51 Matching Annotations
  1. Sep 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Ultrabright chemical labeling enables rapid neural connectivity profiling in large tissue samples
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    sciencedirect.com/science/article/pii/S0896627325006579
  3. Aug 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ENHANCED CLEAVAGE OF GENOMIC CCR5 USING CASX2Max
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265720/
  5. Jul 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12305205/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Focused ultrasound‐mediated APOE4 knockdown in mouse brain
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    pmc.ncbi.nlm.nih.gov/articles/PMC12263348/
  8. www.biorxiv.org www.biorxiv.org
    Engineering a human-based translational activator for targeted protein expression restoration
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    biorxiv.org/content/10.1101/2025.07.09.663984v1
  9. Jun 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR-Cas Genome Editing in Ex Vivo Human Lungs to Rewire the Translational Path of Genome-Targeting Therapeutics
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    pmc.ncbi.nlm.nih.gov/articles/PMC11386987/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR antiviral inhibits neurotrophic JC polyomavirus in 2D and 3D culture models through dual-gRNA excision by SaCas9
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    pmc.ncbi.nlm.nih.gov/articles/PMC12159223/
  12. Apr 2025
  13. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Neuron–non-neuron electrical coupling networks are involved in chronic stress-induced electrophysiological changes in lateral habenular neurons
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP287286
  14. Mar 2025
  15. www.sciencedirect.com www.sciencedirect.com
    Single-cut gene therapy in a one-step generated rhesus monkey model of Duchenne muscular dystrophy
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    sciencedirect.com/science/article/pii/S2666379125001107
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Non-invasive detection of allele-specific CRISPR-SaCas9-KKH disruption of TOR1A DYT1 allele in a xenograft mouse model
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    pmc.ncbi.nlm.nih.gov/articles/PMC11925580/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecularly distinct striatonigral neuron subtypes differentially regulate locomotion
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    pmc.ncbi.nlm.nih.gov/articles/PMC11923167/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Electroporation Induces Unexpected Alterations in Gene Expression: A Tip for Selection of Optimal Transfection Method
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    pmc.ncbi.nlm.nih.gov/articles/PMC11854308/
  19. Feb 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optimal SpCas9- and SaCas9-mediated gene editing by enhancing gRNA transcript levels through scaffold poly-T tract reduction
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    pmc.ncbi.nlm.nih.gov/articles/PMC11823040/
  21. Jan 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rational engineering of minimally immunogenic nucleases for gene therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11696374/
  23. Dec 2024
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    All-in-one AAV-mediated Nrl gene inactivation rescues retinal degeneration in Pde6a mice
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11665581/
  25. www.biorxiv.org www.biorxiv.org
    A Versatile Anti-CRISPR Platform for Opto- and Chemogenetic Control of CRISPR-Cas9 and Cas12 across a Wide Range of Orthologs
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    biorxiv.org/content/10.1101/2024.11.25.625186v1
  26. Nov 2024
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Patch and matrix striatonigral neurons differentially regulate locomotion
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    pmc.ncbi.nlm.nih.gov/articles/PMC11230471/
  28. Aug 2024
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Suppression of HSV-1 infection and viral reactivation by CRISPR-Cas9 gene editing in 2D and 3D culture models
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11339036/
  30. www.cell.com www.cell.com
    Upregulation of utrophin improves the phenotype of Duchenne muscular dystrophy hiPSC-derived CMs
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    cell.com/molecular-therapy-family/nucleic-acids/abstract/S2162-2531(24)00134-3
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome editing in the mouse brain with minimally immunogenic Cas9 RNPs
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    ncbi.nlm.nih.gov/pmc/articles/PMC10422012/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation
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    ncbi.nlm.nih.gov/pmc/articles/PMC7616320/
  33. Jul 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long term rescue of Alzheimer’s deficits in vivo by one-time gene-editing of App C-terminus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11185791/
  35. Jun 2024
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory in mice
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11169449/
  37. 52.53.155.43 52.53.155.43
    Optimization of AAV vectors for transactivator-regulated enhanced gene expression within targeted neuronal populations.
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    52.53.155.43/7f9ee4f71b8a925e453a4463d9dde20f671e0e7e/PIIS2589004224011003-html.html
  38. May 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo genome editing via CRISPR/Cas9-mediated homology-independent targeted integration for Bietti crystalline corneoretinal dystrophy treatment
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11074121/
  40. Mar 2024
  41. 52.53.155.43 52.53.155.43
    Efficient and safe therapeutic use of paired Cas9-nickases for primary hyperoxaluria type 1
    2
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    52.53.155.43/b4a5d5f166b97df7aae394dba3752d5bbdf7ed06/torella-et-al-2024-efficient-and-safe-therapeutic-use-of-paired-cas9-nickases-for-primary-hyperoxaluria-type-1-html.html
  42. Nov 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Unexpected extra exon skipping in the DYSF gene during restoring the reading frame by CRISPR/Cas9
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    sciencedirect.com/science/article/pii/S0303264723002472
  44. Sep 2023
  45. www.mdpi.com www.mdpi.com
    Targeted Delivery of Chimeric Antigen Receptor into T Cells via CRISPR-Mediated Homology-Directed Repair with a Dual-AAV6 Transduction System
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    mdpi.com/1467-3045/45/10/486
  46. Aug 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Neural mechanisms underlying uninstructed orofacial movements during reward-based learning behaviors
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    sciencedirect.com/science/article/pii/S096098222300920X
  48. Jul 2023
  49. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Production of adeno-associated viral vector serotype 6 by triple transfection of suspension HEK293 cells at higher cell densities
    1
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    onlinelibrary.wiley.com/doi/10.1002/biot.202300051
  50. May 2023
  51. www.authorea.com www.authorea.com
    High-cell-density production of adeno-associated viral vector serotype 6 by triple transfection in suspension HEK293 cell cultures
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    authorea.com/users/582383/articles/622468-high-cell-density-production-of-adeno-associated-viral-vector-serotype-6-by-triple-transfection-in-suspension-hek293-cell-cultures
  52. Apr 2023
  53. www.biorxiv.org www.biorxiv.org
    Genome editing in the mouse brain with minimally immunogenic Cas9 RNPs
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    biorxiv.org/content/10.1101/2023.04.13.536294v1
  54. Mar 2023
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Correction of F8 intron 1 inversion in hemophilia A patient-specific iPSCs by CRISPR/Cas9 mediated gene editing
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10033665/
  56. Dec 2022
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-uniform dystrophin re-expression after CRISPR-mediated exon excision in the dystrophin/utrophin double-knockout mouse model of DMD
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    ncbi.nlm.nih.gov/pmc/articles/PMC9664411/
  58. Sep 2022
  59. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous P4HA2 knockout human embryonic stem cell line (FDCHDPe012-A) by CRISPR/Cas9 system
    1
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    sciencedirect.com/science/article/pii/S1873506122002793
  60. Jun 2022
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9205912/
  62. Mar 2022
  63. www.sciencedirect.com www.sciencedirect.com
    Regulation of GTPase function by autophosphorylation
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    sciencedirect.com/science/article/pii/S1097276522001162
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antiviral Targeting of Varicella Zoster Virus Replication and Neuronal Reactivation Using CRISPR/Cas9 Cleavage of the Duplicated Open Reading Frames 62/71
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8880005/
  65. Dec 2021
  66. elifesciences.org elifesciences.org
    scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution
    2
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    elifesciences.org/articles/64175
  67. Oct 2021
  68. www.sciencedirect.com www.sciencedirect.com
    Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories
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    sciencedirect.com/science/article/pii/S0092867421010606
  69. Sep 2021
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unlocking loxP to Track Genome Editing In Vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC8394901/
  71. Aug 2021
  72. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous LRPAP1 knockout human embryonic stem cell line (FDCHDPe009-B) by CRISPR/Cas9 system
    1
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    sciencedirect.com/science/article/pii/S1873506121003639
  73. www.mdpi.com www.mdpi.com
    Adeno-Associated Vector-Delivered CRISPR/SaCas9 System Reduces Feline Leukemia Virus Production In Vitro
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    mdpi.com/1999-4915/13/8/1636/htm
  74. www.jneurosci.org www.jneurosci.org
    Subretinal Human Umbilical Tissue-Derived Cell Transplantation Preserves Retinal Synaptic Connectivity and Attenuates Müller Glial Reactivity
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    jneurosci.org/content/38/12/2923
  75. www.sciencedirect.com www.sciencedirect.com
    CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection
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    sciencedirect.com/science/article/pii/S2211124719307429
  76. Apr 2021
  77. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous LRP2 knockout human embryonic stem cell line (FDCHDPe010-A-56) by CRISPR/Cas9 system
    1
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    sciencedirect.com/science/article/pii/S1873506121001884
  78. Sep 2020
  79. www.jneurosci.org www.jneurosci.org
    Dopaminergic signaling in the nucleus accumbens modulates stress-coping strategies during inescapable stress
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    jneurosci.org/content/40/38/7241
  80. www.sciencedirect.com www.sciencedirect.com
    The Raphe Dopamine System Controls the Expression of Incentive Memory
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    sciencedirect.com/science/article/pii/S0896627320301082
  81. Jan 2020
  82. www.sciencedirect.com www.sciencedirect.com
    Programmable RNA-Guided RNA Effector Proteins Built from Human Parts
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    sciencedirect.com/science/article/pii/S0092867419306208