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Aug 2025
www.sciencedirect.com www.sciencedirect.com

Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer

1
1. scibot 27 Aug 2025
  
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  Addgene83480
  
  DOI: 10.1016/j.devcel.2025.07.023
  
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sciencedirect.com/science/article/pii/S153458072500499X
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SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia

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1. scibot 13 Aug 2025
  
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  Addgene: #83480
  
  DOI: 10.1016/j.celrep.2025.116147
  
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sciencedirect.com/science/article/pii/S2211124725009180
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer

1
1. scibot 10 Aug 2025
  
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  83480
  
  DOI: 10.1038/s44318-025-00495-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12316910/
Jul 2025
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Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids

1
1. scibot 20 Jul 2025
  
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  83480
  
  DOI: 10.1038/s41467-025-60949-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12219648/
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CD81 is a receptor for equine arteritis virus (family: Arteriviridae)

1
1. scibot 20 Jul 2025
  
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  Addgene_83480
  
  DOI: 10.1128/mbio.00623-25
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12239600/
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The use of sialic acids as attachment factors is a common feature of Enterovirus-D species

1
1. scibot 20 Jul 2025
  
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  plasmid_83480
  
  DOI: 10.1128/jvi.00429-25
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12172487/
www.embopress.org www.embopress.org

Hippo pathway controls biopterin metabolism to shield adjacent cells from ferroptosis in lung cancer

1
1. scibot 15 Jul 2025
  
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  plasmid_83480
  
  DOI: 10.1038/s44319-025-00515-4
  
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embopress.org/doi/10.1038/s44319-025-00515-4
Jun 2025
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Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1

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1. scibot 14 Jun 2025
  
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  plasmid_83480
  
  DOI: 10.1073/pnas.2505197122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12146761/
May 2025
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Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities

1
1. scibot 21 May 2025
  
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  Plasmid_83480
  
  DOI: 10.1186/s12943-025-02342-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12070678/
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Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization

1
1. scibot 16 May 2025
  
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  83480
  
  DOI: 10.1038/s41467-025-58909-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11997074/
Apr 2025
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Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation

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1. scibot 19 Apr 2025
  
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sciencedirect.com/science/article/pii/S153561082500128X
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Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling

2
1. scibot 10 Apr 2025
  
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  Addgene, cat. no. 83480
  
  DOI: 10.1038/s41594-025-01522-8
  
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2. scibot 10 Apr 2025
  
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  Addgene, cat. no. 83480
  
  DOI: 10.1038/s41594-025-01522-8
  
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  RRID:Addgene_83480 DOI:10.1038/s41594-025-01522-8
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nature.com/articles/s41594-025-01522-8
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The essential clathrin adapter protein complex-2 is tumor suppressive specifically in vivo

1
1. scibot 11 Mar 2025
  
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  RRID:Addgene_83480
  
  DOI: 10.1038/s41467-025-57521-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11885535/
Feb 2025
www.nature.com www.nature.com

Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen

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1. scibot 07 Feb 2025
  
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  Addgene_83480
  
  DOI: 10.1038/s41467-025-56547-w
  
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nature.com/articles/s41467-025-56547-w
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Transsulfuration pathway activation attenuates oxidative stress and ferroptosis in sickle primary erythroblasts and transgenic mice

1
1. scibot 27 Jan 2025
  
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  83480
  
  DOI: 10.1038/s42003-024-07424-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11704341/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Deacetylated SNAP47 recruits HOPS to facilitate autophagosome-lysosome fusion independent of STX17

1
1. scibot 15 Jan 2025
  
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  Addgene_83480
  
  DOI: 10.1038/s41467-025-55906-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11718230/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Phosphorylation of the selective autophagy receptor TAX1BP1 by TBK1 and IKBKE/IKKi promotes ATG8-family protein-dependent clearance of MAVS aggregates

1
1. scibot 08 Jan 2025
  
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  RRID:Addgene_83480
  
  DOI: 10.1080/15548627.2024.2394306
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11702929/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions

1
1. scibot 27 Sep 2024
  
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  83480
  
  DOI: 10.1038/s41588-024-01874-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387198/
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IRF2 loss is associated with reduced MHC I pathway transcripts in subsets of most human cancers and causes resistance to checkpoint immunotherapy in human and mouse melanomas

1
1. scibot 27 Sep 2024
  
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  83480
  
  DOI: 10.21203/rs.3.rs-4997954/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11398557/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor

1
1. scibot 22 Aug 2024
  
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  plasmid_83480
  
  DOI: 10.1038/s41467-024-51142-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11306234/
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Metabolic and transcriptomic reprogramming during contact inhibition-induced quiescence is mediated by YAP-dependent and YAP-independent mechanisms

1
1. scibot 22 Aug 2024
  
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  plasmid_83480
  
  DOI: 10.1038/s41467-024-51117-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11310444/
www.sciencedirect.com www.sciencedirect.com

Generation of a fluorescent hESC reporter line (Kle033-A-1) for the isolation of distinct midbrain progenitor cell types

1
1. scibot 21 Aug 2024
  
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  Addgene_83480
  
  DOI: 10.1016/j.scr.2024.103523
  
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sciencedirect.com/science/article/pii/S1873506124002216
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness

1
1. scibot 13 Aug 2024
  
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  83480
  
  DOI: 10.1093/nar/gkae313
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11194086/
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A tangible method to assess native ferroptosis suppressor activity

1
1. scibot 13 Aug 2024
  
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  83480
  
  DOI: 10.1016/j.crmeth.2024.100710
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10985226/
Jul 2024
www.cell.com www.cell.com

SART3 reads methylarginine-marked glycine- and arginine-rich motifs

1
1. scibot 16 Jul 2024
  
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  RRID:Addgene_83480
  
  DOI: 10.1016/j.celrep.2024.114459
  
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cell.com/cell-reports/abstract/S2211-1247(24)00788-5
www.cell.com www.cell.com

A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence

1
1. scibot 11 Jul 2024
  
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  RRID:Addgene_83480
  
  DOI: 10.1016/j.cell.2024.06.019
  
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cell.com/cell/fulltext/S0092-8674(24)00693-7
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The immune response to RNA suppresses nucleic acid synthesis by limiting ribose 5-phosphate

1
1. scibot 05 Jul 2024
  
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  RRID:Addgene_83480
  
  DOI: 10.1038/s44318-024-00100-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11217295/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Necroptosis stimulates interferon-mediated protective anti-tumor immunity

1
1. scibot 15 Jun 2024
  
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  plasmid_83480
  
  DOI: 10.1038/s41419-024-06801-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11164861/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR-Cas and CRISPR-based screening system for precise gene editing and targeted cancer therapy

1
1. scibot 03 Jun 2024
  
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  Addgene_83
  
  DOI: 10.1186/s12967-024-05235-2
  
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  RRIDCUR:Incorrect RRIDCUR:Unresolved RRID:Addgene_83480
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ncbi.nlm.nih.gov/pmc/articles/PMC11138051/
May 2024
www.science.org www.science.org

eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer

1
1. scibot 24 May 2024
  
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  plasmid_83480
  
  DOI: 10.1126/scisignal.adh4475
  
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science.org/doi/10.1126/scisignal.adh4475
Apr 2024
www.sciencedirect.com www.sciencedirect.com

Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB

2
1. scibot 26 Apr 2024
  
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  Addgene, Cat# 83480
  
  DOI: 10.1016/j.cell.2024.03.022
  
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  Curator: @abever99
  
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2. scibot 26 Apr 2024
  
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  plasmid_83480
  
  DOI: 10.1016/j.cell.2024.03.022
  
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sciencedirect.com/science/article/pii/S0092867424003131
rupress.org rupress.org

Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization

2
1. scibot 25 Apr 2024
  
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  RRID:Addgene_83480
  
  DOI: 10.1083/jcb.202307026
  
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  RRID:Addgene_83480
2. scibot 25 Apr 2024
  
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  RRID:Addgene_83480
  
  DOI: 10.1083/jcb.202307026
  
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rupress.org/jcb/article/223/4/e202307026/276570/Tunable-DNMT1-degradation-reveals-DNMT1-DNMT3B
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The Scribble/SGEF/Dlg1 complex regulates the stability of apical junctions in epithelial cells

1
1. scibot 23 Apr 2024
  
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  83480
  
  DOI: 10.1101/2024.03.26.586884
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10996629/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Regulation by the RNA-binding protein Unkempt at its effector interface

1
1. scibot 23 Apr 2024
  
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  83480
  
  DOI: 10.1038/s41467-024-47449-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11009413/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Global and single-nucleotide resolution detection of 7-methylguanosine in RNA

1
1. scibot 14 Apr 2024
  
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  83,480
  
  DOI: 10.1080/15476286.2024.2337493
  
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NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis

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Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells

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Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB–dependent IFITM3 expression

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A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer

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Protein supersaturation powers innate immune signaling

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Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition

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The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer

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Tissue-location-specific transcription programs drive tumor dependencies in colon cancer

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Transcriptional memory is conferred by combined heritable maintenance and local removal of selective chromatin modifications

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Machine learning-based prediction models to guide the selection of Cas9 variants for efficient gene editing

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Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells

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Synonymous codon usage regulates translation initiation

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Copy-back viral genomes induce a cellular stress response that interferes with viral protein expression without affecting antiviral immunity

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A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression

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CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression

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MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis

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May 2023
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Copyback viral genomes trigger stress granule formation independent of the antiviral response to interfere with viral translation in acute and persistent infections

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Mar 2023
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Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma

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An adverse tumor-protective effect of IDO1 inhibition

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Dec 2022
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Generation of human induced pluripotent stem cell lines with HMOX1 promoter polymorphism and CRISPR/Cas9-mediated deletion of exon 50 of DMD gene

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RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells

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The SETDB1–TRIM28 complex suppresses antitumor immunity

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May 2022
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The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis

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Apr 2022
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Antithetic effect of interferon-α on cell-free and cell-to-cell HIV-1 infection

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Mar 2022
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Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

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Feb 2022
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Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label therapy

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Sparse dictionary learning recovers pleiotropy from human cell fitness screens

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In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target

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Title: Derivation of human pluripotent stem cell line via CRISPR/Cas9 mediated deletion of exon 3 LAMA2 gene (DMBi001-A-1)

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Aug 2021
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GIPC proteins negatively modulate Plexind1 signaling during vascular development

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Untitled document

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May 2021
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A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation

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Nov 2020
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Activation of Clustered IFNγ Target Genes Drives Cohesin-Controlled Transcriptional Memory

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Jan 2020
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Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing

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Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

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sciencedirect.com/science/article/pii/S0092867419306774

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