68 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KSR1 mediates small-cell lung carcinoma tumor initiation and cisplatin resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12133430/
  3. Nov 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of PTDSS1 in tumor cells improves immunogenicity and response to anti–PD-1 therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12422196/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RESTRICT-seq enables time-gated CRISPR screens and uncovers novel epigenetic dependencies of SCC resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12458112/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN
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    pmc.ncbi.nlm.nih.gov/articles/PMC12627610/
  7. Oct 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The PAX-SIX-EYA-DACH network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC6983716/
  9. Sep 2025
  10. www.biorxiv.org www.biorxiv.org
    Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth
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    biorxiv.org/content/10.1101/2025.09.15.676412v1
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A methyl-to-acetyl switch in H3K27 drives metabolic reprogramming and resistance to BRAFV600E inhibition in melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12446969/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A fetal oncogene NUAK2 is an emerging therapeutic target in glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12423323/
  13. Aug 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIM5α/Cyclophilin A-Modified MDBK Cells for Lentiviral-Based Gene Editing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12298503/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An EGFR Co-Amplified and De Novo Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-Driven Gene Programs
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    pmc.ncbi.nlm.nih.gov/articles/PMC12270211/
  16. www.sciencedirect.com www.sciencedirect.com
    Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells
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    sciencedirect.com/science/article/pii/S1074761325003176
  17. Jul 2025
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12167974/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Wnt5a induces ROR1 dependent NF-κB activation to enhance MMP-9 expression and invasiveness in chronic lymphocytic leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208867/
  20. May 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12059070/
  22. Apr 2025
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR targeting of SNPs associated with age-related macular degeneration in ARPE-19 cells: a potential model for manipulating the complement system
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    pmc.ncbi.nlm.nih.gov/articles/PMC11946884/
  24. Mar 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trans-synaptic molecular context of NMDA receptor nanodomains
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    pmc.ncbi.nlm.nih.gov/articles/PMC10769418/
  26. Feb 2025
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pioneer factor GATA6 promotes colorectal cancer through 3D genome regulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11804904/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of YTHDC1 m6A reading function promotes invasiveness in urothelial carcinoma of the bladder
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    pmc.ncbi.nlm.nih.gov/articles/PMC11799412/
  29. Jan 2025
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A fetal oncogene NUAK2 is an emerging therapeutic target in glioblastoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11722409/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11729867/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss
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    pmc.ncbi.nlm.nih.gov/articles/PMC11701132/
  33. Dec 2024
  34. www.nature.com www.nature.com
    Inhibition of thioredoxin reductase 1 sensitizes glucose-starved glioblastoma cells to disulfidptosis
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    nature.com/articles/s41418-024-01440-0
  35. www.sciencedirect.com www.sciencedirect.com
    CD97 maintains tumorigenicity of glioblastoma stem cells via mTORC2 signaling and is targeted by CAR Th9 cells
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    sciencedirect.com/science/article/pii/S2666379124006153
  36. Sep 2024
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The structural basis for the collagen processing by human P3H1/CRTAP/PPIB ternary complex
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    ncbi.nlm.nih.gov/pmc/articles/PMC11381544/
  38. www.sciencedirect.com www.sciencedirect.com
    Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation
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    sciencedirect.com/science/article/pii/S1074761324004151
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CCR2 cooperativity promotes hematopoietic stem cell homing to the bone marrow
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    ncbi.nlm.nih.gov/pmc/articles/PMC11409967/
  40. Aug 2024
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The structural insight into the functional modulation of human anion exchanger 3
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    ncbi.nlm.nih.gov/pmc/articles/PMC11271275/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VP0 Myristoylation Is Essential for Senecavirus A Replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC11280471/
  43. Jul 2024
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11285331/
  45. Jun 2024
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase
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    ncbi.nlm.nih.gov/pmc/articles/PMC11127050/
  47. May 2024
  48. www.sciencedirect.com www.sciencedirect.com
    SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production
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    sciencedirect.com/science/article/pii/S1934590924001760
  49. Mar 2024
  50. www.sciencedirect.com www.sciencedirect.com
    RPGR is a guanine nucleotide exchange factor for the small GTPase RAB37 required for retinal function via autophagy regulation
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    sciencedirect.com/science/article/pii/S2211124724003383
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10924921/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of murine tumor models refractory to αPD-1/-L1 therapies due to defects in antigen processing/presentation or IFNγ signaling using CRISPR/Cas9
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    ncbi.nlm.nih.gov/pmc/articles/PMC10906908/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10905746/
  54. Feb 2024
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN Mediates the Silencing of Unintegrated HIV-1 DNA
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    ncbi.nlm.nih.gov/pmc/articles/PMC10892664/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10884155/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851011/
  58. www.sciencedirect.com www.sciencedirect.com
    Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells
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    sciencedirect.com/science/article/pii/S240547122400022X
  59. Jan 2024
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of postsynaptic NMDARs drives nanoscale reorganization of Munc13-1 and PSD-95
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    ncbi.nlm.nih.gov/pmc/articles/PMC10802569/
  61. www.sciencedirect.com www.sciencedirect.com
    Massively parallel disruption of enhancers active in human neural stem cells
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    sciencedirect.com/science/article/pii/S2211124724000214
  62. Nov 2023
  63. www.biorxiv.org www.biorxiv.org
    ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers
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    biorxiv.org/content/10.1101/2023.10.24.563645v1
  64. Oct 2023
  65. 52.53.155.43 52.53.155.43
    DHODH: A promising target in the treatment of T-Acute Lymphoblastic Leukemia
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    52.53.155.43/b85b4f7e9b1662b098287ec6861cce0602b37071/bloodadvances.2023010337-html.html
  66. Sep 2023
  67. www.sciencedirect.com www.sciencedirect.com
    CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax
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    sciencedirect.com/science/article/pii/S2211124723010951
  68. Jul 2023
  69. www.sciencedirect.com www.sciencedirect.com
    Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia
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    sciencedirect.com/science/article/pii/S221112472300815X
  70. Jun 2023
  71. www.sciencedirect.com www.sciencedirect.com
    An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets
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    sciencedirect.com/science/article/pii/S1535610823002088
  72. Apr 2023
  73. www.sciencedirect.com www.sciencedirect.com
    N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer
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    sciencedirect.com/science/article/pii/S266637912300112X
  74. Dec 2022
  75. www.embopress.org www.embopress.org
    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
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    embopress.org/doi/10.15252/embj.2022111961
  76. www.sciencedirect.com www.sciencedirect.com
    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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    sciencedirect.com/science/article/pii/S1534580722008152
  77. Nov 2022
  78. www.nature.com www.nature.com
    Arc controls alcohol cue relapse by a central amygdala mechanism
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    nature.com/articles/s41380-022-01849-4
  79. 52.53.155.43 52.53.155.43
    Arc controls alcohol cue relapse by a central amygdala mechanism
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    52.53.155.43/c8fad9c757271fce6679a31d7e760ec2be65dbb4/3be3c943-0ef8-4fd7-8d2f-7e6adc540b23-html.html
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits
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    ncbi.nlm.nih.gov/pmc/articles/PMC9437574/
  81. Sep 2022
  82. www.sciencedirect.com www.sciencedirect.com
    Sublethal cytochrome c release generates drug-tolerant persister cells
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    sciencedirect.com/science/article/pii/S0092867422009783
  83. Aug 2022
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    S146L in MYC is a context-dependent activating substitution in cancer development
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    ncbi.nlm.nih.gov/pmc/articles/PMC9417018/
  85. May 2022
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme
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    ncbi.nlm.nih.gov/pmc/articles/PMC9094746/
  87. Feb 2022
  88. www.sciencedirect.com www.sciencedirect.com
    Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants
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    sciencedirect.com/science/article/pii/S2589004222000803
  89. Jan 2022
  90. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Differential antigenic requirements by diverse MR1-restricted T cells
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    onlinelibrary.wiley.com/doi/10.1111/imcb.12519
  91. Dec 2021
  92. journals.plos.org journals.plos.org
    A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation
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    journals.plos.org/plosbiology/article
  93. Aug 2021
  94. link.springer.com link.springer.com
    Histone H2A.X phosphorylation and Caspase-Initiated Chromatin Condensation in late-stage erythropoiesis
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    link.springer.com/article/10.1186/s13072-021-00408-5
  95. May 2021
  96. www.sciencedirect.com www.sciencedirect.com
    Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells
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    sciencedirect.com/science/article/pii/S1097276520304767
  97. Sep 2020
  98. www.sciencedirect.com www.sciencedirect.com
    Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells
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    sciencedirect.com/science/article/pii/S2211124720303430
  99. Jan 2020
  100. jem.rupress.org jem.rupress.org
    Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis
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    jem.rupress.org/content/216/2/369