Hypothesis

28 Matching Annotations

Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Targeting Monounsaturated Fatty Acid Metabolism for Radiosensitization of KRAS Mutant 3D Lung Cancer Models

1
1. scibot 05 Dec 2025
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1158/1535-7163.MCT-24-0213
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
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  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC12137014/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in KEAP1-Mutant Lung Cancer

1
1. scibot 03 Dec 2025
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1158/0008-5472.CAN-24-4887
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
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  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC12666321/
Aug 2025
www.sciencedirect.com www.sciencedirect.com

High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy

1
1. scibot 19 Aug 2025
  
  in Public
  
  ATCCCat#CRL-5907
  
  DOI: 10.1016/j.xcrm.2025.102291
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1508
  
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  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

sciencedirect.com/science/article/pii/S2666379125003647
www.sciencedirect.com www.sciencedirect.com

A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers

1
1. scibot 08 Aug 2025
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1016/j.ccell.2025.07.006
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
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  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

sciencedirect.com/science/article/pii/S1535610825003101
Jul 2025
www.sciencedirect.com www.sciencedirect.com

KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer

1
1. scibot 15 Jul 2025
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1016/j.ccell.2025.06.011
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
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  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

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sciencedirect.com/science/article/pii/S1535610825002612
Jan 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225001245-main-html.html

1
1. scibot 23 Jan 2025
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1016/j.isci.2025.111864
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
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  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

52.53.155.43/b8347d751839197edb20fe1168219b4048f4b01d/1-s2.0-S2589004225001245-main-html.html
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography

1
1. scibot 21 Dec 2024
  
  in Public
  
  CRL-5907
  
  DOI: 10.1038/s41467-024-54852-4
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @sjvitug
  
  SciCrunch record: RRID:CVCL_1508
  
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  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11652680/
Oct 2024
www.sciencedirect.com www.sciencedirect.com

Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer

1
1. scibot 09 Oct 2024
  
  in Public
  
  Cat# CRL-5907
  
  DOI: 10.1016/j.chembiol.2024.09.004
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @vtello
  
  SciCrunch record: RRID:CVCL_1508
  
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  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

sciencedirect.com/science/article/pii/S2451945624003969
Jul 2024
www.cell.com www.cell.com

Pan-cancer proteogenomics expands the landscape of therapeutic targets

1
1. scibot 24 Jul 2024
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1016/j.cell.2024.05.039
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

cell.com/cell/fulltext/S0092-8674(24)00583-X
May 2024
aacrjournals.org aacrjournals.org

TREX1 inactivation unleashes cancer cell STING-interferon signaling and promotes anti-tumor immunity

2
1. scibot 23 May 2024
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1158/2159-8290.CD-23-0700
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508
2. scibot 23 May 2024
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1158/2159-8290.CD-23-0700
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

aacrjournals.org/cancerdiscovery/article/14/5/752/745044/TREX1-Inactivation-Unleashes-Cancer-Cell-STING
Apr 2024
www.pnas.org www.pnas.org

Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer

1
1. scibot 25 Apr 2024
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1073/pnas.2319429121
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
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  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

pnas.org/doi/10.1073/pnas.2319429121
aacrjournals.org aacrjournals.org

The immune suppressor IGSF1 as a potential target for cancer immunotherapy

1
1. scibot 19 Apr 2024
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1158/2326-6066.CIR-23-0817
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

aacrjournals.org/cancerimmunolres/article/12/4/491/741941/The-Immune-Suppressor-IGSF1-as-a-Potential-Target
Nov 2023
onlinelibrary.wiley.com onlinelibrary.wiley.com

Fast proliferating and slowly migrating non-small cell lung cancer cells are vulnerable to decitabine and retinoic acid combinatorial treatment

1
1. scibot 12 Nov 2023
  
  in Public
  
  RRID: CVCL_1508
  
  DOI: 10.1002/ijc.34783
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @anisehay
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

onlinelibrary.wiley.com/doi/10.1002/ijc.34783
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

1
1. scibot 17 Jun 2023
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1158/0008-5472.CAN-22-3848
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10267679/
May 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors

1
1. scibot 04 May 2023
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1158/0008-5472.CAN-22-3000
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10152234/
Sep 2022
www.sciencedirect.com www.sciencedirect.com

MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

1
1. scibot 24 Sep 2022
  
  in Public
  
  CRL-5907
  
  DOI: 10.1016/j.ccell.2022.08.015
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

sciencedirect.com/science/article/pii/S1535610822003798
Aug 2021
www.sciencedirect.com www.sciencedirect.com

RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer

1
1. scibot 01 Aug 2021
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1016/j.chembiol.2019.12.005
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1508
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RRID:CVCL_1508

RRIDCUR:Validated

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2451945619304015
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

1
1. scibot 01 Aug 2021
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.7554/eLife.45572
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1508
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RRID:CVCL_1508

RRIDCUR:Validated

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6584702/
Jul 2021
www.sciencedirect.com www.sciencedirect.com

PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

1
1. scibot 23 Jul 2021
  
  in Public
  
  CRL-5907
  
  DOI: 10.1016/j.ccell.2021.06.018
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:CVCL_1508

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scibot

URL

sciencedirect.com/science/article/pii/S1535610821003408
www.sciencedirect.com www.sciencedirect.com

Pharmaco-transcriptomic correlation analysis reveals novel responsive signatures to HDAC inhibitors and identifies Dasatinib as a synergistic interactor in small-cell lung cancer

1
1. scibot 09 Jul 2021
  
  in Public
  
  CVCL_1508
  
  DOI: 10.1016/j.ebiom.2021.103457
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

sciencedirect.com/science/article/pii/S2352396421002504
May 2021
www.sciencedirect.com www.sciencedirect.com

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

1
1. scibot 07 May 2021
  
  in Public
  
  CVCL_1508
  
  DOI: 10.1016/j.molcel.2020.10.010
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

sciencedirect.com/science/article/pii/S1097276520306936
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis

1
1. scibot 30 Apr 2021
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1016/j.cmet.2020.12.007
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508
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RRID:CVCL_1508

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scibot

URL

sciencedirect.com/science/article/pii/S1550413120306628
Oct 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma

1
1. scibot 27 Oct 2020
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.7554/eLife.58108
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_1508

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7556868/
Sep 2020
www.sciencedirect.com www.sciencedirect.com

A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers

1
1. scibot 13 Sep 2020
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1016/j.ccell.2020.03.004
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1508
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RRID:CVCL_1508

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S1535610820301057
elifesciences.org elifesciences.org

Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

1
1. scibot 11 Sep 2020
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.7554/eLife.53367
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_1508

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scibot

URL

elifesciences.org/articles/53367
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:CVCL_1508
  
  DOI: 10.1016/j.cmet.2019.11.012
  
  Resource: (ATCC Cat# CRL-5907, RRID:CVCL_1508)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1508
  
  What is this?
  
  RRID:CVCL_1508 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_1508

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scibot

URL

sciencedirect.com/science/article/pii/S1550413119306199
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

1
1. scibot 05 Nov 2018
  
  in Public
  
  CRL-5907
  
  Curator: @Jmenke
  
  Resource used:
  
  (NCI-DTP Cat# NCI-H1944, RRID:CVCL_1508)
  
  SciCrunch record: RRID:CVCL_1508
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1508 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:CVCL_1508

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scibot

URL

sciencedirect.com/science/article/pii/S1535610818303696