151 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SETD2 Deficiency Drives Mitochondrial DNA Leakage and Creates a Druggable Dependency on BCL-xL in Clear Cell Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13244386/
  3. Jun 2026
  4. www.sciencedirect.com www.sciencedirect.com
    Nectin-4 drives aggressive tumor biology and poor prognosis in renal cell carcinoma
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    sciencedirect.com/science/article/pii/S1078143926005314
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structure-guided optimization of SLC1A1/EAAT3-selective inhibitors targeting renal cancer metabolism
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    pmc.ncbi.nlm.nih.gov/articles/PMC13226657/
  6. www.sciencedirect.com www.sciencedirect.com
    Plasma - Activated Medium Engages Redox Signaling to Activate a VDAC1–TRPML1 Lysosomal–Mitochondrial Ca2+ Death Pathway
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    sciencedirect.com/science/article/pii/S0891584926008488
  7. May 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    OSCAR functions as a collagen I receptor to suppress hippo signaling and reprogram lipid metabolism in clear-cell renal cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13187165/
  9. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Integrating Bulk and Single-Cell RNA-Seq Reveals Glycolysis-Associated Macrophages and Its Related Tumor Subgroup Signatures to Predict Prognosis and Therapy in Clear Cell Renal Cell Carcinoma
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    onlinelibrary.wiley.com/doi/10.1155/humu/3125551
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD70 regulates the NF1/Ras/ERK axis to promote metastatic potential in clear cell renal cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13141462/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/HIF2α activation, lipid metabolism rewiring, and ferroptosis evasion
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    pmc.ncbi.nlm.nih.gov/articles/PMC13144475/
  12. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Molecular Glue cc-885 Inhibits VHL-Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202520237
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor-Resident Streptococcus pneumoniae Promotes Malignant Progression and Pazopanib Resistance in Clear Cell Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13136875/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lipid Composition Alters Ferroptosis Sensitivity
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    pmc.ncbi.nlm.nih.gov/articles/PMC13138121/
  15. Apr 2026
  16. www.sciencedirect.com www.sciencedirect.com
    USP15 stabilizes c-Myc to drive sunitinib resistance by suppressing cuproptosis in clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S2211124726004067
  17. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004226011831-main-html.html
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    54.241.53.176/f67967ac177e13a4199544fbeea2378fa30d5e67/1-s2.0-S2589004226011831-main-html.html
  18. www.sciencedirect.com www.sciencedirect.com
    Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression
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    sciencedirect.com/science/article/pii/S2451945626001054
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nutrient Availability Dictates Cancer Metabolism–Based Therapeutic Responses to Nononcology Drugs
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    pmc.ncbi.nlm.nih.gov/articles/PMC13055633/
  20. www.sciencedirect.com www.sciencedirect.com
    High throughput screening identifies sanguinarine chloride as a multi-faceted therapeutic agent for PRCC-TFE3 rRCC by targeting lactylation-driven VEGFB-VEGFR2 signaling and PMN-MDSC infiltration
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    sciencedirect.com/science/article/pii/S2090123226002912
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pharmacologic and Oncohistone Inhibition of SETD2 Converge on Genomic Instability
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    pmc.ncbi.nlm.nih.gov/articles/PMC12984950/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MAGI3 deficiency unleashes β-catenin conformational change to drive metastatic progression and mTOR inhibitor resistance in ccRCC
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    pmc.ncbi.nlm.nih.gov/articles/PMC13039909/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitofusin-2 suppresses tumor immune escape through EGFR/STAT3-mediated PD-L1 transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC13039860/
  24. Mar 2026
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Using 3D Invasion properties of RCC Cell Lines In Vitro to predict their Metastatic Potential In Vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC13031655/
  26. www.sciencedirect.com www.sciencedirect.com
    Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumors
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    sciencedirect.com/science/article/pii/S2666379126001126
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Quantification of Single‐Cell Cysteine Using an Electrochemical Nanosensor for Predicting Tumor Disulfidptosis Susceptibility
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    pmc.ncbi.nlm.nih.gov/articles/PMC12955924/
  28. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004226005730-main-html.html
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    54.241.53.176/c117811237c21d1951e41d10a831e3adf197da7c/1-s2.0-S2589004226005730-main-html.html
  29. Feb 2026
  30. www.sciencedirect.com www.sciencedirect.com
    Generation of a comprehensive epigenomic atlas in clear cell renal cell carcinoma informs kidney cancer progression and heritability
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    sciencedirect.com/science/article/pii/S221112472600046X
  31. www.sciencedirect.com www.sciencedirect.com
    Dynamic assessment of the allocation of copper to cytochrome c oxidase using size-exclusion chromatography (SEC) combined with inductively coupled plasma mass spectrometry (ICP-MS)
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    sciencedirect.com/science/article/pii/S0021925826001481
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting and dissociating HIF2α from the molecular chaperone Hsp70 triggers apoptosis in kidney cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12881505/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell-free DNA epigenomic profiling enables noninvasive detection and monitoring of translocation renal cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12867156/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ZNF395 is a Hypoxia-Responsive Regulator of Mitochondrial Glutaminolysis in Clear Cell Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12875648/
  35. Jan 2026
  36. www.sciencedirect.com www.sciencedirect.com
    Large extracellular vesicles regulate endothelial angiogenic potential via paracrine and autocrine signaling
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    sciencedirect.com/science/article/pii/S0021925826000633
  37. www.sciencedirect.com www.sciencedirect.com
    Protocol to generate human stem cell-derived CD70-directed allogeneic CAR-NKT cells for treating renal cell carcinoma
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    sciencedirect.com/science/article/pii/S2666166725007464
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Empty spiracles homeobox 2 (EMX2) transcription factor functions as a tumor suppressor in renal cell carcinoma by targeting CADM1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12807814/
  39. Dec 2025
  40. www.sciencedirect.com www.sciencedirect.com
    Establishment of patient-derived 3D tumouroids: personalised medicine tools for renal cancer
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    sciencedirect.com/science/article/pii/S1742706125009390
  41. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Targeting PRDX6-dependent localization and function of GPX4 enhances ferroptosis-mediated tumor suppression
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    sciencedirect.com:5037/science/article/pii/S1097276525009402
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TFE3 fusion proteins promoted the progression of Xp11.2 translocation renal cell carcinoma through post-translational modification of PDL1 by upregulating CCND1/Cyclin D1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12698746/
  43. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Extrachromosomal circular miRNA-gene amplifications contribute to the renal cancer phenotype
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    sciencedirect.com:5037/science/article/pii/S2211124725014329
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of glycolysis and stimulation of mitochondrial biogenesis lead to increased ROS levels and cell death in HNF-1ß positive clear cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12669797/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    tRF-21LeuTAA Promotes Oxidative Stress by Altering Glutathione Metabolic Enzymes to Support Prostate Cancer Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12666318/
  46. Nov 2025
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HIF-2-dependent Regulation of PTHrP and Paraneoplastic Hypercalcemia in Aggressive Clear Cell Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12642454/
  48. www.nature.com www.nature.com
    Oncostatin M induces epigenetic reprogramming in renal cell carcinoma-associated endothelial cells
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    nature.com/articles/s42003-025-08907-x
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KDM6A deficiency promotes tumor progression and resistance to cabozantinib treatment in clear cell renal cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12586554/
  50. Oct 2025
  51. onlinelibrary.wiley.com onlinelibrary.wiley.com
    TCIRG1 as a Novel Prognostic Biomarker Triggering Immune Infiltration in Renal Clear Cell Carcinoma: An Integrative Study of Single-Cell and Bulk Data
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    onlinelibrary.wiley.com/doi/full/10.1155/humu/1839494
  52. www.sciencedirect.com www.sciencedirect.com
    STBD1 mediates the crosstalk between glycogen and lipid droplets in clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S2211124725012008
  53. www.sciencedirect.com www.sciencedirect.com
    Intestinal Lachnospiraceae bacterium-derived propionate inhibits the progression of clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S2666379125004835
  54. www.sciencedirect.com www.sciencedirect.com
    ROR2-specific CAR T cells are effective against hematologic and solid tumors and well tolerated in mice
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    sciencedirect.com/science/article/pii/S2666379125004732
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated single-cell and bulk transcriptome analysis revealed high plasticity subpopulation and promising diagnosis model for clear cell renal cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12487111/
  56. Sep 2025
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CA-125 as a Biomarker in Renal Medullary Carcinoma: Integrated Molecular Profiling, Functional Characterization, and Prospective Clinical Validation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11913570/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12457572/
  59. www.biorxiv.org www.biorxiv.org
    Detection and monitoring of translocation renal cell carcinoma via plasma cell-free epigenomic profiling
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    biorxiv.org/content/10.1101/2025.08.31.673338v1
  60. www.nature.com www.nature.com
    Targeting FSP1 to induce ferroptosis in chromophobe renal cell carcinoma
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    nature.com/articles/s41388-025-03562-2
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proteogenomic Analysis Identifies Clinically Relevant Subgroups of Collecting Duct Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12408255/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Anoikis-related genes predicts prognosis and therapeutic response in renal cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12366518/
  63. Aug 2025
  64. www.sciencedirect.com www.sciencedirect.com
    Multimodal targeting of metastatic renal cell carcinoma via CD70-directed allogeneic CAR-NKT cells
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    sciencedirect.com/science/article/pii/S2666379125003945
  65. www.tandfonline.com www.tandfonline.com
    Anoikis-related genes predicts prognosis and therapeutic response in renal cell carcinoma
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    tandfonline.com/doi/full/10.1080/07853890.2025.2548042
  66. www.sciencedirect.com www.sciencedirect.com
    TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation
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    sciencedirect.com/science/article/pii/S221112472500957X
  67. www.sciencedirect.com www.sciencedirect.com
    Design of multi-target peptide modulators for protein chaperone networks
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    sciencedirect.com/science/article/pii/S0969212625002692
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential Efficacy of Bevacizumab and Erlotinib in Preclinical Models of Renal Medullary Carcinoma and Fumarate Hydratase–Deficient Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12323885/
  69. www.sciencedirect.com www.sciencedirect.com
    The extracellular-matrix-remodeling capability exposes therapeutic vulnerability in a subset of renal cell carcinomas with tumor thrombi
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    sciencedirect.com/science/article/pii/S1534580725004484
  70. Jul 2025
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Long-term administration of hydrogen-rich water enhances quality of life in diabetic rats and reduces renal neoplasm incidence through modulation of inflammatory and metabolic pathways
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    pmc.ncbi.nlm.nih.gov/articles/PMC12271932/
  72. www.science.org www.science.org
    CD8+ T cell–derived CD40L mediates noncanonical cytotoxicity in CD40-expressing cancer cells
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    science.org/doi/10.1126/sciadv.adr9331
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265667/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12223508/
  75. Jun 2025
  76. www.nature.com www.nature.com
    PUMA reduces FASN ubiquitination to promote lipid accumulation and tumor progression in human clear cell renal cell carcinoma
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    nature.com/articles/s41419-025-07782-y
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12161473/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Membrane-bound IL-15 co-expression powers a potent and persistent CD70-targeted TRuC T-cell therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12162932/
  79. www.sciencedirect.com www.sciencedirect.com
    Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket
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    sciencedirect.com/science/article/pii/S258900422400124X
  80. May 2025
  81. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225010132-main-html.html
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    52.53.155.43/9003c45fae7689dd9660ec2260acff69b9d30974/1-s2.0-S2589004225010132-main-html.html
  82. www.science.org www.science.org
    CD8+ T cell–derived CD40L mediates noncanonical cytotoxicity in CD40-expressing cancer cells
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    science.org/doi/10.1126/sciadv.adr9331
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12079101/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ankrd1 Promotes Lamellipodia Formation and Cell Motility via Interaction with Talin-1 in Clear Cell Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12072362/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Avelumab induces greater Fc-Fc receptor-dependent natural killer cell activation and dendritic cell crosstalk compared to durvalumab
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    pmc.ncbi.nlm.nih.gov/articles/PMC12051578/
  86. Apr 2025
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11977649/
  88. www.sciencedirect.com www.sciencedirect.com
    An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation
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    sciencedirect.com/science/article/pii/S1097276525001996
  89. www.sciencedirect.com www.sciencedirect.com
    Versatile roles of annexin A4 in clear cell renal cell carcinoma: Impact on membrane repair, transcriptional signatures, and composition of the tumor microenvironment
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    sciencedirect.com/science/article/pii/S2589004225004596
  90. Mar 2025
  91. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/e796403114c957ce0191bc2a029a1689cb8b887b/PDF-html.html
  92. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11988688/
  93. Feb 2025
  94. aacrjournals.org aacrjournals.org
    Hypertension promotes the proliferation and migration of ccRCC cells by downregulation of TIMP3 in tumor endothelial cells through the miR-21-5p/TGFBR2/P38/EGR1 axis
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    aacrjournals.org/mcr/article/21/1/62/711796/Hypertension-Promotes-the-Proliferation-and
  95. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11803400/
  96. Jan 2025
  97. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    APOBEC3C‐mediated NF‐κB activation enhances clear cell renal cell carcinoma progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11705732/
  98. www.sciencedirect.com www.sciencedirect.com
    Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1
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    sciencedirect.com/science/article/pii/S1550413124004807
  99. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis
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