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Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux

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1. scibot 19 Feb 2026
  
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sciencedirect.com/science/article/pii/S0092867425015028
Feb 2026
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Cellular Mg2+ decrease causes a distinctive NF-κB-dependent form of cell death

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1. scibot 12 Feb 2026
  
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  plasmid_98291
  
  DOI: 10.1016/j.celrep.2026.116964
  
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sciencedirect.com/science/article/pii/S2211124726000422
Jan 2026
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Non-canonical EGFR signaling promotes MAPK-dependent extrusion of epithelial cells

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1. scibot 26 Jan 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12752489/
Nov 2025
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ZEB1, a novel junctional adhesion molecule A regulator, impacts sensitivity of pancreatic cancer-associated fibroblasts to reovirus

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1. scibot 24 Nov 2025
  
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  DOI: 10.1016/j.omton.2025.201071
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12617759/
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Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism

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1. scibot 23 Nov 2025
  
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  DOI: 10.1038/s42255-025-01358-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12460162/
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Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer

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1. scibot 23 Nov 2025
  
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  DOI: 10.1038/s41586-025-09503-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12589105/
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Targeting plasticity in the pyrimidine synthesis pathway potentiates macrophage-mediated phagocytosis in pancreatic cancer models

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1. scibot 18 Nov 2025
  
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  DOI: 10.1172/JCI193370
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12618067/
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Cytidine deaminases APOBEC3C and APOBEC3D promote DNA replication stress resistance in pancreatic cancer cells

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1. scibot 01 Nov 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12557688/
Sep 2025
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PIN1 prolyl isomerase promotes initiation and progression of bladder cancer through the SREBP2-mediated cholesterol biosynthesis pathway

1
1. scibot 07 Sep 2025
  
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  RRID:Addgene_98291
  
  DOI: 10.1158/2159-8290.CD-24-0866
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11875963/
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Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer

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1. scibot 06 Sep 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11875910/
Jun 2025
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1-s2.0-S258900422501226X-main-html.html

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1. scibot 21 Jun 2025
  
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  Addgene Cat#98291
  
  DOI: 10.1016/j.isci.2025.112965
  
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52.53.155.43/d1f78810f1eafd7cac950f9c8a5713f79fe4d700/1-s2.0-S258900422501226X-main-html.html
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Genes driving three-dimensional growth of immortalized cells and cancer

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1. scibot 14 Jun 2025
  
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  DOI: 10.1038/s41419-025-07719-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12152191/
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Translation suppresses exogenous target RNA-mediated microRNA decay

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1. scibot 14 Jun 2025
  
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  DOI: 10.1038/s41467-025-60374-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12144122/
May 2025
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Structural basis for OAS2 regulation and its antiviral function

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1. scibot 29 May 2025
  
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  plasmid_98291
  
  DOI: 10.1016/j.molcel.2025.05.001
  
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sciencedirect.com/science/article/pii/S109727652500406X
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Cooperative nutrient scavenging is an evolutionary advantage in cancer

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1. scibot 16 May 2025
  
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  DOI: 10.1038/s41586-025-08588-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11981941/
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An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death

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1. scibot 16 May 2025
  
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  DOI: 10.1038/s41467-025-58619-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11986000/
Apr 2025
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ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition

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1. scibot 24 Apr 2025
  
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  plasmid_98291
  
  DOI: 10.1016/j.molcel.2025.04.004
  
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sciencedirect.com/science/article/pii/S1097276525003077
Mar 2025
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Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment assay

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1. scibot 14 Mar 2025
  
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  DOI: 10.1371/journal.ppat.1012972
  
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journals.plos.org/plospathogens/article
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STING-induced noncanonical autophagy regulates endolysosomal homeostasis

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1. scibot 11 Mar 2025
  
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  98291
  
  DOI: 10.1073/pnas.2415422122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11874320/
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γ-secretase facilitates retromer-mediated retrograde transport

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1. scibot 11 Mar 2025
  
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  Addgene_98291
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11883284/
Feb 2025
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Potentiating anti-tumor immunity by re-engaging immune synapse molecules

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101975
  
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sciencedirect.com/science/article/pii/S2666379125000485
Jan 2025
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Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A–menin to bivalent promoters

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1. scibot 27 Jan 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11735410/
Dec 2024
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Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.ccell.2024.10.014
  
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sciencedirect.com/science/article/pii/S1535610824004021
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dynamic convergence of autism disorder risk genes across neurodevelopment

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1. scibot 29 Sep 2024
  
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  Addgene_98291
  
  DOI: 10.1101/2024.08.23.609190
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11370590/
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In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions

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1. scibot 27 Sep 2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387198/
Aug 2024
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Non-muscle myosin 2 can incorporate into established filaments in cells without an assembly competence domain

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1. scibot 26 Aug 2024
  
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  DOI: 10.1101/2024.07.07.602405
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11257479/
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Interferon Regulatory Factor 6 Determines Intestinal Epithelial Cell Development and Immunity

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1. scibot 26 Aug 2024
  
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  DOI: 10.1016/j.mucimm.2024.03.013
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11323225/
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Metabolic and transcriptomic reprogramming during contact inhibition-induced quiescence is mediated by YAP-dependent and YAP-independent mechanisms

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1. scibot 22 Aug 2024
  
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  plasmid_98291
  
  DOI: 10.1038/s41467-024-51117-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11310444/
Jul 2024
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MUC1-C Dependence for the Progression of Pancreatic Neuroendocrine Tumors Identifies a Druggable Target for the Treatment of This Rare Cancer

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1. scibot 31 Jul 2024
  
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  Plasmid_98291
  
  DOI: 10.3390/biomedicines12071509
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11274714/
Jun 2024
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Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus

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1. scibot 20 Jun 2024
  
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  plasmid_98291
  
  DOI: 10.1084/jem.20232066
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11176256/
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Hippo–YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

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1. scibot 03 Jun 2024
  
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  DOI: 10.1038/s42255-024-01045-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11136666/
Apr 2024
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Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells

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1. scibot 23 Apr 2024
  
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  DOI: 10.1038/s42003-024-06163-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11024093/
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The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity

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  DOI: 10.1016/j.cell.2024.03.002
  
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  DOI: 10.1016/j.cell.2024.03.002
  
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sciencedirect.com/science/article/pii/S0092867424002502
Mar 2024
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FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis

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1. scibot 22 Mar 2024
  
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  Addgene_98291
  
  DOI: 10.1016/j.molcel.2024.02.037
  
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sciencedirect.com/science/article/pii/S1097276524001801
Feb 2024
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Experimental evidence for cancer resistance in a bat species

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1. scibot 21 Feb 2024
  
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  DOI: 10.1038/s41467-024-45767-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10869793/
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SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.cell.2024.01.008
  
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sciencedirect.com/science/article/pii/S0092867424000102
Aug 2023
www.nature.com www.nature.com

Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors

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1. scibot 24 Aug 2023
  
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  Addgene_98291
  
  DOI: 10.1038/s41467-023-40850-5
  
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nature.com/articles/s41467-023-40850-5
Jun 2023
www.sciencedirect.com www.sciencedirect.com

A mitochondrial iron-responsive pathway regulated by DELE1

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1. scibot 21 Jun 2023
  
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  Addgene_98291
  
  DOI: 10.1016/j.molcel.2023.05.031
  
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sciencedirect.com/science/article/pii/S1097276523004136
Apr 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation

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1. scibot 04 Apr 2023
  
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  Addgene_98291
  
  DOI: 10.1038/s42003-023-04683-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10063665/
Nov 2022
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Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression

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1. scibot 19 Nov 2022
  
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  RRID:Addgene_98291
  
  DOI: 10.1158/2767-9764.crc-22-0024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9648413/
Jul 2022
aacrjournals.org aacrjournals.org

Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression

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1. scibot 29 Jul 2022
  
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  RRID:Addgene_98291
  
  DOI: 10.1158/2767-9764.CRC-22-0024
  
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aacrjournals.org/cancerrescommun/article/2/7/679/707059/Bcl-xL-Inhibition-Radiosensitizes-PIK3CA-PTEN-Wild
Mar 2022
www.nature.com www.nature.com

Generation of CRISPR–Cas9-mediated genetic knockout human intestinal tissue–derived enteroid lines by lentivirus transduction and single-cell cloning

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1. scibot 05 Mar 2022
  
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  RRID:Addgene_98291
  
  DOI: 10.1038/s41596-021-00669-0
  
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nature.com/articles/s41596-021-00669-0
Aug 2021
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Gain-of-function p53R172H mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy

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1. scibot 25 Aug 2021
  
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  Addgene Cat# 98291
  
  DOI: 10.1016/j.celrep.2021.109578
  
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sciencedirect.com/science/article/pii/S2211124721010123
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Untitled document

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1. scibot 04 Aug 2021
  
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  Addgene_98291
  
  DOI: 10.1016/j.cell.2018.11.038
  
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sciencedirect.com/science/article/pii/S0092867418315630
May 2021
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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

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1. scibot 12 May 2021
  
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  RRID:Addgene_98291
  
  DOI: 10.1016/j.immuni.2021.04.019
  
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sciencedirect.com/science/article/pii/S1074761321001813
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A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation

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1. scibot 01 May 2021
  
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  Addgene_98291
  
  DOI: 10.1016/j.cmet.2021.01.013
  
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sciencedirect.com/science/article/pii/S1550413121000139
Apr 2021
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SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

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1. scibot 17 Apr 2021
  
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  Addgene_98291
  
  DOI: 10.1016/j.ccell.2020.04.014
  
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  RRIDCUR:Validated RRID:Addgene_98291
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sciencedirect.com/science/article/pii/S1535610820302130