124 Matching Annotations
  1. Last 7 days
  2. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Hypoxia-Induced PRMT1 Lactylation Drives Vimentin Arginine Asymmetric Dimethylation in Tumor Metastasis
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202509861
  3. Aug 2025
  4. www.science.org www.science.org
    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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    science.org/doi/10.1126/sciadv.adt1798
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    Cyclin-dependent kinase 9 inhibitors as oncogene signaling modulators in combination with targeted therapy for the treatment of colorectal cancer
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    biorxiv.org/content/10.1101/2025.08.13.669992v1
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    Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
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    sciencedirect.com/science/article/pii/S1535610825003186
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11802306/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trametinib thwarts activation of survival pathways induced by pro-ferroptotic drug conjugate ACXT-3102 resulting in enhanced pancreatic cancer cell death
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    pmc.ncbi.nlm.nih.gov/articles/PMC12307273/
  9. Jul 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The XPO1 inhibitor Eltanexor modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12260813/
  11. www.biorxiv.org www.biorxiv.org
    High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS G12D Mutated CRC
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    biorxiv.org/content/10.1101/2025.06.27.662039v1
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    Cancer biomarkers discovered using pan-cancer plasma proteomic profiling
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    link.springer.com/article/10.1038/s41551-025-01448-y
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    biorxiv.org/content/10.1101/2025.06.18.660406v1
  14. Jun 2025
  15. www.cell.com www.cell.com
    BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival
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    cell.com/molecular-cell/fulltext/S1097-2765(25)00499-X
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    Integrin β6 expression in colorectal cancer cells promotes liver metastasis through enhanced adhesion to endothelial fibronectin
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35504
  17. May 2025
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    Expression of Prooncogenic Nuclear Receptor 4A (NR4A)-Regulated Genes β1-Integrin and G9a Inhibited by Dual NR4A1/2 Ligands
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    mdpi.com/1422-0067/26/8/3909
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    OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression
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    sciencedirect.com/science/article/pii/S2211124725004528
  20. Apr 2025
  21. 52.53.155.43 52.53.155.43
    618530-html.html
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    52.53.155.43/416789ac7df726491b564812e1d36841853b9ba2/Maunscript_BJP_20230110-html.html
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    A new EGFR and c-Met bispecific NIR-II fluorescent probe for visualising colorectal cancer and metastatic lymph nodes
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    sciencedirect.com/science/article/pii/S2352396425001318
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    Deciphering UBE4B phosphorylation dynamics: a key mechanism in p53 accumulation and cancer cell response to DNA damage
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    nature.com/articles/s41420-025-02441-9
  25. Mar 2025
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    Antitumor effects of immunotherapy combined with BRAF and MEK inhibitors in BRAF V600E metastatic colorectal cancer
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    link.springer.com/article/10.1007/s00262-025-04005-3
  27. Feb 2025
  28. 52.53.155.43 52.53.155.43
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  29. aacrjournals.org aacrjournals.org
    Epigenome reprogramming through H3K27 and H3K4 trimethylation as a resistance mechanism to DNA methylation inhibition in BRAFV600E-mutated colorectal cancer
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    aacrjournals.org/clincancerres/article/30/22/5166/749574/Epigenome-Reprogramming-Through-H3K27-and-H3K4
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC11805377/
  31. Dec 2024
  32. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Nerve Growth Factor Signaling Promotes Nuclear Translocation of TRAF4 to Enhance Tumor Stemness and Metastatic Dormancy Via C-Jun-mediated IL-8 Autocrine
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    onlinelibrary.wiley.com/doi/full/10.1002/advs.202414437
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    Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
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    nature.com/articles/s41418-024-01439-7
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
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    RPF2 and CARM1 cooperate to enhance colorectal cancer metastasis via the AKT/GSK-3β signaling pathway.
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    sciencedirect.com/science/article/pii/S0014482724004658
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    Synergistic anticancer activity of HSP70 and HSF1 inhibitors in colorectal cancer cells: A new strategy for combination therapy
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    sciencedirect.com/science/article/pii/S0925443924006240
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    p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis
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    sciencedirect.com/science/article/pii/S1097276524009183
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    DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states
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  39. Nov 2024
  40. www.sciencedirect.com www.sciencedirect.com
    Degradome analysis to identify direct protein substrates of small-molecule degraders
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    sciencedirect.com/science/article/pii/S2451945624004422
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  42. www.biorxiv.org www.biorxiv.org
    A multivalent adaptor mechanism drives the nuclear import of proteasomes
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    biorxiv.org/content/10.1101/2024.11.08.622636v2
  43. Oct 2024
  44. aacrjournals.org aacrjournals.org
    2-Hydroxylation of Fatty Acids Represses Colorectal Tumorigenesis and Metastasis via the YAP Transcriptional Axis
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    aacrjournals.org/cancerres/article/81/2/289/649623/2-Hydroxylation-of-Fatty-Acids-Represses
  45. Sep 2024
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11365971/
  47. Aug 2024
  48. www.sciencedirect.com www.sciencedirect.com
    RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4
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    sciencedirect.com/science/article/pii/S2211124724009720
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MMP‐9‐dependent proteolysis of the histone H3 N‐terminal tail: a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11306514/
  50. Jul 2024
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mime-seq 2.0: a method to sequence microRNAs from specific mouse cell types
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    ncbi.nlm.nih.gov/pmc/articles/PMC11183118/
  52. May 2024
  53. 52.53.155.43 52.53.155.43
    Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers
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    52.53.155.43/8391d5e75ba57c9ef8c1ebe0973fe3c1602760fc/2024.02.22.581558v3.full-html.html
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11059122/
  55. www.biorxiv.org www.biorxiv.org
    Multiple ubiquitin ligases protect human genome integrity by targeting cancer-associated APOBEC3 deaminases for degradation
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    biorxiv.org/content/10.1101/2024.04.23.590688v1
  56. Apr 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11043890/
  58. www.sciencedirect.com www.sciencedirect.com
    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
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    sciencedirect.com/science/article/pii/S221112472400439X
  59. Feb 2024
  60. www.sciencedirect.com www.sciencedirect.com
    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
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    sciencedirect.com/science/article/pii/S2666379124000570
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10866396/
  62. www.biorxiv.org www.biorxiv.org
    A common druggable signature of oncogenic CMYC, mutant KRAS and mutant p53 reveals functional redundancy and competition of the oncogenes in cancer
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    biorxiv.org/content/10.1101/2023.12.20.572548v1
  63. Jan 2024
  64. www.sciencedirect.com www.sciencedirect.com
    Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3
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    sciencedirect.com/science/article/pii/S2666379123005748
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    A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization
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    sciencedirect.com/science/article/pii/S1535610823004440
  66. Dec 2023
  67. www.sciencedirect.com www.sciencedirect.com
    A helicase-independent role of DHX15 promotes MYC stability and acute leukemia cell survival
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    sciencedirect.com/science/article/pii/S2589004223026482
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    Proteomic characterization of the colorectal cancer response to chemoradiation and targeted therapies reveals potential therapeutic strategies
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    sciencedirect.com/science/article/pii/S2666379123005050
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RPF2 mediates the CARM1‑MYCN axis to promote chemotherapy resistance in colorectal cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10696550/
  70. Nov 2023
  71. www.sciencedirect.com www.sciencedirect.com
    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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    sciencedirect.com/science/article/pii/S2211124723013645
  72. link.springer.com link.springer.com
    TCOF1 promotes the colorectal cancer progression by stabilizing β-catenin
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    link.springer.com/article/10.1007/s12032-023-02218-z
  73. www.sciencedirect.com www.sciencedirect.com
    Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development
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    sciencedirect.com/science/article/pii/S0925443923003071
  74. Oct 2023
  75. www.sciencedirect.com www.sciencedirect.com
    BRD4-binding enhancer promotes CRC progression by interacting with YY1 to activate the Wnt pathway through upregulation of TCF7L2
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    sciencedirect.com/science/article/pii/S0006295223004689
  76. 52.53.155.43 52.53.155.43
    FEBS Press
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    52.53.155.43/7b3101f3d01462bbcf14399b3becbcb8b341bb38/Molecular Oncology - 2023 - Hsieh - Repositioning VU-0365114 as a novel microtubule-destabilizing agent for treating cancer-html.html
  77. Sep 2023
  78. www.sciencedirect.com www.sciencedirect.com
    Natural killer cell therapy targeting cancer stem cells: Old wine in a new bottle
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    sciencedirect.com/science/article/pii/S0304383523002793
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenomic analysis reveals a unique DNA methylation program of metastasis-competent circulating tumor cells in colorectal cancer
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    British J Pharmacology - 2023 - Kleszcz-html.html
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10475482/
  82. Aug 2023
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MHC Class II is Induced by IFNγ and Follows Three Distinct Patterns of Expression in Colorectal Cancer Organoids
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    ncbi.nlm.nih.gov/pmc/articles/PMC10411481/
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    DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
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    sciencedirect.com/science/article/pii/S2211124723009385
  86. Jul 2023
  87. 52.53.155.43 52.53.155.43
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  88. Jun 2023
  89. www.sciencedirect.com www.sciencedirect.com
    Microsatellite instability states serve as predictive biomarkers for tumors chemotherapy sensitivity
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    sciencedirect.com/science/article/pii/S2589004223011227
  90. www.sciencedirect.com www.sciencedirect.com
    Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
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  91. 52.53.155.43 52.53.155.43
    The Natural Alkaloid (-)- N-Hydroxyapiosporamide Suppresses Colorectal Tumor Progression as an NF-κB Pathway Inhibitor by Targeting the TAK1-TRAF6 Complex
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  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10236151/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer
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  94. Feb 2023
  95. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13379
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Downregulation of iNOS/NO Promotes Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9890133/
  97. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    ALKBH1-mediated m1A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13366
  98. Dec 2022
  99. bmccancer.biomedcentral.com bmccancer.biomedcentral.com
    Intense endoplasmic reticulum stress (ERS) / IRE1α enhanced Oxaliplatin efficacy by decreased ABCC10 in colorectal cancer cells
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    bmccancer.biomedcentral.com/articles/10.1186/s12885-022-10415-8
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of insulin‐like growth factor 2 mRNA‐binding protein 1 sensitizes colorectal cancer cells to chemotherapeutics
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    ncbi.nlm.nih.gov/pmc/articles/PMC9721091/
  101. Nov 2022
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Expression of NMU, PPBP and GNG4 in colon cancer and their influences on prognosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC9641087/
  103. Oct 2022
  104. elifesciences.org elifesciences.org
    EHMT2 methyltransferase governs cell identity in the lung and is required for KRASG12D tumor development and propagation
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    elifesciences.org/articles/57648
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    Cancer-specific T helper shared and neo-epitopes uncovered by expression of the MHC class II master regulator CIITA
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    sciencedirect.com/science/article/pii/S2211124722013353
  106. www.nature.com www.nature.com
    A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo
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    nature.com/articles/s41467-022-33430-6
  107. Sep 2022
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    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
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    Special issue “The advance of solid tumor research in China”: Discoidin domain receptor 2 promotes colorectal cancer metastasis by regulating epithelial mesenchymal transition via activating AKT signaling
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34227
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    A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing
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    nature.com/articles/s41557-022-01021-z
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