65 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeted KRASG12V Degradation in vivo Elicits Lung Adenocarcinoma Regression with Subsequent Relapse from Dysregulated Proteolysis
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    pmc.ncbi.nlm.nih.gov/articles/PMC7619155/
  3. Jun 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MAGMAS Inhibition Enhances Temozolomide Efficacy in Chemotherapy-Resistant Glioblastoma Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC13247981/
  5. May 2026
  6. www.sciencedirect.com www.sciencedirect.com
    miR-93-mediated PTEN suppression and CNS-specific T cell exhaustion shape the leukemia niche in infant KMT2A::AFF1+ B-ALL
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    sciencedirect.com/science/article/pii/S2211124726004316
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    Ki-67 promotes circulating tumor cell intravasation and metastasis in breast cancer
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    sciencedirect.com/science/article/pii/S2211124726004328
  8. Apr 2026
  9. aacrjournals.org aacrjournals.org
    Anti–B-cell maturation antigen chimeric antigen receptor T-cell therapy bb21217 for relapsed and refractory multiple myeloma: results from the phase 1 CRB-402 study
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    aacrjournals.org/cancerimmunolres/article/14/4/528/776517/Anti-B-cell-Maturation-Antigen-Chimeric-Antigen
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    Patient-derived pediatric brain tumor orthotopic xenografts and tumor organoids faithfully recapitulate primary tumors
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    science.org/doi/10.1126/sciadv.aea4966
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LRRC15-CAR T cells for the treatment of osteosarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13080327/
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    Synergistic effects through targeting the PI3K and IGFR pathways in treating lung cancer carrying activation alterations along the PI3K pathway
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    sciencedirect.com/science/article/pii/S1936523326000902
  13. Mar 2026
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nanobody-Engineered CLL-1 CAR-T Cells: Optimizing Tumor-Specific Cytotoxicity and Minimizing Off-Tumor Toxicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012018/
  15. Feb 2026
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modelling EWS::FLI1 protein fluctuations reveal determinants of tumor plasticity in Ewing sarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12905378/
  17. Jan 2026
  18. www.science.org www.science.org
    Phenotypic discovery and therapeutic evaluation of an ITGA3B1-targeting antibody-drug conjugate for bladder cancer
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    science.org/doi/10.1126/sciadv.ady0041
  19. Dec 2025
  20. www.nature.com www.nature.com
    Deprivation of EGFR signal causes senolysis in PDAC with CDK4/6 inhibition
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    nature.com/articles/s41418-025-01634-0
  21. Nov 2025
  22. www.sciencedirect.com www.sciencedirect.com
    StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models
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    sciencedirect.com/science/article/pii/S0092867425011365
  23. Oct 2025
  24. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis
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    advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202501791
  25. www.biorxiv.org www.biorxiv.org
    Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer
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    biorxiv.org/content/10.1101/2025.09.05.674562v1
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12493205/
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    Antibody-gamma/delta T cell receptors targeting GPC2 regress neuroblastoma with low antigen density
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    sciencedirect.com/science/article/pii/S2666379125004513
  28. Sep 2025
  29. www.biorxiv.org www.biorxiv.org
    Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer
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    biorxiv.org/content/10.1101/2025.09.05.674562v1
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    Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling
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    sciencedirect.com/science/article/pii/S1934590925003285
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    Dual Inhibition of Carbonic Anhydrase IX and Glutathione Peroxidase 4 as a Novel Strategy for Ferroptosis-Induced Tumor Cell Death
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    sciencedirect.com/science/article/pii/S0223523425008724
  32. Aug 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11802306/
  34. Jun 2025
  35. 52.53.155.43 52.53.155.43
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  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fitness and transcriptional plasticity of human breast cancer single-cell-derived clones
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    pmc.ncbi.nlm.nih.gov/articles/PMC12117018/
  37. May 2025
  38. elifesciences.org elifesciences.org
    Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer
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    elifesciences.org/reviewed-preprints/106511
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PPDPF is not a key regulator of human pancreas development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12037078/
  40. Apr 2025
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870442/
  42. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Comparative single-cell transcriptomic profiling of patient-derived renal carcinoma cells in cellular and animal models of kidney cancer
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    febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.70022
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  44. Jan 2025
  45. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FGFR2-RUNX2 activation: An unexplored therapeutic pathway in luminal breast cancer related to tumor progression
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35302
  46. Dec 2024
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modeling Drug Responses and Evolutionary Dynamics using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple Negative Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617242/
  48. Nov 2024
  49. 52.53.155.43 52.53.155.43
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  50. Aug 2024
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Engineered Drug 3′UTRMYC1-18 Degrades the c-MYC-STAT5A/B-PD-L1 Complex In Vivo to Inhibit Metastatic Triple-Negative Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11311709/
  52. Jul 2024
  53. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
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    sciencedirect.com/science/article/pii/S153561082400237X
  54. Jun 2024
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    Comparable efficacy of oral bendamustine versus intravenous administration in treating hematologic malignancies
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    link.springer.com/article/10.1007/s00280-024-04688-y
  56. May 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PM21-particle stimulation augmented with cytokines enhances NK cell expansion and confers memory-like characteristics with enhanced survival
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    ncbi.nlm.nih.gov/pmc/articles/PMC11070970/
  58. Mar 2024
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10527992/
  60. Feb 2024
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831336/
  62. Oct 2023
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting MALAT1 Augments Sensitivity to PARP Inhibition by Impairing Homologous Recombination in Prostate Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10561629/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10543979/
  65. Sep 2023
  66. 52.53.155.43 52.53.155.43
    Targeting WEE1 kinase as a p53-independent therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia
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  67. Aug 2023
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  69. Jun 2023
  70. www.nature.com www.nature.com
    Neural crest-related NXPH1/α-NRXN signaling opposes neuroblastoma malignancy by inhibiting organotropic metastasis
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    nature.com/articles/s41388-023-02742-2
  71. dx.doi.org dx.doi.org
    Monitoring Therapeutic Response to Anti-Fibroblast Activation Protein (FAP) CAR T Cells using [18F]AlF-FAPI-74
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    dx.doi.org/10.1158/1078-0432.CCR-22-1379
  72. Apr 2022
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9099058/
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cryopreserved PM21-Particle-Expanded Natural Killer Cells Maintain Cytotoxicity and Effector Functions In Vitro and In Vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC9022621/
  75. Feb 2022
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A 3D Platform to Investigate Dynamic Cell-to-Cell Interactions Between Tumor Cells and Mesenchymal Progenitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC8802911/
  77. Oct 2021
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDKN2A-Mutated Pancreatic Ductal Organoids from Induced Pluripotent Stem Cells to Model a Cancer Predisposition Syndrome
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    ncbi.nlm.nih.gov/pmc/articles/PMC8533699/
  79. www.sciencedirect.com www.sciencedirect.com
    Anti-GD2 CAR MSCs against metastatic Ewing's sarcoma
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    sciencedirect.com/science/article/pii/S1936523321002321
  80. www.sciencedirect.com www.sciencedirect.com
    Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas
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    sciencedirect.com/science/article/pii/S2589004221011172
  81. Aug 2021
  82. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S240547121930081X
  83. Jul 2021
  84. www.sciencedirect.com www.sciencedirect.com
    Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124721007920
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rejection of benign melanocytic nevi by nevus-resident CD4+ T cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8221625/
  86. www.nature.com www.nature.com
    Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip
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    nature.com/articles/s41551-021-00757-2
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hormonal regulation of Semaphorin 7a in ER+ breast cancer drives therapeutic resistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC7878309/
  88. May 2021
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATRX Alteration Contributes to Tumor Growth and Immune Escape in Pleomorphic Sarcomas
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    ncbi.nlm.nih.gov/pmc/articles/PMC8124877/
  90. Apr 2021
  91. www.sciencedirect.com www.sciencedirect.com
    Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells
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    sciencedirect.com/science/article/pii/S1934590921001119
  92. www.sciencedirect.com www.sciencedirect.com
    Defining the Teratoma as a Model for Multi-lineage Human Development
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    sciencedirect.com/science/article/pii/S0092867420313817
  93. www.sciencedirect.com www.sciencedirect.com
    Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors
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    sciencedirect.com/science/article/pii/S2666379121000434
  94. Sep 2020
  95. www.sciencedirect.com www.sciencedirect.com
    Establishment and Use of Patient-Derived Xenograft Models for Drug Testing in Head and Neck Squamous Cell Carcinoma
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    sciencedirect.com/science/article/pii/S2666166720300113
  96. Jan 2020
  97. www.sciencedirect.com www.sciencedirect.com
    Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome
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    sciencedirect.com/science/article/pii/S1535610819302983
  98. Nov 2018
  99. www.sciencedirect.com www.sciencedirect.com
    Patient-Derived Xenografts for Prognostication and Personalized Treatment for Head and Neck Squamous Cell Carcinoma
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    sciencedirect.com/science/article/pii/S2211124718315675