143 Matching Annotations
  1. Oct 2025
  2. www.sciencedirect.com www.sciencedirect.com
    The upregulation of GDF15 is controlled epigenetically by oncogenic TCF19 signaling in human hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S258900422501764X
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    CBX4 acetoacetylation as an inhibitory mechanism of HIF-1α activity
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    sciencedirect.com/science/article/pii/S2451945625003009
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    Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid
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    sciencedirect.com/science/article/pii/S1550413125003869
  5. Sep 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    miR-199a-5p/GPR89A axis modulates sorafenib resistance in hepatocellular carcinoma through glutamate metabolic reprogramming
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    pmc.ncbi.nlm.nih.gov/articles/PMC12457768/
  7. journals.asm.org journals.asm.org
    HBV-encoded circRNA-5 promotes hepatocellular carcinoma progression by regulating the miR-9-3p/Hippo signaling axis
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    journals.asm.org/doi/10.1128/spectrum.01439-25
  8. Aug 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11949624/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations
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    pmc.ncbi.nlm.nih.gov/articles/PMC12319405/
  11. www.sciencedirect.com www.sciencedirect.com
    Computational framework for prioritizing candidate compounds overcoming the resistance of pancancer immunotherapy
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    sciencedirect.com/science/article/pii/S2666379125003490
  12. www.nature.com www.nature.com
    Targeting MCM10 disrupts cancer stemness and counteracts sorafenib resistance in hepatocellular carcinoma
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    nature.com/articles/s41417-025-00946-0
  13. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    ASH2L-K312-Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202509477
  14. Jul 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thyroid hormone suppresses cell growth by regulating CDK2 and cyclin E1 expression via Hepsin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12256398/
  16. www.nature.com www.nature.com
    IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma
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    nature.com/articles/s41419-025-07839-y
  17. www.frontiersin.org www.frontiersin.org
    Frontiers | TREM1 is essential for maintaining stemness of liver cancer stem-like cells in hepatocellular carcinoma
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    frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1618342/full
  18. Jun 2025
  19. www.cell.com www.cell.com
    BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival
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    cell.com/molecular-cell/fulltext/S1097-2765(25)00499-X
  20. 52.53.155.43 52.53.155.43
    PDF-html.html
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  21. May 2025
  22. www.nature.com www.nature.com
    ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression
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    nature.com/articles/s41556-025-01651-8
  23. Apr 2025
  24. link.springer.com link.springer.com
    Downregulation of PD-L1 expression by Wnt pathway inhibition to enhance PD-1 blockade efficacy in hepatocellular carcinoma
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    link.springer.com/article/10.1186/s13062-025-00645-8
  25. www.sciencedirect.com www.sciencedirect.com
    RAF1 kinase contributes to autophagic lysosome reformation
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    sciencedirect.com/science/article/pii/S221112472500261X
  26. Mar 2025
  27. www.cmghjournal.org www.cmghjournal.org
    1-s2.0-S2352345X25000268-main-html.html
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    cmghjournal.org/article/S2352-345X(25)00026-8/fulltext
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Anti-tumor efficacy and safety of AEV01 in preclinical glioblastoma and hepatocellular carcinoma models
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    pmc.ncbi.nlm.nih.gov/articles/PMC11865564/
  29. Feb 2025
  30. www.sciencedirect.com www.sciencedirect.com
    AKR1D1 suppresses liver cancer progression by promoting bile acid metabolism-mediated NK cell cytotoxicity
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    sciencedirect.com/science/article/pii/S1550413125000117
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11832924/
  32. www.sciencedirect.com www.sciencedirect.com
    Lactate drives senescence-resistant lineages in hepatocellular carcinoma via histone H2B lactylation of NDRG1
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    sciencedirect.com/science/article/pii/S0304383525001314
  33. www.sciencedirect.com www.sciencedirect.com
    CV1-secreting sCAR-T cells potentiate the abscopal effect of microwave ablation in heterogeneous tumors
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    sciencedirect.com/science/article/pii/S2666379125000382
  34. www.sciencedirect.com www.sciencedirect.com
    ENTPD8 overexpression enhances anti-PD-L1 therapy in hepatocellular carcinoma via miR-214-5p inhibition
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    sciencedirect.com/science/article/pii/S2589004225000793
  35. link.springer.com link.springer.com
    Machine learning-based integration reveals immunological heterogeneity and the clinical potential of T cell receptor (TCR) gene pattern in hepatocellular carcinoma
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    link.springer.com/article/10.1007/s10495-025-02080-6
  36. www.sciencedirect.com www.sciencedirect.com
    Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3
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    sciencedirect.com/science/article/pii/S221112472500021X
  37. Jan 2025
  38. www.sciencedirect.com www.sciencedirect.com
    OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth
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    sciencedirect.com/science/article/pii/S1097276524010669
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MAF1 inhibits hepatocarcinogenesis by fostering an immunostimulatory tumor microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC11749189/
  40. www.nature.com www.nature.com
    Re-evaluation of the relationship between PrPc expression and patient prognosis in primary esophageal squamous cell carcinoma and primary hepatocellular carcinoma
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    nature.com/articles/s41598-024-82398-4
  41. Dec 2024
  42. www.nature.com www.nature.com
    Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
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    nature.com/articles/s41418-024-01439-7
  43. 52.53.155.43 52.53.155.43
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  44. www.sciencedirect.com www.sciencedirect.com
    Carbonic anhydrase 2 facilitates sorafenib resistance by counteracting MCT4-mediated intracellular pH dysregulation in HCC
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    sciencedirect.com/science/article/pii/S2211124724013470
  45. Nov 2024
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    C19MC Drives Nucleolar Invasion of Mitochondria and Meiotic Nuclear Division in Human Cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC11575172/
  47. www.sciencedirect.com www.sciencedirect.com
    ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S2211124724013135
  48. www.sciencedirect.com www.sciencedirect.com
    Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy
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    sciencedirect.com/science/article/pii/S1535610824003969
  49. Oct 2024
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of a [89Zr]Zr-labeled human antibody using a novel phage-displayed human scFv library
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    ncbi.nlm.nih.gov/pmc/articles/PMC10984770/
  51. Aug 2024
  52. www.sciencedirect.com www.sciencedirect.com
    YTHDF3-mediated m6A modification of NKD1 regulates hepatocellular carcinoma invasion and metastasis by activating the WNT/β-catenin signaling axis
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    sciencedirect.com/science/article/pii/S0014482724002830
  53. www.tandfonline.com www.tandfonline.com
    SIGLEC15, negatively correlated with PD-L1 in HCC, could induce CD8+ T cell apoptosis to promote immune evasion
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    tandfonline.com/doi/full/10.1080/2162402X.2024.2376264
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol to analyze the role of various metabolites in impacting global RNA 5-methylcytosine levels in cultured cells by dot blot
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    ncbi.nlm.nih.gov/pmc/articles/PMC10801338/
  55. aacrjournals.org aacrjournals.org
    Hypoxia-responsive lncRNA AC115619 encodes a micropeptide that suppresses m6A modifications and hepatocellular carcinoma progression
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    aacrjournals.org/cancerres/article/83/15/2496/728089/Hypoxia-Responsive-lncRNA-AC115619-Encodes-a
  56. pubs.acs.org pubs.acs.org
    Integrated Compound Profiling Screens Identify the Mitochondrial Electron Transport Chain as the Molecular Target of the Natural Products Manassantin, Sesquicillin, and Arctigenin - ACS Chemical Biology (ACS Publications)
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    pubs.acs.org/doi/full/10.1021/cb300495e
  57. www.sciencedirect.com www.sciencedirect.com
    Therapeutic application of extracellular vesicular EGFR isoform D as a co-drug to target squamous cell cancers with tyrosine kinase inhibitors
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    sciencedirect.com/science/article/pii/S1534580724004428
  58. Jul 2024
  59. www.sciencedirect.com www.sciencedirect.com
    NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers
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    sciencedirect.com/science/article/pii/S2451945624002083
  60. www.cell.com www.cell.com
    Cyclin dependent kinase 9 inhibition reduced programmed death-ligand 1 expression and improved treatment efficacy in hepatocellular carcinoma
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    cell.com/heliyon/fulltext/S2405-8440(24)10320-9
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GPAT3 is a potential therapeutic target to overcome sorafenib resistance in hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11209725/
  62. Jun 2024
  63. www.sciencedirect.com www.sciencedirect.com
    Hypoxia-responsive lncRNA MIR155HG promotes PD-L1 expression in hepatocellular carcinoma cells by enhancing HIF-1α mRNA stability
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    sciencedirect.com/science/article/pii/S1567576924009366
  64. May 2024
  65. aacrjournals.org aacrjournals.org
    DNA of neutrophil extracellular traps binds TMCO6 to impair CD8+ T-cell immunity in hepatocellular carcinoma.
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    aacrjournals.org/cancerres/article/84/10/1613/745317/DNA-of-Neutrophil-Extracellular-Traps-Binds-TMCO6
  66. Apr 2024
  67. www.embopress.org www.embopress.org
    The regulatory relationship between NAMPT and PD-L1 in cancer and identification of a dual-targeting inhibitor
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    embopress.org/doi/full/10.1038/s44321-024-00051-z
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STIM1 promotes acquired resistance to sorafenib by attenuating ferroptosis in hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11402164/
  69. Mar 2024
  70. www.sciencedirect.com www.sciencedirect.com
    Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance
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    sciencedirect.com/science/article/pii/S1074761324000979
  71. www.biorxiv.org www.biorxiv.org
    Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis
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    biorxiv.org/content/10.1101/2024.02.29.582877v1
  72. www.sciencedirect.com www.sciencedirect.com
    A gut-derived hormone regulates cholesterol metabolism
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    sciencedirect.com/science/article/pii/S0092867424002265
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reduced representative methylome profiling of cell-free DNA for breast cancer detection
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    ncbi.nlm.nih.gov/pmc/articles/PMC10898043/
  74. Feb 2024
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10870201/
  76. www.sciencedirect.com www.sciencedirect.com
    Inhibition of RhoGEF/RhoA alleviates regorafenib resistance and cancer stemness via Hippo signaling pathway in hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S0014482724000466
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831937/
  78. Jan 2024
  79. www.sciencedirect.com www.sciencedirect.com
    Neutralizing antibodies evolve to exploit vulnerable sites in the HCV envelope glycoprotein E2 and mediate spontaneous clearance of infection
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    sciencedirect.com/science/article/pii/S1074761323005356
  80. Dec 2023
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exosome-mediated transfer of circRNA563 promoting hepatocellular carcinoma by targeting the microRNA148a-3p/metal-regulatory transcription factor-1 pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10731156/
  82. www.sciencedirect.com www.sciencedirect.com
    PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition
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    sciencedirect.com/science/article/pii/S2666379123005438
  83. www.sciencedirect.com www.sciencedirect.com
    Direct tumor irradiation potentiates adoptive NK cell targeting against parental and stem-like cancer in human liver cancer models.
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    sciencedirect.com/science/article/pii/S0360301623081518
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10682354/
  85. Nov 2023
  86. www.sciencedirect.com www.sciencedirect.com
    Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy
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    sciencedirect.com/science/article/pii/S2451945623003719
  87. link.springer.com link.springer.com
    Loss of Krüppel-like factor-10 facilitates the development of chemical-induced liver cancer in mice
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    link.springer.com/article/10.1186/s10020-023-00751-1
  88. www.nature.com www.nature.com
    Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway
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    nature.com/articles/s41389-023-00494-y
  89. Oct 2023
  90. www.sciencedirect.com www.sciencedirect.com
    Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives
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    sciencedirect.com/science/article/pii/S0944711323005159
  91. Sep 2023
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10514905/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10477178/
  94. Aug 2023
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD58 acts as a tumor promotor in hepatocellular carcinoma via activating the AKT/GSK-3β/β-catenin pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10422835/
  96. Jul 2023
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10328411/
  98. www.sciencedirect.com www.sciencedirect.com
    PPM1H is down-regulated by ATF6 and dephosphorylates p-RPS6KB1 to inhibit progression of hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S2162253123001634
  99. Jun 2023
  100. www.sciencedirect.com www.sciencedirect.com
    QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism
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    sciencedirect.com/science/article/pii/S0092867423005986
  101. link.springer.com link.springer.com
    PSMD4 drives progression of hepatocellular carcinoma via Akt/COX2 pathway and p53 inhibition
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    link.springer.com/article/10.1007/s13577-023-00935-1
  102. 52.53.155.43 52.53.155.43
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  103. May 2023
  104. www.sciencedirect.com www.sciencedirect.com
    Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma
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    sciencedirect.com/science/article/pii/S0006295223002034
  105. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15350
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10152234/
  107. Apr 2023
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950
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    ncbi.nlm.nih.gov/pmc/articles/PMC10112292/
  109. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13417
  110. Mar 2023
  111. www.mdpi.com www.mdpi.com
    Transcriptional Regulation of Liver-Type OATP1B3 (Lt-OATP1B3) and Cancer-Type OATP1B3 (Ct-OATP1B3) Studied in Hepatocyte-Derived and Colon Cancer-Derived Cell Lines
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    mdpi.com/1999-4923/15/3/738
  112. Feb 2023
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Pro-Regenerative Environment Triggers Premalignant to Malignant Transformation of Senescent Hepatocytes
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    ncbi.nlm.nih.gov/pmc/articles/PMC9896023/
  114. Jan 2023
  115. www.sciencedirect.com www.sciencedirect.com
    Functional HIV-1/HCV cross-reactive antibodies isolated from a chronically co-infected donor
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    sciencedirect.com/science/article/pii/S2211124723000554
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    ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/β-Catenin Signaling
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