167 Matching Annotations
  1. Last 7 days
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    ACSL4-associated lipid metabolism is a distinct therapeutic vulnerability in KMT2A-rearranged acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2211124726000884
  3. Feb 2026
  4. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    DualPG-DTA: A Large Language Model-Powered Graph Neural Network Framework for Enhanced Drug-Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti-Leukemia Activity
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202513099
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    Discovery of SKP2-Recruiting PROTACs for Target Protein Degradation
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202515159
  6. Jan 2026
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    Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia
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    sciencedirect.com/science/article/pii/S2451945625003952
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    ΔNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2666379125006135
  9. Dec 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated scFv identification and CAR T cell generation for AML targeting in vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC12712367/
  11. Nov 2025
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    Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S0092867425012334
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12620962/
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    SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12050964/
  15. Oct 2025
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    A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential
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    sciencedirect.com/science/article/pii/S2211124725012677
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    Chronic ER Stress Triggers Cell-Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202511573
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    Balancing Activation and Repression: CoREST-p300 Antagonism Controls Retinoic Acid-Driven Differentiation in AML
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    biorxiv.org/content/10.1101/2025.10.13.682235v1
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    Small-molecule OPA1 inhibitors reverse mitochondrial adaptations to overcome therapy resistance in acute myeloid leukemia
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    science.org/doi/10.1126/sciadv.adx8662
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    AIstain: Enhancing microglial phagocytosis analysis through deep learning
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    sciencedirect.com/science/article/pii/S2667237525002437
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Jab1 promotes immune evasion and progression in acute myeloid leukemia models under oxidative stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC12520683/
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    Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation
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    sciencedirect.com/science/article/pii/S2211124725011507
  23. Sep 2025
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    FLT3L-based drug conjugate effectively targets chemoresistant leukemia stem cells in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2666379125004380
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting scavenger receptor class B type 1 with a bioinspired ligand induces apoptosis or ferroptosis in AML
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    pmc.ncbi.nlm.nih.gov/articles/PMC12418828/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An isoform-specific RUNX1C–BTG2 axis governs AML quiescence and chemoresistance.
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405853/
  27. Aug 2025
  28. www.sciencedirect.com www.sciencedirect.com
    A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation
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    sciencedirect.com/science/article/pii/S1097276525006513
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  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Connecting chemical structure to single cell signaling profiles
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  31. Jul 2025
  32. 52.53.155.43 52.53.155.43
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    Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity
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    sciencedirect.com/science/article/pii/S0092867425006385
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214875/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Downregulation of S6 Kinase and Hedgehog–Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12193305/
  36. Jun 2025
  37. 52.53.155.43 52.53.155.43
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  38. May 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
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    The m5C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism
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    sciencedirect.com/science/article/pii/S2211124725004322
  41. Apr 2025
  42. www.sciencedirect.com www.sciencedirect.com
    Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias
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    sciencedirect.com/science/article/pii/S009286742500399X
  43. aacrjournals.org aacrjournals.org
    Preclinical Development of Tuspetinib for the Treatment of Acute Myeloid Leukemia
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    aacrjournals.org/cancerrescommun/article/5/1/74/751014/Preclinical-Development-of-Tuspetinib-for-the
  44. Mar 2025
  45. www.nature.com www.nature.com
    Superior preclinical efficacy of co-treatment with BRG1/BRM and FLT3 inhibitor against AML cells with FLT3 mutations
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    nature.com/articles/s41408-025-01251-7
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BKT300: A Novel Anti-Leukemic Small Molecule Targeting the Protein Regulator of Cytokinesis 1 (PRC1) Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875301/
  47. Feb 2025
  48. www.sciencedirect.com www.sciencedirect.com
    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
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    sciencedirect.com/science/article/pii/S0006497124004543
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  50. Jan 2025
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    Overcoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells
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  52. Dec 2024
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    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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    ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis
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    lncRNAs maintain the functional phase state of nucleolar prion-like protein to facilitate rRNA processing
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  56. Oct 2024
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    Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance
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  58. Jul 2024
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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11293342/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
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  62. Jun 2024
  63. www.sciencedirect.com www.sciencedirect.com
    A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML
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    sciencedirect.com/science/article/pii/S2666379124002842
  64. molecular-cancer.biomedcentral.com molecular-cancer.biomedcentral.com
    Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients
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    molecular-cancer.biomedcentral.com/articles/10.1186/s12943-024-02034-7
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    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
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  66. May 2024
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LncRNA IRAIN overcomes imatinib resistance in chronic myeloid leukemia via NF-κB/CD44 pathway inhibition
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    ncbi.nlm.nih.gov/pmc/articles/PMC11112338/
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    CD37 is a safe chimeric antigen receptor target to treat acute myeloid leukemia
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11059122/
  70. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    elifesciences.org/articles/90683
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  72. Apr 2024
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    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    sciencedirect.com/science/article/pii/S1535610824001284
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    Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1
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  75. Mar 2024
  76. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13638
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib
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    ncbi.nlm.nih.gov/pmc/articles/PMC10940854/
  78. Feb 2024
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pim kinase inhibitors increase gilteritinib cytotoxicity in FLT3-ITD acute myeloid leukemia through GSK-3β activation and c-Myc and Mcl-1 proteasomal degradation
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    SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells
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    sciencedirect.com/science/article/pii/S1550413124000135
  81. www.biorxiv.org www.biorxiv.org
    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
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    biorxiv.org/content/10.1101/2023.09.28.560054v1
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting BET proteins downregulates miR-33a to promote synergy with PIM inhibitors in CMML
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    ncbi.nlm.nih.gov/pmc/articles/PMC10524644/
  83. Jan 2024
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The predictive value of BTG1 for the response of newly diagnosed acute myeloid leukemia to decitabine
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    ncbi.nlm.nih.gov/pmc/articles/PMC10802042/
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10780038/
  86. Dec 2023
  87. www.biorxiv.org www.biorxiv.org
    MYC–NFATC2 axis maintains cell cycle and mitochondrial function in AML cells
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    biorxiv.org/content/10.1101/2023.11.15.567209v1
  88. Nov 2023
  89. www.embopress.org www.embopress.org
    An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions
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    embopress.org/doi/10.15252/embj.2023114221
  90. www.sciencedirect.com www.sciencedirect.com
    Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
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    sciencedirect.com/science/article/pii/S2666379123004846
  91. Sep 2023
  92. www.sciencedirect.com www.sciencedirect.com
    Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
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    PARP-1 improves leukemia outcomes by inducing parthanatos during chemotherapy
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates
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    ncbi.nlm.nih.gov/pmc/articles/PMC9992000/
  95. Aug 2023
  96. www.biorxiv.org www.biorxiv.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    biorxiv.org/content/10.1101/2023.07.26.550648v2
  97. www.sciencedirect.com www.sciencedirect.com
    TSC22D3 as an immune-related prognostic biomarker for acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2589004223015286
  98. May 2023
  99. www.biorxiv.org www.biorxiv.org
    Killing the enemy or making it your ally? The effects of thiostrepton on tumor associated macrophages
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    biorxiv.org/content/10.1101/2023.03.23.533899v1
  100. Apr 2023
  101. link.springer.com link.springer.com
    Targeting human mitochondrial NAD(P)+-dependent malic enzyme (ME2) impairs energy metabolism and redox state and exhibits antileukemic activity in acute myeloid leukemia
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    link.springer.com/article/10.1007/s13402-023-00812-x
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950
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    ncbi.nlm.nih.gov/pmc/articles/PMC10112292/
  103. www.nature.com www.nature.com
    Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1
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    nature.com/articles/s41408-023-00826-6
  104. Mar 2023
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality
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    ncbi.nlm.nih.gov/pmc/articles/PMC10011883/
  106. Feb 2023
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptionally imprinted glycomic signatures of acute myeloid leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9926860/
  108. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    ACC010, a novel BRD4 inhibitor, synergized with homoharringtonine in acute myeloid leukemia with FLT3-ITD
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13368
  109. aacrjournals.org aacrjournals.org
    Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
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    aacrjournals.org/cancerres/article/83/2/219/715076/Plk1-Inhibitors-and-Abiraterone-Synergistically
  110. Jan 2023
  111. www.sciencedirect.com www.sciencedirect.com
    Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance
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    sciencedirect.com/science/article/pii/S1934590922004878
  112. Dec 2022
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model
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    ncbi.nlm.nih.gov/pmc/articles/PMC9765856/
  114. www.sciencedirect.com www.sciencedirect.com
    Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia
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    sciencedirect.com/science/article/pii/S1535610822005888
  115. Nov 2022
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation
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  128. May 2022
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  162. Jul 2021
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  191. Feb 2021
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