95 Matching Annotations
  1. Aug 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting the CHD3 chromatin remodeler exploits a synthetic lethal vulnerability in dual SMARCA4/SMARCA2-deficient cancers via derepression of PARD3B
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    pmc.ncbi.nlm.nih.gov/articles/PMC13469703/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Virtual Tumors Enable Prediction of Personalized Therapeutic Combinations for Non-Small Cell Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC7619348/
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    Targeting PKM2 and GAPDH by Baicalein and Corilagin from TCM Reduces Lactylation and Enhance Cisplatin Sensitivity in Lung Cancer
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    sciencedirect.com/science/article/pii/S0944711326009220
  5. Jul 2026
  6. 54.241.53.176 54.241.53.176
    MTFR2 promotes VDAC1 oligomerization to reprogram BCAA metabolism in tumor cells to polarize TAMs in LUAD
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    54.241.53.176/05086ace4c7a9d30ef1a5082d0bfcf0e99f62e65/s41419-026-08871-2_reference-html.html
  7. www.nature.com www.nature.com
    Amphiregulin-mediated EGFR activation drives both intrinsic and acquired resistance to KRAS G12C inhibitors in KRAS G12C–mutant non-small cell lung cancer
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    nature.com/articles/s41388-026-03877-8
  8. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70290
  9. Jun 2026
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional genomic analysis reveals HAVCR1 as the key regulator of 5q33.3 locus linked to hyperlipidemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC13262158/
  11. May 2026
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lipid Composition Alters Ferroptosis Sensitivity
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    pmc.ncbi.nlm.nih.gov/articles/PMC13138121/
  13. Apr 2026
  14. aacrjournals.org aacrjournals.org
    Identification and non-clinical characterization of SAR444200, a novel anti-GPC3 NANOBODY® T-cell engager, for the treatment of GPC3+ solid tumors
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    aacrjournals.org/mct/article/25/3/361/774799/Identification-and-Nonclinical-Characterization-of
  15. Mar 2026
  16. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    E2A selectively regulates TGF-β–induced apoptosis in KRAS-mutant non-small cell lung cancer
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70236
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    S6K1 Modulates STAT3 Activation to Promote Resistance to Radiotherapy in Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12940830/
  18. Feb 2026
  19. www.biorxiv.org www.biorxiv.org
    Systematic functional drug testing in patient-derived models reveals ex vivo sensitivities associated with clinical outcome in rare solid tumors
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    biorxiv.org/content/10.64898/2026.02.18.705724v1
  20. www.sciencedirect.com www.sciencedirect.com
    Dual PD-1/IL-2Rα targeting restores CD8+ T cell fitness via STAT5/CD47 axis in SMARCA4-deficient NSCLC
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    sciencedirect.com/science/article/pii/S2666379126000509
  21. Jan 2026
  22. www.sciencedirect.com www.sciencedirect.com
    Mitigating tumor heterogeneity in lung Cancer: A dual-targeted NIR-II imaging strategy for accurate tumor localization and intraoperative navigation
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    sciencedirect.com/science/article/pii/S0304383526000042
  23. Dec 2025
  24. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Study of the blood–brain barrier-penetrating KRAS G12C inhibitor JMKX1899 in KRAS G12C-mutated NSCLC with brain metastases
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    sciencedirect.com:5037/science/article/pii/S266700542500122X
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Impact of MEK inhibition on T-cell infiltration and function after radiotherapy in KRAS-mutant lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12682748/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Monounsaturated Fatty Acid Metabolism for Radiosensitization of KRAS Mutant 3D Lung Cancer Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC12137014/
  27. Nov 2025
  28. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510733
  29. Oct 2025
  30. www.sciencedirect.com www.sciencedirect.com
    Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties
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    sciencedirect.com/science/article/pii/S2666379125004847
  31. Sep 2025
  32. 52.53.155.43 52.53.155.43
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  33. Aug 2025
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Smoking carcinogen induced inflammation promotes lung carcinogenesis via IRAK4 activation
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    USP8 deubiquitylation-boosted NSUN4 potentiates lung squamous cell carcinoma progression by m5C methylation of DHCR24
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    sciencedirect.com/science/article/pii/S1535610825003101
  37. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FBXW5 Promotes Epithelial-Mesenchymal Transition in Lung Adenocarcinoma Through the KLF13/TROAP Signaling Pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.70018
  38. Jul 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
  40. Jun 2025
  41. 52.53.155.43 52.53.155.43
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  42. cancer-nano.biomedcentral.com cancer-nano.biomedcentral.com
    Exosomal encapsulation of a steviol derivative SD9 to overcome TRAIL resistance as a highly effective therapy against lung cancer
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    cancer-nano.biomedcentral.com/articles/10.1186/s12645-025-00329-y
  43. 52.53.155.43 52.53.155.43
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  44. May 2025
  45. www.sciencedirect.com www.sciencedirect.com
    MYC plus class IIa HDAC inhibition drives mitochondrial dysfunction in non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S2211124725004930
  46. Mar 2025
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Impact of Co-mutations and Transcriptional Signatures in Non–Small Cell Lung Cancer Patients Treated with Adagrasib in the KRYSTAL-1 Trial
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    pmc.ncbi.nlm.nih.gov/articles/PMC11911804/
  48. Feb 2025
  49. www.sciencedirect.com www.sciencedirect.com
    TGF-β1-mediated intercellular signaling fuels cooperative cellular invasion
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  50. aacrjournals.org aacrjournals.org
    TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma
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    aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC11795354/
  52. Jan 2025
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11668523/
  54. Dec 2024
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography
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    pmc.ncbi.nlm.nih.gov/articles/PMC11652680/
  56. Sep 2024
  57. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FHL2 expression by cancer-associated fibroblasts promotes metastasis and angiogenesis in lung adenocarcinoma
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35174
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11365971/
  59. Aug 2024
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HTS384 NCI60: The Next Phase of the NCI60 Screen
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    ncbi.nlm.nih.gov/pmc/articles/PMC11292194/
  61. Jul 2024
  62. iubmb.onlinelibrary.wiley.com iubmb.onlinelibrary.wiley.com
    The flavonoid quercetin decreases ACE2 and TMPRSS2 expression but not SARS-CoV-2 infection in cultured human lung cells
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    iubmb.onlinelibrary.wiley.com/doi/10.1002/biof.2084
  63. May 2024
  64. www.sciencedirect.com www.sciencedirect.com
    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    sciencedirect.com/science/article/pii/S2666379124002702
  65. www.sciencedirect.com www.sciencedirect.com
    Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers
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    sciencedirect.com/science/article/pii/S1097276524003241
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
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    ncbi.nlm.nih.gov/pmc/articles/PMC11094420/
  67. Apr 2024
  68. www.sciencedirect.com www.sciencedirect.com
    NECTIN2 is a prognostic biomarker and potential therapeutic target in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2212534524000558
  69. Mar 2024
  70. www.sciencedirect.com www.sciencedirect.com
    Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
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    sciencedirect.com/science/article/pii/S2451945624000874
  71. Feb 2024
  72. www.biorxiv.org www.biorxiv.org
    A common druggable signature of oncogenic CMYC, mutant KRAS and mutant p53 reveals functional redundancy and competition of the oncogenes in cancer
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    biorxiv.org/content/10.1101/2023.12.20.572548v1
  73. Jan 2024
  74. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FBXL16 promotes cell growth and drug resistance in lung adenocarcinomas with KRAS mutation by stabilizing IRS1 and upregulating IRS1/AKT signaling
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13554
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Simplified Synthesis of Renieramycin T Derivatives to Target Cancer Stem Cells via β-Catenin Proteasomal Degradation in Human Lung Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10744608/
  76. Dec 2023
  77. www.sciencedirect.com www.sciencedirect.com
    G-quadruplex is critical to epigenetic activation of the lncRNA HOTAIR in cancer cells
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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATM mutations associate with distinct co-mutational patterns and therapeutic vulnerabilities in NSCLC
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  79. 52.53.155.43 52.53.155.43
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  80. Nov 2023
  81. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Fast proliferating and slowly migrating non-small cell lung cancer cells are vulnerable to decitabine and retinoic acid combinatorial treatment
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34783
  82. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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  83. www.sciencedirect.com www.sciencedirect.com
    Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers
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    sciencedirect.com/science/article/pii/S1074761323004181
  84. Oct 2023
  85. 52.53.155.43 52.53.155.43
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmacological Ascorbate Elicits Anti-Cancer Activities against Non-Small Cell Lung Cancer through Hydrogen-Peroxide-Induced-DNA-Damage
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    ncbi.nlm.nih.gov/pmc/articles/PMC10525775/
  87. Sep 2023
  88. 52.53.155.43 52.53.155.43
    Molecular Oncology - 2023 - Horie-html.html
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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor
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    ncbi.nlm.nih.gov/pmc/articles/PMC10473160/
  90. Jul 2023
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC9938728/
  92. www.nature.com www.nature.com
    MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5
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    nature.com/articles/s41389-023-00478-y
  93. Jun 2023
  94. 52.53.155.43 52.53.155.43
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    Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells
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  96. www.mdpi.com www.mdpi.com
    Ectopically Expressed Meiosis-Specific Cancer Testis Antigen HORMAD1 Promotes Genomic Instability in Squamous Cell Carcinomas
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    mdpi.com/2073-4409/12/12/1627
  97. Sep 2022
  98. www.sciencedirect.com www.sciencedirect.com
    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
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    MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer
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    sciencedirect.com/science/article/pii/S1535610822003798
  100. May 2022
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    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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  102. Apr 2022
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    Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes
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  104. Mar 2022
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases
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    ncbi.nlm.nih.gov/pmc/articles/PMC8919295/
  106. Nov 2021
  107. www.sciencedirect.com www.sciencedirect.com
    HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6
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    sciencedirect.com/science/article/pii/S2589004221013146
  108. Aug 2021
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8337080/
  110. Jul 2021
  111. www.sciencedirect.com www.sciencedirect.com
    Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers
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    Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma
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    sciencedirect.com/science/article/pii/S1535610819303290
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    BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis
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    sciencedirect.com/science/article/pii/S0092867419306336
  114. www.sciencedirect.com www.sciencedirect.com
    Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
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    sciencedirect.com/science/article/pii/S1550413119303171
  115. www.mdpi.com www.mdpi.com
    Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor
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    mdpi.com/2218-273X/9/7/280/htm
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness
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    ncbi.nlm.nih.gov/pmc/articles/PMC8266391/
  117. Jun 2021
  118. www.sciencedirect.com www.sciencedirect.com
    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    sciencedirect.com/science/article/pii/S2211124721006628
  119. May 2021
  120. www.sciencedirect.com www.sciencedirect.com
    3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis
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    sciencedirect.com/science/article/pii/S1097276520306936
  121. Mar 2021
  122. www.sciencedirect.com www.sciencedirect.com
    MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity
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    sciencedirect.com/science/article/pii/S2211124721001224
  123. Sep 2020
  124. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    HSPA2 Chaperone Contributes to the Maintenance of Epithelial Phenotype of Human Bronchial Epithelial Cells but Has Non-Essential Role in Supporting Malignant Features of Non-Small Cell Lung Carcinoma, MCF7, and HeLa Cancer Cells
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    Methylation Patterns and Chromatin Accessibility in Neuroendocrine Lung Cancer
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  126. www.sciencedirect.com www.sciencedirect.com
    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
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    Structure–Activity Relationships and Molecular Docking Analysis of Mcl-1 Targeting Renieramycin T Analogues in Patient-derived Lung Cancer Cells
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    Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma
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  129. www.sciencedirect.com www.sciencedirect.com
    KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer
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  130. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Identification and Target-Modification of SL-BBI: A Novel Bowman–Birk Type Trypsin Inhibitor from Sylvirana latouchii
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  131. Jan 2020
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    Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids
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    MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network
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  135. Nov 2018
  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target
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    Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS
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    Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor
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    Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance
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  140. Nov 2017
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    TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells
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  142. www.sciencedirect.com www.sciencedirect.com
    O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate
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