73 Matching Annotations
  1. Last 7 days
  2. aacrjournals.org aacrjournals.org
    DS-3939a: A TA-MUC1-directed Antibody-Drug Conjugate with Broad Anti-Tumor Activity
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    aacrjournals.org/mct/article/25/1/7/771286/DS-3939a-A-TA-MUC1-Directed-Antibody-Drug
  3. Mar 2026
  4. www.sciencedirect.com www.sciencedirect.com
    Receptor-ubiquitination-targeting antibody-drug conjugates for enhanced endocytosis and lysosomal delivery
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    sciencedirect.com/science/article/pii/S245194562600070X
  5. Feb 2026
  6. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Single-Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202513341
  7. Jan 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thimerosal Inhibits Tumor Malignant Progression through Direct Action and Enhancing the Efficacy of PD-1-Based Immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12848756/
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    MYLK4 promotes colorectal cancer progression by regulating lipid metabolism reprogramming via targeting ferroptosis
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    sciencedirect.com/science/article/pii/S1476558625001496
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    Unveiling tumor senescence-driven prognostic heterogeneity via MALISS in stage II/III colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12816352/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The dysadherin/carbonic anhydrase 9 axis shapes an acidic tumor microenvironment to promote colorectal cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12804794/
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    Afatinib exerts an inhibitory effect on T cell-mediated cytotoxicity
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    link.springer.com/article/10.1007/s00262-025-04279-7
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    Targeted nanoparticle delivery of irinotecan enhances tumor response to PD-L1 blockade in colorectal cancer
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    sciencedirect.com/science/article/pii/S0168365926000106
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    Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer
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    sciencedirect.com/science/article/pii/S266637912500607X
  15. Dec 2025
  16. www.nature.com www.nature.com
    KRT81 promotes metastasis of colorectal cancer by acting as a protein scaffold for ezrin
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    nature.com/articles/s41388-025-03665-w
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
  18. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R-Loop Accumulation and DNA Repair Deficiencies
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202512074
  19. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004225025647-main-html.html
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  20. Nov 2025
  21. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Fatty acids modulate the colorectal cancer immune microenvironment via regulating the interaction and transactivation of PPARα/δ and P53
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    sciencedirect.com:5037/science/article/pii/S2211124725013956
  22. Sep 2025
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CF10 Displayed Improved Activity Relative to 5-FU in a Mouse CRLM Model Under Conditions of Physiological Folate
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    pmc.ncbi.nlm.nih.gov/articles/PMC12427396/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PKN2 is a dependency of the mesenchymal-like cancer cell state
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875962/
  25. Jul 2025
  26. www.oaepublish.com www.oaepublish.com
    CF10/LV overcomes acquired resistance to 5-FU/LV in colorectal cancer cells through downregulation of the c-Myc/ABCB5 axis
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    oaepublish.com/articles/cdr.2025.76
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    BDH2 promotes GLIPR1 promoter methylation and thus increases 5-FU sensitivity in colorectal cancer
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    sciencedirect.com/science/article/pii/S0006295225004186
  28. May 2025
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metformin reverses 5-FU resistance induced by radiotherapy through mediating folate metabolism in colorectal cancer
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    The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202504704
  31. Apr 2025
  32. 52.53.155.43 52.53.155.43
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  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Colorectal cancer stem cells develop NK cell resistance via homotypic cell-in-cell structures suppressed by Stathmin1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11984389/
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    Pentagalloyl Glucose Targets the JAK1/JAK3-STAT3 Pathway to Inhibit Cancer Stem Cells and Epithelial–Mesenchymal Transition in 5-Fluorouracil-Resistant Colorectal Cancer
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  35. Mar 2025
  36. www.sciencedirect.com www.sciencedirect.com
    SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response
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    FSTL3 promotes colorectal cancer by activating the HIF1 pathway
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    sciencedirect.com/science/article/pii/S0378111925002239
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11932694/
  39. Feb 2025
  40. 52.53.155.43 52.53.155.43
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    Targeting both the enzymatic and non-enzymatic functions of DHODH as a therapeutic vulnerability in c-Myc-driven cancer
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    sciencedirect.com/science/article/pii/S2211124725000981
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC11831107/
  43. Jan 2025
  44. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation
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    sciencedirect.com/science/article/pii/S1074761324005685
  46. Dec 2024
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Forced Overexpression and Knockout Analysis of SLC30A and SLC39A Family Genes Suggests Their Involvement in Establishing Resistance to Cisplatin in Human Cancer Cells
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  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    B7-H3–Targeted CAR-Vδ1T Cells Exhibit Potent Broad-Spectrum Activity against Solid Tumors
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    DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states
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    The dysadherin/MMP9 axis modifies the extracellular matrix to accelerate colorectal cancer progression
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    nature.com/articles/s41467-024-54920-9
  52. Oct 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypoxia-Induced Long Noncoding RNA HIF1A-AS2 Regulates Stability of MHC Class I Protein in Head and Neck Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443317/
  54. Sep 2024
  55. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    CT45A1-mediated MLC2 (MYL9) phosphorylation promotes natural killer cell resistance and outer cell fate in a cell-in-cell structure, potentiating the progression of microsatellite instability-high colorectal cancer
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13736
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia
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    ncbi.nlm.nih.gov/pmc/articles/PMC11424096/
  57. Aug 2024
  58. www.sciencedirect.com www.sciencedirect.com
    Spatial characterization and stratification of colorectal adenomas by deep visual proteomics
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    sciencedirect.com/science/article/pii/S2589004224018455
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HTS384 NCI60: The Next Phase of the NCI60 Screen
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    ncbi.nlm.nih.gov/pmc/articles/PMC11292194/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MMP‐9‐dependent proteolysis of the histone H3 N‐terminal tail: a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11306514/
  61. 52.53.155.43 52.53.155.43
    The Natural Alkaloid (-)- N-Hydroxyapiosporamide Suppresses Colorectal Tumor Progression as an NF-κB Pathway Inhibitor by Targeting the TAK1-TRAF6 Complex
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    52.53.155.43/8d57977b9b9f6e94560266e27b39ad1669186ba3/acs.jnatprod.3c00125 (1)-html.html
  62. bmccancer.biomedcentral.com bmccancer.biomedcentral.com
    Super-enhancer-associated long noncoding RNA AC005592.2 promotes tumor progression by regulating OLFM4 in colorectal cancer
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    bmccancer.biomedcentral.com/article/10.1186/s12885-021-07900-x
  63. Mar 2024
  64. 52.53.155.43 52.53.155.43
    Eosinophils exhibit a unique transcriptional signature and increased sensitivity to IL-3-induced activation in response to colorectal cancer cells
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    52.53.155.43/7241ac452b455844d7e12ac1740a76e49c0fc746/qiae063-html.html
  65. Nov 2023
  66. link.springer.com link.springer.com
    TCOF1 promotes the colorectal cancer progression by stabilizing β-catenin
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    link.springer.com/article/10.1007/s12032-023-02218-z
  67. www.sciencedirect.com www.sciencedirect.com
    Inhibitory effects of lidocaine on colon carcinoma progression in a rat model: a pilot study
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    sciencedirect.com/science/article/pii/S0007091223004403
  68. Sep 2023
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AMT-562, a novel HER3-targeting antibody drug conjugate, demonstrates a potential to broaden therapeutic opportunities for HER3-expressing tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10477830/
  70. Jul 2023
  71. 52.53.155.43 52.53.155.43
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    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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    sciencedirect.com/science/article/pii/S2211124723007751
  73. 52.53.155.43 52.53.155.43
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  74. Jun 2023
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10236151/
  76. Apr 2023
  77. www.sciencedirect.com www.sciencedirect.com
    Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a TIP60-independent regulation of the pre-RC complex
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    sciencedirect.com/science/article/pii/S2589004223006405
  78. onlinelibrary.wiley.com onlinelibrary.wiley.com
    An integrated multi-omics analysis of rectal cancer patients identified POU2F3 as a putative druggable target and entinostat as a cytotoxic enhancer of 5-Fluorouracil
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34478
  79. Oct 2022
  80. www.sciencedirect.com www.sciencedirect.com
    Cancer-specific T helper shared and neo-epitopes uncovered by expression of the MHC class II master regulator CIITA
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    sciencedirect.com/science/article/pii/S2211124722013353
  81. www.nature.com www.nature.com
    A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo
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    nature.com/articles/s41467-022-33430-6
  82. Jun 2022
  83. www.sciencedirect.com www.sciencedirect.com
    Supramolecular assembly of GSK3α as a cellular response to amino acid starvation
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    sciencedirect.com/science/article/pii/S1097276522004920
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    Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis
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    sciencedirect.com/science/article/pii/S2211124722006246
  85. May 2022
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FILIP1L loss is a driver of aggressive mucinous colorectal adenocarcinoma and mediates cytokinesis defects through PFDN1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8563430/
  87. Feb 2022
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity
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    ncbi.nlm.nih.gov/pmc/articles/PMC8845119/
  89. Jul 2021
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic potential of the phosphino Cu(I) complex (HydroCuP) in the treatment of solid tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC5655689/
  91. Jun 2021
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition
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    ncbi.nlm.nih.gov/pmc/articles/PMC8195604/
  93. Apr 2021
  94. www.sciencedirect.com www.sciencedirect.com
    Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth
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    sciencedirect.com/science/article/pii/S2451945621000490
  95. Jan 2021
  96. jeccr.biomedcentral.com jeccr.biomedcentral.com
    Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer
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    jeccr.biomedcentral.com/articles/10.1186/s13046-020-01811-8
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Polyphenolic Fraction Obtained From Thalassia testudinum Marine Plant and Thalassiolin B Exert Cytotoxic Effects in Colorectal Cancer Cells and Arrest Tumor Progression in a Xenograft Mouse Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC7774314/
  98. Sep 2020
  99. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14981
  100. www.nature.com www.nature.com
    Zinc-finger antiviral protein acts as a tumor suppressor in colorectal cancer
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    nature.com/articles/s41388-020-01416-7
  101. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A mutant KRAS‐induced factor REG4 Promotes Cancer Stem Cell Properties via Wnt/β‐catenin Signaling
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    onlinelibrary.wiley.com/doi/10.1002/ijc.32728
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC7062870/
  103. Jan 2020
  104. www.sciencedirect.com www.sciencedirect.com
    VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells
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    sciencedirect.com/science/article/pii/S2405471219301905
  105. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S2451945618304355