100 Matching Annotations
  1. Nov 2025
  2. www.nature.com www.nature.com
    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
  3. Oct 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  5. Sep 2025
  6. link.springer.com link.springer.com
    STYK1 as a targetable vulnerability enhances the efficacy of anti-PD-L1 therapy in pancreatic cancer
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    link.springer.com/article/10.1007/s00535-025-02291-3
  7. Aug 2025
  8. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510071
  9. pubs.acs.org pubs.acs.org
    A Nucleoside Analogue Featuring a C3′-Stereogenic All-Carbon Quaternary Center as a Bioenergetic Disruptor of KRAS-Mutated Pancreatic Cancer Cells
    1
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    pubs.acs.org/doi/10.1021/acsmedchemlett.5c00378
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11584292/
  11. www.sciencedirect.com www.sciencedirect.com
    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
    1
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    sciencedirect.com/science/article/pii/S1535610825003101
  12. www.degruyterbrill.com www.degruyterbrill.com
    KRAS-driven pancreatic ductal adenocarcinoma cell lines harbour putative cancer stem cells
    1
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    degruyterbrill.com/document/doi/10.1515/oncologie-2025-0171/html
  13. Jul 2025
  14. www.sciencedirect.com www.sciencedirect.com
    A STAT3/integrin axis accelerates pancreatic cancer initiation and progression
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    sciencedirect.com/science/article/pii/S2211124725007818
  15. Jun 2025
  16. www.sciencedirect.com www.sciencedirect.com
    A first-in-class EGFR-directed KRAS G12V selective inhibitor
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    sciencedirect.com/science/article/pii/S1535610825002259
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stromal Hedgehog Signaling Is Associated with Favorable Outcomes in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12154493/
  18. link.springer.com link.springer.com
    Efficacy of SOAT1 Inhibitors Against Pancreatic Cancer with TP53 Mutations
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    link.springer.com/article/10.1245/s10434-025-17482-8
  19. May 2025
  20. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70062
  21. www.nature.com www.nature.com
    HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity
    1
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    nature.com/articles/s41467-025-60129-1
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Efficacy of Targeted Monoclonal IgA Antibodies Against Pancreatic Ductal Adenocarcinoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12071589/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12076188/
  24. Apr 2025
  25. www.sciencedirect.com www.sciencedirect.com
    CD44 Identified as a Diagnostic Biomarker for Highly Malignant CA19-9 Negative Pancreatic Cancer
    1
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    sciencedirect.com/science/article/pii/S0304383525002794
  26. www.sciencedirect.com www.sciencedirect.com
    PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma
    1
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    sciencedirect.com/science/article/pii/S2211124725003122
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel Amanitin-Based Antibody–Drug Conjugates Targeting TROP2 for the Treatment of Pancreatic Cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962393/
  28. www.nature.com www.nature.com
    Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways
    1
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    nature.com/articles/s41598-025-95766-5
  29. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    PPY-Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer
    1
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202413432
  30. Feb 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel B7-H3 CAR T cells show potent antitumor effects in glioblastoma: a preclinical study
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11784176/
  32. www.sciencedirect.com www.sciencedirect.com
    Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy
    1
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    sciencedirect.com/science/article/pii/S2666379124006980
  33. Jan 2025
  34. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225001026-main-html.html
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    52.53.155.43/9cdc52fc0b70ce3d9f24b335db5892b38840adb3/1-s2.0-S2589004225001026-main-html.html
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11704331/
  36. Dec 2024
  37. 52.53.155.43 52.53.155.43
    mct-24-0266-html.html
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    52.53.155.43/e3c3817ac819dde6c15544fa19222c2e3fb37801/mct-24-0266-html.html
  38. Nov 2024
  39. www.sciencedirect.com www.sciencedirect.com
    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
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    sciencedirect.com/science/article/pii/S2451945624004434
  40. www.sciencedirect.com www.sciencedirect.com
    Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment
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    sciencedirect.com/science/article/pii/S2211124724013238
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mesothelin CAR T-cells secreting anti-FAP/anti-CD3 molecules efficiently target pancreatic adenocarcinoma and its stroma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11062832/
  42. Oct 2024
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DDB2 expression lights the way for precision radiotherapy response in PDAC cells, with or without olaparib
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11436999/
  44. Sep 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11365971/
  46. Aug 2024
  47. cmbl.biomedcentral.com cmbl.biomedcentral.com
    TMEM43 promotes pancreatic cancer progression by stabilizing PRPF3 and regulating RAP2B/ERK axis
    1
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    cmbl.biomedcentral.com/articles/10.1186/s11658-022-00321-z
  48. May 2024
  49. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13658
  50. www.biorxiv.org www.biorxiv.org
    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
    1
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    biorxiv.org/content/10.1101/2024.03.12.584316v1
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11194014/
  52. Apr 2024
  53. www.sciencedirect.com www.sciencedirect.com
    Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
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    sciencedirect.com/science/article/pii/S2666379124001927
  54. jhoonline.biomedcentral.com jhoonline.biomedcentral.com
    Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma
    1
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    jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01538-5
  55. onlinelibrary.wiley.com onlinelibrary.wiley.com
    ELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
    1
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34960
  56. Mar 2024
  57. academic.oup.com academic.oup.com
    LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism
    1
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    academic.oup.com/carcin/advance-article/doi/10.1093/carcin/bgae011/7608949
  58. www.sciencedirect.com www.sciencedirect.com
    A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice
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    sciencedirect.com/science/article/pii/S1097276524001382
  59. Feb 2024
  60. 52.53.155.43 52.53.155.43
    176-html.html
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    52.53.155.43/2ec0d88e67b798a89b6c5516dbe547b3b2c5ce80/176-html.html
  61. aacrjournals.org aacrjournals.org
    Nuclear GRP78 Promotes Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Ductal Adenocarcinoma
    2
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    aacrjournals.org/clincancerres/article/29/24/5183/731660/Nuclear-GRP78-Promotes-Metabolic-Reprogramming-and
  62. www.sciencedirect.com www.sciencedirect.com
    Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells
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    sciencedirect.com/science/article/pii/S0944711324000576
  63. www.biorxiv.org www.biorxiv.org
    A common druggable signature of oncogenic CMYC, mutant KRAS and mutant p53 reveals functional redundancy and competition of the oncogenes in cancer
    1
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    biorxiv.org/content/10.1101/2023.12.20.572548v1
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nudt21-mediated alternative polyadenylation of MZT1 3’UTR contributes to pancreatic cancer progression
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831950/
  65. Jan 2024
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vitamin B6 competition in the tumor microenvironment hampers antitumor functions of NK cells.
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10784745/
  67. Dec 2023
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10690095/
  69. 52.53.155.43 52.53.155.43
    ccr-23-1143-html.html
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    52.53.155.43/aa509a782208f9df8c6754b69c5c07021388a9c4/ccr-23-1143-html.html
  70. Nov 2023
  71. www.sciencedirect.com www.sciencedirect.com
    SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer
    1
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    sciencedirect.com/science/article/pii/S2211124723014468
  72. www.biorxiv.org www.biorxiv.org
    LMO3 is a suppressor of the basal-like/squamous PDAC subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism
    1
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    biorxiv.org/content/10.1101/2023.11.01.564448v1
  73. link.springer.com link.springer.com
    CRISPR/Cas9-mediated knock-in of BRCA1/2 mutations restores response to olaparib in pancreatic cancer cell lines
    1
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    link.springer.com/article/10.1038/s41598-023-45964-w
  74. Oct 2023
  75. 52.53.155.43 52.53.155.43
    ccr-23-1182-html.html
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    52.53.155.43/65c36a5cdd4f77902b5a0c626487c84333ec98dd/ccr-23-1182-html.html
  76. Sep 2023
  77. www.biorxiv.org www.biorxiv.org
    ELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
    1
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    biorxiv.org/content/10.1101/2023.09.23.558894v1
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant KRAS Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10502454/
  79. Aug 2023
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Palbociclib suppresses the cancer stem cell properties and cell proliferation through increased levels of miR-506 or miR-150 in Panc-1 and MiaPaCa-2 cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10387936/
  81. Jun 2023
  82. www.nature.com www.nature.com
    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
    1
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    nature.com/articles/s41467-023-39241-7
  83. aacrjournals.org aacrjournals.org
    MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance
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    aacrjournals.org/mcr/article/21/5/444/726027/MYC-Glutamine-Dependency-Is-a-Therapeutic
  84. aacrjournals.org aacrjournals.org
    Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer
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    aacrjournals.org/cancerres/article/83/5/735/716680/Enhanced-Glutaminolysis-Drives-Hypoxia-Induced
  85. www.sciencedirect.com www.sciencedirect.com
    Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124723005922
  86. Apr 2023
  87. link.springer.com link.springer.com
    Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression
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    link.springer.com/article/10.1007/s10620-023-07931-3
  88. www.sciencedirect.com www.sciencedirect.com
    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
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    sciencedirect.com/science/article/pii/S2666379123001179
  89. Feb 2023
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9357213/
  91. Dec 2022
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9773984/
  93. Oct 2022
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XDec-CHI reveals immunosuppressive interactions in pancreatic ductal adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC9579012/
  95. Sep 2022
  96. www.sciencedirect.com www.sciencedirect.com
    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
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    sciencedirect.com/science/article/pii/S2211124722012694
  97. Aug 2022
  98. insight.jci.org insight.jci.org
    Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer
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    insight.jci.org/articles/view/154475
  99. Jul 2022
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KRAS mutant-driven SUMOylation controls extracellular vesicle transmission to trigger lymphangiogenesis in pancreatic cancer
    2
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    ncbi.nlm.nih.gov/pmc/articles/PMC9282935/
  101. 52.53.155.43 52.53.155.43
    157644.1-20220517111248-covered-e0fd13ba177f913fd3156f593ead4cfd-html.html
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    52.53.155.43/6ff2513f1a3b330377acc02bf74475e062a26292/157644.1-20220517111248-covered-e0fd13ba177f913fd3156f593ead4cfd-html.html
  102. May 2022
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC9064299/
  104. Feb 2022
  105. link.springer.com link.springer.com
    Romidepsin and tamoxifen cooperatively induce senescence of pancreatic cancer cells through downregulation of FOXM1 expression and induction of reactive oxygen species/lipid peroxidation
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    link.springer.com/article/10.1007/s11033-022-07192-9
  106. Jan 2022
  107. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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    journals.sagepub.com/doi/full/10.1177/24725552211038362
  108. www.dovepress.com www.dovepress.com
    <p>Dynamics of Endocytosis and Degradation of Antibody-Drug Conjugate T-DM1 in HER2 Positive Cancer Cells</p>
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    dovepress.com/dynamics-of-endocytosis-and-degradation-of-antibody-drug-conjugate-t-d-peer-reviewed-fulltext-article-DDDT
  109. Dec 2021
  110. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
    3
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    journals.sagepub.com/doi/full/10.1177/24725552211038362
  111. www.nature.com www.nature.com
    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
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    nature.com/articles/s42003-021-02842-3
  112. Nov 2021
  113. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
    2
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    journals.sagepub.com/doi/full/10.1177/24725552211038362
  114. Oct 2021
  115. www.sciencedirect.com www.sciencedirect.com
    Marker-free lineage tracing reveals an environment-instructed clonogenic hierarchy in pancreatic cancer
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    sciencedirect.com/science/article/pii/S221112472101319X
  116. Jul 2021
  117. www.sciencedirect.com www.sciencedirect.com
    DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters
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    sciencedirect.com/science/article/pii/S221112471931527X
  118. www.sciencedirect.com www.sciencedirect.com
    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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    sciencedirect.com/science/article/pii/S1535610818304677
  119. May 2021
  120. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15435
  121. www.sciencedirect.com www.sciencedirect.com
    Pancreatic Cancer Cells Require the Transcription Factor MYRF to Maintain ER Homeostasis
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  122. Apr 2021
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  125. Nov 2020
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    Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer
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  128. Sep 2020
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  140. Nov 2017
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    A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer
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