161 Matching Annotations
  1. Last 7 days
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    Extracellular Matrix-Guided Tumor Stratification and Network Models Reveal Clinical Molecular Grades
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    biorxiv.org/content/10.1101/2025.08.29.672994v1
  3. Sep 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Notch3 mediated TGF-β1 activation enhances epithelial-mesenchymal transition and cancer stemness in non-small lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12370359/
  5. Aug 2025
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    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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    science.org/doi/10.1126/sciadv.adt1798
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    EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202510197
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    HACD3 promotes malignant progression of NSCLC by suppressing the MKK7/MAPK10 signaling axis
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    bmccancer.biomedcentral.com/articles/10.1186/s12885-025-14621-y
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Evaluation of DB-1419, a Novel Bifunctional and Bispecific Anti–B7-H3 × PD-L1 Antibody–Drug Conjugate
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    Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis
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    NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
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    Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures
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    FBXW5 Promotes Epithelial-Mesenchymal Transition in Lung Adenocarcinoma Through the KLF13/TROAP Signaling Pathway
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  15. Jul 2025
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    Novel Aptamer-Drug Conjugate for Targeted Therapy in Triple-Negative Breast Cancer
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    Prediction of Lung Cancer Metastasis Risk Based on Single-Cell Metabolic Profiling of Circulating Tumor Cells
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  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Utility of CK8/18 in identifying circulating tumor cells derived from lesions in patients with non-small cell lung cancer
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  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20–Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models
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    KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer
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    Strictosamide and mitraphylline inhibit cancer cell motility by suppressing epithelial-mesenchymal transition via integrin α4-mediated signaling
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  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prognostic model of lung adenocarcinoma based on disulfidptosis-related genes and analysis of in vitro cell experiments for PPP1R14B in the model
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  24. Jun 2025
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    Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer
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    Membrane-bound IL-15 co-expression powers a potent and persistent CD70-targeted TRuC T-cell therapy
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  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutation of SMARCA4 Induces Cancer Cell–Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy
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    Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation
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  33. May 2025
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Avelumab induces greater Fc-Fc receptor-dependent natural killer cell activation and dendritic cell crosstalk compared to durvalumab
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  35. Apr 2025
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    Combined inhibition of hexokinase 2 and pyruvate dehydrogenase surmounts SHP2 inhibitor resistance in non-small cell lung cancer with hybrid metabolic state harboring KRAS Q61H mutation
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  38. Mar 2025
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    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chromosomal Instability Is Associated with cGAS–STING Activation in EGFR-TKI Refractory Non-Small-Cell Lung Cancer
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    Preclinical evaluation of a novel antibody–drug conjugate OBI-992 for Cancer therapy
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  42. Feb 2025
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    JNJ-78306358, a first-in-class bispecific T cell engaging antibody targeting CD3 and HLA-G
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    Epsin3 promotes non-small cell lung cancer progression via modulating EGFR stability
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    Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment
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    Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2
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  50. Dec 2024
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography
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    A Novel Sensitizer Reduces EGFR-TKI Resistance by Regulating the PI3K/Akt/mTOR Pathway and Autophagy
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  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pericytes Modulate Third‐Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR‐Mutated Lung Cancer Cells Through IL32‐β5‐Integrin Paracrine Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11633494/
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    p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis
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    Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates
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  56. Nov 2024
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells
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  58. Oct 2024
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    Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer
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  60. Sep 2024
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    A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer
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    Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer
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  63. www.nature.com www.nature.com
    Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
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    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
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  65. Aug 2024
  66. www.pnas.org www.pnas.org
    Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer
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    pnas.org/doi/10.1073/pnas.2319429121
  67. aacrjournals.org aacrjournals.org
    MTX-13, a novel PTK7-directed antibody-drug conjugate with widened therapeutic index shows sustained tumor regressions for a broader spectrum of PTK7-positive tumors
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    Molecular Oncology - 2023 - Horie-html.html
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    Genetic alterations predict poor efficacy, outcomes and resistance to second-line osimertinib treatment in non-small cell lung cancer
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  70. Jul 2024
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    Novel ectopic expression of zona pellucida 3 glycoprotein in lung cancer promotes tumor growth
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    NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers
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    Harnessing the CD44-targeted delivery of self-assembled hyaluronan nanogel to reverse the antagonism between Cisplatin and Gefitinib in NSCLC cancer therapy
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    CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma
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  75. May 2024
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
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  77. Apr 2024
  78. aacrjournals.org aacrjournals.org
    EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth
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    S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis
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    IL-17 induces NSCLC cell migration and invasion by elevating MMP19 gene transcription and expression through the interaction of p300-dependent STAT3-K631 acetylation and its Y705-phosphorylation
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  81. Mar 2024
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    Silibinin is a suppressor of the metastasis-promoting transcription factor ID3
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  83. Feb 2024
  84. aacrjournals.org aacrjournals.org
    First-in-Human Study with preclinical data of BCL-2/BCL-xL Inhibitor Pelcitoclax in Locally Advanced or Metastatic Solid Tumors
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    aacrjournals.org/clincancerres/article/30/3/506/733551/First-in-Human-Study-with-Preclinical-Data-of-BCL
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    A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer
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  86. Jan 2024
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    Alisertib inhibits migration and invasion of EGFR-TKI resistant cells by partially reversing the epithelial-mesenchymal transition
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  89. Dec 2023
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    Phosphoprotein dynamics of interacting T cells and tumor cells by HySic
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  91. www.nature.com www.nature.com
    Proximity extracellular protein-protein interaction analysis of EGFR using AirID-conjugated fragment of antigen binding
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  92. Nov 2023
  93. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Fast proliferating and slowly migrating non-small cell lung cancer cells are vulnerable to decitabine and retinoic acid combinatorial treatment
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34783
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    British J Pharmacology - 2023 - Chen - Identification of arnicolide C as a novel chemosensitizer to suppress mTOR E2F1-html.html
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  96. Oct 2023
  97. www.cell.com www.cell.com
    PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C
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  98. Sep 2023
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  100. Aug 2023
  101. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Canagliflozin mediates tumor suppression alone and in combination with radiotherapy in non-small cell lung cancer (NSCLC) through inhibition of HIF-1α
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    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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  105. Jul 2023
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  107. www.nature.com www.nature.com
    E3 ligase MG53 suppresses tumor growth by degrading cyclin D1
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