64 Matching Annotations
  1. Oct 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The PAX-SIX-EYA-DACH network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6983716/
  3. Sep 2025
  4. www.biorxiv.org www.biorxiv.org
    Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth
    1
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    biorxiv.org/content/10.1101/2025.09.15.676412v1
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A methyl-to-acetyl switch in H3K27 drives metabolic reprogramming and resistance to BRAFV600E inhibition in melanoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12446969/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A fetal oncogene NUAK2 is an emerging therapeutic target in glioblastoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12423323/
  7. Aug 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIM5α/Cyclophilin A-Modified MDBK Cells for Lentiviral-Based Gene Editing
    2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12298503/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An EGFR Co-Amplified and De Novo Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-Driven Gene Programs
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12270211/
  10. www.sciencedirect.com www.sciencedirect.com
    Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells
    1
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    sciencedirect.com/science/article/pii/S1074761325003176
  11. Jul 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function
    2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12167974/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Wnt5a induces ROR1 dependent NF-κB activation to enhance MMP-9 expression and invasiveness in chronic lymphocytic leukemia
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208867/
  14. May 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12059070/
  16. Apr 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR targeting of SNPs associated with age-related macular degeneration in ARPE-19 cells: a potential model for manipulating the complement system
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11946884/
  18. Mar 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trans-synaptic molecular context of NMDA receptor nanodomains
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC10769418/
  20. Feb 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pioneer factor GATA6 promotes colorectal cancer through 3D genome regulation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11804904/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of YTHDC1 m6A reading function promotes invasiveness in urothelial carcinoma of the bladder
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11799412/
  23. Jan 2025
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A fetal oncogene NUAK2 is an emerging therapeutic target in glioblastoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11722409/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11729867/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11701132/
  27. Dec 2024
  28. www.nature.com www.nature.com
    Inhibition of thioredoxin reductase 1 sensitizes glucose-starved glioblastoma cells to disulfidptosis
    1
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    nature.com/articles/s41418-024-01440-0
  29. www.sciencedirect.com www.sciencedirect.com
    CD97 maintains tumorigenicity of glioblastoma stem cells via mTORC2 signaling and is targeted by CAR Th9 cells
    1
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    sciencedirect.com/science/article/pii/S2666379124006153
  30. Sep 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The structural basis for the collagen processing by human P3H1/CRTAP/PPIB ternary complex
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11381544/
  32. www.sciencedirect.com www.sciencedirect.com
    Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation
    1
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    sciencedirect.com/science/article/pii/S1074761324004151
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CCR2 cooperativity promotes hematopoietic stem cell homing to the bone marrow
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11409967/
  34. Aug 2024
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The structural insight into the functional modulation of human anion exchanger 3
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11271275/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VP0 Myristoylation Is Essential for Senecavirus A Replication
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11280471/
  37. Jul 2024
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
    2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11285331/
  39. Jun 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11127050/
  41. May 2024
  42. www.sciencedirect.com www.sciencedirect.com
    SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production
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    sciencedirect.com/science/article/pii/S1934590924001760
  43. Mar 2024
  44. www.sciencedirect.com www.sciencedirect.com
    RPGR is a guanine nucleotide exchange factor for the small GTPase RAB37 required for retinal function via autophagy regulation
    1
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    sciencedirect.com/science/article/pii/S2211124724003383
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10924921/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of murine tumor models refractory to αPD-1/-L1 therapies due to defects in antigen processing/presentation or IFNγ signaling using CRISPR/Cas9
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10906908/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10905746/
  48. Feb 2024
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN Mediates the Silencing of Unintegrated HIV-1 DNA
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10892664/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10884155/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851011/
  52. www.sciencedirect.com www.sciencedirect.com
    Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells
    1
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    sciencedirect.com/science/article/pii/S240547122400022X
  53. Jan 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of postsynaptic NMDARs drives nanoscale reorganization of Munc13-1 and PSD-95
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10802569/
  55. www.sciencedirect.com www.sciencedirect.com
    Massively parallel disruption of enhancers active in human neural stem cells
    2
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    sciencedirect.com/science/article/pii/S2211124724000214
  56. Nov 2023
  57. www.biorxiv.org www.biorxiv.org
    ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers
    1
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    biorxiv.org/content/10.1101/2023.10.24.563645v1
  58. Oct 2023
  59. 52.53.155.43 52.53.155.43
    DHODH: A promising target in the treatment of T-Acute Lymphoblastic Leukemia
    1
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    52.53.155.43/b85b4f7e9b1662b098287ec6861cce0602b37071/bloodadvances.2023010337-html.html
  60. Sep 2023
  61. www.sciencedirect.com www.sciencedirect.com
    CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax
    1
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    sciencedirect.com/science/article/pii/S2211124723010951
  62. Jul 2023
  63. www.sciencedirect.com www.sciencedirect.com
    Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia
    1
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    sciencedirect.com/science/article/pii/S221112472300815X
  64. Jun 2023
  65. www.sciencedirect.com www.sciencedirect.com
    An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets
    1
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    sciencedirect.com/science/article/pii/S1535610823002088
  66. Apr 2023
  67. www.sciencedirect.com www.sciencedirect.com
    N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer
    1
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    sciencedirect.com/science/article/pii/S266637912300112X
  68. Dec 2022
  69. www.embopress.org www.embopress.org
    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
    2
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    embopress.org/doi/10.15252/embj.2022111961
  70. www.sciencedirect.com www.sciencedirect.com
    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
    1
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    sciencedirect.com/science/article/pii/S1534580722008152
  71. Nov 2022
  72. www.nature.com www.nature.com
    Arc controls alcohol cue relapse by a central amygdala mechanism
    1
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    nature.com/articles/s41380-022-01849-4
  73. 52.53.155.43 52.53.155.43
    Arc controls alcohol cue relapse by a central amygdala mechanism
    1
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    52.53.155.43/c8fad9c757271fce6679a31d7e760ec2be65dbb4/3be3c943-0ef8-4fd7-8d2f-7e6adc540b23-html.html
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9437574/
  75. Sep 2022
  76. www.sciencedirect.com www.sciencedirect.com
    Sublethal cytochrome c release generates drug-tolerant persister cells
    1
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    sciencedirect.com/science/article/pii/S0092867422009783
  77. Aug 2022
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    S146L in MYC is a context-dependent activating substitution in cancer development
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9417018/
  79. May 2022
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9094746/
  81. Feb 2022
  82. www.sciencedirect.com www.sciencedirect.com
    Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants
    2
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    sciencedirect.com/science/article/pii/S2589004222000803
  83. Jan 2022
  84. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Differential antigenic requirements by diverse MR1-restricted T cells
    1
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    onlinelibrary.wiley.com/doi/10.1111/imcb.12519
  85. Dec 2021
  86. journals.plos.org journals.plos.org
    A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation
    1
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    journals.plos.org/plosbiology/article
  87. Aug 2021
  88. link.springer.com link.springer.com
    Histone H2A.X phosphorylation and Caspase-Initiated Chromatin Condensation in late-stage erythropoiesis
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    link.springer.com/article/10.1186/s13072-021-00408-5
  89. May 2021
  90. www.sciencedirect.com www.sciencedirect.com
    Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells
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    sciencedirect.com/science/article/pii/S1097276520304767
  91. Sep 2020
  92. www.sciencedirect.com www.sciencedirect.com
    Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells
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    sciencedirect.com/science/article/pii/S2211124720303430
  93. Jan 2020
  94. jem.rupress.org jem.rupress.org
    Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis
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    jem.rupress.org/content/216/2/369