184 Matching Annotations
  1. Nov 2025
  2. link.springer.com link.springer.com
    Network pharmacology, molecular docking, and experimental validation-based approach to explore the mechanism of action of ginsenoside Rh4 on acute myeloid leukemia cells
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    link.springer.com/article/10.1007/s12032-025-03128-y
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12620962/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel strategy to target metabolic dependencies in acute myeloid leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12586699/
  5. www.sciencedirect.com www.sciencedirect.com
    Exosomal microRNA-20b-5p contributes to cytarabine resistance in acute myeloid leukemia via the microtubule-associated serine/threonine kinase-like–phosphatidylinositol 3-kinase–protein kinase B signaling axis
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    sciencedirect.com/science/article/pii/S0141813025093079
  6. Oct 2025
  7. www.sciencedirect.com www.sciencedirect.com
    A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential
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    sciencedirect.com/science/article/pii/S2211124725012677
  8. www.biorxiv.org www.biorxiv.org
    Balancing Activation and Repression: CoREST-p300 Antagonism Controls Retinoic Acid-Driven Differentiation in AML
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    biorxiv.org/content/10.1101/2025.10.13.682235v1
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    Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation
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    sciencedirect.com/science/article/pii/S2211124725011507
  10. Sep 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of extracellular matrix protein fibulin-3 reduces immunosuppressive signaling and increases macrophage activation in glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12423750/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting scavenger receptor class B type 1 with a bioinspired ligand induces apoptosis or ferroptosis in AML
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    pmc.ncbi.nlm.nih.gov/articles/PMC12418828/
  13. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    CD123 Targeted Epigenetic Nanotherapy for Fusion Oncoprotein MLL-AF9 Rearranged Acute Myeloid Leukemia in Preclinical and Patient Derived Xenograft Models
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/adhm.202503118
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An isoform-specific RUNX1C–BTG2 axis governs AML quiescence and chemoresistance.
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405853/
  15. Aug 2025
  16. www.biorxiv.org www.biorxiv.org
    IRE1α-XBP1s axis is required for BCG-induced trained immunity against viral infection by inhibiting AHR signaling
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    biorxiv.org/content/10.1101/2025.08.21.671435v1
  17. 52.53.155.43 52.53.155.43
    lysikova-et-al-2025-extracellular-serine-proteases-activate-amiloride-insensitive-enac-channels-and-decrease-migration-html.html
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    52.53.155.43/bd5f45e70b8147ce729ff5651c4add7097c2cce4/lysikova-et-al-2025-extracellular-serine-proteases-activate-amiloride-insensitive-enac-channels-and-decrease-migration-html.html
  18. www.sciencedirect.com www.sciencedirect.com
    SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2211124725009180
  19. www.biorxiv.org www.biorxiv.org
    Investigating the relationship Between AMBRA1 and Cell Proliferation in Melanoma
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    biorxiv.org/content/10.1101/2025.07.29.667464v1
  20. www.sciencedirect.com www.sciencedirect.com
    Pharmacodynamic analyses of LAT1 inhibitors in vitro and in vivo by targeted metabolomics reveal target-independent effects
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    sciencedirect.com/science/article/pii/S0753332225005967
  21. Jul 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modular DNA barcoding of nanobodies enables multiplexed in situ protein imaging and high-throughput biomolecule detection
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    pmc.ncbi.nlm.nih.gov/articles/PMC12283080/
  23. 52.53.155.43 52.53.155.43
    cir-23-0692-html.html
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    52.53.155.43/1f4b1703c319970f6796ecb5a8f69e90cf12a77f/cir-23-0692-html.html
  24. Jun 2025
  25. www.sciencedirect.com www.sciencedirect.com
    Phenotypic screens for SIRPA expression reveal RAB21 as a general regulator of macrophage surface identity
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    sciencedirect.com/science/article/pii/S2211124725006928
  26. 52.53.155.43 52.53.155.43
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  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11611684/
  28. May 2025
  29. www.nature.com www.nature.com
    Decoding post-transcriptional regulatory networks by RNA-linked CRISPR screening in human cells
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    nature.com/articles/s41592-025-02702-6
  30. www.cell.com www.cell.com
    CD97-directed CAR-T cells with enhanced persistence eradicate acute myeloid leukemia in diverse xenograft models
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    cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00221-6
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spns2-dependent S1P Transport as a Therapeutic Target
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    pmc.ncbi.nlm.nih.gov/articles/PMC12034028/
  32. www.sciencedirect.com www.sciencedirect.com
    The m5C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism
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    sciencedirect.com/science/article/pii/S2211124725004322
  33. Apr 2025
  34. 52.53.155.43 52.53.155.43
    Single-Nuclei Analysis of the Unfolded Protein Response (SNUPR): A Novel Method revealing bortezomib resistance mechanisms in Multiple Myeloma
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    52.53.155.43/5480965c1766ce5dc1f2ceec9f18c523a1b9a8ab/2024.10.22.617161.full-html.html
  35. translational-medicine.biomedcentral.com translational-medicine.biomedcentral.com
    Vorinostat impairs the cancer-driving potential of leukemia-secreted extracellular vesicles
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    translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06361-1
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Augmenting CAR T Cell Functions with LIGHT
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    pmc.ncbi.nlm.nih.gov/articles/PMC11444887/
  37. Mar 2025
  38. www.sciencedirect.com www.sciencedirect.com
    A niche driven mechanism determines response and a mutation-independent therapeutic approach for myeloid malignancies
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    sciencedirect.com/science/article/pii/S1535610825001084
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BKT300: A Novel Anti-Leukemic Small Molecule Targeting the Protein Regulator of Cytokinesis 1 (PRC1) Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875301/
  40. www.sciencedirect.com www.sciencedirect.com
    Synergistic effects of HO-1 inhibition and chemotherapy on tumor proliferation and immune infiltration: An in vitro and in vivo approach to enhancing prostate cancer treatment
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    sciencedirect.com/science/article/pii/S1936523325000701
  41. Feb 2025
  42. www.sciencedirect.com www.sciencedirect.com
    NAPE-PLD is target of thiazide diuretics
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    sciencedirect.com/science/article/pii/S2451945625000315
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pharmacological rescue of mutant p53 triggers spontaneous tumor regression via immune responses
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    pmc.ncbi.nlm.nih.gov/articles/PMC11970324/
  44. www.sciencedirect.com www.sciencedirect.com
    Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation
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    sciencedirect.com/science/article/pii/S193459092500013X
  45. aacrjournals.org aacrjournals.org
    MR1 gene and protein expression are enhanced by inhibition of the extracellular signal-regulated kinase ERK
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    aacrjournals.org/cancerimmunolres/article/12/10/1452/748716/MR1-Gene-and-Protein-Expression-Are-Enhanced-by
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An IgE antibody targeting HER2 identified by clonal selection restricts breast cancer growth via immune-stimulating activities
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    pmc.ncbi.nlm.nih.gov/articles/PMC11818027/
  47. 52.53.155.43 52.53.155.43
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  48. Jan 2025
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11742192/
  50. www.sciencedirect.com www.sciencedirect.com
    Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1
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    sciencedirect.com/science/article/pii/S1535610824004434
  51. www.sciencedirect.com www.sciencedirect.com
    Overcoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells
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    sciencedirect.com/science/article/pii/S2211124724014736
  52. Dec 2024
  53. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.17308
  54. www.sciencedirect.com www.sciencedirect.com
    1-s2.0-S2589004224027901-main-html.html
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    sciencedirect.com/science/article/pii/S2589004224027901
  55. www.sciencedirect.com www.sciencedirect.com
    Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening
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    sciencedirect.com/science/article/pii/S2405471224003375
  56. www.sciencedirect.com www.sciencedirect.com
    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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    sciencedirect.com/science/article/pii/S235239642400495X
  57. www.sciencedirect.com www.sciencedirect.com
    ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis
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    sciencedirect.com/science/article/pii/S2211124724013391
  58. Nov 2024
  59. www.nature.com www.nature.com
    Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis
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    nature.com/articles/s41467-024-54486-6
  60. www.sciencedirect.com www.sciencedirect.com
    A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites
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    sciencedirect.com/science/article/pii/S0092867424012145
  61. Oct 2024
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blocking M2-Like Macrophage Polarization Using Decoy Oligodeoxynucleotide-Based Gene Therapy Prevents Immune Evasion for Pancreatic Cancer Treatment
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443249/
  63. Sep 2024
  64. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.17245
  65. www.sciencedirect.com www.sciencedirect.com
    CD14 is a decision-maker between Fas-mediated death and inflammation
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    sciencedirect.com/science/article/pii/S2211124724010362
  66. Aug 2024
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glutathione-S-Transferase Theta 2 (GSTT2) Modulates the Response to Bacillus Calmette–Guérin Immunotherapy in Bladder Cancer Patients
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    ncbi.nlm.nih.gov/pmc/articles/PMC11354831/
  68. www.cell.com www.cell.com
    SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation
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    cell.com/cell-reports/fulltext/S2211-1247(24)00865-9
  69. www.liebertpub.com www.liebertpub.com
    The Microenvironment of Solid Tumors: Components and Current Challenges of Tumor-on-a-Chip Models
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    liebertpub.com/doi/10.1089/ten.teb.2024.0088
  70. www.sciencedirect.com www.sciencedirect.com
    Isolation, expansion, and adoptive transfer of human ILC2s for the treatment of mice bearing liquid and solid tumors
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    sciencedirect.com/science/article/pii/S2666166724002612
  71. www.embopress.org www.embopress.org
    The glycine arginine-rich domain of the RNA-binding protein nucleolin regulates its subcellular localization
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    embopress.org/doi/full/10.15252/embj.2020107158
  72. Jul 2024
  73. www.sciencedirect.com www.sciencedirect.com
    PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
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    sciencedirect.com/science/article/pii/S1097276524004799
  74. 52.53.155.43 52.53.155.43
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  75. www.nature.com www.nature.com
    Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
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    nature.com/articles/s41375-024-02328-1
  76. www.sciencedirect.com www.sciencedirect.com
    The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11217734/
  78. Jun 2024
  79. link.springer.com link.springer.com
    β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo
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    link.springer.com/article/10.1007/s43440-024-00614-4
  80. molecular-cancer.biomedcentral.com molecular-cancer.biomedcentral.com
    Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients
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    molecular-cancer.biomedcentral.com/articles/10.1186/s12943-024-02034-7
  81. www.sciencedirect.com www.sciencedirect.com
    A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML
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    sciencedirect.com/science/article/pii/S2666379124002842
  82. www.sciencedirect.com www.sciencedirect.com
    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
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    sciencedirect.com/science/article/pii/S1534580724003277
  83. May 2024
  84. 52.53.155.43 52.53.155.43
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LncRNA IRAIN overcomes imatinib resistance in chronic myeloid leukemia via NF-κB/CD44 pathway inhibition
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    ncbi.nlm.nih.gov/pmc/articles/PMC11112338/
  86. 52.53.155.43 52.53.155.43
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  87. Apr 2024
  88. www.sciencedirect.com www.sciencedirect.com
    Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization
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    sciencedirect.com/science/article/pii/S1535610824001193
  89. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Acquired immune resistance is associated with interferon signature and modulation of KLF6/c-MYB transcription factors in myeloid leukemia
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    onlinelibrary.wiley.com/doi/10.1002/eji.202350717
  90. www.sciencedirect.com www.sciencedirect.com
    The Legionella pneumophila effector DenR hijacks the host NRas proto-oncoprotein to downregulate MAPK signaling
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    sciencedirect.com/science/article/pii/S2211124724003619
  91. Feb 2024
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-Vα24Jα18 TCR antibody tunes iNKT cell responses to target and kill CD1d-negative tumors in an FcγRII (CD32)-dependent manner
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    ncbi.nlm.nih.gov/pmc/articles/PMC10875981/
  93. www.sciencedirect.com www.sciencedirect.com
    SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells
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    sciencedirect.com/science/article/pii/S1550413124000135
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831336/
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting BET proteins downregulates miR-33a to promote synergy with PIM inhibitors in CMML
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    ncbi.nlm.nih.gov/pmc/articles/PMC10524644/
  96. Jan 2024
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An unexpected role of neutrophils in clearing apoptotic hepatocytes in vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC10511239/
  98. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Non-IL-2-blocking anti-CD25 antibody inhibits tumor growth by depleting Tregs and has synergistic effects with anti-CTLA-4 therapy
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34823
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Direct translation of incoming retroviral genomes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10770327/
  100. www.sciencedirect.com www.sciencedirect.com
    Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death
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    sciencedirect.com/science/article/pii/S0092867423013478
  101. Nov 2023
  102. www.sciencedirect.com www.sciencedirect.com
    Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
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    sciencedirect.com/science/article/pii/S2666379123004846
  103. Oct 2023
  104. www.sciencedirect.com www.sciencedirect.com
    Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma
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    sciencedirect.com/science/article/pii/S2666379123004159
  105. 52.53.155.43 52.53.155.43
    Blocking oligomerization is the most viable strategy to inhibit STING
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  106. www.sciencedirect.com www.sciencedirect.com
    Cooperative CAR targeting to selectively eliminate AML and minimize escape
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