75 Matching Annotations
  1. Jul 2026
  2. www.sciencedirect.com www.sciencedirect.com
    Optimization of hinge domain enhances antitumor efficacy of globo H-targeted CAR-T cells in solid tumor models
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    sciencedirect.com/science/article/pii/S2589004226019553
  3. Jun 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structure-guided optimization of SLC1A1/EAAT3-selective inhibitors targeting renal cancer metabolism
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    pmc.ncbi.nlm.nih.gov/articles/PMC13226657/
  5. May 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    OSCAR functions as a collagen I receptor to suppress hippo signaling and reprogram lipid metabolism in clear-cell renal cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13187165/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD70 regulates the NF1/Ras/ERK axis to promote metastatic potential in clear cell renal cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13141462/
  8. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Molecular Glue cc-885 Inhibits VHL-Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202520237
  9. Apr 2026
  10. www.sciencedirect.com www.sciencedirect.com
    USP15 stabilizes c-Myc to drive sunitinib resistance by suppressing cuproptosis in clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S2211124726004067
  11. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004226011831-main-html.html
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  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    2,3-Bisphosphoglycerate Mutase (BPGM), a Metabolic Player Shaping Stress-Adaptive Transcriptional States in Clear Cell Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13072826/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ERMP1 Exerts Tumor‐Suppressive Functions in KIRC by Inhibiting PI3K/AKT Signaling and Remodeling the Immune Microenvironment: A Pan‐Cancer Analysis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13057433/
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    Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression
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    sciencedirect.com/science/article/pii/S2451945626001054
  15. Mar 2026
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A TXNIP-driven bioluminescent reporter for high-throughput discovery of glycolytic inhibitors against renal cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13011687/
  17. Feb 2026
  18. www.sciencedirect.com www.sciencedirect.com
    Generation of a comprehensive epigenomic atlas in clear cell renal cell carcinoma informs kidney cancer progression and heritability
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    sciencedirect.com/science/article/pii/S221112472600046X
  19. onlinelibrary.wiley.com onlinelibrary.wiley.com
    RB-BC: A Novel Ribociclib Derivative Targeting p53-Mediated Apoptosis and Inhibition of Tumor Growth in Breast Cancer
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    onlinelibrary.wiley.com/doi/full/10.1002/cbdv.202502267
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting and dissociating HIF2α from the molecular chaperone Hsp70 triggers apoptosis in kidney cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12881505/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ZNF395 is a Hypoxia-Responsive Regulator of Mitochondrial Glutaminolysis in Clear Cell Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12875648/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell-free DNA epigenomic profiling enables noninvasive detection and monitoring of translocation renal cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12867156/
  23. Dec 2025
  24. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Mitochondrial VHL rewires cell metabolism in hypoxia
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    sciencedirect.com:5037/science/article/pii/S1550413125005273
  25. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Targeting PRDX6-dependent localization and function of GPX4 enhances ferroptosis-mediated tumor suppression
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    sciencedirect.com:5037/science/article/pii/S1097276525009402
  26. Nov 2025
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs
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    pmc.ncbi.nlm.nih.gov/articles/PMC12618888/
  28. Oct 2025
  29. www.sciencedirect.com www.sciencedirect.com
    STBD1 mediates the crosstalk between glycogen and lipid droplets in clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S2211124725012008
  30. Sep 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CA-125 as a Biomarker in Renal Medullary Carcinoma: Integrated Molecular Profiling, Functional Characterization, and Prospective Clinical Validation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11913570/
  32. www.biorxiv.org www.biorxiv.org
    Detection and monitoring of translocation renal cell carcinoma via plasma cell-free epigenomic profiling
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    biorxiv.org/content/10.1101/2025.08.31.673338v1
  33. www.sciencedirect.com www.sciencedirect.com
    HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics
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    sciencedirect.com/science/article/pii/S0092867425009298
  34. Jul 2025
  35. www.science.org www.science.org
    CD8+ T cell–derived CD40L mediates noncanonical cytotoxicity in CD40-expressing cancer cells
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    science.org/doi/10.1126/sciadv.adr9331
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265667/
  37. www.sciencedirect.com www.sciencedirect.com
    Coordinated expression of retained introns and poison exons in renal cell carcinoma
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    sciencedirect.com/science/article/pii/S2211124725007569
  38. Jun 2025
  39. www.nature.com www.nature.com
    PUMA reduces FASN ubiquitination to promote lipid accumulation and tumor progression in human clear cell renal cell carcinoma
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    nature.com/articles/s41419-025-07782-y
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12161473/
  41. cancer-nano.biomedcentral.com cancer-nano.biomedcentral.com
    Exosomal encapsulation of a steviol derivative SD9 to overcome TRAIL resistance as a highly effective therapy against lung cancer
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    cancer-nano.biomedcentral.com/articles/10.1186/s12645-025-00329-y
  42. May 2025
  43. www.science.org www.science.org
    CD8+ T cell–derived CD40L mediates noncanonical cytotoxicity in CD40-expressing cancer cells
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    science.org/doi/10.1126/sciadv.adr9331
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ankrd1 Promotes Lamellipodia Formation and Cell Motility via Interaction with Talin-1 in Clear Cell Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12072362/
  45. link.springer.com link.springer.com
    Retroelement co-option disrupts the cancer transcriptional programme
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    link.springer.com/article/10.1186/s13073-025-01479-9
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12079101/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Avelumab induces greater Fc-Fc receptor-dependent natural killer cell activation and dendritic cell crosstalk compared to durvalumab
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    pmc.ncbi.nlm.nih.gov/articles/PMC12051578/
  48. Apr 2025
  49. www.sciencedirect.com www.sciencedirect.com
    An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation
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    sciencedirect.com/science/article/pii/S1097276525001996
  50. www.sciencedirect.com www.sciencedirect.com
    Versatile roles of annexin A4 in clear cell renal cell carcinoma: Impact on membrane repair, transcriptional signatures, and composition of the tumor microenvironment
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    sciencedirect.com/science/article/pii/S2589004225004596
  51. Mar 2025
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11988688/
  53. Feb 2025
  54. www.nature.com www.nature.com
    Multitarget mechanism of MYC inhibition by the bacterial lon protease in disease
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    nature.com/articles/s41598-025-88093-2
  55. www.sciencedirect.com www.sciencedirect.com
    Potentiating anti-tumor immunity by re-engaging immune synapse molecules
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    sciencedirect.com/science/article/pii/S2666379125000485
  56. Jan 2025
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ACE Loss Drives Renal Cell Carcinoma Growth and Invasion by Modulating AKT-FOXO1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11665188/
  58. www.sciencedirect.com www.sciencedirect.com
    A thermoplastic chip for 2D and 3D correlative assays combining screening and high-resolution imaging of immune cell responses
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    sciencedirect.com/science/article/pii/S2667237525000013
  59. Dec 2024
  60. www.sciencedirect.com www.sciencedirect.com
    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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    sciencedirect.com/science/article/pii/S235239642400495X
  61. Nov 2024
  62. www.nature.com www.nature.com
    Design, performance, processing, and validation of a pooled CRISPR perturbation screen for bacterial toxins
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    nature.com/articles/s41596-024-01075-y
  63. Aug 2024
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SOX11 as a prognostic biomarker linked to m6A modification and immune infiltration in renal clear cell carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11319951/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HTS384 NCI60: The Next Phase of the NCI60 Screen
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    ncbi.nlm.nih.gov/pmc/articles/PMC11292194/
  66. Jul 2024
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11215406/
  68. May 2024
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Radix Actinidiae chinensis induces the autophagy and apoptosis in renal cell carcinoma cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11103827/
  70. aacrjournals.org aacrjournals.org
    Bile acid metabolism mediates cholesterol homeostasis and promotes tumorigenesis in clear cell renal cell carcinoma
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    aacrjournals.org/cancerres/article/84/10/1570/745316/Bile-Acid-Metabolism-Mediates-Cholesterol
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SETD2 Deficiency Confers Sensitivity to Dual Inhibition of DNA Methylation and PARP in Kidney Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10843145/
  72. Mar 2024
  73. www.sciencedirect.com www.sciencedirect.com
    Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
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    sciencedirect.com/science/article/pii/S2451945624000874
  74. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13619
  75. Feb 2024
  76. jeccr.biomedcentral.com jeccr.biomedcentral.com
    Transfection with Plasmid-Encoding lncRNA-SLERCC nanoparticle-mediated delivery suppressed tumor progression in renal cell carcinoma
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    jeccr.biomedcentral.com/articles/10.1186/s13046-022-02467-2
  77. Dec 2023
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10690095/
  79. Oct 2023
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10586807/
  81. 52.53.155.43 52.53.155.43
    ccr-23-1182-html.html
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  82. Aug 2023
  83. www.sciencedirect.com www.sciencedirect.com
    CYP19A1 mediates severe SARS-CoV-2 disease outcome in males
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  84. Jun 2023
  85. www.nature.com www.nature.com
    piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination
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    nature.com/articles/s12276-023-01010-3
  86. May 2023
  87. www.sciencedirect.com www.sciencedirect.com
    Miniaturized and multiplexed high-content screening of drug and immune sensitivity in a multichambered microwell chip
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    sciencedirect.com/science/article/pii/S2667237522001291
  88. Jan 2023
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    RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer
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    sciencedirect.com/science/article/pii/S221112472300027X
  90. Dec 2022
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    Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness
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  92. Jul 2022
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    Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition
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    sciencedirect.com/science/article/pii/S0960982222010004
  94. Jun 2022
  95. www.sciencedirect.com www.sciencedirect.com
    An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S1097276522005391
  96. Jul 2021
  97. www.sciencedirect.com www.sciencedirect.com
    Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
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    sciencedirect.com/science/article/pii/S1550413119303171
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long non-coding RNA HOTAIR promotes cell migration by upregulating insulin growth factor–binding protein 2 in renal cell carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC5607269/
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC5605498/
  100. Jun 2021
  101. www.nature.com www.nature.com
    Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex
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    nature.com/articles/s41467-021-23748-y
  102. Mar 2021
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oncometabolite L‐2‐hydroxyglurate directly induces vasculogenic mimicry through PHLDB2 in renal cell carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC7986127/
  104. Feb 2021
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translation in amino-acid-poor environments is limited by tRNAGln charging
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    ncbi.nlm.nih.gov/pmc/articles/PMC7744096/
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SETD2 mutation in renal clear cell carcinoma suppress autophagy via regulation of ATG12
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    ncbi.nlm.nih.gov/pmc/articles/PMC6985262/
  107. www.jci.org www.jci.org
    Active bacterial modification of the host environment through RNA Polymerase II inhibition
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    jci.org/articles/view/140333
  108. Sep 2020
  109. academic.oup.com academic.oup.com
    The effects of 20-kDa human placental GH in male and female GH deficient mice: an improved human GH?
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    academic.oup.com/endo/article/161/8/bqaa097/5859553
  110. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Novel engineered TRAIL‐based chimeric protein strongly inhibits tumor growth and bypasses TRAIL resistance
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    onlinelibrary.wiley.com/doi/10.1002/ijc.32845
  111. www.sciencedirect.com www.sciencedirect.com
    Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma
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    sciencedirect.com/science/article/pii/S1535610820301641
  112. Jan 2020
  113. www.sciencedirect.com www.sciencedirect.com
    Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation
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    sciencedirect.com/science/article/pii/S1550413119305121
  114. mct.aacrjournals.org mct.aacrjournals.org
    Specific RITA modification produces hyperselective cytotoxicity while maintaining in vivo antitumor efficacy
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    mct.aacrjournals.org/content/18/10/1765