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Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission

1
1. scibot 03 Dec 2025
  
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  Addgene_71236
  
  DOI: 10.1038/s41467-025-66356-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12663438/
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RUNX2 cooperates with SREBP1 to rewire cancer metabolism and promote aggressiveness

1
1. scibot 24 Nov 2025
  
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  71236
  
  DOI: 10.1186/s13046-025-03549-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12577400/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A gene regulatory element modulates myosin expression and controls cardiomyocyte response to stress

1
1. scibot 24 Nov 2025
  
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  71236
  
  DOI: 10.1101/gr.280825.125
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12581865/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Interrogating subclonal heterogeneity of liver cancer with single-cell multi-omics analysis

1
1. scibot 24 Nov 2025
  
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  71236
  
  DOI: 10.1038/s41598-025-24732-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12594797/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Modification of adipose mass by targeting distal enhancers of Ptrf

1
1. scibot 23 Nov 2025
  
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  71236
  
  DOI: 10.1186/s12915-025-02405-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12482881/
54.241.53.176 54.241.53.176

1-s2.0-S2589004225023016-main-html.html

1
1. scibot 18 Nov 2025
  
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  RRID:Addgene_71236
  
  DOI: 10.1016/j.isci.2025.114040
  
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54.241.53.176/2dc2795dad89007f55257c4b18d6264229fd76eb/1-s2.0-S2589004225023016-main-html.html
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

hnRNPL–CstF64 complex: coordinating CSR and LSR in IgH locus recombination dynamics through eRNA and NHEJ regulation

1
1. scibot 06 Sep 2025
  
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  71236
  
  DOI: 10.1093/nar/gkaf810
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12407099/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription

1
1. scibot 06 Sep 2025
  
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  plasmid_71236
  
  DOI: 10.1038/s42003-025-08794-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12405439/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Stage-specific requirement for METTL3-dependent m6A epitranscriptomic regulation during myogenesis

1
1. scibot 06 Sep 2025
  
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  Addgene_71236
  
  DOI: 10.1038/s42003-025-08759-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12398539/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

p62 mRNA suppresses NLRP1 expression in cutaneous SCC cells through miR-34a-5p

1
1. scibot 20 Jul 2025
  
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  71236
  
  DOI: 10.1038/s41419-025-07785-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12218052/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Prion-induced ferroptosis is facilitated by RAC3

1
1. scibot 20 Jul 2025
  
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  Addgene_71236
  
  DOI: 10.1038/s41467-025-60793-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12198409/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Genetically encoded fluorescent reporter for polyamines

1
1. scibot 15 Jun 2025
  
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  plasmid_7123678
  
  DOI: 10.1038/s41467-025-60147-z
  
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  SciCrunch record: RRID:Addgene_71236
  
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  RRID:Addgene_71236 RRIDCUR:Incorrect RRIDCUR:Unresolved
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pmc.ncbi.nlm.nih.gov/articles/PMC12117157/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Reshaping the chromatin landscape in HUVECs from small-for-gestational-age newborns

1
1. scibot 17 May 2025
  
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  71236
  
  DOI: 10.1172/jci.insight.186812
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12038915/
Apr 2025
www.nature.com www.nature.com

Targeting PIKfyve-driven lipid metabolism in pancreatic cancer

1
1. scibot 24 Apr 2025
  
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  RRID:Addgene_71236
  
  DOI: 10.1038/s41586-025-08917-z
  
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nature.com/articles/s41586-025-08917-z
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Involvement of lncRNA MIR205HG in idiopathic pulmonary fibrosis and IL-33 regulation via Alu elements

1
1. scibot 07 Apr 2025
  
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  71236
  
  DOI: 10.1172/jci.insight.187172
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11949018/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

KLF4 promotes a KRT13+ hillock-like state in squamous lung cancer

1
1. scibot 07 Apr 2025
  
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  RRID:Addgene_71236
  
  DOI: 10.1101/2025.03.10.641898
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11952405/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Tumour-wide RNA splicing aberrations generate actionable public neoantigens

1
1. scibot 23 Mar 2025
  
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  71236
  
  DOI: 10.1038/s41586-024-08552-0
  
  Resource: RRID:Addgene_71236
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11903331/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Inhibition of triglyceride metabolism‐associated enhancers alters lipid deposition during adipocyte differentiation

1
1. scibot 11 Mar 2025
  
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  71236
  
  DOI: 10.1096/fj.202401137R
  
  Resource: RRID:Addgene_71236
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11774232/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The lncRNA DUBR is regulated by CTCF and coordinates chromatin landscape and gene expression in hematopoietic cells

1
1. scibot 11 Mar 2025
  
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  71236
  
  DOI: 10.1093/nar/gkaf093
  
  Resource: RRID:Addgene_71236
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11850227/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

DNA Methylation in the CYP3A Distal Regulatory Region (DRR) Is Associated with the Expression of CYP3A5 and CYP3A7 in Human Liver Samples

1
1. scibot 22 Dec 2024
  
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  plasmid_71236
  
  DOI: 10.3390/molecules29225407
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11596782/
Nov 2024
www.sciencedirect.com www.sciencedirect.com

Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome

1
1. scibot 24 Nov 2024
  
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  Addgene71236
  
  DOI: 10.1016/j.cmet.2024.10.007
  
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sciencedirect.com/science/article/pii/S1550413124004030
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A genetically encoded fluorescent reporter for polyamines

1
1. scibot 28 Sep 2024
  
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  plasmid_7123673
  
  DOI: 10.1101/2024.08.24.609500
  
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  RRID:Addgene_71236 RRIDCUR:Incorrect RRIDCUR:Unresolved
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ncbi.nlm.nih.gov/pmc/articles/PMC11383275/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Exploring the transcriptional cooperation between RUNX2 and its associated elncRNA RAIN

1
1. scibot 26 Sep 2024
  
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  plasmid_71236
  
  DOI: 10.1038/s41419-024-07058-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11399121/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements

1
1. scibot 13 Aug 2024
  
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  71236
  
  DOI: 10.1016/j.ajhg.2023.12.015
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10870142/
Jun 2024
www.sciencedirect.com www.sciencedirect.com

Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression

2
1. scibot 04 Jun 2024
  
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  Addgene_71236
  
  DOI: 10.1016/j.devcel.2024.05.013
  
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2. scibot 04 Jun 2024
  
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  Addgene_71236
  
  DOI: 10.1016/j.devcel.2024.05.013
  
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sciencedirect.com/science/article/pii/S1534580724003307
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments

1
1. scibot 19 May 2024
  
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  Addgene_71236
  
  DOI: 10.1038/s41556-024-01402-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11098743/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Lineage specific transcription factor waves reprogram neuroblastoma from self-renewal to differentiation

1
1. scibot 30 Apr 2024
  
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  Addgene_71236
  
  DOI: 10.1038/s41467-024-47166-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11039666/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia

1
1. scibot 30 Apr 2024
  
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  Addgene_71236
  
  DOI: 10.1038/s41419-024-06681-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11039673/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons

1
1. scibot 13 Apr 2024
  
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  Addgene_71236
  
  DOI: 10.1038/s41467-024-47440-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11006854/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

1
1. scibot 11 Apr 2024
  
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  RRID:Addgene_71236
  
  DOI: 10.1101/2024.03.18.585580
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983929/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2

1
1. scibot 17 Mar 2024
  
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  Addgene_71236
  
  DOI: 10.1038/s41420-024-01901-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10924942/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma

1
1. scibot 28 Feb 2024
  
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  RRID:Addgene_71236
  
  DOI: 10.1038/s41467-024-45902-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10894237/
www.biorxiv.org www.biorxiv.org

BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III

1
1. scibot 15 Feb 2024
  
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  RRID:Addgene_71236
  
  DOI: 10.1101/2024.02.02.578646
  
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biorxiv.org/content/10.1101/2024.02.02.578646v1
journals.plos.org journals.plos.org

CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly

1
1. scibot 09 Feb 2024
  
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  Addgene_71236
  
  DOI: 10.1371/journal.pgen.1011138
  
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journals.plos.org/plosgenetics/article
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness

1
1. scibot 01 Feb 2024
  
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  Supplementary Material
  
  DOI: 10.1101/2024.01.10.574997
  
  Resource: RRID:Addgene_71236
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10802421/
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer

1
1. scibot 20 Sep 2023
  
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  Plasmid_71236
  
  DOI: 10.1158/1078-0432.CCR-23-0547
  
  Resource: RRID:Addgene_71236
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10502465/
dx.doi.org dx.doi.org

FOXA2 Cooperates with Mutant KRAS to Drive Invasive Mucinous Adenocarcinoma of the Lung

1
1. scibot 15 Sep 2023
  
  in Public
  
  Plasmid_71236
  
  DOI: 10.1158/0008-5472.CAN-22-2805
  
  Resource: RRID:Addgene_71236
  
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dx.doi.org/10.1158/0008-5472.CAN-22-2805
www.nature.com www.nature.com

Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor

1
1. scibot 08 Sep 2023
  
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  RRID:Addgene_71236
  
  DOI: 10.1038/s41418-023-01209-x
  
  Resource: RRID:Addgene_71236
  
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nature.com/articles/s41418-023-01209-x
May 2023
www.embopress.org www.embopress.org

Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry

1
1. scibot 28 May 2023
  
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  RRID:Addgene_71236
  
  DOI: 10.15252/embj.2022112095
  
  Resource: RRID:Addgene_71236
  
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embopress.org/doi/10.15252/embj.2022112095
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease

1
1. scibot 21 May 2023
  
  in Public
  
  plasmid_71236
  
  DOI: 10.1093/noajnl/vdad048
  
  Resource: RRID:Addgene_71236
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10195208/
Apr 2023
www.nature.com www.nature.com

Optimization of Cas9 activity through the addition of cytosine extensions to single-guide RNAs

1
1. scibot 11 Apr 2023
  
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  RRID:Addgene_71236
  
  DOI: 10.1038/s41551-023-01011-7
  
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nature.com/articles/s41551-023-01011-7
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inhibition of karyopherin β1-mediated nuclear import disrupts oncogenic lineage- defining transcription factor activity in small cell lung cancer

1
1. scibot 05 Mar 2023
  
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  RRID:Addgene_71236
  
  DOI: 10.1158/0008-5472.CAN-21-3713
  
  Resource: RRID:Addgene_71236
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9444950/
Dec 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A novel intergenic enhancer that regulates Bdnf expression in developing cortical neurons

1
1. scibot 30 Dec 2022
  
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  Addgene 71236
  
  DOI: 10.1016/j.isci.2022.105695
  
  Resource: RRID:Addgene_71236
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9792897/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Systematic discovery and functional dissection of enhancers needed for cancer cell fitness and proliferation

1
1. scibot 02 Dec 2022
  
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  Plasmid_71236
  
  DOI: 10.1016/j.celrep.2022.111630
  
  Resource: RRID:Addgene_71236
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9687083/
Aug 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPRi-mediated knock-down of PRDM1/BLIMP1 programs central memory differentiation in ex vivo-expanded human T cells

1
1. scibot 22 Aug 2022
  
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  RRID:Addgene_71236
  
  DOI: 10.34172/bi.2021.23522
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9376159/
Jul 2022
52.53.155.43 52.53.155.43

can-21-3713-html.html

2
1. scibot 29 Jul 2022
  
  in Public
  
  RRID:Addgene_7123
  
  DOI: 10.1158/0008-5472.can-21-3713
  
  Resource: RRID:Addgene_71236
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:Addgene_71236
  
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  RRIDCUR:Unresolved RRID:Addgene_71236
2. scibot 29 Jul 2022
  
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  plasmid_71236
  
  DOI: 10.1158/0008-5472.can-21-3713
  
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52.53.155.43/10b1307b786c1d01a6cf28f8a0210c58728fe8fb/can-21-3713-html.html
Jun 2022
link.springer.com link.springer.com

Repression of HIV-1 reactivation mediated by CRISPR/dCas9-KRAB in lymphoid and myeloid cell models

1
1. scibot 23 Jun 2022
  
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  RRID:Addgene_71236
  
  DOI: 10.1186/s12977-022-00600-9
  
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link.springer.com/article/10.1186/s12977-022-00600-9
www.sciencedirect.com www.sciencedirect.com

Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1

1
1. scibot 15 Jun 2022
  
  in Public
  
  Plasmid_71236
  
  DOI: 10.1016/j.celrep.2022.110971
  
  Resource: RRID:Addgene_71236
  
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sciencedirect.com/science/article/pii/S2211124722007574
Apr 2022
www.sciencedirect.com www.sciencedirect.com

CRISPRi-mediated transcriptional silencing in iPSCs for the study of human brain development

1
1. scibot 15 Apr 2022
  
  in Public
  
  Plasmid_71236
  
  DOI: 10.1016/j.xpro.2022.101285
  
  Resource: RRID:Addgene_71236
  
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sciencedirect.com/science/article/pii/S2666166722001654
Mar 2022
link.springer.com link.springer.com

OVOL2 impairs RHO GTPase signaling to restrain mitosis and aggressiveness of Anaplastic Thyroid Cancer

1
1. scibot 26 Mar 2022
  
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  RRID:Addgene_71236
  
  DOI: 10.1186/s13046-022-02316-2
  
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link.springer.com/article/10.1186/s13046-022-02316-2
Dec 2021
link.springer.com link.springer.com

Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin

1
1. scibot 15 Dec 2021
  
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  RRID:Addgene_71236
  
  DOI: 10.1186/s40170-021-00277-2
  
  Resource: RRID:Addgene_71236
  
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link.springer.com/article/10.1186/s40170-021-00277-2
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression

1
1. scibot 15 Aug 2021
  
  in Public
  
  Plasmid_71236
  
  DOI: 10.1158/2159-8290.CD-20-0775
  
  Resource: RRID:Addgene_71236
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7858242/
May 2021
www.sciencedirect.com www.sciencedirect.com

Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly

1
1. scibot 08 May 2021
  
  in Public
  
  Addgene_71236
  
  DOI: 10.1016/j.neuron.2020.10.035
  
  Resource: RRID:Addgene_71236
  
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sciencedirect.com/science/article/pii/S089662732030859X
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

1
1. scibot 22 Apr 2021
  
  in Public
  
  plasmid_71236
  
  DOI: 10.1016/j.ccell.2020.08.015
  
  Resource: RRID:Addgene_71236
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_71236
  
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  RRIDCUR:Validated RRID:Addgene_71236
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sciencedirect.com/science/article/pii/S1535610820304268
Mar 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Identification of a long non-coding RNA regulator of liver carcinoma cell survival

1
1. scibot 09 Mar 2021
  
  in Public
  
  RRID:Addgene_71236
  
  DOI: 10.1038/s41419-021-03453-w
  
  Resource: RRID:Addgene_71236
  
  Curator: @evieth
  
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  RRID:Addgene_71236 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7884843/
Feb 2021
www.sciencedirect.com www.sciencedirect.com

The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages

1
1. scibot 24 Feb 2021
  
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  71236
  
  DOI: 10.1016/j.molcel.2020.12.040
  
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  RRIDCUR:Missing RRID:Addgene_71236
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sciencedirect.com/science/article/pii/S1097276520309618
Jan 2021
www.sciencedirect.com www.sciencedirect.com

Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

1
1. scibot 20 Jan 2021
  
  in Public
  
  addgene_71236
  
  DOI: 10.1016/j.xcrm.2020.100188
  
  Resource: RRID:Addgene_71236
  
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  RRIDCUR:Validated RRID:Addgene_71236
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sciencedirect.com/science/article/pii/S2666379120302433
Sep 2020
www.cell.com www.cell.com

Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs

1
1. scibot 17 Sep 2020
  
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  RRID:Addgene_71236
  
  DOI: 10.1016/j.stem.2019.03.012
  
  Resource: RRID:Addgene_71236
  
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  RRID:Addgene_71236 RRIDCUR:Validated
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cell.com/cell-stem-cell/abstract/S1934-5909(19)30111-0
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Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS

1
1. scibot 05 Sep 2020
  
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  RRID:Addgene_71236
  
  DOI: 10.1016/j.cell.2020.03.002
  
  Resource: RRID:Addgene_71236
  
  Curator: @ethanbadger
  
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  RRIDCUR:Validated RRID:Addgene_71236
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sciencedirect.com/science/article/pii/S0092867420302646