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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

1
1. scibot 29 Mar 2026
  
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  Addgene_62196
  
  DOI: 10.1016/j.cell.2025.12.038
  
  Resource: RRID:Addgene_62196
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12978015/
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Mapping cis- and trans-regulatory target genes of human-specific deletions

1
1. scibot 01 Feb 2026
  
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  62196
  
  DOI: 10.1038/s41467-025-67424-x
  
  Resource: RRID:Addgene_62196
  
  Curator: @olekpark
  
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  RRID:Addgene_62196
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pmc.ncbi.nlm.nih.gov/articles/PMC12727812/
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Core passive and facultative mTOR-mediated mechanisms coordinate mammalian protein synthesis and decay

1
1. scibot 23 Dec 2025
  
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  Plasmid_62196
  
  DOI: 10.1016/j.cels.2025.101456
  
  Resource: RRID:Addgene_62196
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_62196
  
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  RRID:Addgene_62196
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sciencedirect.com:5037/science/article/pii/S2405471225002893
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Multi-omic phenotyping of iPSC-derived neurons harboring the MAPT V337M mutation reveals tau hypophosphorylation and perturbed axon morphology pathways

1
1. scibot 23 Nov 2025
  
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  Addgene_62196
  
  DOI: 10.1101/2024.06.04.597496
  
  Resource: RRID:Addgene_62196
  
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  RRID:Addgene_62196
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pmc.ncbi.nlm.nih.gov/articles/PMC11185762/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Bidirectional regulation of glycoprotein nonmetastatic melanoma protein B by β-glucocerebrosidase deficiency in GBA1 isogenic dopaminergic neurons from a patient with Gaucher disease and parkinsonism

1
1. scibot 11 Aug 2025
  
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  62196
  
  DOI: 10.1101/2025.06.23.661126
  
  Resource: RRID:Addgene_62196
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12262256/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Combining light-induced aggregation and biotin proximity labeling implicates endolysosomal proteins in early α-synuclein oligomerization

1
1. scibot 20 Jul 2025
  
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  62196
  
  DOI: 10.1016/j.isci.2025.112823
  
  Resource: RRID:Addgene_62196
  
  Curator: @olekpark
  
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  RRID:Addgene_62196
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pmc.ncbi.nlm.nih.gov/articles/PMC12221657/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RNA-binding proteins DND1 and NANOS3 cooperatively suppress the entry of germ cell lineage

1
1. scibot 15 Jun 2025
  
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  62196
  
  DOI: 10.1038/s41467-025-57490-6
  
  Resource: RRID:Addgene_62196
  
  Curator: @olekpark
  
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  RRID:Addgene_62196
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pmc.ncbi.nlm.nih.gov/articles/PMC12102168/
May 2025
www.sciencedirect.com www.sciencedirect.com

IGF2BP1 restricts the induction of human primordial germ cell fate in an m6A-dependent manner

1
1. scibot 29 May 2025
  
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  RRID:Addgene_62196
  
  DOI: 10.1016/j.stem.2025.05.001
  
  Resource: RRID:Addgene_62196
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_62196
  
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  RRID:Addgene_62196
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sciencedirect.com/science/article/pii/S193459092500181X
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Large-scale CRISPRi screens link metabolic stress to glioblastoma chemoresistance

1
1. scibot 11 Mar 2025
  
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  Addgene_62196
  
  DOI: 10.1186/s12967-025-06261-4
  
  Resource: RRID:Addgene_62196
  
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  RRID:Addgene_62196
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pmc.ncbi.nlm.nih.gov/articles/PMC11887098/
www.nature.com www.nature.com

Comparative characterization of human accelerated regions in neurons

1
1. scibot 07 Mar 2025
  
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  62196, Addgene
  
  DOI: 10.1038/s41586-025-08622-x
  
  Resource: RRID:Addgene_62196
  
  Curator: @sjvitug
  
  SciCrunch record: RRID:Addgene_62196
  
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  RRID:Addgene_62196
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nature.com/articles/s41586-025-08622-x
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

C-terminal amides mark proteins for degradation via SCF–FBXO31

1
1. scibot 16 Feb 2025
  
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  62196
  
  DOI: 10.1038/s41586-024-08475-w
  
  Resource: RRID:Addgene_62196
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_62196
  
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  RRID:Addgene_62196
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pmc.ncbi.nlm.nih.gov/articles/PMC11821526/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Distinct differentiation trajectories leave lasting impacts on gene regulation and function of V2a interneurons

1
1. scibot 28 Dec 2024
  
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  plasmid_62196
  
  DOI: 10.1101/2024.12.03.626573
  
  Resource: RRID:Addgene_62196
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_62196
  
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  RRID:Addgene_62196
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pmc.ncbi.nlm.nih.gov/articles/PMC11642877/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Prion protein pathology in Ubiquilin 2 models of ALS

1
1. scibot 27 Dec 2024
  
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  62196
  
  DOI: 10.1016/j.nbd.2024.106674
  
  Resource: RRID:Addgene_62196
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_62196
  
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  RRID:Addgene_62196
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pmc.ncbi.nlm.nih.gov/articles/PMC11651290/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Therapeutic validation of MMR-associated genetic modifiers in a human ex vivo model of Huntington disease

1
1. scibot 20 Jun 2024
  
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  addgene_62196
  
  DOI: 10.1016/j.ajhg.2024.04.015
  
  Resource: RRID:Addgene_62196
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_62196
  
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  RRID:Addgene_62196
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ncbi.nlm.nih.gov/pmc/articles/PMC11179424/
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson’s disease

1
1. scibot 19 May 2024
  
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  Addgene_62196
  
  DOI: 10.1101/2024.03.22.586364
  
  Resource: RRID:Addgene_62196
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_62196
  
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  RRID:Addgene_62196
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ncbi.nlm.nih.gov/pmc/articles/PMC11071283/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening

1
1. scibot 14 Apr 2024
  
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  Addgene_62
  
  DOI: 10.1186/s13046-024-03027-6
  
  Resource: RRID:Addgene_62196
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_62196
  
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  RRIDCUR:Unresolved RRID:Addgene_62196 RRIDCUR:Incorrect
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RRID:Addgene_62196

RRIDCUR:Unresolved

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ncbi.nlm.nih.gov/pmc/articles/PMC10986136/
Feb 2024
link.springer.com link.springer.com

Targeted CRISPR activation is functional in engineered human pluripotent stem cells but undergoes silencing after differentiation into cardiomyocytes and endothelium

1
1. scibot 22 Feb 2024
  
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  Addgene_62196
  
  DOI: 10.1007/s00018-023-05101-2
  
  Resource: RRID:Addgene_62196
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_62196
  
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  RRID:Addgene_62196
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link.springer.com/article/10.1007/s00018-023-05101-2
Jun 2023
www.sciencedirect.com www.sciencedirect.com

Comparative landscape of genetic dependencies in human and chimpanzee stem cells

1
1. scibot 21 Jun 2023
  
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  Addgene_62196
  
  DOI: 10.1016/j.cell.2023.05.043
  
  Resource: RRID:Addgene_62196
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_62196
  
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  RRID:Addgene_62196
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sciencedirect.com/science/article/pii/S0092867423005950
Dec 2022
www.sciencedirect.com www.sciencedirect.com

Generation of AAVS1 and CLYBL STRAIGHT-IN v2 acceptor human iPSC lines for integrating DNA payloads

1
1. scibot 06 Dec 2022
  
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  Addgene_62196
  
  DOI: 10.1016/j.scr.2022.102991
  
  Resource: RRID:Addgene_62196
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_62196
  
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  RRID:Addgene_62196
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sciencedirect.com/science/article/pii/S1873506122003403
Jul 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

1
1. scibot 06 Jul 2022
  
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  RRID:Addgene_62196
  
  DOI: 10.1038/s41593-021-00862-0
  
  Resource: RRID:Addgene_62196
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_62196
  
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  RRID:Addgene_62196
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ncbi.nlm.nih.gov/pmc/articles/PMC8254803/
Mar 2021
www.sciencedirect.com www.sciencedirect.com

Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells

1
1. scibot 18 Mar 2021
  
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  Addgene_62196
  
  DOI: 10.1016/j.celrep.2019.12.062
  
  Resource: RRID:Addgene_62196
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_62196
  
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  RRID:Addgene_62196 RRIDCUR:Validated
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RRID:Addgene_62196

RRIDCUR:Validated

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scibot

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sciencedirect.com/science/article/pii/S221112471931719X