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Integrative multiomic analysis links TDP-43-driven splicing defects to cascading proteomic disruption of ALS/FTD pathways

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  DOI: 10.1101/2025.09.29.679403
  
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biorxiv.org/content/10.1101/2025.09.29.679403v1
Sep 2025
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Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

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  DOI: 10.7554/eLife.104057
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12448747/
Aug 2025
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Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells

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  DOI: 10.1158/0008-5472.CAN-24-2938
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12314522/
Jul 2025
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Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503

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pmc.ncbi.nlm.nih.gov/articles/PMC12236722/
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Novel drug-inducible CRISPRa/i systems for rapid and reversible manipulation of gene transcription

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pmc.ncbi.nlm.nih.gov/articles/PMC12185803/
Jun 2025
www.nature.com www.nature.com

Mechanism of cytarabine-induced neurotoxicity

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  DOI: 10.1038/s41586-025-09210-9
  
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nature.com/articles/s41586-025-09210-9
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Elucidating the genetic mechanisms governing cytosine base editing outcomes through CRISPRi screens

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  DOI: 10.1038/s41467-025-59948-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12092667/
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Neddylation as a target in PIK3CA-mutated head and neck cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12036330/
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Serotonin and neurotensin inputs in the vCA1 dictate opposing social valence

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pmc.ncbi.nlm.nih.gov/articles/PMC12137126/
May 2025
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Allelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33

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pmc.ncbi.nlm.nih.gov/articles/PMC12044007/
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Comprehensive interrogation of synthetic lethality in the DNA damage response

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pmc.ncbi.nlm.nih.gov/articles/PMC12018271/
Apr 2025
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An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation

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  DOI: 10.1016/j.molcel.2025.03.006
  
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sciencedirect.com/science/article/pii/S1097276525001996
Mar 2025
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Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain

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  DOI: 10.1101/gad.352235.124
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11874980/
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SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation

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1. scibot 11 Mar 2025
  
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  DOI: 10.1038/s41467-025-56130-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11760969/
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Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer

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1. scibot 11 Mar 2025
  
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  DOI: 10.1038/s41467-025-57476-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11880418/
Feb 2025
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Long-range enhancer-controlled genes are hypersensitive to regulatory factor perturbations

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1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.xgen.2025.100778
  
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sciencedirect.com/science/article/pii/S2666979X25000345
Jan 2025
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Plasmid Delivery and Single-Cell Plasmid Expression Analysis for CRISPR/dCas9-Based Epigenetic Editing

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1. scibot 30 Jan 2025
  
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  DOI: 10.1007/978-1-0716-4051-7_13
  
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link.springer.com/protocol/10.1007/978-1-0716-4051-7_13
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation

1
1. scibot 22 Aug 2024
  
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  DOI: 10.1101/2024.07.23.604857
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11291168/
Jun 2024
journals.plos.org journals.plos.org

CRISPRi screen of long non-coding RNAs identifies LINC03045 regulating glioblastoma invasion

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1. scibot 22 Jun 2024
  
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  DOI: 10.1371/journal.pgen.1011314
  
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journals.plos.org/plosgenetics/article
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In Vivo Genome-Wide CRISPR Screening Identifies CITED2 as a Driver of Prostate Cancer Bone Metastasis

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1. scibot 21 Jun 2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11101692/
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Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications

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  DOI: 10.1038/s41588-024-01706-w
  
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nature.com/articles/s41588-024-01706-w
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Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

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DOI:10.1016/j.devcel.2024.05.010

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sciencedirect.com/science/article/pii/S1534580724003277
May 2024
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Protocol for mass spectrometric profiling of lysine malonylation by lysine acetyltransferase in CRISPRi K562 cell lines

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  DOI: 10.1016/j.xpro.2024.103074
  
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sciencedirect.com/science/article/pii/S2666166724002399
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A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments

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  DOI: 10.1038/s41556-024-01402-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11098743/
Apr 2024
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TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers

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1. scibot 23 Apr 2024
  
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  DOI: 10.1038/s41419-024-06654-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11024179/
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Improving prime editing with an endogenous small RNA-binding protein

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  DOI: 10.1038/s41586-024-07259-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11023932/
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A benchmarked, high-efficiency prime editing platform for multiplexed dropout screening

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ncbi.nlm.nih.gov/pmc/articles/PMC10996517/
Mar 2024
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A novel regulatory pathway recognizes and degrades transcripts with long 3′ untranslated regions

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biorxiv.org/content/10.1101/2024.03.11.584429v1
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The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA

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  DOI: 10.1016/j.devcel.2024.02.008
  
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  DOI: 10.1016/j.devcel.2024.02.008
  
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sciencedirect.com/science/article/pii/S1534580724001072
Jan 2024
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Selective gene expression maintains human tRNA anticodon pools during differentiation

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  DOI: 10.1038/s41556-023-01317-3
  
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link.springer.com/article/10.1038/s41556-023-01317-3
Oct 2023
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Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation

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1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.stem.2023.09.007
  
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sciencedirect.com/science/article/pii/S1934590923003284
Mar 2023
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Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis

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1. scibot 10 Mar 2023
  
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  DOI: 10.1016/j.cub.2023.02.060
  
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sciencedirect.com/science/article/pii/S0960982223002002
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Histone malonylation is regulated by SIRT5 and KAT2A

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1. scibot 09 Mar 2023
  
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  DOI: 10.1016/j.isci.2023.106193
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9985052/
Feb 2023
elifesciences.org elifesciences.org

T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation

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1. scibot 02 Feb 2023
  
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  DOI: 10.7554/eLife.83077
  
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elifesciences.org/articles/83077
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Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins

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1. scibot 02 Feb 2023
  
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  DOI: 10.1016/j.celrep.2023.112065
  
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sciencedirect.com/science/article/pii/S2211124723000761
Jan 2023
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Production of CRISPRi-engineered primary human mammary epithelial cells with baboon envelope pseudotyped lentiviral vectors

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1. scibot 21 Jan 2023
  
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  plasmid_60955
  
  DOI: 10.1016/j.xpro.2023.102055
  
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sciencedirect.com/science/article/pii/S2666166723000138
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma

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1. scibot 20 Jan 2023
  
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  RRID:Addgene_60955
  
  DOI: 10.1158/0008-5472.CAN-21-3217
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9298960/
May 2022
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XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation

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1. scibot 25 May 2022
  
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  Plasmid_60955
  
  DOI: 10.1016/j.cell.2022.04.034
  
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sciencedirect.com/science/article/pii/S0092867422005323
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Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation

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1. scibot 04 May 2022
  
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  Addgene_60955
  
  DOI: 10.1016/j.cell.2022.04.005
  
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sciencedirect.com/science/article/pii/S0092867422004433
Aug 2021
elifesciences.org elifesciences.org

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

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1. scibot 02 Aug 2021
  
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  Addgene_60955
  
  DOI: 10.7554/eLife.19760
  
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elifesciences.org/articles/19760
Jul 2021
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A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity

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1. scibot 30 Jul 2021
  
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  RRID:Addgene_60955
  
  DOI: 10.7554/eLife.50036
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6897534/
May 2021
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In vivo CRISPR screening for novel noncoding RNA functional targets in glioblastoma models

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1. scibot 18 May 2021
  
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  RRID:Addgene_60955
  
  DOI: 10.1002/jnr.24850
  
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onlinelibrary.wiley.com/doi/10.1002/jnr.24850
Jan 2021
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Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination

1
1. scibot 21 Jan 2021
  
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  pU6-sgRNA- EF1α-puro-T2A-BFP
  
  DOI: 10.1016/j.molcel.2020.12.025
  
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sciencedirect.com/science/article/pii/S1097276520309461
Oct 2020
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Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells

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1. scibot 31 Oct 2020
  
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  Addgene_60955
  
  DOI: 10.1016/j.cels.2020.10.002
  
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sciencedirect.com/science/article/pii/S2405471220303707
Jan 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes

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1. scibot 13 Jan 2020
  
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  RRID:Addgene_60955
  
  DOI: 10.7554/eLife.47544
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6728143/
elifesciences.org elifesciences.org

PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

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1. scibot 13 Jan 2020
  
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  RRID:Addgene_60955
  
  DOI: 10.7554/eLife.48625
  
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elifesciences.org/articles/48625