172/jci.insight.176057

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    ncbi.nlm.nih.gov/pmc/articles/PMC11141930/
  14. May 2024
  15. www.sciencedirect.com www.sciencedirect.com
    Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition
    1
    1. scibot 23 May 2024
      RRID:Addgene_48139

      DOI: 10.1016/j.devcel.2024.04.021

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    sciencedirect.com/science/article/pii/S1534580724002971
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis
    2
    1. scibot 19 May 2024
      Plasmid_48139

      DOI: 10.1038/s41467-024-48330-0

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    2. scibot 19 May 2024
      Plasmid_48139

      DOI: 10.1038/s41467-024-48330-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11096184/
  17. 52.53.155.43 52.53.155.43
    jitc-2023-December-11-12--inline-supplementary-material-1-html.html
    2
    1. scibot 17 May 2024
      plasmid_48139

      DOI: 10.1136/jitc-2023-007631

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    2. scibot 02 May 2024
      plasmid_48139

      DOI: 10.1136/jitc-2023-007631

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    52.53.155.43/17adc8dcdfe32fd9d6f43443a5653eac72124dab/jitc-2023-December-11-12--inline-supplementary-material-1-html.html
  18. www.sciencedirect.com www.sciencedirect.com
    Deciphering lineage specification during early embryogenesis in mouse gastruloids using multilayered proteomics
    1
    1. scibot 16 May 2024
      plasmid_48139

      DOI: 10.1016/j.stem.2024.04.017

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    sciencedirect.com/science/article/pii/S1934590924001449
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Validation of positional candidates Rps6ka6 and Pou3f4 for a locus associated with skeletal muscle mass variability
    1
    1. scibot 12 May 2024
      48139

      DOI: 10.1093/g3journal/jkae046

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    ncbi.nlm.nih.gov/pmc/articles/PMC11075558/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inactivation of mitochondrial MUL1 E3 ubiquitin ligase deregulates mitophagy and prevents diet-induced obesity in mice
    1
    1. scibot 12 May 2024
      pSpCas9(BB)-2A-Puro

      DOI: 10.3389/fmolb.2024.1397565

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    ncbi.nlm.nih.gov/pmc/articles/PMC11079312/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAT10 mediates the sorafenib-resistance of hepatocellular carcinoma cells by stabilizing E3 ligase NEDD4 to enhance PTEN/AKT pathway-induced autophagy
    1
    1. scibot 12 May 2024
      Plasmid_48139

      DOI: 10.62347/EPIT4481

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    ncbi.nlm.nih.gov/pmc/articles/PMC11076247/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The phosphatidylinositol-5′ phosphatase synaptojanin1 limits integrin-mediated invasion of Staphylococcus aureus
    1
    1. scibot 12 May 2024
      plasmid_48139

      DOI: 10.1128/spectrum.02006-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC10986543/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling
    1
    1. scibot 04 May 2024
      RRID:Addgene_48139

      DOI: 10.1158/0008-5472.CAN-23-2268

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    ncbi.nlm.nih.gov/pmc/articles/PMC11063763/
  24. Apr 2024
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome
    1
    1. scibot 30 Apr 2024
      48139

      DOI: 10.1084/jem.20231941

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    ncbi.nlm.nih.gov/pmc/articles/PMC11040501/
  26. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous DNAJC19 knockout human embryonic stem cell line by CRISPR/ Cas9 system
    1
    1. scibot 30 Apr 2024
      Addgene_48139

      DOI: 10.1016/j.scr.2024.103427

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    sciencedirect.com/science/article/pii/S1873506124001259
  27. rupress.org rupress.org
    WW domains form a folded type of nuclear localization signal to guide YAP1 nuclear import
    1
    1. scibot 25 Apr 2024
      RRID:Addgene_48139

      DOI: 10.1083/jcb.202308013

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    rupress.org/jcb/article/223/6/e202308013/276631/WW-domains-form-a-folded-type-of-nuclear
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcript-specific induction of stop codon readthrough using a CRISPR-dCas13 system
    1
    1. scibot 23 Apr 2024
      48139

      DOI: 10.1038/s44319-024-00115-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC11015002/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
    1
    1. scibot 14 Apr 2024
      48139

      DOI: 10.21203/rs.3.rs-3979098/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10984014/
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor Burden Dictates the Neoantigen Features Required to Generate an Effective Cancer Vaccine
    1
    1. scibot 14 Apr 2024
      SpCas9–2A-Puro (PX459)

      DOI: 10.1158/2326-6066.CIR-23-0609

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    ncbi.nlm.nih.gov/pmc/articles/PMC10985473/
  31. www.biorxiv.org www.biorxiv.org
    The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges
    1
    1. scibot 12 Apr 2024
      RRID:Addgene_48139

      DOI: 10.1101/2024.04.07.588476

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    biorxiv.org/content/10.1101/2024.04.07.588476v1
  32. www.sciencedirect.com www.sciencedirect.com
    Temporal dynamics and stoichiometry in human Notch signaling from Notch synaptic complex formation to nuclear entry of the Notch intracellular domain
    1
    1. scibot 04 Apr 2024
      RRID:Addgene_48139

      DOI: 10.1016/j.devcel.2024.03.021

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    sciencedirect.com/science/article/pii/S1534580724001898
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
    1
    1. scibot 01 Apr 2024
      48139

      DOI: 10.1038/s43018-023-00712-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10965441/
  34. Mar 2024
  35. www.sciencedirect.com www.sciencedirect.com
    Generation of a TSC2 knockout embryonic stem cell line by CRISPR/Cas9 editing
    1
    1. scibot 29 Mar 2024
      Addgene_48139

      DOI: 10.1016/j.scr.2024.103399

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    sciencedirect.com/science/article/pii/S1873506124000977
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway
    1
    1. scibot 17 Mar 2024
      48139

      DOI: 10.1038/s41389-024-00514-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC10920805/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons
    1
    1. scibot 17 Mar 2024
      48139

      DOI: 10.1038/s41586-024-07093-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC10937380/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lamin B1 curtails early human papillomavirus infection by safeguarding nuclear compartmentalization and autophagic capacity
    1
    1. scibot 17 Mar 2024
      Addgene_48139

      DOI: 10.1007/s00018-024-05194-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC10940392/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer
    1
    1. scibot 12 Mar 2024
      plasmid_48139

      DOI: 10.1038/s41420-024-01890-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10924943/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cathepsin D promotes polarization of tumor-associated macrophages and metastasis through TGFBI-CCL20 signaling
    1
    1. scibot 08 Mar 2024
      pSpCas9 (BB)-2A-Puro (PX459)

      DOI: 10.1038/s12276-024-01163-9

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    ncbi.nlm.nih.gov/pmc/articles/PMC10907383/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucosylceramide flippases contribute to cellular glucosylceramide homeostasis
    1
    1. scibot 08 Mar 2024
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      DOI: 10.1016/j.jlr.2024.100508

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    ncbi.nlm.nih.gov/pmc/articles/PMC10910339/
  42. Feb 2024
  43. www.sciencedirect.com www.sciencedirect.com
    Restoration of miR-299-3p promotes macrophage phagocytosis and suppresses malignant phenotypes in breast cancer carcinogenesis via dual-targeting CD47 and ABCE1
    1
    1. scibot 23 Feb 2024
      RRID:Addgene_48139

      DOI: 10.1016/j.intimp.2024.111708

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    sciencedirect.com/science/article/pii/S1567576924002261
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy
    1
    1. scibot 21 Feb 2024
      RRID:Addgene_48139

      DOI: 10.1038/s42003-024-05834-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10869362/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer
    1
    1. scibot 08 Feb 2024
      plasmid_48139

      DOI: 10.1038/s41698-023-00489-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC10781691/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The chromatin-associated lncREST ensures effective replication stress response by promoting the assembly of fork signaling factors
    1
    1. scibot 04 Feb 2024
      48139

      DOI: 10.1038/s41467-024-45183-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC10834948/
  47. Jan 2024
  48. www.sciencedirect.com www.sciencedirect.com
    XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells
    1
    1. scibot 05 Jan 2024
      plasmid_48139

      DOI: 10.1016/j.cell.2023.11.033

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    A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells
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  50. Dec 2023
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    Interactome analysis reveals a link of the novel ALMS1-CEP70 complex to centrosomal clusters
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  52. Oct 2023
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repair of CRISPR-guided RNA breaks enables site-specific RNA editing in human cells
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  54. Jul 2023
  55. www.sciencedirect.com www.sciencedirect.com
    Mechanism of orphan subunit recognition during assembly quality control
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    Title: TET1 Facilitates Specification of Early Human Lineages including Germ Cells
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  57. May 2023
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    The Abl/Abi signaling links WAVE regulatory complex to Cbl E3 ubiquitin ligase and is essential for breast cancer cell metastasis
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  59. Apr 2023
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    ERCC6L2 mitigates replication stress and promotes centromere stability
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  61. Mar 2023
  62. rupress.org rupress.org
    GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease
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  63. Feb 2023
  64. www.sciencedirect.com www.sciencedirect.com
    Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules
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  65. Jan 2023
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    Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy
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    In-cell chemical crosslinking identifies hotspots for SQSTM-1/p62-IκBα interaction that underscore a critical role of p62 in limiting NF-κB activation through IκBα-stabilization
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    ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen
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  69. Nov 2022
  70. www.tandfonline.com www.tandfonline.com
    Autophagy inactivation in osteosarcoma leads to the appearance of poor prognosis-associated factors
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  71. Sep 2022
  72. www.tandfonline.com www.tandfonline.com
    Autophagy inactivation in osteosarcoma leads to the appearance of poor prognosis-associated factors
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    A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration
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    TGF-β generates a population of cancer cells residing in G1 phase with high motility and metastatic potential via KRTAP2-3
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    Generation of a homozygous TAZ knockout hESCs line by CRISPR/Cas9 system
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  76. Aug 2022
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells
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  78. www.nature.com www.nature.com
    Enhanced phosphorylation of c-Jun by cisplatin treatment as a potential predictive biomarker for cisplatin response in combination with patient-derived tumor organoids
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    Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis
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  80. Jun 2022
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    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
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    Generation of a homozygous knock-in human embryonic stem cell line expressing mEos4b-tagged CTR1
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    Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer
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  84. May 2022
  85. www.sciencedirect.com www.sciencedirect.com
    DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism
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    The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling
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    Generation of homozygous PRKN, PINK1 and double PINK1/PRKN knockout cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 editing
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  88. www.nature.com www.nature.com
    Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content
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  89. Apr 2022
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    Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance
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    Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage
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  92. Mar 2022
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    Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria
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    SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones
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  95. Jan 2022
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death
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  97. Dec 2021
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel live-cell imaging assay reveals regulation of endosome maturation
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  99. Oct 2021
  100. journals.biologists.com journals.biologists.com
    GRASP55 restricts early-stage autophagy and regulates spatial organization of the early secretory network
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  101. www.jneurosci.org www.jneurosci.org
    Comparison of ciliary targeting of two rhodopsin-like GPCRs: role of C-terminal localization sequences in relation to cilium type
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  102. Sep 2021
  103. www.sciencedirect.com www.sciencedirect.com
    Visualization of individual cell division history in complex tissues using iCOUNT
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    DNA polymerase delta Exo domain stabilizes mononucleotide microsatellites in human cells
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  105. Aug 2021
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    Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity
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  107. www.cell.com www.cell.com
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    Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer
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  122. Jun 2021
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  126. May 2021
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    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
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    HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis
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  131. Apr 2021
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    Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors
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  134. Mar 2021
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    Generation of a homozygous CRISPR/Cas9-mediated knockout H9 hESC subline for the MerTK locus
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  136. Feb 2021
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    Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice
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  138. elifesciences.org elifesciences.org
    The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1
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  139. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single‐Cell Analysis of Transcriptome and Telomeres
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  142. Dec 2020
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  144. Oct 2020
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  148. Sep 2020
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    FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
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    CRISPR/CAS9-mediated knockout of Abi1 inhibits p185 Bcr-Abl -induced leukemogenesis and signal transduction to ERK and PI3K/Akt pathways
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    Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions
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    Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons
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  156. Jan 2020
  157. elifesciences.org elifesciences.org
    Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72
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    53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination
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