307 Matching Annotations
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  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CircKIAA1617 promotes stemness via USP14/PGRMC1-mediated autophagy and lipid metabolism reprogramming in ER-positive breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12952063/
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    Sym024 interacts with a unique epitope on the CD73 homodimer, favoring effective bivalent binding to improve anti-PD1 therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12950896/
  4. Mar 2026
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  6. Feb 2026
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    Spermine Oxidase Serves as a Key Functional Node in Microbial Dysbiosis-Induced Breast Carcinogenesis
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    Targeting the SIN1 mediated TTK/LDHA-H3K18la-GLUT3 Axis Disrupts Metabolic-Epigenetic Crosstalk and Suppresses Progression in Hyperglycolytic Breast Cancer
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    Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition
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    IL-6R blockade with tocilizumab disrupts pericyte– and tumor cell–driven IL-6/STAT3 signaling, enhancing docetaxel efficacy in ER+ breast cancer
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    biorxiv.org/content/10.64898/2026.01.29.702661v1
  11. Jan 2026
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    Notch1 regulates Orai1 and Orai3 expression in breast cancer cells
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    CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction
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    Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer
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  15. Dec 2025
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    Vesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancer
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  17. Nov 2025
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    Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding
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    System analysis links SMARCD3 regulons to growth signaling and MEK inhibitor response in everolimus-resistant ER+ breast cancer cells
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    Co-targeting CDK4/6 enhances anti-cancer activity and alleviates immune-related adverse events of anti-PD-1 antibody for breast cancer
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  21. Oct 2025
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    GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer
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    biorxiv.org/content/10.1101/2025.10.17.682994v1
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    Overexpression of RUNX2 promotes breast cancer multi-organ metastasis through stabilizing c-Myc
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    Germline-somatic liaison dictates cancer subtype via de novo steroid biosynthesis
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    Mapping the Subtype-Specific PARP1 ADP-ribosylated Proteome in Breast Cancer Cells
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    The Janus Face of SPAG6: Inducing EMT in Luminal Breast Cancer Cells Amidst Widespread Expression Loss in Breast Tumours
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    YEATS4 reads histone crotonylation to promote fatty acid metabolism and cancer cell stemness
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    Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors
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  29. Sep 2025
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    PDE7A inhibition suppresses triple-negative breast cancer by attenuating de novo pyrimidine biosynthesis
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  31. Aug 2025
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    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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    Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis
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    Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance
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    53BP1 regulates p53-E2F7-dependent transcriptional gene repression and participates in the Fanconi anemia pathway
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    Distinct 2-phenyl-imidazo[1, 2α] pyridine derivatives drive ER degradation and selectively impair proliferation of ER+ breast cancer cells via the aryl hydrocarbon receptor
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  40. Jul 2025
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    Curcumin Induces Homologous Recombination Deficiency by BRCA2 Degradation in Breast Cancer and Normal Cells
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  44. Jun 2025
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    Altered cofactor recruitment and nucleosome dynamics underlie bisphenol A’s impact on ERα-mediated transcriptional bursting
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    A bedside-to-bench translational analysis of NF1 alterations and CDK4/6 inhibitor resistance in hormone receptor-positive metastatic breast cancer
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    PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer
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    Discovery and validation of cell-free DNA methylation markers for specific diagnosis, differentiation from benign tumors, and prognosis of breast cancer
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    Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer
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    Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition
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  54. May 2025
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    Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells
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    Therapeutic targeting of circTNK2 with nanoparticles restores tamoxifen sensitivity and enhances NK cell-mediated immunity in ER-positive breast cancer
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    Microtubule associated serine/threonine kinase-3 inhibits the malignant phenotype of breast cancer by promoting phosphorylation-mediated ubiquitination degradation of yes-associated protein
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  59. Apr 2025
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    CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers
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    Potent estrogen receptor β agonists with inhibitory activity in vitro, fail to suppress xenografts of endocrine-resistant cyclin-dependent kinase 4/6 inhibitor-resistant breast cancer cells
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    The histone acetyltransferase CBP participates in regulating the DNA damage response through ATM after double-strand breaks
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    Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis
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    Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP
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  65. Mar 2025
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  71. Feb 2025
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    Imlunestrant Is an Oral, Brain-Penetrant Selective Estrogen Receptor Degrader with Potent Antitumor Activity in ESR1 Wild-Type and Mutant Breast Cancer
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    Metabolic Profiling of Breast Cancer Cell Lines: Unique and Shared Metabolites
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    RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer
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    Discovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients
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  77. Jan 2025
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    Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1
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    The EstroGene2.0 database for endocrine therapy response and resistance in breast cancer
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    FGFR2-RUNX2 activation: An unexplored therapeutic pathway in luminal breast cancer related to tumor progression
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    Targeting ROR2 homooligomerization disrupts ROR2-dependent signaling and suppresses stem-like cell properties of human breast adenocarcinoma
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  84. Dec 2024
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    Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
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  87. Nov 2024
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    MicroRNA-145-5p inhibits the tumorigenesis of breast cancer through SENP2-regulated ubiquitination of ERK2
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    C19MC Drives Nucleolar Invasion of Mitochondria and Meiotic Nuclear Division in Human Cancers
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    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
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  92. Oct 2024
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
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  94. Sep 2024
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    Protrusion force and cell-cell adhesion play a critical role in collective tumor cluster migration
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    biorxiv.org/content/10.1101/2024.09.18.613706v1
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    Global and single-cell proteomics view of the co-evolution between neural progenitors and breast cancer cells in a co-culture model
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    ESR1 Fusions Invoke Breast Cancer Subtype-Dependent Enrichment of Ligand-Independent Oncogenic Signatures and Phenotypes
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  102. Aug 2024
  103. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    The Engineered Drug 3′UTRMYC1-18 Degrades the c-MYC-STAT5A/B-PD-L1 Complex In Vivo to Inhibit Metastatic Triple-Negative Breast Cancer
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  213. Jul 2022
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  216. Jun 2022
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  219. May 2022
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  223. Apr 2022
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    A defect of amphiregulin release predicted longer survival independently of YAP expression in patients with pleural mesothelioma in the IFCT-0701 MAPS phase 3 trial
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    MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
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  231. Feb 2022
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  235. Jan 2022
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  238. Dec 2021
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  243. Nov 2021
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  246. Oct 2021
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    Beta 2 Adrenergic Receptor Antagonist Propranolol and Opioidergic Receptor Antagonist Naltrexone Produce Synergistic Effects on Breast Cancer Growth Prevention by Acting on Cancer Cells and Immune Environment in a Preclinical Model of Breast Cancer
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