297 Matching Annotations
  1. Dec 2025
  2. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Vesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancer
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    sciencedirect.com:5037/science/article/pii/S2666379125005518
  3. Nov 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding
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    pmc.ncbi.nlm.nih.gov/articles/PMC12631751/
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    System analysis links SMARCD3 regulons to growth signaling and MEK inhibitor response in everolimus-resistant ER+ breast cancer cells
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    sciencedirect.com/science/article/pii/S2666379125004987
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    Co-targeting CDK4/6 enhances anti-cancer activity and alleviates immune-related adverse events of anti-PD-1 antibody for breast cancer
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    sciencedirect.com/science/article/pii/S2666379125005026
  7. Oct 2025
  8. www.biorxiv.org www.biorxiv.org
    GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer
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    biorxiv.org/content/10.1101/2025.10.17.682994v1
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    Overexpression of RUNX2 promotes breast cancer multi-organ metastasis through stabilizing c-Myc
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    pmc.ncbi.nlm.nih.gov/articles/PMC12501288/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Germline-somatic liaison dictates cancer subtype via de novo steroid biosynthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12498101/
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    Mapping the Subtype-Specific PARP1 ADP-ribosylated Proteome in Breast Cancer Cells
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    biorxiv.org/content/10.1101/2025.09.30.679484v1
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Janus Face of SPAG6: Inducing EMT in Luminal Breast Cancer Cells Amidst Widespread Expression Loss in Breast Tumours
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    pmc.ncbi.nlm.nih.gov/articles/PMC12510430/
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    YEATS4 reads histone crotonylation to promote fatty acid metabolism and cancer cell stemness
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    sciencedirect.com/science/article/pii/S2211124725011714
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    Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors
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    sciencedirect.com/science/article/pii/S2451945625002685
  15. Sep 2025
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    PDE7A inhibition suppresses triple-negative breast cancer by attenuating de novo pyrimidine biosynthesis
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    sciencedirect.com/science/article/pii/S266637912500429X
  17. Aug 2025
  18. www.science.org www.science.org
    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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    science.org/doi/10.1126/sciadv.adt1798
  19. www.nature.com www.nature.com
    Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis
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    nature.com/articles/s41467-025-62486-3
  20. www.sciencedirect.com www.sciencedirect.com
    Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance
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    sciencedirect.com/science/article/pii/S107476132500322X
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    53BP1 regulates p53-E2F7-dependent transcriptional gene repression and participates in the Fanconi anemia pathway
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    sciencedirect.com/science/article/pii/S2211124725009234
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    Building simplified cancer subtyping and prediction models with glycan gene signatures
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    sciencedirect.com/science/article/pii/S2667237525001766
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tissue-dependent mechanosensing by cells derived from human tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328224/
  24. www.biorxiv.org www.biorxiv.org
    Distinct 2-phenyl-imidazo[1, 2α] pyridine derivatives drive ER degradation and selectively impair proliferation of ER+ breast cancer cells via the aryl hydrocarbon receptor
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    biorxiv.org/content/10.1101/2025.07.28.666967v1
  25. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70089
  26. Jul 2025
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Curcumin Induces Homologous Recombination Deficiency by BRCA2 Degradation in Breast Cancer and Normal Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12248657/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12232590/
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    Unlocking the therapeutic potential of rigosertib as a selective therapy for ovarian cancer
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    sciencedirect.com/science/article/pii/S2666379125002915
  30. Jun 2025
  31. www.tandfonline.com www.tandfonline.com
    Valency-affinity mapping of multivalent liposomes for tunable target cell discrimination
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    tandfonline.com/doi/full/10.1080/10717544.2025.2512950
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    Altered cofactor recruitment and nucleosome dynamics underlie bisphenol A’s impact on ERα-mediated transcriptional bursting
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    A bedside-to-bench translational analysis of NF1 alterations and CDK4/6 inhibitor resistance in hormone receptor-positive metastatic breast cancer
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    sciencedirect.com/science/article/pii/S2352396425002725
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  35. www.nature.com www.nature.com
    PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer
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    nature.com/articles/s41388-025-03468-z
  36. breast-cancer-research.biomedcentral.com breast-cancer-research.biomedcentral.com
    Discovery and validation of cell-free DNA methylation markers for specific diagnosis, differentiation from benign tumors, and prognosis of breast cancer
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    breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-025-02066-x
  37. 52.53.155.43 52.53.155.43
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    Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer
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  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12128487/
  40. May 2025
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells
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    Therapeutic targeting of circTNK2 with nanoparticles restores tamoxifen sensitivity and enhances NK cell-mediated immunity in ER-positive breast cancer
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    sciencedirect.com/science/article/pii/S0304383525003908
  43. link.springer.com link.springer.com
    Microtubule associated serine/threonine kinase-3 inhibits the malignant phenotype of breast cancer by promoting phosphorylation-mediated ubiquitination degradation of yes-associated protein
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    Protrusion force and cell-cell adhesion-induced polarity alignment govern collective migration modes
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    sciencedirect.com/science/article/pii/S0006349525002371
  45. Apr 2025
  46. www.sciencedirect.com www.sciencedirect.com
    CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers
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  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Potent estrogen receptor β agonists with inhibitory activity in vitro, fail to suppress xenografts of endocrine-resistant cyclin-dependent kinase 4/6 inhibitor-resistant breast cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11979155/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The histone acetyltransferase CBP participates in regulating the DNA damage response through ATM after double-strand breaks
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    Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis
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    sciencedirect.com/science/article/pii/S1097276525002023
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP
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    pmc.ncbi.nlm.nih.gov/articles/PMC11951697/
  51. Mar 2025
  52. 52.53.155.43 52.53.155.43
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  53. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The transcription factor RIP140 regulates interferon γ signaling in breast cancer
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35405
  54. www.sciencedirect.com www.sciencedirect.com
    The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis
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    sciencedirect.com/science/article/pii/S2211124725001743
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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70030
  56. www.sciencedirect.com www.sciencedirect.com
    Combinatorial screen of targeted agents with the PI3K inhibitors inavolisib, alpelisib, duvelisib, and copanlisib in multi-cell type tumor spheroids
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  57. Feb 2025
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850729/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Imlunestrant Is an Oral, Brain-Penetrant Selective Estrogen Receptor Degrader with Potent Antitumor Activity in ESR1 Wild-Type and Mutant Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11831106/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolic Profiling of Breast Cancer Cell Lines: Unique and Shared Metabolites
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    pmc.ncbi.nlm.nih.gov/articles/PMC11816582/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11808005/
  62. www.nature.com www.nature.com
    Discovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients
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    nature.com/articles/s41598-025-87122-4
  63. Jan 2025
  64. elifesciences.org elifesciences.org
    A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms
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    elifesciences.org/articles/93183
  65. www.sciencedirect.com www.sciencedirect.com
    Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1
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    sciencedirect.com/science/article/pii/S1535610824004434
  66. www.nature.com www.nature.com
    The EstroGene2.0 database for endocrine therapy response and resistance in breast cancer
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    nature.com/articles/s41523-024-00709-4
  67. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FGFR2-RUNX2 activation: An unexplored therapeutic pathway in luminal breast cancer related to tumor progression
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35302
  68. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13762
  69. www.sciencedirect.com www.sciencedirect.com
    Targeting ROR2 homooligomerization disrupts ROR2-dependent signaling and suppresses stem-like cell properties of human breast adenocarcinoma
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    sciencedirect.com/science/article/pii/S2589004224028165
  70. Dec 2024
  71. www.nature.com www.nature.com
    Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
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    nature.com/articles/s41418-024-01439-7
  72. 52.53.155.43 52.53.155.43
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  73. Nov 2024
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MicroRNA-145-5p inhibits the tumorigenesis of breast cancer through SENP2-regulated ubiquitination of ERK2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11584840/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    C19MC Drives Nucleolar Invasion of Mitochondria and Meiotic Nuclear Division in Human Cancers
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  76. www.biorxiv.org www.biorxiv.org
    Aberrant expression of CD14 in breast tumor cells is associated with poor outcome
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    biorxiv.org/content/10.1101/2024.11.07.622456v1
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    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
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    sciencedirect.com/science/article/pii/S2451945624004434
  78. Oct 2024
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443213/
  80. Sep 2024
  81. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Dynamic methylation and expression of alternative promoters for oestrogen receptor alpha in cell line models of fulvestrant resistance
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13713
  82. www.biorxiv.org www.biorxiv.org
    Protrusion force and cell-cell adhesion play a critical role in collective tumor cluster migration
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    biorxiv.org/content/10.1101/2024.09.18.613706v1
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic effects of PARP inhibition and cholesterol biosynthesis pathway modulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11403291/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Global and single-cell proteomics view of the co-evolution between neural progenitors and breast cancer cells in a co-culture model
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    ncbi.nlm.nih.gov/pmc/articles/PMC11404160/
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    Computational pipeline predicting cell death suppressors as targets for cancer therapy
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    sciencedirect.com/science/article/pii/S2589004224020844
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ESR1 Fusions Invoke Breast Cancer Subtype-Dependent Enrichment of Ligand-Independent Oncogenic Signatures and Phenotypes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11384147/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Siglec‐7 and Siglec‐9 expression in primary triple negative and oestrogen receptor positive breast cancer and in vitro signalling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11378723/
  88. Aug 2024
  89. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    cell.com/cell/fulltext/S0092-8674(20)30163-X
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Engineered Drug 3′UTRMYC1-18 Degrades the c-MYC-STAT5A/B-PD-L1 Complex In Vivo to Inhibit Metastatic Triple-Negative Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11311709/
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TAS3681, an androgen receptor antagonist, prevents drug resistance driven by aberrant androgen receptor signaling in prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11306513/
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HTS384 NCI60: The Next Phase of the NCI60 Screen
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    ncbi.nlm.nih.gov/pmc/articles/PMC11292194/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human 3D ovarian cancer models reveal malignant cell intrinsic and extrinsic factors that influence CAR T cell activity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11292204/
  94. www.cell.com www.cell.com
    ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines
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    cell.com/cell-reports/fulltext/S2211-1247(24)00762-9
  95. breast-cancer-research.biomedcentral.com breast-cancer-research.biomedcentral.com
    Small molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in estrogen receptor-positive breast cancer overcomes tamoxifen resistance
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    breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-024-01790-0
  96. genomebiology.biomedcentral.com genomebiology.biomedcentral.com
    The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer
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    genomebiology.biomedcentral.com/articles/10.1186/s13059-023-03161-y
  97. www.nature.com www.nature.com
    TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells
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    nature.com/articles/s41417-023-00696-x
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alternative promoters and splicing create multiple functionally distinct isoforms of oestrogen receptor alpha in breast cancer and healthy tissues
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    ncbi.nlm.nih.gov/pmc/articles/PMC10557849/
  99. Jul 2024
  100. www.biorxiv.org www.biorxiv.org
    The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization
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    biorxiv.org/content/10.1101/2024.07.22.604482v1
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    Loss of ZNF408 attenuates STING-mediated immune surveillance in breast carcinogenesis
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    Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance
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  224. Dec 2021
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  229. Nov 2021
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