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175 Matching Annotations

Nov 2025
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RhoA allosterically activates phospholipase Cε via its EF hands

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Nanoscale conformational dynamics of human propionyl-CoA carboxylase

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Oct 2025
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Evolution of antibody cross-reactivity to influenza H5N1 neuraminidase from an N2-specific germline

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Cryo-EM structure of phospholipase Cε defines N-terminal domains and their roles in activity

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Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1

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Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements

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Sep 2025
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A conserved PIWI silencing complex detects piRNA-target engagement

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Aug 2025
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Design of a selective peptide inhibitor targeting KDM5C demethylase activity

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Structural insights into the activation of TMEM175 by small molecule

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A regulator of amino acid sensing links lipid peroxidation and lipid droplet-dependent antioxidant response

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KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1

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A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation

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NuMA mechanically reinforces the spindle independently of its partner dynein

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BPS Publications

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PALB2 and 53BP1 govern post-resection homologous recombination DNA repair

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Jul 2025
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Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2

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Construction of synthetic constitutive promoters and evaluation of their expression strengths in Sf9, HEK293T, and BmN cells

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Construction of synthetic constitutive promoters and evaluation of their expression strengths in Sf9, HEK293T, and BmN cells

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STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20–Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models

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pmc.ncbi.nlm.nih.gov/articles/PMC12260510/
Jun 2025
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PDF-html.html

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52.53.155.43/3e81ed4154fee0b68ed39cd7c108fb3e26bd25fc/PDF-html.html
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Structural Insights into the High Basal Activity and Inverse Agonism of the Orphan GPR6 Receptor Implicated in Parkinson’s Disease

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pmc.ncbi.nlm.nih.gov/articles/PMC11850111/
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Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2

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May 2025
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Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

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ATP-release pannexin channels are gated by lysophospholipids

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Condensation-dependent multivalent interactions of EB1 and CENP-R regulate chromosome oscillations in mitosis

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The structure of human sweetness

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Proton perception and activation of a proton-sensing GPCR

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Mar 2025
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PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth

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Discovery of the first isoform-specific sGC activator: selective activation of GC-1 by runcaciguat

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Feb 2025
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Structural basis for channel gating and blockade in tri-heteromeric GluN1-2B-2D NMDA receptor

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Structural basis of CXCR4 assembly and regulation

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Jan 2025
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Molecular structures of human ACAT2 disclose mechanism for selective inhibition

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Atomic insights into ML-SI3 mediated human TRPML1 inhibition

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Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor

1
1. scibot 30 Jan 2025
  
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  ATCCCat#CRL-1711
  
  DOI: 10.1016/j.neuron.2019.07.030
  
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Voltage Sensor Movements during Hyperpolarization in the HCN Channel

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1. scibot 30 Jan 2025
  
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  DOI: 10.1016/j.cell.2019.11.006
  
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The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

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  DOI: 10.7554/eLife.96743
  
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GABAA receptor π forms channels that stimulate ERK through a G-protein-dependent pathway

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Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson’s disease

1
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  DOI: 10.1126/scisignal.ado8741
  
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Resolving the differential distribution of structural proteins in baculovirus using single-molecule localization microscopy

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TRPML1 gating modulation by allosteric mutations and lipids

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Cryo-EM Structure of Phospholipase Cε Defines N-terminal Domains and their Roles in Activity

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Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2

1
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Cryo-EM-based discovery of a pathogenic parvovirus causing epidemic mortality by black wasting disease in farmed beetles

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Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake

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An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies

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Structure and assembly of the human IL-12 signaling complex

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Prior Fc receptor activation primes macrophages for increased sensitivity to IgG via long-term and short-term mechanisms

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Structural Insights into Subunit-Dependent Functional Regulation in Epithelial Sodium Channels

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Cryo-EM structure of monomeric CXCL12-bound CXCR4 in the active state

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Assembly mechanism of Integrator’s RNA cleavage module

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Molecular mechanism of contactin 2 homophilic interaction

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A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2

1
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POT1 recruits and regulates CST-Polα/primase at human telomeres

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cell.com/cell/fulltext/S0092-8674(24)00493-8
May 2024
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mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway

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Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals

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Aurora-A condensation mediated by BuGZ aids its mitotic centrosome functions

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ncbi.nlm.nih.gov/pmc/articles/PMC11090908/
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Type I interferon regulation by USP18 is a key vulnerability in cancer

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ncbi.nlm.nih.gov/pmc/articles/PMC11022047/
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RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells

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Visualizing chaperone-mediated multistep assembly of the human 20S proteasome

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Cryo-EM structures reveal two allosteric inhibition modes of PI3KαH1047R involving a re-shaping of the activation loop

2
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Structural mechanisms for VMAT2 inhibition by tetrabenazine

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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH

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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis

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Evolution of human H3N2 influenza virus receptor specificity has substantially expanded the receptor-binding domain site

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IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors

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Biochemical characterization of the Drosophila insulin receptor kinase and longevity-associated mutants

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Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase

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Widespread impact of immunoglobulin V-gene allelic polymorphisms on antibody reactivity

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Biochemical and biophysical characterization of natural polyreactivity in antibodies

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Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

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  DOI: 10.1101/2023.09.25.559255
  
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New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

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sciencedirect.com/science/article/pii/S2451945623001502
May 2023
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Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate

1
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  DOI: 10.1016/j.cell.2023.04.028
  
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Unconventional initiation of PINK1/Parkin mitophagy by Optineurin

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Feb 2023
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Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation

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  DOI: 10.1126/sciadv.adg2997
  
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Dec 2022
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Membrane curvature sensing and stabilization by the autophagic LC3 lipidation machinery

1
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Structure and gating mechanism of the α7 nicotinic acetylcholine receptor

1
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Structure of human phagocyte NADPH oxidase in the resting state

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Nov 2022
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Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses

1
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Structural and functional analyses of a GPCR-inhibited ion channel TRPM3

1
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Aug 2022
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Distinct impact of IgG subclass on autoantibody pathogenicity in different IgG4-mediated diseases

1
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Hemagglutinin stalk-binding antibodies enhance effectiveness of neuraminidase inhibitors against influenza via Fc-dependent effector functions

1
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EML2-S constitutes a new class of proteins that recognizes and regulates the dynamics of tyrosinated microtubules

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Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C

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Jun 2022
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A glycine-rich PE_PGRS protein governs mycobacterial actin-based motility

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May 2022
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A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination

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A highland-adaptation mutation of the Epas1 protein increases its stability and disrupts the circadian clock in the plateau pika

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Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response

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Apr 2022
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Dynamic immunodominance hierarchy of neutralizing antibody responses to evolving GII.4 noroviruses

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Facile discovery of surrogate cytokine agonists

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cell.com/cell/fulltext/S0092-8674(22)00247-1
Mar 2022
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Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination

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Structural basis for catalyzed assembly of the Sonic hedgehog–Patched1 signaling complex

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Inactivated and live-attenuated seasonal influenza vaccines boost broadly neutralizing antibodies in children

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Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography

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Compartmentalization of telomeres through DNA-scaffolded phase separation

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Structures of activin ligand traps using natural sets of type I and type II TGFβ receptors.

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Dec 2021
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Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis

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Oct 2021
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ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes

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A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells

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TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

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Sep 2021
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Structural basis and regulation of the reductive stress response

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Characterization of the subunit composition and structure of adult human glycine receptors

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TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase

1
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The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum

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Untitled document

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Untitled document

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Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10

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Structural and functional characterization of an otopetrin family proton channel

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  DOI: 10.7554/eLife.46710
  
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TMC1 and TMC2 Proteins Are Pore-Forming Subunits of Mechanosensitive Ion Channels

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Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies

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OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin

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Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

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Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1

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Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1

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BPS Publications

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Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations

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Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

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Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage

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A Weak Link with Actin Organizes Tight Junctions to Control Epithelial Permeability

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The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response

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TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation

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Structural determination of human Nav1.4 and Nav1.7 using single particle cryo-electron microscopy

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A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection

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Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells

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A Cellular Mechanism to Detect and Alleviate Reductive Stress

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The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design

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Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons

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Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

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Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

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cell.com/structure/fulltext/S0969-2126(20)30470-6
Feb 2021
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Dopamine‐induced interactions of female mouse hypothalamic proteins with progestin receptor‐A in the absence of hormone

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Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

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Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

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Structure of the human core transcription-export complex reveals a hub for multivalent interactions

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Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth

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Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

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BPS Publications

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Sep 2020
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BPS Publications

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A Steric “Ball-and-Chain” Mechanism for pH-Mediated Regulation of Gap Junction Channels

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Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

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Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2

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Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

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The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition

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Structure of the human BBSome core complex

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Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes

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Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter

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Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity

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Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

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Convergent Evolution in Breadth of Two VH6-1-Encoded Influenza Antibody Clonotypes from a Single Donor

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BPS Publications

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Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling

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Regulation of Eag1 gating by its intracellular domains

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Regulatory switch at the cytoplasmic interface controls TRPV channel gating

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Profilin and formin constitute a pacemaker system for robust actin filament growth

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Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

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Untitled document

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The Roc‐COR tandem domain of leucine‐rich repeat kinase 2 forms dimers and exhibits conventional Ras‐like GTPase properties

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Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein

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Structure of the CLC-1 chloride channel from Homo sapiens

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Structure-based membrane dome mechanism for Piezo mechanosensitivity

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Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint

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Golgi-Resident Gαo Promotes Protrusive Membrane Dynamics

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Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9

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LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels

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Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors

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