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Tissue-specific restriction of transposon-derived regulatory elements safeguards cell-type identity

2
1. scibot 15 Jan 2026
  
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  Addgene plasmid Cat#57823
  
  DOI: 10.1016/j.celrep.2025.116817
  
  Resource: RRID:Addgene_57823
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
2. scibot 15 Jan 2026
  
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  Addgene_57823
  
  DOI: 10.1016/j.celrep.2025.116817
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S221112472501589X
Oct 2025
www.sciencedirect.com www.sciencedirect.com

Group 3 innate lymphoid cell-derived CSF2 tunes homeostasis of tissue macrophages and neutrophils

1
1. scibot 15 Oct 2025
  
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  RRID:Addgene_57823
  
  DOI: 10.1016/j.mucimm.2025.10.004
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1933021925001060
Sep 2025
www.sciencedirect.com www.sciencedirect.com

IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation

1
1. scibot 27 Sep 2025
  
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  Addgene_57823
  
  DOI: 10.1016/j.celrep.2025.116330
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2211124725011015
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer

1
1. scibot 06 Aug 2025
  
  in Public
  
  Addgene_57823
  
  DOI: 10.1158/1541-7786.MCR-24-0672
  
  Resource: RRID:Addgene_57823
  
  Curator: @sonofthor
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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pmc.ncbi.nlm.nih.gov/articles/PMC12319404/
www.sciencedirect.com www.sciencedirect.com

Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells

1
1. scibot 01 Aug 2025
  
  in Public
  
  RRID:Addgene_57823
  
  DOI: 10.1016/j.immuni.2025.07.008
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1074761325003176
Apr 2025
www.biorxiv.org www.biorxiv.org

TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia

1
1. scibot 13 Apr 2025
  
  in Public
  
  RRID:Addgene_57823
  
  DOI: 10.1101/2025.04.07.647605
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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biorxiv.org/content/10.1101/2025.04.07.647605v1
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SAMHD1 dysfunction impairs DNA damage response and increases sensitivity to PARP inhibition in chronic lymphocytic leukemia

1
1. scibot 07 Apr 2025
  
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  57823
  
  DOI: 10.1038/s41598-025-93629-7
  
  Resource: RRID:Addgene_57823
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_57823
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11947222/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Phosphoproteomic Profiling Reveals mTOR Signaling in Sustaining Macrophage Phagocytosis of Cancer Cells

1
1. scibot 29 Dec 2024
  
  in Public
  
  plasmid_57823
  
  DOI: 10.3390/cancers16244238
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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pmc.ncbi.nlm.nih.gov/articles/PMC11674635/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure

1
1. scibot 26 Sep 2024
  
  in Public
  
  pLKO5.0.sgRNA.EFS.tRFP
  
  DOI: 10.1038/s44161-024-00441-z
  
  Resource: RRID:Addgene_57823
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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ncbi.nlm.nih.gov/pmc/articles/PMC11343478/
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer

2
1. scibot 31 Jul 2024
  
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  RRID:Addgene_57823
  
  DOI: 10.1158/2159-8290.CD-23-0539
  
  Resource: Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
2. scibot 31 Jul 2024
  
  in Public
  
  RRID:Addgene_57823
  
  DOI: 10.1158/2159-8290.CD-23-0539
  
  Resource: Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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ncbi.nlm.nih.gov/pmc/articles/PMC11285331/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Precise correction of a spectrum of β-thalassemia mutations in coding and non-coding regions by base editors

1
1. scibot 03 Jun 2024
  
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  57823
  
  DOI: 10.1016/j.omtn.2024.102205
  
  Resource: RRID:Addgene_57823
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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ncbi.nlm.nih.gov/pmc/articles/PMC11137594/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx

1
1. scibot 23 Apr 2024
  
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  57823
  
  DOI: 10.1038/s41592-024-02190-0
  
  Resource: RRID:Addgene_57823
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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ncbi.nlm.nih.gov/pmc/articles/PMC11009108/
Feb 2024
www.biorxiv.org www.biorxiv.org

Saturation resistance profiling of EGFR variants against tyrosine kinase inhibitors using prime editing

1
1. scibot 09 Feb 2024
  
  in Public
  
  Addgene_57823
  
  DOI: 10.1101/2023.12.03.569825
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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biorxiv.org/content/10.1101/2023.12.03.569825v1
Nov 2023
dx.doi.org dx.doi.org

Epigenetic profiles guide improved CRISPR/Cas9-mediated gene knockout in human T cells

1
1. scibot 26 Nov 2023
  
  in Public
  
  RRID:Addgene_57823
  
  DOI: 10.1093/nar/gkad1076
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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dx.doi.org/10.1093/nar/gkad1076
www.biorxiv.org www.biorxiv.org

ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers

1
1. scibot 03 Nov 2023
  
  in Public
  
  RRID:Addgene_57823
  
  DOI: 10.1101/2023.10.24.563645
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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biorxiv.org/content/10.1101/2023.10.24.563645v1
www.sciencedirect.com www.sciencedirect.com

The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency

1
1. scibot 02 Nov 2023
  
  in Public
  
  RRID:Addgene_57823
  
  DOI: 10.1016/j.celrep.2023.113285
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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sciencedirect.com/science/article/pii/S2211124723012974
Sep 2023
www.nature.com www.nature.com

Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia

1
1. scibot 20 Sep 2023
  
  in Public
  
  plasmid_57823
  
  DOI: 10.1038/s41375-022-01755-2
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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nature.com/articles/s41375-022-01755-2
Aug 2023
52.53.155.43 52.53.155.43

Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression

2
1. scibot 16 Aug 2023
  
  in Public
  
  RRID:Addgene_57823
  
  DOI: 10.1016/j.celrep.2023.112979
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
2. scibot 16 Aug 2023
  
  in Public
  
  RRID:Addgene_57823
  
  DOI: 10.1016/j.celrep.2023.112979
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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52.53.155.43/491f3628ae56ca418965e7c0fc6856d1761b345d/PIIS2211124723009907-html.html
Jul 2023
www.sciencedirect.com www.sciencedirect.com

Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer

1
1. scibot 21 Jul 2023
  
  in Public
  
  Plasmid_57823
  
  DOI: 10.1016/j.ccell.2023.06.010
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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sciencedirect.com/science/article/pii/S1535610823002350
Apr 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation

1
1. scibot 04 Apr 2023
  
  in Public
  
  Addgene_57823
  
  DOI: 10.7554/eLife.83342
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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ncbi.nlm.nih.gov/pmc/articles/PMC10042546/
Mar 2023
www.sciencedirect.com www.sciencedirect.com

Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion

1
1. scibot 23 Mar 2023
  
  in Public
  
  RRID:Addgene_57823
  
  DOI: 10.1016/j.molcel.2023.02.026
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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sciencedirect.com/science/article/pii/S1097276523001533
Dec 2022
link.springer.com link.springer.com

The Efficiency of Gene Activation Using CRISPR/dCas9-Based Transactivation Systems Depends on the System Run Time

1
1. scibot 13 Dec 2022
  
  in Public
  
  RRID:Addgene_57823
  
  DOI: 10.1134/S0026893322060048
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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link.springer.com/article/10.1134/S0026893322060048
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

1
1. scibot 06 Aug 2022
  
  in Public
  
  Cat# 57823; Addgene
  
  DOI: 10.1016/j.stem.2022.07.005
  
  Resource: RRID:Addgene_57823
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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sciencedirect.com/science/article/pii/S1934590922003009
Jul 2022
www.jneurosci.org www.jneurosci.org

Modulating the excitability of olfactory output neurons affects whole-body metabolism

2
1. scibot 29 Jul 2022
  
  in Public
  
  plasmid_57823
  
  DOI: 10.1523/JNEUROSCI.0190-22.2022
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
2. scibot 29 Jul 2022
  
  in Public
  
  RRID:Addgene_57
  
  DOI: 10.1523/JNEUROSCI.0190-22.2022
  
  Resource: RRID:Addgene_57823
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRIDCUR:Unresolved RRID:Addgene_57823
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RRIDCUR:Unresolved

RRID:Addgene_57823

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scibot

URL

jneurosci.org/content/42/30/5966
Mar 2022
www.sciencedirect.com www.sciencedirect.com

The PAF1 complex promotes 3′ processing of pervasive transcripts

1
1. scibot 16 Mar 2022
  
  in Public
  
  plasmid_57823
  
  DOI: 10.1016/j.celrep.2022.110519
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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sciencedirect.com/science/article/pii/S2211124722002558
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin

1
1. scibot 04 Mar 2022
  
  in Public
  
  RRID:Addgene_57823
  
  DOI: 10.7554/eLife.65421
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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ncbi.nlm.nih.gov/pmc/articles/PMC8865852/
Nov 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses

1
1. scibot 19 Nov 2021
  
  in Public
  
  Addgene_57823
  
  DOI: 10.1038/s41467-021-26771-1
  
  Resource: RRID:Addgene_57823
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823
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ncbi.nlm.nih.gov/pmc/articles/PMC8586369/
Feb 2021
www.sciencedirect.com www.sciencedirect.com

Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation

1
1. scibot 11 Feb 2021
  
  in Public
  
  Plasmid_57823
  
  DOI: 10.1016/j.ccell.2020.03.001
  
  Resource: RRID:Addgene_57823
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRIDCUR:Validated RRID:Addgene_57823
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RRIDCUR:Validated

RRID:Addgene_57823

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scibot

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sciencedirect.com/science/article/pii/S153561082030101X
Jan 2021
www.sciencedirect.com www.sciencedirect.com

Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

1
1. scibot 20 Jan 2021
  
  in Public
  
  Addgene_57823
  
  DOI: 10.1016/j.xcrm.2020.100188
  
  Resource: RRID:Addgene_57823
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRIDCUR:Validated RRID:Addgene_57823
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RRID:Addgene_57823

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sciencedirect.com/science/article/pii/S2666379120302433
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_57823
  
  DOI: 10.1016/j.immuni.2019.08.006
  
  Resource: RRID:Addgene_57823
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_57823
  
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  RRID:Addgene_57823 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_57823

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scibot

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sciencedirect.com/science/article/pii/S1074761319303322