160 Matching Annotations
  1. Last 7 days
  2. onlinelibrary.wiley.com onlinelibrary.wiley.com
    From Molecular Docking to Rat Models: Butyrate From a High-Fiber Diet Inhibits HDAC1 and NLRP3 Inflammasome to Alleviate Oxidative Stress and Inflammation After Spinal Cord Injury
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    onlinelibrary.wiley.com/doi/10.1111/jnc.70250
  3. Sep 2025
  4. onlinelibrary.wiley.com onlinelibrary.wiley.com
    14-3-3 Proteins Negatively Regulate Microglial Activation via Inhibition of the NF-κB Pathway
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.70228
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolic Profiling Reveals a Glycolytic Shift and an IRG1/Itaconate/NF2L2 Axis Regulating Neurotoxic Oxidative Stress in Inflammatory Microglia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12413559/
  6. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Dual Pro-Angiogenic and Pro-Fibrotic MARCO+ Microglial Phenotype in Diabetic Retinopathy
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202502138R
  7. Aug 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12339548/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanistic Study of Jaceosidin in Regulating Secondary Inflammation After Spinal Cord Injury in Mouse by Inhibiting PKM2 Activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12325413/
  10. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70102
  11. Jul 2025
  12. www.sciencedirect.com www.sciencedirect.com
    Treadmill Exercise Alleviates STING-mediated Microglia Pyroptosis and Polarization via Activating Mitophagy post-TBI
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    sciencedirect.com/science/article/pii/S0891584925008494
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Blood–brain barrier disruption and neuroinflammation in the hippocampus of a cardiac arrest porcine model: Single-cell RNA sequencing analysis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12220692/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fat mass and obesity–mediated N6-methyladenosine modification modulates neuroinflammatory responses after traumatic brain injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC12220718/
  15. Jun 2025
  16. journals.lww.com journals.lww.com
    M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury
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    journals.lww.com/nrronline/fulltext/2022/05000/m1_type_microglia_can_induce_astrocytes_to_deposit.34.aspx
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    Phenotypic screens for SIRPA expression reveal RAB21 as a general regulator of macrophage surface identity
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    sciencedirect.com/science/article/pii/S2211124725006928
  18. www.sciencedirect.com www.sciencedirect.com
    Inhibition of phosphodiesterase-4 by rolipram alleviates anxiety-like behavior in mice with PTSD by modulating neuroinflammation and synaptic plasticity via cAMP signaling
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    sciencedirect.com/science/article/pii/S1567576925011063
  19. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70108
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Murine norovirus allosteric escape mutants mimic gut activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12172446/
  21. May 2025
  22. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Human Amniotic Fluid-Derived Exosomes Alleviate Neuropathic Pain by Inducing an Anti-Inflammatory Transition in Microglia
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202500334R
  23. www.sciencedirect.com www.sciencedirect.com
    Poliumoside alleviates microglia-mediated inflammation and blood-brain barrier disruption via modulating the polarization of microglia after ischemic stroke in mice
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    sciencedirect.com/science/article/pii/S0944711325005197
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prostaglandin endoperoxide synthase 2 regulates neuroinflammation to mediate postoperative cognitive dysfunction in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12089394/
  25. www.sciencedirect.com www.sciencedirect.com
    Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S1074761325001815
  26. Apr 2025
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of Co-29, a 5-cyano-2-thiacetyl aromatic pyrimidinone, as a potential inhibitor targeting the RdRp of norovirus
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    pmc.ncbi.nlm.nih.gov/articles/PMC11969896/
  28. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    S-ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide-Induced Depression Via Targeting SIRT2
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202416481
  29. Mar 2025
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A microglia clonal inflammatory disorder in Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908784/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dopamine D1 receptor agonist alleviates post-weaning isolation-induced neuroinflammation and depression-like behaviors in female mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11895232/
  32. www.biorxiv.org www.biorxiv.org
    Glioma-induced DNMT3A-dependent reduction of DNA methylation in microglia promotes a transient anti-tumoral phenotype
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    biorxiv.org/content/10.1101/2025.02.22.639606v1
  33. journals.lww.com journals.lww.com
    Pharmacological targeting cGAS/STING/NF-κB axis by... : Neural Regeneration Research
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    journals.lww.com/nrronline/fulltext/2025/11000/pharmacological_targeting_cgas_sting_nf__b_axis_by.31.aspx
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Machine learning-assisted design of immunomodulatory lipid nanoparticles for delivery of mRNA to repolarize hyperactivated microglia
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    pmc.ncbi.nlm.nih.gov/articles/PMC11878168/
  35. Feb 2025
  36. www.sciencedirect.com www.sciencedirect.com
    Microglial pyroptosis drives neuropathic pain and targeting NLRP3 alleviates pain and neuroinflammation
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    sciencedirect.com/science/article/pii/S0925443925000821
  37. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17344
  38. Jan 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11759022/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions
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    pmc.ncbi.nlm.nih.gov/articles/PMC11743796/
  41. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Actions of dexmedetomidine in regulating NLRP3 in postoperative cognitive dysfunction in aged mice via the autophagy–lysosome pathway
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17378
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nogo-A exacerbates sepsis-associated encephalopathy by modulating microglial SHP-2/NLRP3 balance and inducing ROS and M1 polarization
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    pmc.ncbi.nlm.nih.gov/articles/PMC11647263/
  43. Dec 2024
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Exosome-based therapies for inflammatory disorders: a review of recent advances
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    pmc.ncbi.nlm.nih.gov/articles/PMC11657721/
  45. www.sciencedirect.com www.sciencedirect.com
    Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus
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    sciencedirect.com/science/article/pii/S1074761324005132
  46. www.sciencedirect.com www.sciencedirect.com
    Selenoprotein P is a target for regulating extracellular vesicle biogenesis and secretion from activated microglia in vivo
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    sciencedirect.com/science/article/pii/S2211124724013767
  47. Nov 2024
  48. www.sciencedirect.com www.sciencedirect.com
    Microbiota-derived lysophosphatidylcholine alleviates Alzheimer’s disease pathology via suppressing ferroptosis
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    sciencedirect.com/science/article/pii/S1550413124004029
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia
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    pmc.ncbi.nlm.nih.gov/articles/PMC11539848/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TREM-1 mediates interaction between substantia nigra microglia and peripheral neutrophils
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    ncbi.nlm.nih.gov/pmc/articles/PMC11467918/
  51. Oct 2024
  52. www.sciencedirect.com www.sciencedirect.com
    Phytochemical constituents from root barks of Eleutherococcus henryi Oliv. and their anti-neuroinflammatory effect
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    sciencedirect.com/science/article/pii/S0378874124011760
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke
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    ncbi.nlm.nih.gov/pmc/articles/PMC11433893/
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model
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    ncbi.nlm.nih.gov/pmc/articles/PMC11433905/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming
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    ncbi.nlm.nih.gov/pmc/articles/PMC11438333/
  56. Sep 2024
  57. www.sciencedirect.com www.sciencedirect.com
    Transcriptome analysis unveils PLSCR1 associated with microglial polarization in neuropathic pain
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    sciencedirect.com/science/article/pii/S0378111924008424
  58. Aug 2024
  59. www.sciencedirect.com www.sciencedirect.com
    Prolonged extracellular low sodium concentrations and subsequent their rapid correction modulate nitric oxide production dependent on NFAT5 in microglia
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    sciencedirect.com/science/article/pii/S0891584924006063
  60. journals.lww.com journals.lww.com
    Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury
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    journals.lww.com/nrronline/fulltext/2024/09000/exosomes_derived_from_microglia_overexpressing.33.aspx
  61. Jul 2024
  62. www.mdpi.com www.mdpi.com
    Impact of Interleukin-6 Activation and Arthritis on Epidermal Growth Factor Receptor (EGFR) Activation in Sensory Neurons and the Spinal Cord
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    mdpi.com/1422-0067/25/13/7168
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ID2-ETS2 axis regulates the transcriptional acquisition of pro-tumoral microglia phenotype in glioma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11255298/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular vesicles released from microglia after palmitate exposure impact brain function
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    ncbi.nlm.nih.gov/pmc/articles/PMC11253458/
  65. www.sciencedirect.com www.sciencedirect.com
    The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation
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    sciencedirect.com/science/article/pii/S2211124724007460
  66. May 2024
  67. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Accumulation of extracellular elastin-derived peptides disturbed neuronal morphology and neuron–microglia crosstalk in aged brain
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    onlinelibrary.wiley.com/doi/10.1111/jnc.16039
  68. www.sciencedirect.com www.sciencedirect.com
    Cannabidiol prevents LPS-induced inflammation by inhibiting the NLRP3 inflammasome and iNOS activity in BV2 microglia cells via CB2 receptors and PPARγ
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    sciencedirect.com/science/article/pii/S0197018624000962
  69. Apr 2024
  70. link.springer.com link.springer.com
    Lactate Protects Microglia and Neurons from Oxygen–Glucose Deprivation/Reoxygenation
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    link.springer.com/article/10.1007/s11064-024-04135-7
  71. Mar 2024
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10960275/
  73. Feb 2024
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The reversible activation of norovirus by metal ions
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    ncbi.nlm.nih.gov/pmc/articles/PMC10878237/
  75. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke
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    onlinelibrary.wiley.com/doi/10.1111/jnc.16058
  76. www.mdpi.com www.mdpi.com
    Neuroprotection via Carbon Monoxide Depends on the Circadian Regulation of CD36-Mediated Microglial Erythrophagocytosis in Hemorrhagic Stroke
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    mdpi.com/1422-0067/25/3/1680
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activated microglia release β−galactosidase that promotes inflammatory neurodegeneration
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    ncbi.nlm.nih.gov/pmc/articles/PMC10811154/
  78. Jan 2024
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Three methods for examining the de novo proteome of microglia using BONCAT bioorthogonal labeling and FUNCAT click chemistry
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    ncbi.nlm.nih.gov/pmc/articles/PMC10511912/
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The COP9 signalosome reduces neuroinflammation and attenuates ischemic neuronal stress in organotypic brain slice culture model
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    ncbi.nlm.nih.gov/pmc/articles/PMC10439869/
  81. Dec 2023
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10749599/
  83. www.sciencedirect.com www.sciencedirect.com
    Diosmin ameliorates LPS-induced depression-like behaviors in mice: inhibition of inflammation and oxidative stress in the prefrontal cortex
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    sciencedirect.com/science/article/pii/S036192302300268X
  84. elifesciences.org elifesciences.org
    Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s disease
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    elifesciences.org/articles/85279
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10687467/
  86. Oct 2023
  87. www.mdpi.com www.mdpi.com
    Oncolytic Viral Therapy for Glioma by Recombinant Sindbis Virus
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    mdpi.com/2072-6694/15/19/4738
  88. Jul 2023
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cyclo (MQCNS) has the potential to treat ischemic stroke
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    ncbi.nlm.nih.gov/pmc/articles/PMC10360098/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vav1 promotes inflammation and neuronal apoptosis in cerebral ischemia/reperfusion injury by upregulating microglial and NLRP3 inflammasome activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10360116/
  91. www.sciencedirect.com www.sciencedirect.com
    Low and high doses of oral maslinic acid protect against Parkinson’s disease via distinct gut microbiota-related mechanisms
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    sciencedirect.com/science/article/pii/S0753332223008910
  92. May 2023
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The neuroprotective N-terminal amyloid-β core hexapeptide reverses reactive gliosis and gliotoxicity in Alzheimer’s disease pathology models
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    ncbi.nlm.nih.gov/pmc/articles/PMC10225108/
  94. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PERK-Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti-Tumoral Polarization of Microglia
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    onlinelibrary.wiley.com/doi/10.1002/advs.202205949
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Poly(ADP-ribose) polymerase family member 14 promotes... : Neural Regeneration Research
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    ncbi.nlm.nih.gov/pmc/articles/PMC10154507/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exendin-4 and linagliptin attenuate neuroinflammation in a... : Neural Regeneration Research
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    ncbi.nlm.nih.gov/pmc/articles/PMC10154509/
  97. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel sorbicillinoid compound as a potent anti-inflammation agent through inducing NLRP3 protein degradation
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16058
  98. Apr 2023
  99. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia
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    pmc.ncbi.nlm.nih.gov/articles/PMC10493665/
  100. Mar 2023
  101. www.sciencedirect.com www.sciencedirect.com
    Leaked genomic and mitochondrial DNA contribute to the host response to noroviruses in a STING-dependent manner
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    sciencedirect.com/science/article/pii/S2211124723001900
  102. link.springer.com link.springer.com
    Necrostatin-1S mitigates type-2 diabetes-associated cognitive decrement and lipotoxicity-induced neuro-microglia changes through p-RIPK-RIPK3-p-MLKL axis
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    link.springer.com/article/10.1007/s11011-023-01185-8
  103. link.springer.com link.springer.com
    KDM4A, involved in the inflammatory and oxidative stress caused by traumatic brain injury-hemorrhagic shock, partly through the regulation of the microglia M1 polarization
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    link.springer.com/article/10.1186/s12868-023-00784-6
  104. Feb 2023
  105. www.sciencedirect.com www.sciencedirect.com
    The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia
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    sciencedirect.com/science/article/pii/S2589004223000706
  106. link.springer.com link.springer.com
    Transmission of NLRP3-IL-1β Signals in Cerebral Ischemia and Reperfusion Injury: from Microglia to Adjacent Neuron and Endothelial Cells via IL-1β/IL-1R1/TRAF6
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    link.springer.com/article/10.1007/s12035-023-03232-y
  107. Jan 2023
  108. journals.lww.com journals.lww.com
    Emodin attenuates inflammation and demyelination in... : Neural Regeneration Research
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    journals.lww.com/nrronline/Fulltext/2023/07000/Emodin_attenuates_inflammation_and_demyelination.27.aspx
  109. onlinelibrary.wiley.com onlinelibrary.wiley.com
    P2Y6 receptor-dependent microglial phagocytosis of synapses mediates synaptic and memory loss in aging
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