79 Matching Annotations
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    A bioavailable GPX4 inhibitor for ferroptosis induction in vivo and tumor suppression
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  3. Oct 2026
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    Mitochondria-targeted tetraoxanes initiate lipid peroxidation to drive ferroptosis and tumor suppression
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    sciencedirect.com/science/article/pii/S0092867426011414
  5. Aug 2026
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    Toward Personalized Theranostics: A Modular PET Platform for Antibody-Based Imaging and Therapy
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    Excess intracellular lactate represses mRNA translation and tumor progression through lactate-tRNA charging
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    HER2 heterogeneous breast cancer models reveal novel therapeutic targets and subclonal dynamics during evolution to resistance to HER2-targeted therapies
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  9. Jul 2026
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    EZH2 Inhibitors Sensitize Breast Cancer to HER2 Kinase Inhibitors through Cooperative Effects on YAP and Pro-apoptotic Regulators
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  12. Jun 2026
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    Design optimization of antibody-ligand motifs to enhance CAR-T redirection activity against solid tumors
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  14. Apr 2026
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    Potency and safety of novel [225Ac]Ac-labeled pertuzumab-PEGylated emtansine drug conjugate against HER2-positive breast cancer
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    Selective MOSPD2-STARD3 interaction at ER contact sites governs late endosome/lysosome dynamics and cholesterol homeostasis
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    PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis
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    Payload Diversification Overcomes Resistance and Guides Sequential Antibody-Drug Conjugate Therapy in Breast Cancer
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    AXL–SHC1 signaling axis mediates adaptive resistance to HER2-targeted tyrosine kinase inhibitors in HER2-aberrant lung and gastric cancers
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    A 3D morphogenetic blueprint for metastatic outgrowth in breast cancer
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  21. Mar 2026
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo Auto-tuning of Antibody-Drug Conjugate Delivery to Maximize Efficacy using High-Avidity, Low-Affinity Antibodies
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    AXL-Driven Stemness and Hedgehog Signaling in HER2-Positive Breast Cancer with Acquired Trastuzumab Resistance: Synergistic Potential of AXL and HER2 Co-Targeting
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  24. Jan 2026
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  26. Dec 2025
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    Machine learning-based development of a cytotoxicity prediction model for NK cell therapy in cancers
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    Vesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancer
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    The Bi-steric, mTORC1-Selective Inhibitor, RMC-5552, in Advanced Solid Tumors: A Phase 1 Trial
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  30. Nov 2025
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    Developing a therapeutic elastase that stimulates anti-tumor immunity by selectively killing cancer cells
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  32. Oct 2025
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    Metabolic Alterations driven by PFKFB3 upregulation confer Resistance to Trastuzumab in HER2-Positive Breast Cancer
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    Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties
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    Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors
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  36. Sep 2025
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    PDE7A inhibition suppresses triple-negative breast cancer by attenuating de novo pyrimidine biosynthesis
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    Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer
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    Mucin 5AC promotes breast cancer brain metastasis through cMET/CD44v6
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  40. Jul 2025
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    A Novel B7-H4xCD3 Bispecific T-cell Engager (PF-07260437) Synergizes with Breast Cancer Standard of Care and Immune Checkpoint Therapies
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  42. May 2025
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    Sumoylated Etv1 establishes mouse mammary cancer stem cells that support tumorigenesis by non-stem cancer cells
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  44. Apr 2025
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    Non-invasive multi-cancer detection using DNA hypomethylation of LINE-1 retrotransposons
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  46. Feb 2025
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  48. Jan 2025
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  50. Nov 2024
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    Aberrant expression of CD14 in breast tumor cells is associated with poor outcome
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  52. Sep 2024
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  54. Apr 2024
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    Type I interferon regulation by USP18 is a key vulnerability in cancer
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  56. Feb 2024
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    Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
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    SAA1-dependent reprogramming of adipocytes by tumor cells is associated with triple negative breast cancer aggressiveness
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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An estrogen-regulated long non-coding RNA NCALD promotes luminal breast cancer proliferation by activating GRHL2
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  60. Jan 2024
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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  63. Nov 2023
  64. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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  65. Oct 2023
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  67. Aug 2023
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    CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis
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  70. Jul 2023
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  72. Apr 2023
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    Original research: Targeting tumor vasculature to improve antitumor activity of T cells armed ex vivo with T cell engaging bispecific antibody
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  74. Mar 2023
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    Sustained oncogenic signaling in the cytostatic state enables targeting of non-proliferating persistent cancer cells
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    Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis
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  77. Feb 2023
  78. aacrjournals.org aacrjournals.org
    Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
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  79. Jan 2023
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    Therapy-induced senescence enhances the efficacy of HER2-targeted antibody-drug conjugates in breast cancer
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  81. Dec 2022
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  85. Mar 2022
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    Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases
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    MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
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  88. Feb 2022
  89. www.sciencedirect.com www.sciencedirect.com
    An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer
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    Original research: Overcoming tumor heterogeneity by ex vivo arming of T cells using multiple bispecific antibodies
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  91. Jan 2022
  92. www.nature.com www.nature.com
    FTY720 in resistant human epidermal growth factor receptor 2-positive breast cancer
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    Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness
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  94. Aug 2021
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Clinical Implications of Sub-grouping HER2 Positive Tumors by Amplicon Structure and Co-amplified Genes
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    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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    Durability of cell line xenograft resection models to interrogate tumor micro-environment targeting agents
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    nature.com/articles/s41598-019-45444-0
  98. Jul 2021
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    Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion
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    CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling
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    embopress.org/doi/10.15252/embr.201948058
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    Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
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    Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity
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  103. May 2021
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    Deciphering the signaling network of breast cancer improves drug sensitivity prediction
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  105. Apr 2021
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC8384339/
  107. Nov 2020
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    G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program
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  109. Oct 2020
  110. www.cell.com www.cell.com
    Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing
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    cell.com/cell-chemical-biology/abstract/S2451-9456(20)30284-1
  111. Sep 2020
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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  113. mct.aacrjournals.org mct.aacrjournals.org
    ARX788, a Site-specific anti-HER2 Antibody Drug Conjugate, Demonstrates Potent and Selective Activity in HER2 Low and T-DM1 Resistant Breast and Gastric Cancers
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  114. Jan 2020
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    Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy
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    Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion
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  117. Nov 2018
  118. www.sciencedirect.com www.sciencedirect.com
    Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes
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  119. Nov 2017
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    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
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    Synergistic interactions with PI3K inhibition that induce apoptosis
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    elifesciences.org/articles/24523
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    Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis
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