172 Matching Annotations
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    Integrative genomics and experimental validation identify a mechanosensitive gene signature associated with colorectal cancer liver metastasis
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    sciencedirect.com/science/article/pii/S2589004226033092
  3. Oct 2026
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    IPO5 contributes to cetuximab resistance in colorectal cancer by modulating Ras signaling
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    sciencedirect.com/science/article/pii/S2589004226030956
  5. Sep 2026
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    PPM1L-dependent PD-L1 dephosphorylation orchestrates tumor-type-specific ubiquitin ligase recognition to govern its degradation
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    sciencedirect.com/science/article/pii/S2211124726010338
  7. Aug 2026
  8. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    A Novel tRNA Half mt-5’-tiRNA-Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.77042
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death
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    pmc.ncbi.nlm.nih.gov/articles/PMC13401815/
  10. Jul 2026
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    DHODH is a synthetic lethal target in PIK3CA-mutant colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124726007977
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    SOCS5 suppresses antitumor immunity in colorectal cancer by promoting IFNAR1 ubiquitylation and type I interferon response
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    sciencedirect.com/science/article/pii/S0925443926002309
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    Repurposed ethoxzolamide reprograms antitumor immunity through β-TrCP-dependent PD-L1 ubiquitination
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    sciencedirect.com/science/article/pii/S266637912600337X
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    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70290
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LINE1 RNA demethylation sensitizes cancer cells to PARPi through global chromatin remodeling
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    pmc.ncbi.nlm.nih.gov/articles/PMC13321487/
  16. 54.241.53.176 54.241.53.176
    Apatinib enhances anti-PD-1 efficacy by inhibiting Exo70-mediated exosome secretion in pMMR/MSS colorectal cancer
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    54.241.53.176/77e7d215f5a58155aacfdc7d95a38ea528017e01/s41698-026-01518-7_reference-html.html
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A whole genomic CRISPR-Cas9 screen identifies the amino acid transporter SLC43A1 (LAT3) as a major determinant of oxaliplatin sensitivity in colorectal cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13317012/
  18. Jun 2026
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13131504/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DDR1 Promotes Immune Evasion in Colorectal Cancer by Orchestrating IL33-Mediated M2-like Polarization of Tumor-Associated Macrophages
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    pmc.ncbi.nlm.nih.gov/articles/PMC13227095/
  21. May 2026
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFITM1-targeted NIR-II fluorescence imaging enables visualisation of colorectal cancer and metastatic lymph nodes
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    pmc.ncbi.nlm.nih.gov/articles/PMC13134288/
  23. www.biorxiv.org www.biorxiv.org
    Comparison studies between Cesium-137 and X-ray irradiators in epithelial injury using in vitro and in vivo models
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    biorxiv.org/content/10.64898/2026.04.17.719248v1
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13131504/
  25. Apr 2026
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hypoxic CAF studies unveil PTHrP-vitamin D-RAS axis as pivotal in the CAF
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    pmc.ncbi.nlm.nih.gov/articles/PMC13107517/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pooled single-cell screen in colorectal cancer defines transcriptional modules linked to oncogenes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12954089/
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    Mosperafenib, a novel paradox breaker BRAF inhibitor with potent preclinical activity in BRAF mutated colorectal cancer
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    AURKA-mediated destabilization of SAPS3 drives ferroptosis evasion via 7-dehydrocholesterol biosynthesis in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13039981/
  30. Mar 2026
  31. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202516557
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    Targeting the noncanonical function of metabolic enzyme PHGDH in driving PD-L1 expression and cancer immune evasion
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    sciencedirect.com/science/article/pii/S2666379126001217
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A multivalent adaptor mechanism drives the nuclear import of proteasomes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12979645/
  34. Feb 2026
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors
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  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12913773/
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    Mechanosensation promotes broad-spectrum antiviral defense through membrane remodeling
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  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A nuclear isoform of hydroxyacyl-COA dehydrogenase inhibits tumor progression in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12860641/
  39. journals.plos.org journals.plos.org
    The lipid-metabolic enzyme HSD17B12 drives lysosomal degradation of PD-L1 potentiating anti-tumor immunity in a mouse model
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  40. Jan 2026
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thimerosal Inhibits Tumor Malignant Progression through Direct Action and Enhancing the Efficacy of PD-1-Based Immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12848756/
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    Pregnenolone promotes immune evasion through blocking endogenous retrovirus expression
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    sciencedirect.com/science/article/pii/S1550413125005844
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    Basroparib inhibits YAP-driven cancers by stabilizing angiomotin
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70209
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    p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer
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    Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer
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  46. Dec 2025
  47. www.nature.com www.nature.com
    KRT81 promotes metastasis of colorectal cancer by acting as a protein scaffold for ezrin
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    Nuclear translocation of Cx43 promotes to CRC progression and associates with β-catenin accumulation
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  49. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R-Loop Accumulation and DNA Repair Deficiencies
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202512074
  50. Nov 2025
  51. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Fatty acids modulate the colorectal cancer immune microenvironment via regulating the interaction and transactivation of PPARα/δ and P53
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    Fosl1 is a transcriptional effector of BRAFV600E-driven intestinal tumorigenesis
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  53. 54.241.53.176 54.241.53.176
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  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer
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  55. Oct 2025
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    Purinergic Ecto-Enzyme CD73 is a Context-Dependent Tumor Suppressor in Colorectal Cancer
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  57. Sep 2025
  58. www.biorxiv.org www.biorxiv.org
    Dual EZH1/2 inhibition enhances DNMT inhibitor efficacy in colon cancer through targeting H3K27me1
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    biorxiv.org/content/10.1101/2025.09.16.676613v1
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2
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    GALNT7 stratifies dMMR/MSI colorectal cancer into distinct molecular subsets associated with prognosis and PD-L1 expression
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    Chemotherapy modulation by a cancer-associated microbiota metabolite
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  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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  64. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Hypoxia-Induced PRMT1 Lactylation Drives Vimentin Arginine Asymmetric Dimethylation in Tumor Metastasis
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  65. Aug 2025
  66. www.science.org www.science.org
    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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    Cyclin-dependent kinase 9 inhibitors as oncogene signaling modulators in combination with targeted therapy for the treatment of colorectal cancer
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    Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
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  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11802306/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trametinib thwarts activation of survival pathways induced by pro-ferroptotic drug conjugate ACXT-3102 resulting in enhanced pancreatic cancer cell death
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  71. Jul 2025
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The XPO1 inhibitor Eltanexor modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis
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  73. www.biorxiv.org www.biorxiv.org
    High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS G12D Mutated CRC
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    biorxiv.org/content/10.1101/2025.06.27.662039v1
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    Cancer biomarkers discovered using pan-cancer plasma proteomic profiling
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    link.springer.com/article/10.1038/s41551-025-01448-y
  75. www.biorxiv.org www.biorxiv.org
    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    biorxiv.org/content/10.1101/2025.06.18.660406v1
  76. Jun 2025
  77. www.cell.com www.cell.com
    BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival
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    cell.com/molecular-cell/fulltext/S1097-2765(25)00499-X
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    Integrin β6 expression in colorectal cancer cells promotes liver metastasis through enhanced adhesion to endothelial fibronectin
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35504
  79. May 2025
  80. www.mdpi.com www.mdpi.com
    Expression of Prooncogenic Nuclear Receptor 4A (NR4A)-Regulated Genes β1-Integrin and G9a Inhibited by Dual NR4A1/2 Ligands
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    OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression
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    sciencedirect.com/science/article/pii/S2211124725004528
  82. Apr 2025
  83. 52.53.155.43 52.53.155.43
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    A new EGFR and c-Met bispecific NIR-II fluorescent probe for visualising colorectal cancer and metastatic lymph nodes
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    sciencedirect.com/science/article/pii/S2352396425001318
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    Deciphering UBE4B phosphorylation dynamics: a key mechanism in p53 accumulation and cancer cell response to DNA damage
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    nature.com/articles/s41420-025-02441-9
  87. Mar 2025
  88. link.springer.com link.springer.com
    Antitumor effects of immunotherapy combined with BRAF and MEK inhibitors in BRAF V600E metastatic colorectal cancer
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    link.springer.com/article/10.1007/s00262-025-04005-3
  89. Feb 2025
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  91. aacrjournals.org aacrjournals.org
    Epigenome reprogramming through H3K27 and H3K4 trimethylation as a resistance mechanism to DNA methylation inhibition in BRAFV600E-mutated colorectal cancer
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    aacrjournals.org/clincancerres/article/30/22/5166/749574/Epigenome-Reprogramming-Through-H3K27-and-H3K4
  92. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC11805377/
  93. Dec 2024
  94. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Nerve Growth Factor Signaling Promotes Nuclear Translocation of TRAF4 to Enhance Tumor Stemness and Metastatic Dormancy Via C-Jun-mediated IL-8 Autocrine
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    onlinelibrary.wiley.com/doi/full/10.1002/advs.202414437
  95. www.nature.com www.nature.com
    Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
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    nature.com/articles/s41418-024-01439-7
  96. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
  97. www.sciencedirect.com www.sciencedirect.com
    RPF2 and CARM1 cooperate to enhance colorectal cancer metastasis via the AKT/GSK-3β signaling pathway.
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    sciencedirect.com/science/article/pii/S0014482724004658
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    Synergistic anticancer activity of HSP70 and HSF1 inhibitors in colorectal cancer cells: A new strategy for combination therapy
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    sciencedirect.com/science/article/pii/S0925443924006240
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    p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis
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    DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states
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  101. Nov 2024
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    Degradome analysis to identify direct protein substrates of small-molecule degraders
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    A multivalent adaptor mechanism drives the nuclear import of proteasomes
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    biorxiv.org/content/10.1101/2024.11.08.622636v2
  105. Oct 2024
  106. aacrjournals.org aacrjournals.org
    2-Hydroxylation of Fatty Acids Represses Colorectal Tumorigenesis and Metastasis via the YAP Transcriptional Axis
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  223. Nov 2018
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    Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1
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    Co-optation of Tandem DNA Repeats for the Maintenance of Mesenchymal Identity
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  228. Nov 2017
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    Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication
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    Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases
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    Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC5127641/