247 Matching Annotations
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    A comprehensive review of anti-colorectal cancer alkaloids from traditional Chinese medicine: Sources, chemical structures, mechanisms and therapeutic applications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70343
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    Colorectal cancer-derived osteopontin rewires macrophages into a pro-metastatic M2 state via the PI3K/AKT/CSF1-CSF1R axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12894849/
  4. Feb 2026
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    Functional characterization of CASP, a CUX1 isoform, reveals its tumor-promoting role in colorectal cancer via TRIM21-mediated signaling
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    SERPINA3 mediates liver cancer cells escape from chemotherapy-induced neutrophil extracellular trap killing
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  7. Jan 2026
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    Thimerosal Inhibits Tumor Malignant Progression through Direct Action and Enhancing the Efficacy of PD-1-Based Immunotherapy
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    Basroparib inhibits YAP-driven cancers by stabilizing angiomotin
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    Distinct Regulation of the ARF and TAp73 Tumor Suppressor Genes by the Transcription Factor E2F1 Enables Discrimination of Cancer Cells from Normal Growing Cells
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    HMMR/RHAMM recruits SACK1D/FAM83D-CK1α complex at the mitotic spindle to control spindle alignment
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    BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation
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    Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer
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  14. Dec 2025
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    A TRIM21–UCHL3–ITCH–SIPA1 axis promotes colorectal cancer growth and metastasis
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    Mitochondrial VHL rewires cell metabolism in hypoxia
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    KRT81 promotes metastasis of colorectal cancer by acting as a protein scaffold for ezrin
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    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    A novel β-carboline alkaloid derivative targeting MDM2-p53 pathway suppresses colorectal cancer progression
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  21. Nov 2025
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    Colorectal cancer cell-derived exosomes induce metabolic reprogramming of cancer-associated fibroblasts to promote colorectal cancer growth
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    Cytoplasmic HMGB1 promotes and interacts with BECN1 through ZNF460 to induce autophagy and accelerate radioresistance in colorectal cancer cells
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  25. Oct 2025
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    Purinergic Ecto-Enzyme CD73 is a Context-Dependent Tumor Suppressor in Colorectal Cancer
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    CANDiT: A machine learning framework for differentiation therapy in colorectal cancer
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    MM-129 Counteracts 5-Fluorouracil-Induced Cellular Senescence in Colon Cancer via SIRT1/STAT3 Signaling Pathway
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    Cancer-associated fibroblasts expressing FSTL3 promote vasculogenic mimicry formation and drive colon cancer malignancy
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    Extracellular Vesicle-Packaged circTAX1BP1 from Cancer-Associated Fibroblasts Regulates RNA m6A Modification through Lactylation of VIRMA in Colorectal Cancer Cells
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  32. Sep 2025
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    FET fusion oncoproteins enrich SWI/SNF complex subtypes and interaction partners
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer
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  39. Aug 2025
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    TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation
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    Cyclin-dependent kinase 9 inhibitors as oncogene signaling modulators in combination with targeted therapy for the treatment of colorectal cancer
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    Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics
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  48. Jul 2025
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    The XPO1 inhibitor Eltanexor modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis
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    A novel MIR100HG transcript enhances tumorigenesis by inducing BCLAF1-mediated alternative splicing in colorectal cancer
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    LCN2 promotes focal adhesion formation and invasion by stimulating c-Src activation
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    Overcoming multidrug resistance in gastrointestinal cancers with a CDH17-targeted ADC conjugated to a DNA topoisomerase inhibitor
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    biorxiv.org/content/10.1101/2025.06.18.660406v1
  55. Jun 2025
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    Ribosomal RNA transcription regulates splicing through ribosomal protein RPL22
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    TR-107, An Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells
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    Integrin β6 expression in colorectal cancer cells promotes liver metastasis through enhanced adhesion to endothelial fibronectin
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  59. May 2025
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    Discovery of Z1362873773: a novel fascin inhibitor from a large chemical library for colorectal cancer
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  62. Apr 2025
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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    Quantitative AI-based DNA fiber workflow to study replication stress
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  65. Mar 2025
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation
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  67. Feb 2025
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Salicylate-Elicited Activation of AMP-Activated Protein Kinase Directly Triggers Degradation of C-Myc in Colorectal Cancer Cells
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    Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation
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    Parecoxib and 5-Fluorouracil Synergistic Inhibition of Metastasis of Colorectal Cancer Cells by Targeting Akt/NF-κB and EMT Pathways
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    A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
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    Identification of Lipid Species Signatures in FOLFOXIRI-Resistant Colorectal Cancer Cells
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    RIOK3 mediates the degradation of 40S ribosomes
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    Rhodoquinone carries electrons in the mammalian electron transport chain
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  75. Jan 2025
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination
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    A thermoplastic chip for 2D and 3D correlative assays combining screening and high-resolution imaging of immune cell responses
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    Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation
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  79. Dec 2024
  80. www.cell.com www.cell.com
    Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti-tumor immunity
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    cell.com/cancer-cell/abstract/S1535-6108(24)00476-8
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    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    AMIGO2 characterizes cancer‐associated fibroblasts in metastatic colon cancer and induces the release of paracrine active tumorigenic secretomes
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    Synergistic anticancer activity of HSP70 and HSF1 inhibitors in colorectal cancer cells: A new strategy for combination therapy
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    Inhibiting de novo lipogenesis identifies a therapeutic vulnerability in therapy-resistant colorectal cancer
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    The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release
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    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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  88. Nov 2024
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance
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    4’-Ethynyl-2’-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
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  91. Sep 2024
  92. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    CASCADES, a novel SOX2 super-enhancer-associated long noncoding RNA, regulates cancer stem cell specification and differentiation in glioblastoma
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    CT45A1-mediated MLC2 (MYL9) phosphorylation promotes natural killer cell resistance and outer cell fate in a cell-in-cell structure, potentiating the progression of microsatellite instability-high colorectal cancer
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    Novel immunotherapeutics against LGR5 to target multiple cancer types
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    14-3-3σ restricts YY1 to the cytoplasm, promoting therapy resistance, and tumor progression in colorectal cancer
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    Enhanced pharmacological activities of AKR1C3-activated prodrug AST-3424 in cancer cells with defective DNA repair
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    RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis
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    A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancer
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  99. Aug 2024
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    RAD51 protects abasic sites to prevent replication fork breakage
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  210. Dec 2021
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  216. Nov 2021
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  218. Oct 2021
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  220. Sep 2021
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  224. Aug 2021
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    A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53
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  234. Jul 2021
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  245. Jun 2021
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