209 Matching Annotations
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    Polyserine-mediated targeting of FAF2/UBXD8 ameliorates tau aggregation
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    sciencedirect.com/science/article/pii/S0896627325005872
  3. Aug 2025
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    NIHMS1525541-supplement-2-html.html
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    Corn Oil Supplementation Enhances Locomotor Performance and Mitochondrial Function in Drosophila melanogaster
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  8. Jul 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mbt/PAK4 together with SRC modulates N-Cadherin adherens junctions in the developing Drosophila eye
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    pmc.ncbi.nlm.nih.gov/articles/PMC6451336/
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    Loss of Prune in Circadian Cells Decreases the Amplitude of the Circadian Locomotor Rhythm in Drosophila
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    The RNA Helicase BELLE Is Involved in Circadian Rhythmicity and in Transposons Regulation in Drosophila melanogaster
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    An RNAi-based platform for spatiotemporal control of histone gene expression during animal development
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    Protocol to study DNA strand breaks during development and apoptosis using in situ nick translation in Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617862/
  16. Jun 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Maintenance of Rhodopsin levels in Drosophila photoreceptor and phototransduction requires Protein Kinase D
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    pmc.ncbi.nlm.nih.gov/articles/PMC6988883/
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    Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson’s disease
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  19. 52.53.155.43 52.53.155.43
    De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
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  20. May 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Drosophila HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development
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    pmc.ncbi.nlm.nih.gov/articles/PMC6210797/
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    De novo variants in KDM2A cause a syndromic neurodevelopmental disorder
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  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fate mapping during regeneration: cells that undergo compensatory proliferation in damaged Drosophila eye imaginal discs differentiate into multiple retinal accessory cell types
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    pmc.ncbi.nlm.nih.gov/articles/PMC6287490/
  24. Apr 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons
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  28. Mar 2025
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Developmentally regulated autophagy is required for eye formation in Drosophila
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  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson’s disease
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  31. Feb 2025
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    Ouabain activates transcription factor EB and exerts neuroprotection in models of Alzheimer's disease
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  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Examining the potential involvement of NONO in TDP‐43 proteinopathy in Drosophila
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  37. Dec 2024
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  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    clifford B.4.1 , an allele of CG1603 , causes tissue overgrowth in the Drosophila melanogaster eye
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  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lmx1a is required for the development of the ovarian stem cell niche in Drosophila
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  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models
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  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The integrated stress response regulates BMP signalling through effects on translation
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  43. Nov 2024
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  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A large-scale in vivo screen to investigate the roles of human genes in Drosophila melanogaster
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  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rab11 suppresses neuronal stress signaling by localizing dual leucine zipper kinase to axon terminals for protein turnover
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  47. Sep 2024
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SR protein B52/SRp55 regulates splicing of the period thermosensitive intron and mid-day siesta in Drosophila
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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila
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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches
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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC5789956/
  52. dx.doi.org dx.doi.org
    Juvenile and adult expression of polyglutamine expanded huntingtin produce distinct aggregate distributions in Drosophila muscle
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    dx.doi.org/10.1093/hmg/ddad098
  53. Aug 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy
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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects
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    ncbi.nlm.nih.gov/pmc/articles/PMC11289317/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis
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  58. Jul 2024
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exploring Excitotoxicity and Regulation of a Constitutively Active TRP Ca2+ Channel in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC7808436/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A conventional PKC critical for both the light-dependent and the light-independent regulation of the actin cytoskeleton in Drosophila photoreceptors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10318518/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic Targeting of dSAMTOR, A Negative dTORC1 Regulator, during Drosophila Aging: A Tissue-Specific Pathology
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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster
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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrin–ECM interactions and membrane-associated Catalase cooperate to promote resilience of the Drosophila intestinal epithelium
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    ncbi.nlm.nih.gov/pmc/articles/PMC9116668/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster
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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A pair of ascending neurons in the subesophageal zone mediates aversive sensory inputs-evoked backward locomotion in Drosophila larvae
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rpt2 proteasome subunit reduction causes Parkinson's disease like symptoms in Drosophila
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Drosophila functional Smad suppressing element fuss, a homologue of the human Skor genes, retains pro-oncogenic properties of the Ski/Sno family
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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Teflon promotes chromosomal recruitment of homolog conjunction proteins during Drosophila male meiosis
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Method for Rapid Selection of Randomly Induced Mutations in a Gene of Interest Using CRISPR/Cas9 Mediated Activation of Gene Expression
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Using Drosophila to identify naturally occurring genetic modifiers of amyloid beta 42- and tau-induced toxicity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10468303/
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mask, a component of the Hippo Pathway, is required for Drosophila eye morphogenesis.
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    ncbi.nlm.nih.gov/pmc/articles/PMC7416169/
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drosophila model to study Retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8
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    ncbi.nlm.nih.gov/pmc/articles/PMC7328144/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Validation of a Drosophila model of wild-type and T315I mutated BCR-ABL1 in chronic myeloid leukemia: an effective platform for treatment screening
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    ncbi.nlm.nih.gov/pmc/articles/PMC7012492/
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinetochore protein Spindly controls microtubule polarity in Drosophila axons
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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    C9orf72-Associated Arginine-Rich Dipeptide Repeat Proteins Reduce the Number of Golgi Outposts and Dendritic Branches in Drosophila Neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC7528685/
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo antagonistic role of the Human T-Cell Leukemia Virus Type 1 regulatory proteins Tax and HBZ
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    ncbi.nlm.nih.gov/pmc/articles/PMC7817025/
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protein manipulation using single copies of short peptide tags in cultured cells and in Drosophila melanogaster
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    ncbi.nlm.nih.gov/pmc/articles/PMC7990863/
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC8664476/
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC8810759/
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting of copper-trafficking chaperones causes gene-specific systemic pathology in Drosophila melanogaster: prospective expansion of mutational landscapes that regulate tumor resistance to cisplatin
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    ncbi.nlm.nih.gov/pmc/articles/PMC6826294/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Quantitative Model of Sporadic Axonal Degeneration in the Drosophila Visual System
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    ncbi.nlm.nih.gov/pmc/articles/PMC9188428/
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alterations of RNA-binding protein found in neurons in Drosophila neurons and glia influence synaptic transmission and lifespan
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    ncbi.nlm.nih.gov/pmc/articles/PMC9693765/
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PtdIns4P exchange at endoplasmic reticulum-autolysosome contacts is essential for autophagy and neuronal homeostasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10472871/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drosophila Phosphatase of Regenerating Liver Is Critical for Photoreceptor Cell Polarity and Survival during Retinal Development
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    ncbi.nlm.nih.gov/pmc/articles/PMC10380645/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin
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    ncbi.nlm.nih.gov/pmc/articles/PMC10356786/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drosophila ClC‐a is required in glia of the stem cell niche for proper neurogenesis and wiring of neural circuits
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    ncbi.nlm.nih.gov/pmc/articles/PMC6851788/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sec20 Is Required for Autophagic and Endocytic Degradation Independent of Golgi-ER Retrograde Transport
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    ncbi.nlm.nih.gov/pmc/articles/PMC6721519/
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans
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    ncbi.nlm.nih.gov/pmc/articles/PMC11144269/
  92. Jun 2024
  93. www.tandfonline.com www.tandfonline.com
    Characterizing a gene expression toolkit for eye- and photoreceptor-specific expression in Drosophila
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    tandfonline.com/doi/full/10.1080/19336934.2021.1915683
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy
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    ncbi.nlm.nih.gov/pmc/articles/PMC9733332/
  95. May 2024
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A comparison study of pathological features and drug efficacy between Drosophila models of C9orf72 ALS/FTD
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    ncbi.nlm.nih.gov/pmc/articles/PMC10880080/
  97. Apr 2024
  98. www.sciencedirect.com www.sciencedirect.com
    Pan-neuronal expression of human mutant SOD1 in Drosophila impairs survival and motor performance, induces early neuroinflammation and chromosome aberrations
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    sciencedirect.com/science/article/pii/S0925443924001819
  99. Mar 2024
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Zika virus protein expression screen in Drosophila to investigate targeted host pathways during development
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    ncbi.nlm.nih.gov/pmc/articles/PMC10924231/
  101. Feb 2024
  102. www.biorxiv.org www.biorxiv.org
    Examining the potential involvement of NONO in TDP-43 proteinopathy in Drosophila
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    biorxiv.org/content/10.1101/2023.12.13.571416v1
  103. Jan 2024
  104. www.sciencedirect.com www.sciencedirect.com
    Regulation and mechanism of Astragalus polysaccharide on ameliorating aging in Drosophila melanogaster
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    sciencedirect.com/science/article/abs/pii/S0141813023005251
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Herzog is not required for mushroom body development or courtship learning & memory but is required for eye development in Drosophila melanogaster
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  106. Dec 2023
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    Astrocytic expression of the chaperone DNAJB6 results in non-cell autonomous protection in Huntington’s disease
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  108. Aug 2023
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    FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo
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  110. Jan 2023
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    Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration
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  112. Sep 2022
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    Photoreceptors generate neuronal diversity in their target field through a Hedgehog morphogen gradient in Drosophila
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    Nucleoporins are degraded via upregulation of ESCRT-III/Vps4 complex in Drosophila models of C9-ALS/FTD
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    sciencedirect.com/science/article/pii/S2211124722012141
  115. Mar 2022
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    Drosophila functional screening of de novo variants in autism uncovers damaging variants and facilitates discovery of rare neurodevelopmental diseases
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    ncbi.nlm.nih.gov/pmc/articles/PMC8983390/
  117. Feb 2022
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    A phosphoswitch at acinus-serine437 controls autophagic responses to cadmium exposure and neurodegenerative stress
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  119. Jan 2022
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    Transposable element activation promotes neurodegeneration in a Drosophila model of Huntington's disease
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  121. Aug 2021
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    EDEM Function in ERAD Protects against Chronic ER Proteinopathy and Age-Related Physiological Decline in Drosophila
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    Allatostatin-C/AstC-R2 Is a Novel Pathway to Modulate the Circadian Activity Pattern in Drosophila
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    Neuron-specific knockouts indicate the importance of network communication to Drosophila rhythmicity
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  126. Jul 2021
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    Daywake, an Anti-siesta Gene Linked to a Splicing-Based Thermostat from an Adjoining Clock Gene
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    Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo
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  130. Jun 2021
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    Robustness of epithelial sealing is an emerging property of local ERK feedback driven by cell elimination
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  132. May 2021
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    Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease
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  134. Apr 2021
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    Systematic functional analysis of rab GTPases reveals limits of neuronal robustness to environmental challenges in flies
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    UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction
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  137. Mar 2021
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    A SUMO1-derived peptide targeting SUMO-interacting motif inhibits α-synuclein aggregation
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