106 Matching Annotations
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    Untranslated region rewiring defines a novel class of oncogene fusions
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    sciencedirect.com/science/article/pii/S2211124726012246
  3. Oct 2026
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    A genome-scale adaptation map identifies the FANCM-RMI1/2 complex as an opposing modulator of cell fitness upon BRCA1 or BRCA2 loss
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    sciencedirect.com/science/article/pii/S109727652600660X
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    MTAP loss upregulates BCAT1 in pancreatic cancer and drives branched-chain amino acid dependency
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    sciencedirect.com/science/article/pii/S2211124726011241
  6. Sep 2026
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    ARNTL2 promotes metastatic phenotypes through SERPINE1 transcription in KRAS G12D pancreatic cancer
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    sciencedirect.com/science/article/pii/S2589004226028580
  8. Aug 2026
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    Targeting addiction to HMGB2-driven transcriptional programs in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124726007278
  10. Jun 2026
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A malignant subpopulation of H2AFZ+ cells interacts with myeloid cells to promote an anti-inflammatory microenvironment and drive hepatic metastasis, revealing an immunotherapeutic strategy for pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13266339/
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    Targeting HAS2 to enhance anti-tumor immunity in pancreatic cancer via PD-L1 regulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13237160/
  13. Apr 2026
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70455
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    Loss of Regulator of G protein signaling 11 promotes pro-tumorigenic features in pancreatic cancer
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    aacrjournals.org/mcr/article/24/1/34/771151/Loss-of-Regulator-of-G-Protein-Signaling-11
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    DS-3939a: A TA-MUC1-directed Antibody-Drug Conjugate with Broad Anti-Tumor Activity
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  17. Mar 2026
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo Auto-tuning of Antibody-Drug Conjugate Delivery to Maximize Efficacy using High-Avidity, Low-Affinity Antibodies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12964248/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer
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  20. Feb 2026
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    Supplemental_Material.pdf
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  22. Jan 2026
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    Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML
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    sciencedirect.com/science/article/pii/S155041312600001X
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    Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
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    Basroparib inhibits YAP-driven cancers by stabilizing angiomotin
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    SLC6A14-mediated glutamine promotes SYTL4–CXCL8 axis activation to drive gemcitabine resistance and immune evasion in pancreatic cancer
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    nature.com/articles/s12276-025-01596-w
  27. Dec 2025
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combination of the MTA-Cooperative PRMT5 Inhibitor BMS-986504 and KRAS Inhibitors is an Effective Treatment Strategy for MTAP-Deleted KRAS-Mutant Pancreatic Cancer
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    IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer
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    Dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-mutant prostate cancer
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  31. Oct 2025
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    Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma
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    Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses
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  34. Sep 2025
  35. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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  36. Aug 2025
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    Genome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potency
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    SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
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    The role of formin-like protein 1 in pancreatic cancer and its specific effects on immunity
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    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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  42. Jul 2025
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    A STAT3/integrin axis accelerates pancreatic cancer initiation and progression
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    SenExo-cCCT2 Reprograms Senescence Response and Anti-Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma
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  45. Jun 2025
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    EMT-associated bias in the Parsortix® system observed with pancreatic cancer cell lines
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  47. Apr 2025
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    CD44 Identified as a Diagnostic Biomarker for Highly Malignant CA19-9 Negative Pancreatic Cancer
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    Novel Amanitin-Based Antibody–Drug Conjugates Targeting TROP2 for the Treatment of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962393/
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    Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways
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  51. Mar 2025
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    Preclinical evaluation of a novel antibody–drug conjugate OBI-992 for Cancer therapy
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  53. Feb 2025
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    Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors
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    The integrated stress response drives MET oncogene overexpression in cancers
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  56. Jan 2025
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    Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer
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  59. Dec 2024
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    Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A
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  62. Nov 2024
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    Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms
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    Biases in the Parsortix® system observed with pancreatic cancer cell lines
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  65. Oct 2024
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    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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    CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment
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    ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK
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  69. Aug 2024
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    Dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-mutant prostate cancer
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    A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer
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    Isolation, expansion, and adoptive transfer of human ILC2s for the treatment of mice bearing liquid and solid tumors
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    LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism
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    Human splenic TER cells: A relevant prognostic factor acting via the Artemin‐GFRα3‐ERK pathway in pancreatic ductal adenocarcinoma
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  75. Jul 2024
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    Biomarker screen for efficacy of oncolytic virotherapy in patient-derived pancreatic cancer cultures
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Placental co-transcriptional activator Vestigial-like 1 (VGLL1) drives tumorigenesis via increasing transcription of proliferation and invasion genes
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  78. May 2024
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    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    biorxiv.org/content/10.1101/2024.03.12.584316v1
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    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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  81. Apr 2024
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    Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
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    ELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34960
  84. Feb 2024
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    Nuclear GRP78 Promotes Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Ductal Adenocarcinoma
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  87. Jan 2024
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CCDC85A is regulated by miR-224-3p and augments cancer cell resistance to endoplasmic reticulum stress
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    Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death
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  90. Dec 2023
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    PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition
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  93. Nov 2023
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    SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124723014468
  95. www.biorxiv.org www.biorxiv.org
    LMO3 is a suppressor of the basal-like/squamous PDAC subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism
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    biorxiv.org/content/10.1101/2023.11.01.564448v1
  96. Sep 2023
  97. www.biorxiv.org www.biorxiv.org
    ELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
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    Deubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/abs/pii/S0304383523003622
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  100. Jun 2023
  101. www.nature.com www.nature.com
    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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    nature.com/articles/s41467-023-39241-7
  102. aacrjournals.org aacrjournals.org
    Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer
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    aacrjournals.org/cancerres/article/83/5/735/716680/Enhanced-Glutaminolysis-Drives-Hypoxia-Induced
  103. May 2023
  104. www.sciencedirect.com www.sciencedirect.com
    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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  105. Jan 2023
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel B7-H6–Targeted IgG-Like T Cell–Engaging Antibody for the Treatment of Gastrointestinal Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC9713360/
  107. Sep 2022
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EMT-induced gemcitabine resistance in pancreatic cancer involves the functional loss of equilibrative nucleoside transporter 1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9464091/
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    Decellularization of xenografted tumors provides cell-specific in vitro 3D environment
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    ncbi.nlm.nih.gov/pmc/articles/PMC9434107/
  110. Aug 2022
  111. insight.jci.org insight.jci.org
    Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer
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    insight.jci.org/articles/view/154475
  112. May 2022
  113. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer
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    onlinelibrary.wiley.com/doi/10.1002/cam4.4823
  114. Jan 2022
  115. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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    journals.sagepub.com/doi/full/10.1177/24725552211038362
  116. Dec 2021
  117. www.sciencedirect.com www.sciencedirect.com
    Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis
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  118. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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  119. www.nature.com www.nature.com
    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
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  120. Nov 2021
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    Novel colchicine derivative CR42-24 demonstrates potent anti-tumor activity in urothelial carcinoma
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    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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  124. Sep 2021
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  126. Jul 2021
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    Targeting the N Terminus of eIF4AI for Inhibition of Its Catalytic Recycling
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    Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
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    MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer
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  131. Jun 2021
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    The Gain-of-Function p53 R248W Mutant Promotes Migration by STAT3 Deregulation in Human Pancreatic Cancer Cells
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  133. May 2021
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    Pancreatic Cancer Cells Require the Transcription Factor MYRF to Maintain ER Homeostasis
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  135. Apr 2021
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    SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy
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  137. Nov 2020
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    Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer
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  139. Sep 2020
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    Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone
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    Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement
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    Proton Pump Inhibitors Reduce Pancreatic Adenocarcinoma Progression by Selectively Targeting H+, K+-ATPases in Pancreatic Cancer and Stellate Cells
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  143. Jan 2020
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    NO•/RUNX3/Kynurenine Metabolic Signaling Enhances Disease Aggressiveness in Pancreatic Cancer
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  145. Apr 2019
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    RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks
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  147. Nov 2018
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    CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
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    Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer
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  150. Nov 2017
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    Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo
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