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Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity

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1. scibot 11 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-0521
  
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aacrjournals.org/cancerres/article/86/5/1252/774876/Antibody-Mediated-Targeting-of-Secretory-Protein
Jun 2026
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Genome instability triggers intercellular DNA transfer between human cells

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1. scibot 06 Jun 2026
  
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  DOI: 10.1016/j.cell.2026.04.041
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13193222/
May 2026
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The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells

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1. scibot 19 May 2026
  
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  DOI: 10.7554/eLife.102680
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13179060/
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The cytotoxic effect of prexasertib is a consequence of dual inhibition on both CHK1 and AMPK

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1. scibot 01 May 2026
  
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  DOI: 10.1016/j.chembiol.2026.04.003
  
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sciencedirect.com/science/article/pii/S2451945626001121
Apr 2026
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LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture

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1. scibot 08 Apr 2026
  
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  DOI: 10.1158/2159-8290.CD-25-1085
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13040219/
Mar 2026
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Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks

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1. scibot 17 Mar 2026
  
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  DOI: 10.1016/j.molcel.2026.02.016
  
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sciencedirect.com/science/article/pii/S1097276526001309
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Transient proliferation by reversible YAP and mitogen control of the cyclin D1/p27 ratio

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1. scibot 11 Mar 2026
  
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  DOI: 10.1038/s42003-026-09590-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12957376/
www.nature.com www.nature.com

High-throughput ligand diversification to discover chemical inducers of proximity

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1. scibot 05 Mar 2026
  
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  DOI: 10.1038/s41589-025-02137-2
  
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nature.com/articles/s41589-025-02137-2
Jan 2026
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Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer

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1. scibot 26 Jan 2026
  
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  DOI: 10.7554/eLife.104545
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12747521/
Nov 2025
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Cancer cell-derived IL-1β reverses chemo-immunotherapy resistance in non-small cell lung cancer

1
1. scibot 24 Nov 2025
  
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  Addgene_5066139
  
  DOI: 10.1038/s41467-025-64839-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12639146/
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Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer

1
1. scibot 23 Nov 2025
  
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  50661
  
  DOI: 10.1101/2024.11.11.623139
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11601343/
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Coordinated control of genome–nuclear lamina interactions by topoisomerase 2B and lamin B receptor

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1. scibot 23 Nov 2025
  
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  DOI: 10.1093/nar/gkaf964
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12464825/
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RNA/DNA-binding protein TDP43 regulates DNA mismatch repair genes with implications for genome stability

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1. scibot 23 Nov 2025
  
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  DOI: 10.1093/nar/gkaf920
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12455596/
Oct 2025
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A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function

1
1. scibot 23 Oct 2025
  
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  RRID:Addgene_50661
  
  DOI: 10.1016/j.cub.2024.08.058
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11496028/
Sep 2025
www.biorxiv.org www.biorxiv.org

Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation

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1. scibot 18 Sep 2025
  
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  RRID:Addgene_50661
  
  DOI: 10.1101/2025.09.05.673478
  
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biorxiv.org/content/10.1101/2025.09.05.673478v1
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Non-catalytic role of SETD1A promotes gastric cancer cell proliferation through the E2F4–TAF6 axis in the cell cycle

1
1. scibot 06 Sep 2025
  
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  Addgene_50661
  
  DOI: 10.1038/s41419-025-07976-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12373860/
Aug 2025
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E2F activity determines mitosis versus whole-genome duplication in G2-arrested cells

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1. scibot 11 Aug 2025
  
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  50661
  
  DOI: 10.1038/s41467-025-62061-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12279939/
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On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions

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1. scibot 11 Aug 2025
  
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  Addgene_50661
  
  DOI: 10.1101/2025.08.03.668359
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12324462/
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Inhibiting the RNA helicase DDX3X in Burkitt lymphoma induces oxydative stress and impedes tumor progression in xenografts

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1. scibot 08 Aug 2025
  
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  Addgene_50661
  
  DOI: 10.3389/fcell.2025.1642006
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12325266/
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PALB2 and 53BP1 govern post-resection homologous recombination DNA repair

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1. scibot 01 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.07.003
  
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sciencedirect.com/science/article/pii/S1097276525006045
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SNAI2 cooperates with MEK1/2 and HDACs to suppress BIM- and BMF-dependent apoptosis in TERT promoter mutant cancers

1
1. scibot 20 Jul 2025
  
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  50661
  
  DOI: 10.1371/journal.pone.0322961
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12193877/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination

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1. scibot 20 Jul 2025
  
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  DOI: 10.1126/sciadv.ads5272
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12180482/
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BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication

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1. scibot 20 Jul 2025
  
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  Addgene_50661
  
  DOI: 10.1038/s41467-025-61284-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12219854/
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The role of gene duplication and paralog specialisation in the evolution of the mammalian PRPS complex

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1. scibot 20 Jul 2025
  
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  Addgene_50661
  
  DOI: 10.1038/s41467-025-61216-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12238573/
Jun 2025
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DDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition

1
1. scibot 14 Jun 2025
  
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  plasmid_50661
  
  DOI: 10.1038/s44319-025-00448-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12152147/
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Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer

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1. scibot 11 Jun 2025
  
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  RRID:Addgene_50661
  
  DOI: 10.1016/j.celrep.2025.115792
  
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sciencedirect.com/science/article/pii/S2211124725005637
May 2025
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The transcription factor IID subunit Taf13 is dispensable for TATA binding protein promoter recruitment and RNA polymerase II transcription

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1. scibot 22 May 2025
  
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  Addgene_50661
  
  DOI: 10.1016/j.isci.2025.112286
  
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sciencedirect.com/science/article/pii/S2589004225005474
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Genetic Screen in a Pre-Clinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities

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1. scibot 20 May 2025
  
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  RRID:Addgene_50661
  
  DOI: 10.1158/1078-0432.CCR-24-1238
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11530313/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory

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1. scibot 19 May 2025
  
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  Plasmid_50661
  
  DOI: 10.1038/s41467-025-59186-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12037779/
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Rab40 GTPases regulate AMBRA1-mediated transcription and cell migration

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1. scibot 17 May 2025
  
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  #50661
  
  DOI: 10.1242/jcs.263707
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12045048/
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

H1‐0 is a specific mediator of the repressive ETV6::RUNX1 transcriptional landscape in preleukemia and B cell acute lymphoblastic leukemia

1
1. scibot 05 Apr 2025
  
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  50661
  
  DOI: 10.1002/hem3.70116
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11962653/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RNA-targeted proteomics identifies YBX1 as critical for efficient HCMV mRNA translation

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1. scibot 23 Mar 2025
  
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  50661
  
  DOI: 10.1073/pnas.2421155122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11912382/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CDK8/19 inhibition attenuates G1 arrest induced by BCR-ABL antagonists and accelerates death of chronic myelogenous leukemia cells

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1. scibot 18 Feb 2025
  
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  DOI: 10.1038/s41420-025-02339-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11830074/
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor

1
1. scibot 30 Jan 2025
  
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  addgene_50661
  
  DOI: 10.1096/fj.202400490R
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11774231/
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Patient-derived response estimates from zero-passage organoids of luminal breast cancer

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1. scibot 04 Jan 2025
  
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  Addgene, #50661
  
  DOI: 10.1186/s13058-024-01931-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11687200/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Mitochondria-targeted oligomeric α-synuclein induces TOM40 degradation and mitochondrial dysfunction in Parkinson’s disease and parkinsonism-dementia of Guam

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1. scibot 24 Dec 2024
  
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  50661
  
  DOI: 10.1038/s41419-024-07258-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11655978/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence

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1. scibot 11 Dec 2024
  
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  Addgene_50661
  
  DOI: 10.1016/j.isci.2024.111311
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11617384/
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BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A

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Generation of a conditional cellular senescence model using proximal tubule cells and fibroblasts from human kidneys

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Aug 2024
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The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks

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HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair

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Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health

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MicroRNA-focused CRISPR/Cas9 screen identifies miR-142 as a key regulator of Epstein-Barr virus reactivation

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Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC

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cell.com/iscience/abstract/S2589-0042(24)01357-9
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Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence

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Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER

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RNA/DNA Binding Protein TDP43 Regulates DNA Mismatch Repair Genes with Implications for Genome Stability

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Compaction of Active Chromatin Domains and Promoters by H3S10 Phosphorylation during Mitosis Preserves Interphase-Specific Chromatin Structure and Function

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Apr 2024
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A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function

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Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis

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Mitochondria-Targeted Oligomeric α-Synuclein Induces TOM40 Degradation and Mitochondrial Dysfunction in Parkinson’s Disease and Parkinsonism-Dementia of Guam

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ΔNp63 regulates MDSC survival and metabolism in triple-negative breast cancer

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Feb 2024
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Heat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival

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Micronucleus is not a potent inducer of the cGAS/STING pathway

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Jan 2024
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Strategies for single base gene editing in an immortalized human cell line by CRISPR/Cas9 technology

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Transcriptional determinants of lipid mobilization in human adipocytes

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Dec 2023
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Unraveling the Mechanisms of Sensitivity to Anti-FGF Therapies in Imatinib-Resistant Gastrointestinal Stromal Tumors (GIST) Lacking Secondary KIT Mutations

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Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition

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CRISPR prime editing for unconstrained correction of oncogenic KRAS variants

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Aug 2023
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Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects

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Siglec-15 promotes evasion of adaptive immunity in B-cell acute lymphoblastic leukemia

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crc-23-0056-html.html

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Jun 2023
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CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis

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ncbi.nlm.nih.gov/pmc/articles/PMC7614657/
Apr 2023
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VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms

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MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ

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INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

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Mar 2023
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EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in neurons

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Feb 2023
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HER2-driven breast cancer suppression by the JNK signaling pathway

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Oct 2022
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The phospholipid flippase ATP8B1 is required for lysosomal fusion in macrophages

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May 2022
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AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma

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DNA-PK promotes DNA end resection at DNA double strand breaks in G0 cells

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Novel roles of RTN4 and CLIMP-63 in regulating mitochondrial structure, bioenergetics and apoptosis

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Selective requirement of MYB for oncogenic hyperactivation of a translocated enhancer in leukemia

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Apr 2022
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CAMKs support development of acute myeloid leukemia

1
1. scibot 14 Apr 2022
  
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  plasmid_50661
  
  DOI: 10.1186/s13045-018-0574-8
  
  Resource: RRID:Addgene_50661
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5828341/
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LAMP2A regulates the loading of proteins into exosomes

1
1. scibot 07 Apr 2022
  
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  RRID:Addgene_50661
  
  DOI: 10.1126/sciadv.abm1140
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8956266/
Mar 2022
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OVOL2 impairs RHO GTPase signaling to restrain mitosis and aggressiveness of Anaplastic Thyroid Cancer

1
1. scibot 26 Mar 2022
  
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  RRID:Addgene_50661
  
  DOI: 10.1186/s13046-022-02316-2
  
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link.springer.com/article/10.1186/s13046-022-02316-2
Jan 2022
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MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells

1
1. scibot 26 Jan 2022
  
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  Addgene_50661
  
  DOI: 10.1016/j.ccell.2021.12.009
  
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sciencedirect.com/science/article/pii/S1535610821006620
Sep 2021
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The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation

1
1. scibot 23 Sep 2021
  
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  RRID:Addgene_50661
  
  DOI: 10.1016/j.molcel.2021.08.033
  
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sciencedirect.com/science/article/pii/S1097276521007139
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LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells

1
1. scibot 11 Sep 2021
  
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  Addgene_50661
  
  DOI: 10.7554/eLife.68466
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8416021/
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REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps

1
1. scibot 11 Sep 2021
  
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  plasmid_50661
  
  DOI: 10.1016/j.molcel.2021.08.016
  
  Resource: RRID:Addgene_50661
  
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sciencedirect.com/science/article/pii/S1097276521006833
Jul 2021
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Molecular control of cell density-mediated exit to quiescence

1
1. scibot 31 Jul 2021
  
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  plasmid_50661
  
  DOI: 10.1016/j.celrep.2021.109436
  
  Resource: RRID:Addgene_50661
  
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sciencedirect.com/science/article/pii/S2211124721008536
May 2021
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Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway

1
1. scibot 14 May 2021
  
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  RRID:Addgene_50661
  
  DOI: 10.1016/j.cub.2021.04.075
  
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sciencedirect.com/science/article/pii/S0960982221006229
Apr 2021
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Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation

2
1. scibot 29 Apr 2021
  
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  Addgene_50
  
  DOI: 10.1016/j.chembiol.2021.02.019
  
  Resource: RRID:Addgene_50661
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_50661
  
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  RRIDCUR:Unresolved RRID:Addgene_50661 RRIDCUR:SyntaxError
2. scibot 28 Apr 2021
  
  in Public
  
  RRID:Addgene_50661
  
  DOI: 10.1016/j.chembiol.2021.02.019
  
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sciencedirect.com/science/article/pii/S2451945621001045
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Cell Lineage-Based Stratification for Glioblastoma

2
1. scibot 20 Apr 2021
  
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  Addgene_50661
  
  DOI: 10.1016/j.ccell.2020.06.003
  
  Resource: RRID:Addgene_50661
  
  Curator: @Naa003
  
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  RRID:Addgene_50661 RRIDCUR:Validated
2. scibot 20 Apr 2021
  
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  RRID:RRID:Addgene_50661
  
  DOI: 10.1016/j.ccell.2020.06.003
  
  Resource: RRID:Addgene_50661
  
  Curator: @Naa003
  
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  RRID:Addgene_50661 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S153561082030307X
Mar 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia

1
1. scibot 09 Mar 2021
  
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  plasmid_50661
  
  DOI: 10.15252/emmm.201910895
  
  Resource: RRID:Addgene_50661
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7136967/
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Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer

1
1. scibot 01 Mar 2021
  
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  Plasmid_50661
  
  DOI: 10.1016/j.cell.2020.12.031
  
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sciencedirect.com/science/article/pii/S0092867420317530
Feb 2021
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Single-cell RNA sequencing of developing maize ears facilitates functional analysis and trait candidate gene discovery

1
1. scibot 28 Feb 2021
  
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  RRID:Addgene_50661
  
  DOI: 10.1016/j.devcel.2020.12.015
  
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sciencedirect.com/science/article/pii/S1534580720310212
Jan 2021
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Optimized protocol for gene editing in adipocytes using CRISPR-Cas9 technology

1
1. scibot 29 Jan 2021
  
  in Public
  
  pCW-Cas9
  
  DOI: 10.1016/j.xpro.2021.100307
  
  Resource: RRID:Addgene_50661
  
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  RRID:Addgene_50661 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S2666166721000149
onlinelibrary.wiley.com onlinelibrary.wiley.com

HnRNPA2B1 promotes the proliferation of breast cancer MCF‐7 cells via the STAT3 pathway

1
1. scibot 21 Jan 2021
  
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  RRID:Addgene_50661
  
  DOI: 10.1002/jcb.29875
  
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  RRID:Addgene_50661 RRIDCUR:Validated
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onlinelibrary.wiley.com/doi/10.1002/jcb.29875
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Heterogeneous nuclear ribonucleoprotein A2/B1 is a negative regulator of human breast cancer metastasis by maintaining the balance of multiple genes and pathways

1
1. scibot 26 Sep 2020
  
  in Public
  
  RRID:Addgene_50661
  
  DOI: 10.1016/j.ebiom.2019.11.044
  
  Resource: RRID:Addgene_50661
  
  Curator: @ethanbadger
  
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  RRID:Addgene_50661 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC6948170/
www.mdpi.com www.mdpi.com

Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer

1
1. scibot 17 Sep 2020
  
  in Public
  
  RRID:Addgene_50661
  
  DOI: 10.3390/cancers12051325
  
  Resource: RRID:Addgene_50661
  
  Curator: @Naa003
  
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  RRID:Addgene_50661 RRIDCUR:Validated
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mdpi.com/2072-6694/12/5/1325
Jan 2020
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Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_50661
  
  DOI: 10.1016/j.immuni.2019.08.006
  
  Resource: RRID:Addgene_50661
  
  Curator: @ethanbadger
  
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  RRID:Addgene_50661 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1074761319303322

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