321 Matching Annotations
  1. Oct 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties
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    sciencedirect.com/science/article/pii/S2666379125004847
  3. www.sciencedirect.com www.sciencedirect.com
    A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases
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    sciencedirect.com/science/article/pii/S2211124725011799
  4. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibiting Cyclin-Dependent Kinase 13-Mediated Nuclear Ubiquitous Casein Kinase and Cyclin-Dependent Kinase Substrate 1 Phosphorylation Facilitates Oxidative Stress-Induced Apoptosis in Melanoma
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    onlinelibrary.wiley.com/doi/10.1002/mc.70040
  5. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Laeverin is Cell-Surface Target for Liquid-Phase Metastasizing Cancer Cells
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202511349
  6. www.sciencedirect.com www.sciencedirect.com
    CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma
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    sciencedirect.com/science/article/pii/S2211124725011337
  7. www.sciencedirect.com www.sciencedirect.com
    USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization
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    sciencedirect.com/science/article/pii/S221112472501143X
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    Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis
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    sciencedirect.com/science/article/pii/S2666379125004446
  9. Sep 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RHOJ enhances adhesion and proliferation capabilities and suppresses apoptosis of melanoma cells by activating the Rap1 signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12432792/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phase Ib Study of Pembrolizumab in Combination with Intratumoral Injection of Clostridium novyi-NT in Patients with Advanced Solid Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12434394/
  12. www.sciencedirect.com www.sciencedirect.com
    mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport
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    sciencedirect.com/science/article/pii/S1097276525007063
  13. www.sciencedirect.com www.sciencedirect.com
    RAD23B acquires a copper metalloadaptor function in amphibian-to-reptile evolution to increase metabolism and regulate genomic integrity
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    sciencedirect.com/science/article/pii/S1097276525007099
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PKN2 is a dependency of the mesenchymal-like cancer cell state
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875962/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1 Mutant Melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12221223/
  16. www.sciencedirect.com www.sciencedirect.com
    Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response
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    sciencedirect.com/science/article/pii/S1097276525006641
  17. www.nature.com www.nature.com
    Cytotoxicity of activator expression in CRISPR-based transcriptional activation systems
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    nature.com/articles/s41467-025-63570-4
  18. Aug 2025
  19. www.biorxiv.org www.biorxiv.org
    DFFB suppresses interferon to enable cancer persister cell regrowth
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    biorxiv.org/content/10.1101/2025.08.15.670603v1
  20. www.science.org www.science.org
    Targeting lipid scrambling potentiates ferroptosis and triggers tumor immune rejection
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    science.org/doi/10.1126/sciadv.adx6587
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting lipid scrambling potentiates ferroptosis and triggers tumor immune rejection
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    pmc.ncbi.nlm.nih.gov/articles/PMC12356262/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Evaluation of DB-1419, a Novel Bifunctional and Bispecific Anti–B7-H3 × PD-L1 Antibody–Drug Conjugate
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    pmc.ncbi.nlm.nih.gov/articles/PMC12351279/
  23. www.biorxiv.org www.biorxiv.org
    A Nanovial-Based Platform for Functional Discovery of Antigen-Reactive TCRs from Unconventional T Cells
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    biorxiv.org/content/10.1101/2025.08.06.668816v2
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tissue-dependent mechanosensing by cells derived from human tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328224/
  25. www.sciencedirect.com www.sciencedirect.com
    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    sciencedirect.com/science/article/pii/S1535610825003101
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12322234/
  27. www.biorxiv.org www.biorxiv.org
    Investigating the relationship Between AMBRA1 and Cell Proliferation in Melanoma
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    biorxiv.org/content/10.1101/2025.07.29.667464v1
  28. Jul 2025
  29. www.nature.com www.nature.com
    Secretogranin 2 binds LILRB4 resulting in immunosuppression
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    nature.com/articles/s41590-025-02233-4
  30. www.nature.com www.nature.com
    Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversion
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    nature.com/articles/s41419-025-07863-y
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IgSF11–RAP1 signaling promotes cell migration and invasion of cutaneous melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12243136/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability
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    pmc.ncbi.nlm.nih.gov/articles/PMC11735329/
  33. www.sciencedirect.com www.sciencedirect.com
    CDC42-effector interaction inhibitors alter patterns of vessel arborization in skin and tumors in vivo
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    sciencedirect.com/science/article/pii/S2589004225012325
  34. www.biorxiv.org www.biorxiv.org
    Salmonella hijacks a host glucose transporter for intravacuolar proliferation
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    biorxiv.org/content/10.1101/2025.06.10.658782v1
  35. www.sciencedirect.com www.sciencedirect.com
    A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2666379125003064
  36. www.sciencedirect.com www.sciencedirect.com
    Identification of UBE3C as an E3 ubiquitin ligase for mutant BRAF
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    sciencedirect.com/science/article/pii/S002432052500462X
  37. Jun 2025
  38. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70049
  39. www.sciencedirect.com www.sciencedirect.com
    Ribosomal RNA transcription regulates splicing through ribosomal protein RPL22
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    sciencedirect.com/science/article/pii/S2451945625001734
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Oncofoetal Chondroitin Sulphate Allows Identification of Tumour‐Derived Extracellular Vesicles
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    pmc.ncbi.nlm.nih.gov/articles/PMC12173530/
  41. www.nature.com www.nature.com
    A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome
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    nature.com/articles/s41467-024-44905-z
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-Cell Transcriptomic Landscape Deciphers Intratumoral Heterogeneity and Subtypes of Acral and Mucosal Melanomas
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    pmc.ncbi.nlm.nih.gov/articles/PMC12163602/
  43. 52.53.155.43 52.53.155.43
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    52.53.155.43/bbb28230632658450b2bbad03fe0ee90e846e4ab/PDF-html.html
  44. 52.53.155.43 52.53.155.43
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  45. www.sciencedirect.com www.sciencedirect.com
    Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket
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    sciencedirect.com/science/article/pii/S258900422400124X
  46. 52.53.155.43 52.53.155.43
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    52.53.155.43/39661a60067369c81e4f8c30deffb29c14ec6c80/PDF-html.html
  47. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.70144
  48. www.sciencedirect.com www.sciencedirect.com
    EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
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    sciencedirect.com/science/article/pii/S2589004225010119
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Potentiating T cell tumor targeting using a combination of TCR with a Siglec-7 based CSR
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    pmc.ncbi.nlm.nih.gov/articles/PMC12106334/
  50. www.cell.com www.cell.com
    Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming
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    cell.com/cell-metabolism/abstract/S1550-4131(25)00265-7
  51. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Dose-dependent induction of epithelial-mesenchymal transition in 3D melanoma models by non-thermal plasma treatment
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70055
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human CSPG4-targeting CAR-macrophages inhibit melanoma growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12122381/
  53. May 2025
  54. www.sciencedirect.com www.sciencedirect.com
    Machine-learning-assisted universal protein activation in living mice
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    sciencedirect.com/science/article/pii/S0092867425005173
  55. 52.53.155.43 52.53.155.43
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    52.53.155.43/76052131b420a79d64f86d012d13a41695e401e2/PDF-html.html
  56. www.sciencedirect.com www.sciencedirect.com
    Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis
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    sciencedirect.com/science/article/pii/S0092867425005021
  57. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70114
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Small Molecule Functional Converter of B-Cell Lymphoma-2 (Bcl-2) Suppresses Breast Cancer Lung Metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11091964/
  59. www.sciencedirect.com www.sciencedirect.com
    Generation of T cell responses against broad KRAS hotspot neoantigens for cell therapy or TCR discovery
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    sciencedirect.com/science/article/pii/S2667237525000852
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
  61. www.sciencedirect.com www.sciencedirect.com
    Stromal lipid species dictate melanoma metastasis and tropism
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    sciencedirect.com/science/article/pii/S1535610825001382
  62. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Liposome-Polymer Nanoparticles Loaded with Copper Diethyldithiocarbamate and 6-Bromo-Indirubin-3′-Oxime Enable the Treatment of Refractive Melanoma
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    onlinelibrary.wiley.com/doi/10.1002/smll.202409012
  63. Apr 2025
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LncRNA SLNCR phenocopies the E2F1 DNA binding site to promote melanoma progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12172627/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing the Efficacy of CAR-T Cell Production Using BX795 and Rosuvastatin in a Serum-Free Medium
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    pmc.ncbi.nlm.nih.gov/articles/PMC11988885/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol to profile tumor and microenvironment from ovarian cancer patient samples and evaluate cell-based therapy using in vitro killing assays
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    pmc.ncbi.nlm.nih.gov/articles/PMC12002649/
  67. aacrjournals.org aacrjournals.org
    SEMA3G-NRP1 Signaling Functions as an Immune Checkpoint that Enables Tumor Immune Evasion by Impairing T Cell Cytotoxicity
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    aacrjournals.org/cancerres/article/85/5/912/751997/SEMA3G-NRP1-Signaling-Functions-as-an-Immune
  68. www.sciencedirect.com www.sciencedirect.com
    Library-based single-cell analysis of CAR signaling reveals drivers of in vivo persistence
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    sciencedirect.com/science/article/pii/S2405471225000936
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962400/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pan-KRAS Inhibitors BI-2493 and BI-2865 Display Potent Antitumor Activity in Tumors with KRAS Wild-type Allele Amplification
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962398/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Augmenting CAR T Cell Functions with LIGHT
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    pmc.ncbi.nlm.nih.gov/articles/PMC11444887/
  72. www.sciencedirect.com www.sciencedirect.com
    Homeostatic regulation of nucleoporins is a central driver of nuclear pore biogenesis
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    sciencedirect.com/science/article/pii/S2211124725002396
  73. Mar 2025
  74. www.sciencedirect.com www.sciencedirect.com
    Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma
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    sciencedirect.com/science/article/pii/S1534580725001212
  75. www.sciencedirect.com www.sciencedirect.com
    Antagonistic roles for MITF and TFE3 in melanoma plasticity
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    sciencedirect.com/science/article/pii/S2211124725002451
  76. www.sciencedirect.com www.sciencedirect.com
    Translation dysregulation in cancer as a source for targetable antigens
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    sciencedirect.com/science/article/pii/S1535610825000820
  77. 52.53.155.43 52.53.155.43
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  78. www.biorxiv.org www.biorxiv.org
    Interaction with tumor cell spheroids induces suppression in primary human cytotoxic T cells
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    biorxiv.org/content/10.1101/2025.03.18.643973v1
  79. www.sciencedirect.com www.sciencedirect.com
    Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits
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    sciencedirect.com/science/article/pii/S0092867425001977
  80. www.sciencedirect.com www.sciencedirect.com
    Overexpression of LMOD1 induces oxidative stress and enhances cell apoptosis of melanoma through the RIG-I like receptor pathway
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    sciencedirect.com/science/article/pii/S0925443925001073
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Recognition of MR1-antigen complexes by TCR Vγ9Vδ2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11876030/
  82. www.cell.com www.cell.com
    Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma
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    cell.com/cell-metabolism/fulltext/S1550-4131(25)00021-X
  83. www.sciencedirect.com www.sciencedirect.com
    Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33
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    sciencedirect.com/science/article/pii/S1535610825000698
  84. www.sciencedirect.com www.sciencedirect.com
    The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma
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    sciencedirect.com/science/article/pii/S2211124725001366
  85. Feb 2025
  86. www.sciencedirect.com www.sciencedirect.com
    An epitope-directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding
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    sciencedirect.com/science/article/pii/S2666379125000540
  87. aacrjournals.org aacrjournals.org
    MR1 gene and protein expression are enhanced by inhibition of the extracellular signal-regulated kinase ERK
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    aacrjournals.org/cancerimmunolres/article/12/10/1452/748716/MR1-Gene-and-Protein-Expression-Are-Enhanced-by
  88. aacrjournals.org aacrjournals.org
    The E3 ubiquitin ligase FBXO38 maintains the antitumor function of natural killer cells by sustaining IL-15R signaling
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    aacrjournals.org/cancerimmunolres/article/12/10/1438/748724/The-E3-Ubiquitin-Ligase-FBXO38-Maintains-the
  89. aacrjournals.org aacrjournals.org
    Targeting Tumor-Associated Sialic Acids using Chimeric Switch Receptors based on Siglec-9 Enhances the Antitumor Efficacy of Engineered T Cells
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    aacrjournals.org/cancerimmunolres/article/12/10/1380/748721/Targeting-Tumor-Associated-Sialic-Acids-Using
  90. aacrjournals.org aacrjournals.org
    ILT2 and ILT4 drive myeloid suppression via both overlapping and distinct mechanisms
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    aacrjournals.org/cancerimmunolres/article/12/5/592/745126/ILT2-and-ILT4-Drive-Myeloid-Suppression-via-Both
  91. www.sciencedirect.com www.sciencedirect.com
    The IAP antagonist tolinapant enhances the anti-tumor activity of cell therapies
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    sciencedirect.com/science/article/pii/S0014299925001542
  92. 52.53.155.43 52.53.155.43
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  93. Jan 2025
  94. www.cell.com www.cell.com
    CDK2 activity crosstalk on the ERK kinase translocation reporter can be resolved computationally
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    cell.com/cell-systems/abstract/S2405-4712(24)00367-3
  95. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11734436/
  96. Dec 2024
  97. 52.53.155.43 52.53.155.43
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  194. Mar 2023
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  200. Jan 2023
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    Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964
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