115 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Detection of dedifferentiated stem cells in Drosophila testis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12547877/
  3. Oct 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A single-cell atlas of adult Drosophila ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC7205450/
  5. www.biorxiv.org www.biorxiv.org
    Organ-specific rewiring of mitochondrial integrity through COX7A dictates cellular ploidy control
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    biorxiv.org/content/10.1101/2025.09.29.678879v1
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuronally expressed anti-tau scFv prevents tauopathy-induced phenotypes in Drosophila models
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    pmc.ncbi.nlm.nih.gov/articles/PMC7178494/
  7. Sep 2025
  8. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004225018255-main-html.html
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  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modular tissue-specific regulation of doublesex underpins sexually dimorphic development in Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC6679366/
  10. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225017778-main-html.html
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    52.53.155.43/4005d9dc3de7c586d344b29d9fb94e379d469dd5/1-s2.0-S2589004225017778-main-html.html
  11. Aug 2025
  12. 52.53.155.43 52.53.155.43
    Temporal coordination of tissue transformation, olfactory sensory neural development and central axon projections through morphogens
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    52.53.155.43/4a357c1e5d903976d603f1c2eb701dc67dcbe4c5/2025.07.21.666031v1.full-html.html
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High Dietary Sugar Reshapes Sweet Taste to Promote Feeding Behavior in Drosophila melanogaster
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    pmc.ncbi.nlm.nih.gov/articles/PMC6561488/
  14. Jul 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuronal Activity in Non-LNv Clock Cells is Required to Produce Free-Running Rest:Activity Rhythms in Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC7153773/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    YAP/Yorkie in the germline modulates the age-related decline of germline stem cells and niche cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC6447158/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A toolset to study functions of Cytosolic non-specific dipeptidase 2 (CNDP2) using Drosophila as a model organism
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    pmc.ncbi.nlm.nih.gov/articles/PMC6421639/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Conserved regulation of neurodevelopmental processes and behavior by FoxP in Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC6372147/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Drosophila hamlet mediates epithelial tissue assembly of the reproductive system
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227202/
  20. Jun 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Linking expression and function of Drosophila type-I TGF-β receptor baboon isoforms: Multiple roles of BaboA isoform in shaping of the adult central nervous system
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    pmc.ncbi.nlm.nih.gov/articles/PMC12124520/
  22. May 2025
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Restoring calcium crosstalk between ER and mitochondria promotes intestinal stem cell rejuvenation through autophagy in aged Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC12116733/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Expression Pattern of the AB1-Gal4 Driver in Drosophila Third-Instar Larvae
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    pmc.ncbi.nlm.nih.gov/articles/PMC12071433/
  25. www.embopress.org www.embopress.org
    Slik sculpts the plasma membrane into cytonemes to control cell-cell communication
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    embopress.org/doi/10.1038/s44318-025-00401-8
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Slik sculpts the plasma membrane into cytonemes to control cell-cell communication
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    pmc.ncbi.nlm.nih.gov/articles/PMC12000455/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Steroid hormone-induced wingless ligands tune female intestinal size in Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC11704138/
  28. Apr 2025
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Role of Hemocytes in the Aging of Drosophila Male Germline
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    pmc.ncbi.nlm.nih.gov/articles/PMC11854897/
  30. Mar 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PACS deficiency disrupts Golgi architecture and causes cytokinesis failures and seizure-like phenotype in Drosophila melanogaster
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    pmc.ncbi.nlm.nih.gov/articles/PMC11858789/
  32. www.biorxiv.org www.biorxiv.org
    Myc and Tor drive growth and cell competition in the regeneration blastema of Drosophila wing imaginal discs
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    biorxiv.org/content/10.1101/2025.03.15.643479v1
  33. www.cell.com www.cell.com
    Drosophila complement-like Mcr acts as a wound-induced inflammatory chemoattractant
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    cell.com/current-biology/abstract/S0960-9822(25)00200-3
  34. Feb 2025
  35. 52.53.155.43 52.53.155.43
    Neuropeptide Dynamics Coordinate Layered Plasticity Mechanisms Adapting Drosophila Circadian Behavior to Changing Environment.
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    52.53.155.43/e253a9157fad0f68f91ce909880f1feb219273bc/2024.10.15.618497.full-html.html
  36. Dec 2024
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modulation of RNA processing genes during sleep-dependent memory
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    pmc.ncbi.nlm.nih.gov/articles/PMC11623928/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Unravelling the Molecular Determinants of Bee Sensitivity to Neonicotinoid Insecticides
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    pmc.ncbi.nlm.nih.gov/articles/PMC5887109/
  39. Sep 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Age-Related Changes in the Expression of the Circadian Clock Protein PERIOD in Drosophila Glial Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC5767304/
  41. academic.oup.com academic.oup.com
    Fourth Chromosome Resource Project: a comprehensive resource for genetic analysis in Drosophila that includes humanized stocks
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    academic.oup.com/genetics/article/226/2/iyad201/7429096
  42. www.sciencedirect.com www.sciencedirect.com
    Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut
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    sciencedirect.com/science/article/pii/S2211124724010441
  43. Aug 2024
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Conserved chamber-specific polyploidy maintains heart function in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC10482010/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Versatile nanobody-based approach to image, track and reconstitute functional Neurexin-1 in vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC11258300/
  46. www.tandfonline.com www.tandfonline.com
    TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2
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    tandfonline.com/doi/full/10.1080/15548627.2019.1704117
  47. www.tandfonline.com www.tandfonline.com
    Phenotypic and transcriptomic impact of expressing mammalian TET2 in the Drosophila melanogaster model
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    tandfonline.com/doi/full/10.1080/15592294.2023.2192375
  48. Jul 2024
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Drosophila melanogaster Neprilysin Nepl15 is involved in lipid and carbohydrate storage
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    ncbi.nlm.nih.gov/pmc/articles/PMC7822871/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spenito-dependent metabolic sexual dimorphism intrinsic to fat storage cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9949119/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptomic analysis of feminizing somatic stem cells in the Drosophila testis reveals putative downstream effectors of the transcription factor Chinmo
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    ncbi.nlm.nih.gov/pmc/articles/PMC8759813/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging
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    ncbi.nlm.nih.gov/pmc/articles/PMC10558556/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drosophila Tet Is Required for Maintaining Glial Homeostasis in Developing and Adult Fly Brains
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    ncbi.nlm.nih.gov/pmc/articles/PMC9045479/
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimized assay for transposase-accessible chromatin by sequencing (ATAC-seq) library preparation from adult Drosophila melanogaster neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC9001676/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex determination gene transformer regulates the male-female difference in Drosophila fat storage via the adipokinetic hormone pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC8594944/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Social reprogramming in ants induces longevity-associated glia remodeling
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    ncbi.nlm.nih.gov/pmc/articles/PMC7438095/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic and Molecular Interactions between HΔCT, a Novel Allele of the Notch Antagonist Hairless, and the Histone Chaperone Asf1 in Drosophila melanogaster
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    ncbi.nlm.nih.gov/pmc/articles/PMC9858708/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FGF signaling promotes myoblast proliferation through activation of wingless signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC7648665/
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex-specific evolution of a Drosophila sensory system via interacting cis- and trans-regulatory changes
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    ncbi.nlm.nih.gov/pmc/articles/PMC9179014/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The transcription factor Spalt and human homologue SALL4 induce cell invasion via the dMyc-JNK pathway in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC7104861/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vestigial-dependent induction contributes to robust patterning but is not essential for wing-fate recruitment in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC10214856/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC7210301/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown
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    ncbi.nlm.nih.gov/pmc/articles/PMC6994176/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A multi-gene knockdown approach reveals a new role for Pax6 in controlling organ number in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC8172120/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Isolation and RNA sequencing of single nuclei from Drosophila tissues
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    ncbi.nlm.nih.gov/pmc/articles/PMC9127693/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nuclear Prospero allows one-division potential to neural precursors and post-mitotic status to neurons via opposite regulation of Cyclin E
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    ncbi.nlm.nih.gov/pmc/articles/PMC9359583/
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC10784524/
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Single MicroRNA-Hox Gene Module Controls Equivalent Movements in Biomechanically Distinct Forms of Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC6710004/
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Iterative assay for transposase-accessible chromatin by sequencing to isolate functionally relevant neuronal subtypes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10971406/
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Wolbachia WalE1 effector alters Drosophila endocytosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11003677/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Condensin-mediated restriction of retrotransposable elements facilitates brain development in Drosophila melanogaster
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    ncbi.nlm.nih.gov/pmc/articles/PMC10978865/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The amyloid precursor protein intracellular domain induces sleep disruptions and its nuclear localization fluctuates in circadian pacemaker neurons in Drosophila and mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10932905/
  73. 52.53.155.43 52.53.155.43
    pnas.2318760121.sapp-html.html
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cholesterol Dietary Intake and Tumor Cell Homeostasis Drive Early Epithelial Tumorigenesis: A Potential Modelization of Early Prostate Tumorigenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11172085/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    mTORC1 is required for differentiation of germline stem cells in the Drosophila melanogaster testis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10956854/
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Drosophila glial cell atlas reveals a mismatch between transcriptional and morphological diversity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10619882/
  78. Jun 2024
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC9701223/
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging
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    ncbi.nlm.nih.gov/pmc/articles/PMC9759524/
  81. May 2024
  82. academic.oup.com academic.oup.com
    Fourth Chromosome Resource Project: a comprehensive resource for genetic analysis in Drosophila that includes humanized stocks
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    academic.oup.com/genetics/article/226/2/iyad201/7429096
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A distinct Acyl-CoA binding protein (ACBP6) shapes tissue plasticity during nutrient adaptation in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC10663470/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Convergent insulin and TGF‐β signalling drives cancer cachexia by promoting aberrant fat body ECM accumulation in a Drosophila tumour model
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    ncbi.nlm.nih.gov/pmc/articles/PMC10702797/
  85. Apr 2024
  86. www.sciencedirect.com www.sciencedirect.com
    scRNA-seq data from the larval Drosophila ventral cord provides a resource for studying motor systems function and development
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    sciencedirect.com/science/article/pii/S1534580724001862
  87. Feb 2024
  88. www.biorxiv.org www.biorxiv.org
    Developmental regulation of oocyte lipid uptake via ‘patent’ follicular epithelium in Drosophila melanogaster
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    biorxiv.org/content/10.1101/2019.12.31.891838v2
  89. Dec 2023
  90. www.jneurosci.org www.jneurosci.org
    MicroRNA-Dependent Control of Sensory Neuron Function Regulates Posture Behavior in Drosophila
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    jneurosci.org/content/41/40/8297
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Drosophila drop-dead gene is required for eggshell integrity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10697589/
  92. Aug 2023
  93. www.sciencedirect.com www.sciencedirect.com
    Regulation of feeding and energy homeostasis by clock-mediated Gart in Drosophila
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    sciencedirect.com/science/article/pii/S2211124723009233
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Continuous muscle, glial, epithelial, neuronal, and hemocyte cell lines for Drosophila research
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    ncbi.nlm.nih.gov/pmc/articles/PMC10393297/
  95. May 2023
  96. www.biorxiv.org www.biorxiv.org
    The Drosophila drop-dead gene is required for eggshell integrity
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    biorxiv.org/content/10.1101/2023.04.25.538335v1
  97. Apr 2023
  98. www.biorxiv.org www.biorxiv.org
    Conserved Chamber-Specific Polyploidy Maintains Heart Function in Drosophila
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    biorxiv.org/content/10.1101/2023.02.10.528086v1
  99. Mar 2023
  100. www.mdpi.com www.mdpi.com
    Modeling Notch-Induced Tumor Cell Survival in the Drosophila Ovary Identifies Cellular and Transcriptional Response to Nuclear NICD Accumulation
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    mdpi.com/2073-4409/10/9/2222
  101. Feb 2023
  102. journals.sagepub.com journals.sagepub.com
    Inducible Reporter Lines for Tissue-specific Monitoring of Drosophila Circadian Clock Transcriptional Activity
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    journals.sagepub.com/doi/full/10.1177/07487304221138946
  103. Dec 2022
  104. journals.sagepub.com journals.sagepub.com
    Inducible Reporter Lines for Tissue-specific Monitoring of Drosophila Circadian Clock Transcriptional Activity
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    journals.sagepub.com/doi/full/10.1177/07487304221138946
  105. Jul 2022
  106. www.sciencedirect.com www.sciencedirect.com
    Regulation of Drosophila oviduct muscle contractility by octopamine
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    sciencedirect.com/science/article/pii/S2589004222009695
  107. Jun 2022
  108. www.sciencedirect.com www.sciencedirect.com
    γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor
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    sciencedirect.com/science/article/pii/S1534580722003343
  109. Mar 2022
  110. www.sciencedirect.com www.sciencedirect.com
    Microbes affect gut epithelial cell composition through immune-dependent regulation of intestinal stem cell differentiation
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    sciencedirect.com/science/article/pii/S2211124722003163
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drosophila functional screening of de novo variants in autism uncovers damaging variants and facilitates discovery of rare neurodevelopmental diseases
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    ncbi.nlm.nih.gov/pmc/articles/PMC8983390/
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies
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  113. Nov 2021
  114. www.science.org www.science.org
    Dissecting the evolutionary role of the Hox gene proboscipedia in Drosophila mouthpart diversification by full locus replacement
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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dissecting the evolutionary role of the Hox gene proboscipedia in Drosophila mouthpart diversification by full locus replacement
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  116. Sep 2021
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dorsal clock neurons in Drosophila sculpt locomotor outputs but are dispensable for circadian activity rhythms
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  118. Aug 2021
  119. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The astrocyte network in the ventral nerve cord neuropil of the Drosophila third‐instar larva
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    onlinelibrary.wiley.com/doi/10.1002/cne.24852
  120. Jul 2021
  121. www.sciencedirect.com www.sciencedirect.com
    Learning a Spatial Task by Trial and Error in Drosophila
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    sciencedirect.com/science/article/pii/S0960982219307729
  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The BMP2/4 ortholog Dpp can function as an inter-organ signal that regulates developmental timing
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    ncbi.nlm.nih.gov/pmc/articles/PMC6243201/
  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hormone-dependent control of developmental timing through regulation of chromatin accessibility
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  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling
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  126. Mar 2021
  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bidirectional regulation of glial potassium buffering – glioprotection versus neuroprotection
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  128. Jan 2020
  129. jcb.rupress.org jcb.rupress.org
    SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K+ and water
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    jcb.rupress.org/content/early/2019/10/22/jcb.201907138
  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Peptidoglycan-dependent NF-κB activation in a small subset of brain octopaminergic neurons controls female oviposition
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  131. www.jneurosci.org www.jneurosci.org
    Circuit Dysfunction in SOD1-ALS Model First Detected in Sensory Feedback Prior to Motor Neuron Degeneration Is Alleviated by BMP Signaling
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    jneurosci.org/content/39/12/2347
  132. www.sciencedirect.com www.sciencedirect.com
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  133. Nov 2018
  134. www.sciencedirect.com www.sciencedirect.com
    Reconfiguration of a Multi-oscillator Network by Light in the Drosophila Circadian Clock
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  135. www.sciencedirect.com www.sciencedirect.com
    The InR/Akt/TORC1 Growth-Promoting Signaling Negatively Regulates JAK/STAT Activity and Migratory Cell Fate during Morphogenesis
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  136. www.sciencedirect.com www.sciencedirect.com
    Pleiotropic and novel phenotypes in the Drosophila gut caused by mutation of drop-dead
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    sciencedirect.com/science/article/pii/S0022191017303773