Hypothesis

30 Matching Annotations

Jan 2026
www.sciencedirect.com www.sciencedirect.com

ANP32A-mediated Histone 3 K27 Acetylation is Essential for Sotorasib Activity in KRAS-mutant Non-Small Cell Lung Cancer

1
1. scibot 06 Jan 2026
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1016/j.jbc.2025.111110
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1517
  
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  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

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sciencedirect.com/science/article/pii/S002192582502962X
Dec 2025
www.nature.com www.nature.com

Engineered antibodies that stabilize drug-modified KRASG12C neoantigens enable selective and potent cross-HLA immunotherapy

1
1. scibot 23 Dec 2025
  
  in Public
  
  CRL-5914
  
  DOI: 10.1038/s41467-025-66132-w
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:CVCL_1517
  
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  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

nature.com/articles/s41467-025-66132-w
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Study of the blood–brain barrier-penetrating KRAS G12C inhibitor JMKX1899 in KRAS G12C-mutated NSCLC with brain metastases

1
1. scibot 11 Dec 2025
  
  in Public
  
  RRID: CVCL-1517
  
  DOI: 10.1016/j.jncc.2025.11.003
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1517
  
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  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

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sciencedirect.com:5037/science/article/pii/S266700542500122X
Sep 2025
www.sciencedirect.com www.sciencedirect.com

Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response

1
1. scibot 06 Sep 2025
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1016/j.molcel.2025.08.014
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1517
  
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  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

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sciencedirect.com/science/article/pii/S1097276525006641
Jul 2025
www.sciencedirect.com www.sciencedirect.com

KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer

1
1. scibot 15 Jul 2025
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1016/j.ccell.2025.06.011
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1517
  
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  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

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sciencedirect.com/science/article/pii/S1535610825002612
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

1
1. scibot 04 Jul 2025
  
  in Public
  
  CVCL_1517
  
  DOI: 10.1158/0008-5472.CAN-23-3256
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @sonofthor
  
  SciCrunch record: RRID:CVCL_1517
  
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  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
Jun 2025
www.sciencedirect.com www.sciencedirect.com

PLK1-mediated PDHA1 phosphorylation drives mitochondrial dysfunction, mitophagy, and cancer progression in Cr(VI)-associated lung cancer

1
1. scibot 24 Jun 2025
  
  in Public
  
  CVCL_1517
  
  DOI: 10.1016/j.jbc.2025.110406
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1517
  
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  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

sciencedirect.com/science/article/pii/S0021925825022562
Apr 2025
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 13 Apr 2025
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1158/0008-5472.can-24-3481
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @sjvitug
  
  SciCrunch record: RRID:CVCL_1517
  
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  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

52.53.155.43/4e618aba3cd65bbf93907d966435a11f880c620c/PDF-html.html
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Impact of Co-mutations and Transcriptional Signatures in Non–Small Cell Lung Cancer Patients Treated with Adagrasib in the KRYSTAL-1 Trial

1
1. scibot 19 Mar 2025
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1158/1078-0432.CCR-24-2310
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1517
  
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  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11911804/
Feb 2025
aacrjournals.org aacrjournals.org

TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma

1
1. scibot 13 Feb 2025
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1158/0008-5472.CAN-22-3009
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1517
  
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  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models

1
1. scibot 07 Feb 2025
  
  in Public
  
  CVCL_1517
  
  DOI: 10.1158/2767-9764.CRC-24-0411
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:CVCL_1517
  
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  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11795354/
Jul 2024
onlinelibrary.wiley.com onlinelibrary.wiley.com

Novel ectopic expression of zona pellucida 3 glycoprotein in lung cancer promotes tumor growth

1
1. scibot 30 Jul 2024
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1002/ijc.35098
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1517
  
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  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

onlinelibrary.wiley.com/doi/full/10.1002/ijc.35098
May 2024
www.sciencedirect.com www.sciencedirect.com

Genetic dependencies associated with transcription factor activities in human cancer cell lines

1
1. scibot 01 May 2024
  
  in Public
  
  CRL-5914
  
  DOI: 10.1016/j.celrep.2024.114175
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @abever99
  
  SciCrunch record: RRID:CVCL_1517
  
  What is this?
  
  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

sciencedirect.com/science/article/pii/S2211124724005035
Nov 2023
onlinelibrary.wiley.com onlinelibrary.wiley.com

Fast proliferating and slowly migrating non-small cell lung cancer cells are vulnerable to decitabine and retinoic acid combinatorial treatment

1
1. scibot 12 Nov 2023
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1002/ijc.34783
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1517
  
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  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

onlinelibrary.wiley.com/doi/10.1002/ijc.34783
Jul 2023
www.nature.com www.nature.com

MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5

1
1. scibot 06 Jul 2023
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1038/s41389-023-00478-y
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1517
  
  What is this?
  
  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

nature.com/articles/s41389-023-00478-y
Jun 2023
52.53.155.43 52.53.155.43

can-22-3009-html.html

1
1. scibot 30 Jun 2023
  
  in Public
  
  CVCL_1517
  
  DOI: 10.1158/0008-5472.can-22-3009
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1517
  
  What is this?
  
  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

52.53.155.43/23465825fc5c1614cd30949f4c30491df07cc998/can-22-3009-html.html
Sep 2022
www.sciencedirect.com www.sciencedirect.com

MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

1
1. scibot 24 Sep 2022
  
  in Public
  
  CRL-5914
  
  DOI: 10.1016/j.ccell.2022.08.015
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:CVCL_1517
  
  What is this?
  
  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

sciencedirect.com/science/article/pii/S1535610822003798
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

1
1. scibot 23 Aug 2022
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1016/j.molcel.2022.07.014
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1517
  
  What is this?
  
  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

sciencedirect.com/science/article/pii/S1097276522007109
Aug 2021
www.sciencedirect.com www.sciencedirect.com

RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer

1
1. scibot 01 Aug 2021
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1016/j.chembiol.2019.12.005
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1517
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1517
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RRIDCUR:Validated

RRID:CVCL_1517

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scibot

URL

sciencedirect.com/science/article/pii/S2451945619304015
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

1
1. scibot 31 Jul 2021
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1016/j.cmet.2019.01.020
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1517
  
  What is this?
  
  RRID:CVCL_1517 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_1517

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scibot

URL

sciencedirect.com/science/article/pii/S1550413119300208
www.sciencedirect.com www.sciencedirect.com

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

1
1. scibot 30 Jul 2021
  
  in Public
  
  NCI-H2030
  
  DOI: 10.1016/j.celrep.2019.08.090
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1517
  
  What is this?
  
  RRIDCUR:Missing RRID:CVCL_1517
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RRID:CVCL_1517

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2211124719311520
www.sciencedirect.com www.sciencedirect.com

Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

1
1. scibot 29 Jul 2021
  
  in Public
  
  RRID: CVCL_1517
  
  DOI: 10.1016/j.cmet.2019.11.012
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1517
  
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  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

sciencedirect.com/science/article/pii/S1550413119306199
Jun 2021
www.nature.com www.nature.com

Pericentromeric Satellite III transcripts induce etoposide resistance

1
1. scibot 02 Jun 2021
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1038/s41419-021-03810-9
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1517
  
  What is this?
  
  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

nature.com/articles/s41419-021-03810-9
May 2021
www.sciencedirect.com www.sciencedirect.com

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

1
1. scibot 07 May 2021
  
  in Public
  
  CVCL_1517
  
  DOI: 10.1016/j.molcel.2020.10.010
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1517
  
  What is this?
  
  RRID:CVCL_1517
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RRID:CVCL_1517

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scibot

URL

sciencedirect.com/science/article/pii/S1097276520306936
Oct 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma

1
1. scibot 27 Oct 2020
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.7554/eLife.58108
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1517
  
  What is this?
  
  RRID:CVCL_1517 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_1517

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7556868/
Sep 2020
www.sciencedirect.com www.sciencedirect.com

A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers

1
1. scibot 14 Sep 2020
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1016/j.ccell.2020.03.004
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1517
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1517
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RRIDCUR:Validated

RRID:CVCL_1517

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scibot

URL

sciencedirect.com/science/article/pii/S1535610820301057
www.sciencedirect.com www.sciencedirect.com

Defining and Targeting Adaptations to Oncogenic KRASG12C Inhibition Using Quantitative Temporal Proteomics

1
1. scibot 04 Sep 2020
  
  in Public
  
  H2030
  
  DOI: 10.1016/j.celrep.2020.03.021
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1517
  
  What is this?
  
  RRID:CVCL_1517 RRIDCUR:Missing
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RRID:CVCL_1517

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720303284
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:CVCL_1517
  
  DOI: 10.1016/j.cmet.2019.01.020
  
  Resource: (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1517
  
  What is this?
  
  RRID:CVCL_1517 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_1517

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scibot

URL

sciencedirect.com/science/article/pii/S1550413119300208
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

1
1. scibot 05 Nov 2018
  
  in Public
  
  CRL-5914
  
  Curator: @Jmenke
  
  Resource used:
  
  (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  SciCrunch record: RRID:CVCL_1517
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1517 RRIDCUR:Missing
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RRID:CVCL_1517

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1535610818303696
www.sciencedirect.com www.sciencedirect.com

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

1
1. scibot 05 Nov 2018
  
  in Public
  
  CRL-5914
  
  Curator: @Jmenke
  
  Resource used:
  
  (ATCC Cat# CRL-5914, RRID:CVCL_1517)
  
  SciCrunch record: RRID:CVCL_1517
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1517 RRIDCUR:Missing
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RRID:CVCL_1517

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S0092867418300412