43 Matching Annotations
  1. Oct 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-resolution promoter interaction analysis implicates genes involved in the activation of Type 3 Innate Lymphoid Cells in autoimmune disease risk
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    pmc.ncbi.nlm.nih.gov/articles/PMC12821085/
  3. Sep 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HOTAIR Promotes Prostate Cancer Progression by facilitating CDK9-Pol II Association and Transcriptional Elongation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13618222/
  5. Jun 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel anti-CD20, concabody, enhances immunotherapy efficacy by targeting MPZL1 and augmenting antibody-induced cell death
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    pmc.ncbi.nlm.nih.gov/articles/PMC13124566/
  7. May 2026
  8. www.sciencedirect.com www.sciencedirect.com
    A CRISPR activation screen identifies SPART as a pan-orthoflavivirus restriction factor
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    sciencedirect.com/science/article/pii/S1931312826001745
  9. Apr 2026
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CENPF Overexpression Induced by HBV Infection Facilitates the G1/S Cell Cycle Transition of Hepatocellular Carcinoma Cells via MYC Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13051194/
  11. Feb 2026
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The castration-resistant prostate cancer-associated SNP rs11067228 facilitates neuroendocrine differentiation through an enhancer-mediated chromatin interaction with SRRM4
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    pmc.ncbi.nlm.nih.gov/articles/PMC12837743/
  13. Nov 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PIM3-mediated phosphorylation stabilizes myeloid leukemia factor 2 to promote metastasis in osteosarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12520695/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reversion of passaged nucleus pulposus cells to notochordal-type cells by FoxA2 upregulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12578846/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Family with sequence similarity 114 member A1 orchestrates immune evasion in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12624017/
  17. Oct 2025
  18. www.nature.com www.nature.com
    PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition
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    nature.com/articles/s44161-025-00737-8
  19. Sep 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A methyl-to-acetyl switch in H3K27 drives metabolic reprogramming and resistance to BRAFV600E inhibition in melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12446969/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An isoform-specific RUNX1C–BTG2 axis governs AML quiescence and chemoresistance.
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405853/
  22. www.nature.com www.nature.com
    Cytotoxicity of activator expression in CRISPR-based transcriptional activation systems
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    nature.com/articles/s41467-025-63570-4
  23. Aug 2025
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Zika virus non-structural protein NS2A mediated endoplasmic reticulum stress through interacting with Sarco/endoplasmic reticulum Ca2+-ATPase 2
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12282174/
  25. Jul 2025
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12215363/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Leveraging CRISPR activation for rapid assessment of gene editing products in human pluripotent stem cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12181958/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CDX2 loss in colorectal cancer cells is associated with invasive properties and tumor budding
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    pmc.ncbi.nlm.nih.gov/articles/PMC12230109/
  29. Apr 2025
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modified screening of MYC promotor region elements using the CRISPR library in ovarian cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11963443/
  31. Mar 2025
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lethal co-expression intolerance underlies the mutually exclusive expression of ASCL1 and NEUROD1 in SCLC cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11906894/
  33. www.biorxiv.org www.biorxiv.org
    PRDM16 controls smooth muscle cell fate in atherosclerosis
    1
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    biorxiv.org/content/10.1101/2025.02.19.639186v1
  34. Dec 2024
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Direct cardiac reprogramming via combined CRISPRa-mediated endogenous Gata4 activation and exogenous Mef2c and Tbx5 expression
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11666955/
  36. Nov 2024
  37. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PPM1G Inhibits Epithelial–Mesenchymal Transition in Cholangiocarcinoma by Catalyzing TET1 Dephosphorylation for Destabilization to Impair Its Targeted Demethylation of the CLDN3 Promoter
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    onlinelibrary.wiley.com/doi/10.1002/advs.202407323
  38. Sep 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The disruption of NEAT1-miR-125b-5p-SLC1A5 cascade defines the oncogenicity and differential immune profile in head and neck squamous cell carcinoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11369192/
  40. www.biorxiv.org www.biorxiv.org
    Cytotoxicity of Activator Expression in CRISPR-based Transcriptional Activation Systems
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    biorxiv.org/content/10.1101/2024.09.23.614524v1
  41. Mar 2024
  42. www.sciencedirect.com www.sciencedirect.com
    The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA
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    sciencedirect.com/science/article/pii/S1534580724001072
  43. Feb 2024
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10893712/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy
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    ncbi.nlm.nih.gov/pmc/articles/PMC10761979/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tracing back primed resistance in cancer via sister cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10850087/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10766990/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10840274/
  49. Jan 2024
  50. www.sciencedirect.com www.sciencedirect.com
    PAPAS promotes differentiation of mammary epithelial cells and suppresses breast carcinogenesis
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    sciencedirect.com/science/article/pii/S2211124723016558
  51. Oct 2023
  52. www.sciencedirect.com www.sciencedirect.com
    Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
    1
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    sciencedirect.com/science/article/pii/S1934590923003284
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LINE-1 activation in the cerebellum drives ataxia
    2
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    ncbi.nlm.nih.gov/pmc/articles/PMC9588660/
  54. Jan 2023
  55. www.sciencedirect.com www.sciencedirect.com
    Resurrection of endogenous retroviruses during aging reinforces senescence
    1
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    sciencedirect.com/science/article/pii/S0092867422015306
  56. Nov 2022
  57. www.sciencedirect.com www.sciencedirect.com
    Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma
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    sciencedirect.com/science/article/pii/S1535610822005037
  58. May 2022
  59. www.nature.com www.nature.com
    Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content
    1
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    nature.com/articles/s41467-022-29942-w
  60. Feb 2022
  61. www.sciencedirect.com www.sciencedirect.com
    LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland
    1
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    sciencedirect.com/science/article/pii/S2211124722000961
  62. May 2021
  63. www.sciencedirect.com www.sciencedirect.com
    Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
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    sciencedirect.com/science/article/pii/S193459092030494X
  64. www.sciencedirect.com www.sciencedirect.com
    A Single-Cell Transcriptomic Atlas of Human Skin Aging
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    sciencedirect.com/science/article/pii/S1534580720308777
  65. Sep 2020
  66. www.sciencedirect.com www.sciencedirect.com
    Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS
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    sciencedirect.com/science/article/pii/S0092867420302646
  67. Jan 2020
  68. www.sciencedirect.com www.sciencedirect.com
    BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis
    1
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    sciencedirect.com/science/article/pii/S0092867419306336