155 Matching Annotations
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    ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances
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    nature.com/articles/s41420-026-03027-9
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    Targeting the noncanonical function of metabolic enzyme PHGDH in driving PD-L1 expression and cancer immune evasion
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    sciencedirect.com/science/article/pii/S2666379126001217
  4. Mar 2026
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12999485/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12934820/
  7. Feb 2026
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    Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux
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    sciencedirect.com/science/article/pii/S0092867425015028
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    Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12867483/
  10. Nov 2025
  11. www.biorxiv.org www.biorxiv.org
    The Small Non-coding RNA miR-16-1-3p Hampers Cancer Stem Cell Self-renewal and Invasiveness, Boosting Chemosensitivity by Adjusting TGF-β1 Signaling via MDM2/p53 Axis in Human Osteosarcoma
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    biorxiv.org/content/10.1101/2025.11.19.689220v1
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    FGD3 mediates lytic cell death, enhancing efficacy and immunogenicity of chemotherapy agents in breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12613929/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual-edged mechanisms of α-tomatine in hepatocellular carcinoma by suppression of Wnt/β-catenin signaling versus RelB-Driven resistance in tumor therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12497816/
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    ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12551705/
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    Hypoxia increases susceptibility of human intestinal epithelial cells to rotavirus infection through repression of interferon induction
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    pmc.ncbi.nlm.nih.gov/articles/PMC12456215/
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    Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD
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    pmc.ncbi.nlm.nih.gov/articles/PMC12552132/
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    Membrane receptors cluster phosphatidylserine to activate LC3-associated phagocytosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12527911/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide mapping of EBV-induced genomic variations identifies the role of MUC19 in EBV latency
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    pmc.ncbi.nlm.nih.gov/articles/PMC12607598/
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    Development of D2HG biosensors inspired by the molecular mechanism of D2HG regulation of DhdR
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    sciencedirect.com/science/article/pii/S2451945625003411
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    DHHC enzymes in alphavirus glycoprotein acylation: A target for broad-spectrum antiviral therapy
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    sciencedirect.com/science/article/pii/S2211124725013117
  21. Oct 2025
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    Purinergic Ecto-Enzyme CD73 is a Context-Dependent Tumor Suppressor in Colorectal Cancer
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    sciencedirect.com/science/article/pii/S0021925825027164
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    Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12500318/
  24. Sep 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PIN1 prolyl isomerase promotes initiation and progression of bladder cancer through the SREBP2-mediated cholesterol biosynthesis pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875963/
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    Atypical cadherin FAT1 promotes tumorigenesis by suppressing autophagic cell death in glioblastoma under hypoxia or nutrient stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC12409952/
  27. Aug 2025
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    Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer
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    NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
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    nature.com/articles/s41586-025-09299-y
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIM5α/Cyclophilin A-Modified MDBK Cells for Lentiviral-Based Gene Editing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12298503/
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    SMARCA5 is required for the development of granule cell neuron precursors and Sonic Hedgehog Medulloblastoma growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12274346/
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    A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12302539/
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    RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12332072/
  34. 52.53.155.43 52.53.155.43
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    Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells
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  36. Jul 2025
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Whole-cell response of coronavirus-infected BMDCs through proteomic and transcriptomic analyses
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    RSK1-driven TRIM28/E2F1 feedback loop promotes castration-resistant prostate cancer progression
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  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFITM proteins are key entry factors for porcine epidemic diarrhea coronavirus
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    BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12167974/
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    Gasdermin E in glioblastoma –pyroptosis resistance and tumor-promoting functions
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    Inhibition of serotonin-Htr2b signaling in skeletal muscle mitigates obesity-induced insulin resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227683/
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    ARV1 is a component of the enzyme initiating glycosylphosphatidylinositol biosynthesis[image]
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    A fluorescent STING ligand sensor for high-throughput screening of compounds that can enhance tumor immunotherapy
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    B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with MYC and BCL2 Rearrangements
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    Glycosphingolipid synthesis mediates immune evasion in Kras-driven cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11892728/
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    HIV Vpr activates a nucleolar-specific ATR pathway to degrade the nucleolar stress sensor CCDC137
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    pmc.ncbi.nlm.nih.gov/articles/PMC12203918/
  48. Jun 2025
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    Microprotein SMIM26 drives oxidative metabolism via serine-responsive mitochondrial translation
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    Linear ubiquitination of p31comet by HOIP couples cytokine response with mitotic regulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12135451/
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    Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12086175/
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    TAMs-specific ARF1 inhibition reprograms glioma microenvironment and enhances the therapeutic effect of oncolytic adenovirus
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    sciencedirect.com/science/article/pii/S2589004225009575
  54. May 2025
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    RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer
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  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities
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    pmc.ncbi.nlm.nih.gov/articles/PMC12070678/
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    A chimeric viral platform for directed evolution in mammalian cells
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    Cooperative nutrient scavenging is an evolutionary advantage in cancer
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    N‐terminomics and proteomics analysis of Calpain‐2 reveal key proteolytic processing of metabolic and cell adhesion proteins
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  60. Apr 2025
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity
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    Targeting FANCM by antisense oligonucleotides in ALT-positive cancers
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  63. Mar 2025
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylation of YAP
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    The phagosome-mediated anti-bacterial immunity is governed by the proton-activated chloride channel in peritoneal macrophages
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    Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin
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    Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death
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    Isocyanic acid–mediated NLRP3 carbamoylation reduces NLRP3-NEK7 interaction and limits inflammasome activation
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    STING-induced noncanonical autophagy regulates endolysosomal homeostasis
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    Hypoxia inducible factor-1α drives cancer resistance to cuproptosis
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    HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy
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  72. Feb 2025
  73. www.sciencedirect.com www.sciencedirect.com
    Potentiating anti-tumor immunity by re-engaging immune synapse molecules
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    Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11839913/
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    PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1
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    sciencedirect.com/science/article/pii/S1934590925000104
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    PHGDH inhibition and FOXO3 modulation drives PUMA-dependent apoptosis in osteosarcoma
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    ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation
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    sciencedirect.com/science/article/pii/S0092867425000960
  78. Jan 2025
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A–menin to bivalent promoters
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    pmc.ncbi.nlm.nih.gov/articles/PMC11735410/
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    Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis
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  81. Dec 2024
  82. 52.53.155.43 52.53.155.43
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    ZBTB48 is a priming factor regulating B-cell-specific CIITA expression
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    Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain
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  86. Nov 2024
  87. www.biorxiv.org www.biorxiv.org
    Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth
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    biorxiv.org/content/10.1101/2023.07.15.549147v1
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    Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence-Associated Pathologies
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    onlinelibrary.wiley.com/doi/full/10.1002/advs.202404109
  89. Sep 2024
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptome analysis reveals EBF1 ablation-induced injuries in cardiac system
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    ncbi.nlm.nih.gov/pmc/articles/PMC11373621/
  91. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    OSGN-1 is a conserved flavin-containing monooxygenase required to stabilize the intercellular bridge in late cytokinesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC10945809/
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387198/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
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    ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
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    MIG6 loss increased RET inhibitor tolerant persister cells in RET-rearranged non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S0304383524006153
  95. Aug 2024
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-muscle myosin 2 can incorporate into established filaments in cells without an assembly competence domain
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    ncbi.nlm.nih.gov/pmc/articles/PMC11257479/
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CAR T-cells targeting FGFR4 and CD276 simultaneously show potent antitumor effect against childhood rhabdomyosarcoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11266617/
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11304869/
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    The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11175508/
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
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  183. Apr 2021
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  189. Oct 2020
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  191. Sep 2020
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  196. Jan 2020
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