26 Matching Annotations
  1. Oct 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combinatorial and Inducible CRISPRa/i Enables Canalized hiPSC Forward Programming and Iterative Refinement via Single-Cell Genomics
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    pmc.ncbi.nlm.nih.gov/articles/PMC13252116/
  3. Jun 2026
  4. www.sciencedirect.com www.sciencedirect.com
    Generation of WTC11 CLYBL-CAG_GCaMP8f cell line for fast and sensitive calcium tracking
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    sciencedirect.com/science/article/pii/S1873506126001170
  5. 54.241.53.176 54.241.53.176
    2026.06.04.730242.full-html.html
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    54.241.53.176/880a3fee5b49e4dd23b88b08dfca54c5c7493374/2026.06.04.730242.full-html.html
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multi-omic phenotyping of MAPT V337M neurons reveals early changes in axonogenesis and tau phosphorylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13110130/
  7. Apr 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neurogenin-2 Reprograms Human Microglial Lineage Cells into Neurons In Vitro and in Chimeric Brains
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    pmc.ncbi.nlm.nih.gov/articles/PMC13015545/
  9. Mar 2026
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12978015/
  11. Feb 2026
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mapping cis- and trans-regulatory target genes of human-specific deletions
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    pmc.ncbi.nlm.nih.gov/articles/PMC12727812/
  13. Dec 2025
  14. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Core passive and facultative mTOR-mediated mechanisms coordinate mammalian protein synthesis and decay
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    sciencedirect.com:5037/science/article/pii/S2405471225002893
  15. Nov 2025
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multi-omic phenotyping of iPSC-derived neurons harboring the MAPT V337M mutation reveals tau hypophosphorylation and perturbed axon morphology pathways
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    pmc.ncbi.nlm.nih.gov/articles/PMC11185762/
  17. Aug 2025
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bidirectional regulation of glycoprotein nonmetastatic melanoma protein B by β-glucocerebrosidase deficiency in GBA1 isogenic dopaminergic neurons from a patient with Gaucher disease and parkinsonism
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    pmc.ncbi.nlm.nih.gov/articles/PMC12262256/
  19. Jul 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combining light-induced aggregation and biotin proximity labeling implicates endolysosomal proteins in early α-synuclein oligomerization
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    pmc.ncbi.nlm.nih.gov/articles/PMC12221657/
  21. Jun 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNA-binding proteins DND1 and NANOS3 cooperatively suppress the entry of germ cell lineage
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    pmc.ncbi.nlm.nih.gov/articles/PMC12102168/
  23. May 2025
  24. www.sciencedirect.com www.sciencedirect.com
    IGF2BP1 restricts the induction of human primordial germ cell fate in an m6A-dependent manner
    1
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    sciencedirect.com/science/article/pii/S193459092500181X
  25. Mar 2025
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Large-scale CRISPRi screens link metabolic stress to glioblastoma chemoresistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11887098/
  27. www.nature.com www.nature.com
    Comparative characterization of human accelerated regions in neurons
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    nature.com/articles/s41586-025-08622-x
  28. Feb 2025
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    C-terminal amides mark proteins for degradation via SCF–FBXO31
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    pmc.ncbi.nlm.nih.gov/articles/PMC11821526/
  30. Dec 2024
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Distinct differentiation trajectories leave lasting impacts on gene regulation and function of V2a interneurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC11642877/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prion protein pathology in Ubiquilin 2 models of ALS
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    pmc.ncbi.nlm.nih.gov/articles/PMC11651290/
  33. Jun 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic validation of MMR-associated genetic modifiers in a human ex vivo model of Huntington disease
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11179424/
  35. May 2024
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson’s disease
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11071283/
  37. Apr 2024
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening
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    ncbi.nlm.nih.gov/pmc/articles/PMC10986136/
  39. Feb 2024
  40. link.springer.com link.springer.com
    Targeted CRISPR activation is functional in engineered human pluripotent stem cells but undergoes silencing after differentiation into cardiomyocytes and endothelium
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    link.springer.com/article/10.1007/s00018-023-05101-2
  41. Jun 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Comparative landscape of genetic dependencies in human and chimpanzee stem cells
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    sciencedirect.com/science/article/pii/S0092867423005950
  43. Dec 2022
  44. www.sciencedirect.com www.sciencedirect.com
    Generation of AAVS1 and CLYBL STRAIGHT-IN v2 acceptor human iPSC lines for integrating DNA payloads
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    sciencedirect.com/science/article/pii/S1873506122003403
  45. Jul 2022
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC8254803/
  47. Mar 2021
  48. www.sciencedirect.com www.sciencedirect.com
    Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells
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    sciencedirect.com/science/article/pii/S221112471931719X