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Functional Characterization of <i>SDHB</i> Variants Clarifies Hereditary Pheochromocytoma and Paraganglioma Risk and Genotype–Phenotype Relationships

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1. scibot 24 Apr 2026
  
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  RRID:Addgene_89359
  
  DOI: 10.1172/JCI198165
  
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jci.org/articles/view/198165
Mar 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis

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1. scibot 27 Mar 2026
  
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  89359
  
  DOI: 10.1038/s41594-026-01759-x
  
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  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12999485/
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

p53 Drives Lung Cancer Regression through a TSC2/TFEB-dependent Senescence Program

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1. scibot 10 Feb 2026
  
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  plasmid_89359
  
  DOI: 10.1158/2159-8290.CD-25-0525
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12877752/
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2

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1. scibot 24 Nov 2025
  
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  89359
  
  DOI: 10.1242/jcs.264193
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12582440/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia

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1. scibot 24 Nov 2025
  
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  Addgene_89359
  
  DOI: 10.1126/sciadv.aeb7238
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12571082/
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A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology

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1. scibot 22 Nov 2025
  
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  RRID:Addgene_89359
  
  DOI: 10.1016/j.devcel.2025.10.015
  
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sciencedirect.com/science/article/pii/S1534580725006665
Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function

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1. scibot 23 Oct 2025
  
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  RRID:Addgene_89359
  
  DOI: 10.1016/j.cub.2024.08.058
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11496028/
Nov 2024
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Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair

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1. scibot 17 Nov 2024
  
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  AddgeneCat#89359
  
  DOI: 10.1016/j.cell.2024.10.010
  
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  Curator: @vtello
  
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sciencedirect.com/science/article/pii/S0092867424011589
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer

1
1. scibot 25 Sep 2024
  
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  RRID:Addgene_89359
  
  DOI: 10.1016/j.celrep.2024.114606
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11407228/
Jul 2024
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The extracellular matrix integrates mitochondrial homeostasis

1
1. scibot 19 Jul 2024
  
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  RRID:Addgene_89359
  
  DOI: 10.1016/j.cell.2024.05.057
  
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sciencedirect.com/science/article/pii/S009286742400638X
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Alpha-defensin binding expands human adenovirus tropism

1
1. scibot 14 Jul 2024
  
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  RRID:Addgene_89359
  
  DOI: 10.1371/journal.ppat.1012317
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11230588/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

High-Throughput Discovery and Characterization of Viral Transcriptional Effectors in Human Cells

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1. scibot 03 Jul 2024
  
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  Addgene_89359
  
  DOI: 10.1016/j.cels.2023.05.008
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10350249/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

DNA-PKcs suppresses illegitimate chromosome rearrangements

1
1. scibot 07 Jun 2024
  
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  DOI: 10.1093/nar/gkae140
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11109964/
www.biorxiv.org www.biorxiv.org

Alpha-defensin binding expands human adenovirus tropism

1
1. scibot 04 Jun 2024
  
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  RRID:Addgene_89359
  
  DOI: 10.1101/2024.05.30.596681
  
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biorxiv.org/content/10.1101/2024.05.30.596681v1
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function

1
1. scibot 30 Apr 2024
  
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  RRID:Addgene_89359
  
  DOI: 10.1101/2024.04.02.587836
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11014585/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Small-molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding states

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1. scibot 15 Apr 2024
  
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  Addgene_89359
  
  DOI: 10.1091/mbc.E23-08-0336
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10881158/
www.biorxiv.org www.biorxiv.org

DNA-PKcs Suppresses Illegitimate Chromosome Rearrangements

1
1. scibot 07 Apr 2024
  
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  Addgene_89359
  
  DOI: 10.1101/2023.12.30.573736
  
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biorxiv.org/content/10.1101/2023.12.30.573736v1
Jul 2023
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Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation

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1. scibot 27 Jul 2023
  
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  RRID:Addgene_89359
  
  DOI: 10.1016/j.devcel.2023.07.001
  
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sciencedirect.com/science/article/pii/S1534580723003313
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Coding and non-coding elements comprise a regulatory network controlling transcription in Kaposi’s sarcoma-associated herpesvirus

1
1. scibot 25 Jul 2023
  
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  plasmid_89359
  
  DOI: 10.1101/2023.07.08.548212
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10350069/
Jan 2023
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A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes

1
1. scibot 19 Jan 2023
  
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  plasmid_89359
  
  DOI: 10.1016/j.cub.2022.12.041
  
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sciencedirect.com/science/article/pii/S0960982222019789
May 2021
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Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway

1
1. scibot 14 May 2021
  
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  RRID:Addgene_89359
  
  DOI: 10.1016/j.cub.2021.04.075
  
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sciencedirect.com/science/article/pii/S0960982221006229
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LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP

1
1. scibot 08 May 2021
  
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  RRID:Addgene_89359
  
  DOI: 10.1016/j.molcel.2020.10.021
  
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sciencedirect.com/science/article/pii/S1097276520307280
Feb 2021
www.cell.com www.cell.com

Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway

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1. scibot 24 Feb 2021
  
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  Plasmid_89359
  
  DOI: 10.1016/j.celrep.2020.01.013
  
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cell.com/cell-reports/abstract/S2211-1247(20)30022-X
Jan 2020
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SLC19A1 Is an Importer of the Immunotransmitter cGAMP

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1. scibot 13 Jan 2020
  
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  RRID:Addgene_89359
  
  DOI: 10.1016/j.molcel.2019.05.006
  
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  Curator: @ethanbadger
  
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  RRID:Addgene_89359 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276519303594