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www.pnas.org www.pnas.org

Hide-and-Seek genome editing reveals that Gephyrin is required for axo-axonic synapse assembly

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1. scibot 29 Oct 2025
  
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  plasmid_60957
  
  DOI: 10.1073/pnas.2500726122
  
  Resource: RRID:Addgene_60957
  
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pnas.org/doi/abs/10.1073/pnas.2500726122
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons

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1. scibot 31 Jul 2025
  
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  RRID:Addgene_60957
  
  DOI: 10.1016/j.xpro.2025.103945
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12305205/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Single-Particle Tracking of AMPA Receptor-Containing Vesicles

1
1. scibot 20 Jul 2025
  
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  60957
  
  DOI: 10.21769/BioProtoc.5325
  
  Resource: RRID:Addgene_60957
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12177357/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CRISPR screen reveals modifiers of rAAV production including known rAAV infection genes playing an unexpected role in vector production

1
1. scibot 23 Feb 2025
  
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  PX551
  
  DOI: 10.1016/j.omtm.2025.101408
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11840188/
Nov 2024
www.sciencedirect.com www.sciencedirect.com

Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice

1
1. scibot 20 Nov 2024
  
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  RRID:Addgene_60957
  
  DOI: 10.1016/j.cell.2024.10.034
  
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sciencedirect.com/science/article/pii/S0092867424012169
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cas9 editing of ATXN1 in a spinocerebellar ataxia type 1 mice and human iPSC-derived neurons

1
1. scibot 27 Sep 2024
  
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  60957
  
  DOI: 10.1016/j.omtn.2024.102317
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11417534/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Plasticity-induced actin polymerization in the dendritic shaft regulates intracellular AMPA receptor trafficking

1
1. scibot 26 Aug 2024
  
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  Addgene_60957
  
  DOI: 10.7554/eLife.80622
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11326776/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory in mice

1
1. scibot 15 Jun 2024
  
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  plasmid_60957
  
  DOI: 10.1038/s41467-024-48430-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11169449/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety

1
1. scibot 15 Apr 2024
  
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  pAAV-pMecp2-SpCas9-spA
  
  DOI: 10.1038/s41398-024-02879-y
  
  Resource: RRID:Addgene_60957
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10954635/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Personalized allele-specific CRISPR-Cas9 strategies for myofibrillar myopathy 6

1
1. scibot 21 Feb 2024
  
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  http://n2t.net/addgene:60957)
  
  DOI: 10.1101/2024.02.03.24302252
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10863003/
Dec 2023
www.sciencedirect.com www.sciencedirect.com

Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function

1
1. scibot 22 Dec 2023
  
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  RRID:Addgene_60957
  
  DOI: 10.1016/j.neuron.2023.11.020
  
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sciencedirect.com/science/article/pii/S0896627323008942
Oct 2023
www.nature.com www.nature.com

Antibody-directed extracellular proximity biotinylation reveals that Contactin-1 regulates axo-axonic innervation of axon initial segments

1
1. scibot 27 Oct 2023
  
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  plasmid_60957
  
  DOI: 10.1038/s41467-023-42273-8
  
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nature.com/articles/s41467-023-42273-8
May 2023
52.53.155.43 52.53.155.43

Spatially Resolved Proteomic Profiling Uncovers Structural and Functional Regulators of the Axon Initial Segment

1
1. scibot 25 May 2023
  
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  Addgene_60957
  
  DOI: 10.1101/2023.03.06.531334
  
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52.53.155.43/1b0cedf04512903e90b9ef1858ffefd94df1235f/2023.03.06.531334v1.full-html.html
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis

1
1. scibot 25 May 2023
  
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  Addgene_60957
  
  DOI: 10.1101/gad.328336.119
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6942053/
Apr 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Antibody-directed extracellular proximity biotinylation reveals Contactin-1 regulates axo-axonic innervation of axon initial segments

1
1. scibot 12 Apr 2023
  
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  plasmid_60957
  
  DOI: 10.1101/2023.03.06.531378
  
  Resource: RRID:Addgene_60957
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10028829/
Jan 2023
www.sciencedirect.com www.sciencedirect.com

Targeted long-read sequencing captures CRISPR editing and AAV integration outcomes in brain

1
1. scibot 25 Jan 2023
  
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  RRID:Addgene_60957
  
  DOI: 10.1016/j.ymthe.2023.01.004
  
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sciencedirect.com/science/article/pii/S1525001623000047
Aug 2022
www.sciencedirect.com www.sciencedirect.com

De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

1
1. scibot 22 Aug 2022
  
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  Addgene Cat# 60957
  
  DOI: 10.1016/j.ccell.2022.07.011
  
  Resource: RRID:Addgene_60957
  
  Curator: @sophiastull
  
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sciencedirect.com/science/article/pii/S1535610822003245
Jul 2022
www.jneurosci.org www.jneurosci.org

Direct Observation of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels

1
1. scibot 14 Jul 2022
  
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  RRID:Addgene_60957
  
  DOI: 10.1523/JNEUROSCI.0086-22.2022
  
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jneurosci.org/content/42/28/5482
Mar 2021
www.sciencedirect.com www.sciencedirect.com

Optic nerve regeneration screen identifies multiple genes restricting adult neural repair

1
1. scibot 03 Mar 2021
  
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  Plasmid_60957
  
  DOI: 10.1016/j.celrep.2021.108777
  
  Resource: RRID:Addgene_60957
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_60957
  
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  RRID:Addgene_60957 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124721000905
Sep 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Antisense oligonucleotide- and CRISPR-Cas9-mediated rescue of mRNA splicing for a deep intronic CLRN1 mutation

1
1. scibot 10 Sep 2020
  
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  RRID:Addgene_60957
  
  DOI: 10.1016/j.omtn.2020.07.036
  
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  Curator: @Naa003
  
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  RRID:Addgene_60957 RRIDCUR:Validated
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pubmed.ncbi.nlm.nih.gov/32841912/
elifesciences.org elifesciences.org

Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons

1
1. scibot 09 Sep 2020
  
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  RRID:Addgene_60957
  
  DOI: 10.7554/eLife.56054
  
  Resource: RRID:Addgene_60957
  
  Curator: @evieth
  
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  RRID:Addgene_60957 RRIDCUR:Validated
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elifesciences.org/articles/56054