67 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The cell autonomous and non-autonomous functions of Rab27 in longevity and neuroprotection in Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC12758210/
  3. Dec 2025
  4. 54.241.53.176 54.241.53.176
    2025.11.28.691107v1.full-html.html
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    54.241.53.176/12f36846ba50001ff4708bb6adbb38d3bbe5cca1/2025.11.28.691107v1.full-html.html
  5. Nov 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NELF‐A controls Drosophila healthspan by regulating heat‐shock protein‐mediated cellular protection and heterochromatin maintenance
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    pmc.ncbi.nlm.nih.gov/articles/PMC8135010/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    http://biorxiv.org/cgi/content/short/2020.12.20.423533
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    pmc.ncbi.nlm.nih.gov/articles/PMC7781322/
  8. Sep 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-fat diet impairs intermediate-term memory by autophagic-lysosomal dysfunction in Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC12370196/
  10. Aug 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tissue-specific alteration of gene expression and function by RU486 and the GeneSwitch system
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    pmc.ncbi.nlm.nih.gov/articles/PMC6529481/
  12. 52.53.155.43 52.53.155.43
    NIHMS1525541-supplement-2-html.html
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    52.53.155.43/c29ffa732963c27a8cc066d449b14f9959685a46/NIHMS1525541-supplement-2-html.html
  13. Jul 2025
  14. 52.53.155.43 52.53.155.43
    NIHMS1018824-supplement-supp-html.html
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    52.53.155.43/6927fee858ddc6cadd659cfab8afde443c75e10f/NIHMS1018824-supplement-supp-html.html
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing autophagy by redox regulation extends lifespan in Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC12198390/
  16. Jun 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC6460439/
  18. www.mdpi.com www.mdpi.com
    Tissue-Specific Fluorescent Protein Turnover in Free-Moving Flies
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    mdpi.com/2075-4450/16/6/583
  19. Apr 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy
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    pmc.ncbi.nlm.nih.gov/articles/PMC6148241/
  21. Dec 2024
  22. 52.53.155.43 52.53.155.43
    OXR1 maintains the retromer to delay brain aging under dietary restriction
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    52.53.155.43/b2d9ae773adaa873dfba750e4f392de3454b4520/41467_2023_Article_44343-html.html
  23. Nov 2024
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mifepristone and rapamycin have non-additive benefits for life span in mated female Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC11514543/
  25. Sep 2024
  26. www.biorxiv.org www.biorxiv.org
    Mis-regulation of GSK-3β causes axonal microtubule curling through Shot and Tau
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    biorxiv.org/content/10.1101/2024.09.08.611864v1
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegeneration
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    ncbi.nlm.nih.gov/pmc/articles/PMC10533867/
  28. Aug 2024
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A phosphorylation-deficient mutant of Sik3, a homolog of Sleepy, alters circadian sleep regulation by PDF neurons in Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC10469759/
  30. www.frontiersin.org www.frontiersin.org
    Mifepristone Increases Life Span of Virgin Female Drosophila on Regular and High-fat Diet Without Reducing Food Intake
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    frontiersin.org/articles/10.3389/fgene.2021.751647
  31. www.frontiersin.org www.frontiersin.org
    Mifepristone Increases Life Span in Female Drosophila Without Detectable Antibacterial Activity
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    frontiersin.org/articles/10.3389/fragi.2022.924957
  32. Jul 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A neuroendocrine pathway modulating osmotic stress in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC7971876/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS
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    ncbi.nlm.nih.gov/pmc/articles/PMC10280928/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An optimized temporally controlled Gal4 system in Drosophila reveals degeneration caused by adult-onset neuronal Vps13D knockdown
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    ncbi.nlm.nih.gov/pmc/articles/PMC10339317/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The FUS gene is dual‐coding with both proteins contributing to FUS‐mediated toxicity
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    ncbi.nlm.nih.gov/pmc/articles/PMC7788448/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC8188407/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vimar/RAP1GDS1 promotes acceleration of brain aging after flies and mice reach middle age
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    ncbi.nlm.nih.gov/pmc/articles/PMC10105717/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock
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    ncbi.nlm.nih.gov/pmc/articles/PMC10110236/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myc suppresses male–male courtship in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC8982623/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster
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    ncbi.nlm.nih.gov/pmc/articles/PMC9174495/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Roles of ZnT86D in Neurodevelopment and Pathogenesis of Alzheimer Disease in a Drosophila melanogaster Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC9569493/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control
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    ncbi.nlm.nih.gov/pmc/articles/PMC7205319/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dissecting the Genetic Basis of Variation in Drosophila Sleep Using a Multiparental QTL Mapping Resource
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    ncbi.nlm.nih.gov/pmc/articles/PMC7140804/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response
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    ncbi.nlm.nih.gov/pmc/articles/PMC9616999/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolic Signatures of Life Span Regulated by Mating, Sex Peptide, and Mifepristone/RU486 in Female Drosophila melanogaster
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    ncbi.nlm.nih.gov/pmc/articles/PMC7812429/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GWAS for Lifespan and Decline in Climbing Ability in Flies upon Dietary Restriction Reveal decima as a Mediator of Insulin-like Peptide Production
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    ncbi.nlm.nih.gov/pmc/articles/PMC7375902/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC7198565/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8570292/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Effects of poly-GA and poly-PR C9orf72 Dipeptide Repeats on Sleep Patterns in Drosophila melanogaster
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    ncbi.nlm.nih.gov/pmc/articles/PMC10943360/
  51. 52.53.155.43 52.53.155.43
    PMC10784588-html.html
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    52.53.155.43/0d4f4a1744e053bf921a7c29744fe98d26945d6f/PMC10784588-html.html
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Conditional chemoconnectomics (cCCTomics) as a strategy for efficient and conditional targeting of chemical transmission
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    ncbi.nlm.nih.gov/pmc/articles/PMC11060718/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuronal ageing is promoted by the decay of the microtubule cytoskeleton
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    ncbi.nlm.nih.gov/pmc/articles/PMC10962844/
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sulfated disaccharide protects membrane and DNA damages from arginine-rich dipeptide repeats in ALS
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    ncbi.nlm.nih.gov/pmc/articles/PMC10889363/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    dNAGLU Extends Life Span and Promotes Fitness and Stress Resistance in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC9694703/
  56. Jun 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A screen of small molecule and genetic modulators of life span in female Drosophila identifies etomoxir, RH5849 and unanticipated temperature effects
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    ncbi.nlm.nih.gov/pmc/articles/PMC9683069/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy
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    ncbi.nlm.nih.gov/pmc/articles/PMC9733332/
  59. May 2024
  60. www.sciencedirect.com www.sciencedirect.com
    Upregulation of neuronal ER-phagy improves organismal fitness and alleviates APP toxicity
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    sciencedirect.com/science/article/pii/S2211124724005837
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A tailed mirtron promotes longevity in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC10853799/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD
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    ncbi.nlm.nih.gov/pmc/articles/PMC10728118/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dhr96[1] mutation and maternal tudor[1] mutation increase life span and reduce the beneficial effects of mifepristone in mated female Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC10735022/
  64. Apr 2024
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional identity of hypothalamic melanocortin neurons depends on Tbx3
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    ncbi.nlm.nih.gov/pmc/articles/PMC8291379/
  66. Feb 2024
  67. bmcgenomics.biomedcentral.com bmcgenomics.biomedcentral.com
    The metabolome as a link in the genotype-phenotype map for peroxide resistance in the fruit fly, Drosophila melanogaster
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    bmcgenomics.biomedcentral.com/articles/10.1186/s12864-020-6739-1
  68. link.springer.com link.springer.com
    Simultaneous activation of the hydrogen sulfide biosynthesis genes (CBS and CSE) induces sex-specific geroprotective effects in Drosophila melanogaster
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    link.springer.com/article/10.1007/s10522-023-10017-2
  69. www.biorxiv.org www.biorxiv.org
    Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegeneration
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    biorxiv.org/content/10.1101/2023.03.14.532519v1
  70. Jan 2024
  71. www.mdpi.com www.mdpi.com
    Neuronal atg1 Coordinates Autophagy Induction and Physiological Adaptations to Balance mTORC1 Signalling
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    mdpi.com/2073-4409/12/16/2024
  72. Aug 2023
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD
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    ncbi.nlm.nih.gov/pmc/articles/PMC10393046/
  74. Jul 2023
  75. link.springer.com link.springer.com
    A Novel Drosophila-based Drug Repurposing Platform Identified Fingolimod As a Potential Therapeutic for TDP-43 Proteinopathy
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    link.springer.com/article/10.1007/s13311-023-01406-z
  76. Jun 2022
  77. www.sciencedirect.com www.sciencedirect.com
    Identification of the stress granule transcriptome via RNA-editing in single cells and in vivo
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    sciencedirect.com/science/article/pii/S2667237522001047
  78. Aug 2021
  79. www.sciencedirect.com www.sciencedirect.com
    Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31
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    sciencedirect.com/science/article/pii/S089662731730154X
  80. Jul 2021
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo imaging reveals mitophagy independence in the maintenance of axonal mitochondria during normal aging
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    ncbi.nlm.nih.gov/pmc/articles/PMC5595681/
  82. Apr 2021
  83. www.sciencedirect.com www.sciencedirect.com
    Huntingtin-mediated axonal transport requires arginine methylation by PRMT6
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    sciencedirect.com/science/article/pii/S2211124721002941
  84. Feb 2021
  85. www.cell.com www.cell.com
    Clock neurons gate memory extinction in Drosophila
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    cell.com/current-biology/fulltext/S0960-9822(21)00041-5
  86. Sep 2020
  87. www.cell.com www.cell.com
    Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling
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    cell.com/cell-reports/fulltext/S2211-1247(18)31768-6
  88. Aug 2020
  89. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27
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    onlinelibrary.wiley.com/doi/10.1111/acel.13179
  90. Jan 2020
  91. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S2211124718317686
  92. Nov 2018
  93. www.jneurosci.org www.jneurosci.org
    Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress
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    jneurosci.org/content/38/37/8071
  94. www.sciencedirect.com www.sciencedirect.com
    mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington’s Disease
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    sciencedirect.com/science/article/pii/S1097276518306014
  95. Nov 2017
  96. www.sciencedirect.com www.sciencedirect.com
    Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31
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    sciencedirect.com/science/article/pii/S089662731730154X