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Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons

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  DOI: 10.1186/s40478-025-02103-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12406597/
Aug 2025
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Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice

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pmc.ncbi.nlm.nih.gov/articles/PMC12288896/
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Lysosomal Protease-Mediated APP Degradation is pH-Dependent, Mutation-Sensitive, and Facilitates Tau Proteolysis

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1. scibot 11 Aug 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12265180/
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2025.07.26.666977v1.full-html.html

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  DOI: 10.1101/2025.07.26.666977
  
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52.53.155.43/523aba7c04d08b4157ea984183976bbd000aa86d/2025.07.26.666977v1.full-html.html
Jul 2025
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Generation of iPSC Lines with Tagged α-Synuclein for Visualization of Endogenous Protein in Human Cellular Models of Neurodegenerative Disorders

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1. scibot 20 Jul 2025
  
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  DOI: 10.1523/ENEURO.0093-25.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12186606/
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An improved immunoassay detects Aβ oligomers in human biofluids: their CSF levels rise with tau and phosphotau levels

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pmc.ncbi.nlm.nih.gov/articles/PMC12255133/
Jun 2025
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Experimental evidence that readily diffusible forms of Aβ from Alzheimer’s disease brain have seeding activity

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pmc.ncbi.nlm.nih.gov/articles/PMC12102860/
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The ADCY1-mediated cAMP signaling pathway mediates functional effects of montelukast treatment in brain organoids

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1. scibot 14 Jun 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12141180/
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Ngn2-Induced Differentiation of the NG108-15 Cell Line Enhances Motor Neuronal Differentiation and Neuromuscular Junction Formation

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1. scibot 12 Jun 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12108711/
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Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures

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  DOI: 10.1016/j.celrep.2025.115777
  
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sciencedirect.com/science/article/pii/S2211124725005480
May 2025
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CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.neuron.2025.03.034
  
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sciencedirect.com/science/article/pii/S0896627325002545
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The Hippo pathway effector YAP inhibits NF-κB signaling and ccRCC growth by opposing ZHX2

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.jbc.2025.108430
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12018991/
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Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease

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1. scibot 16 May 2025
  
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  DOI: 10.1002/glia.24677
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12012329/
Mar 2025
www.biorxiv.org www.biorxiv.org

Protective ApoE variants support neuronal function by extracting peroxidated lipids

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1. scibot 14 Mar 2025
  
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  DOI: 10.1101/2025.03.05.641722
  
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biorxiv.org/content/10.1101/2025.03.05.641722v1
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The Hippo pathway effector YAP inhibits NF-κB signaling and ccRCC growth by opposing ZHX2

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1. scibot 11 Mar 2025
  
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  DOI: 10.1101/2024.06.21.600079
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11230290/
Dec 2024
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KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.nbd.2024.106759
  
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sciencedirect.com/science/article/pii/S0969996124003619
Sep 2024
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KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons

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1. scibot 28 Sep 2024
  
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  DOI: 10.1101/2024.09.06.611684
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11418931/
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Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.celrep.2022.110877
  
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sciencedirect.com/science/article/pii/S2211124722006520
Aug 2024
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Distinctive In Vitro Phenotypes in iPSC-Derived Neurons From Patients With Gain- and Loss-of-Function SCN2A Developmental and Epileptic Encephalopathy

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1. scibot 26 Aug 2024
  
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  DOI: 10.1523/JNEUROSCI.0692-23.2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10883610/
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Protocol for neurogenin-2-mediated induction of human stem cell-derived neural progenitor cells

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1. scibot 02 Aug 2024
  
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  DOI: 10.1016/j.xpro.2024.102878
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10865475/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ENGINEERED NANOBODIES WITH PROGRAMMABLE TARGET ANTIGEN PROTEOLYSIS (PTAP) FUSIONS REGULATE INTRACELLULAR ALPHA-SYNUCLEIN IN VITRO AND IN VIVO

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  DOI: 10.21203/rs.3.rs-4088206/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10996777/
Feb 2024
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High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia

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ncbi.nlm.nih.gov/pmc/articles/PMC10794252/
Nov 2023
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An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.jare.2023.11.022
  
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sciencedirect.com/science/article/pii/S2090123223003612
Oct 2023
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Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation

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  DOI: 10.1038/s41420-023-01639-z
  
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nature.com/articles/s41420-023-01639-z
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths

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  DOI: 10.1038/s41467-023-40803-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10475046/
Aug 2023
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Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons

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1. scibot 30 Aug 2023
  
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  DOI: 10.1016/j.xgen.2023.100399
  
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sciencedirect.com/science/article/pii/S2666979X23002136
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Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression

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  DOI: 10.1038/s41596-023-00863-2
  
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nature.com/articles/s41596-023-00863-2
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Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1

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  DOI: 10.1016/j.celrep.2023.112994
  
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sciencedirect.com/science/article/pii/S2211124723010057
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Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons

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  DOI: 10.1016/j.xpro.2023.102486
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10400954/
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The efficient induction of human retinal ganglion-like cells provides a platform for studying optic neuropathies

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  DOI: 10.1007/s00018-023-04890-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10403410/
Jan 2023
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Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons

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  DOI: 10.1016/j.stem.2022.12.010
  
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sciencedirect.com/science/article/pii/S1934590922004945
Nov 2022
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Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation

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1. scibot 24 Nov 2022
  
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  DOI: 10.1016/j.molcel.2022.11.002
  
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sciencedirect.com/science/article/abs/pii/S1097276522010644
Oct 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons

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1. scibot 19 Oct 2022
  
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  DOI: 10.1016/j.isci.2022.105187
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9574418/
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In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

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  DOI: 10.1016/j.neuron.2022.09.001
  
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cell.com/neuron/fulltext/S0896-6273(22)00806-6
Sep 2022
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Molecular convergence between Down syndrome and fragile X syndrome identified using human pluripotent stem cell models

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1. scibot 08 Sep 2022
  
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  DOI: 10.1016/j.celrep.2022.111312
  
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sciencedirect.com/science/article/pii/S2211124722011366
Mar 2022
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APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons

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  DOI: 10.1038/s41380-022-01454-5
  
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nature.com/articles/s41380-022-01454-5
Oct 2021
www.sciencedirect.com www.sciencedirect.com

A synaptic temperature sensor for body cooling

1
1. scibot 21 Oct 2021
  
  in Public
  
  52047
  
  DOI: 10.1016/j.neuron.2021.10.001
  
  Resource: RRID:Addgene_52047
  
  Curator: @Naa003
  
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  RRID:Addgene_52047 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S0896627321007698
Sep 2021
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Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors

1
1. scibot 03 Sep 2021
  
  in Public
  
  plasmid_52047
  
  DOI: 10.1016/j.neuron.2021.08.003
  
  Resource: RRID:Addgene_52047
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S089662732100578X
Jul 2021
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Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

1
1. scibot 31 Jul 2021
  
  in Public
  
  plasmid_52047
  
  DOI: 10.1016/j.molcel.2018.11.028
  
  Resource: RRID:Addgene_52047
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_52047
  
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  RRID:Addgene_52047 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276518309985
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Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses

1
1. scibot 30 Jul 2021
  
  in Public
  
  FUW-TetO-Ng2-T2A-puromycin (lentiviral vector)
  
  DOI: 10.1016/j.cell.2019.09.011
  
  Resource: RRID:Addgene_52047
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_52047
  
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  RRID:Addgene_52047 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S0092867419310177
May 2021
www.nature.com www.nature.com

Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs

1
1. scibot 22 May 2021
  
  in Public
  
  RRID:Addgene_52047
  
  DOI: 10.1038/s42003-021-02104-2
  
  Resource: RRID:Addgene_52047
  
  Curator: @scibot
  
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nature.com/articles/s42003-021-02104-2
Mar 2021
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H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model

1
1. scibot 22 Mar 2021
  
  in Public
  
  RRID:Addgene_52047
  
  DOI: 10.1016/j.ccell.2021.01.005
  
  Resource: RRID:Addgene_52047
  
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sciencedirect.com/science/article/pii/S1535610821000490
Feb 2021
elifesciences.org elifesciences.org

Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

1
1. scibot 11 Feb 2021
  
  in Public
  
  RRID:Addgene_52047
  
  DOI: 10.7554/eLife.64434
  
  Resource: RRID:Addgene_52047
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_52047
  
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  RRID:Addgene_52047 RRIDCUR:Validated
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elifesciences.org/articles/64434
Dec 2020
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Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens

1
1. scibot 07 Dec 2020
  
  in Public
  
  plasmid_52047
  
  DOI: 10.1016/j.celrep.2020.108460
  
  Resource: RRID:Addgene_52047
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_52047
  
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  RRIDCUR:Validated RRID:Addgene_52047
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sciencedirect.com/science/article/pii/S2211124720314492
www.sciencedirect.com www.sciencedirect.com

Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and Microglia

1
1. scibot 07 Dec 2020
  
  in Public
  
  Addgene_52047
  
  DOI: 10.1016/j.xpro.2020.100190
  
  Resource: RRID:Addgene_52047
  
  Curator: @Naa003
  
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  RRIDCUR:Validated RRID:Addgene_52047
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sciencedirect.com/science/article/pii/S2666166720301775
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons

1
1. scibot 26 Sep 2020
  
  in Public
  
  RRID:Addgene_52047
  
  DOI: 10.1523/JNEUROSCI.0642-19.2019
  
  Resource: RRID:Addgene_52047
  
  Curator: @Naa003
  
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  RRID:Addgene_52047 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC6867816/
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Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons

1
1. scibot 03 Sep 2020
  
  in Public
  
  Cat#52047 Addgene
  
  DOI: 10.1016/j.molcel.2020.01.020
  
  Resource: RRID:Addgene_52047
  
  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S1097276520300411
Jan 2020
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Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

1
1. scibot 13 Jan 2020
  
  in Public
  
  plasmid_52047
  
  DOI: 10.1016/j.molcel.2018.11.028
  
  Resource: RRID:Addgene_52047
  
  Curator: @Naa003
  
  SciCrunch record: plasmid_52047
  
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  RRID:Addgene_52047 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276518309985