89 Matching Annotations
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    Functional genomic analysis reveals HAVCR1 as the key regulator of 5q33.3 locus linked to hyperlipidemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC13262158/
  3. May 2026
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    Lipid Composition Alters Ferroptosis Sensitivity
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  5. Apr 2026
  6. aacrjournals.org aacrjournals.org
    Identification and non-clinical characterization of SAR444200, a novel anti-GPC3 NANOBODY® T-cell engager, for the treatment of GPC3+ solid tumors
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  7. Mar 2026
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    E2A selectively regulates TGF-β–induced apoptosis in KRAS-mutant non-small cell lung cancer
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70236
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    S6K1 Modulates STAT3 Activation to Promote Resistance to Radiotherapy in Lung Cancer
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  10. Feb 2026
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    Systematic functional drug testing in patient-derived models reveals ex vivo sensitivities associated with clinical outcome in rare solid tumors
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    biorxiv.org/content/10.64898/2026.02.18.705724v1
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    Dual PD-1/IL-2Rα targeting restores CD8+ T cell fitness via STAT5/CD47 axis in SMARCA4-deficient NSCLC
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  13. Jan 2026
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    Mitigating tumor heterogeneity in lung Cancer: A dual-targeted NIR-II imaging strategy for accurate tumor localization and intraoperative navigation
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  15. Dec 2025
  16. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Study of the blood–brain barrier-penetrating KRAS G12C inhibitor JMKX1899 in KRAS G12C-mutated NSCLC with brain metastases
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    Impact of MEK inhibition on T-cell infiltration and function after radiotherapy in KRAS-mutant lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12682748/
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    Targeting Monounsaturated Fatty Acid Metabolism for Radiosensitization of KRAS Mutant 3D Lung Cancer Models
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  19. Nov 2025
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    Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma
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  21. Oct 2025
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    Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties
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  23. Sep 2025
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  25. Aug 2025
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    Smoking carcinogen induced inflammation promotes lung carcinogenesis via IRAK4 activation
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    USP8 deubiquitylation-boosted NSUN4 potentiates lung squamous cell carcinoma progression by m5C methylation of DHCR24
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    FBXW5 Promotes Epithelial-Mesenchymal Transition in Lung Adenocarcinoma Through the KLF13/TROAP Signaling Pathway
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  30. Jul 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma
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  32. Jun 2025
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    Exosomal encapsulation of a steviol derivative SD9 to overcome TRAIL resistance as a highly effective therapy against lung cancer
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  36. May 2025
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    MYC plus class IIa HDAC inhibition drives mitochondrial dysfunction in non-small cell lung cancer
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  38. Mar 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Impact of Co-mutations and Transcriptional Signatures in Non–Small Cell Lung Cancer Patients Treated with Adagrasib in the KRYSTAL-1 Trial
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  40. Feb 2025
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    TGF-β1-mediated intercellular signaling fuels cooperative cellular invasion
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    TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma
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    The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
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  44. Jan 2025
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2
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  46. Dec 2024
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography
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  48. Sep 2024
  49. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FHL2 expression by cancer-associated fibroblasts promotes metastasis and angiogenesis in lung adenocarcinoma
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    A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancer
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  51. Aug 2024
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    HTS384 NCI60: The Next Phase of the NCI60 Screen
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  53. Jul 2024
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    The flavonoid quercetin decreases ACE2 and TMPRSS2 expression but not SARS-CoV-2 infection in cultured human lung cells
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  55. May 2024
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    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers
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    Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
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  59. Apr 2024
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    NECTIN2 is a prognostic biomarker and potential therapeutic target in lung adenocarcinoma
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  61. Mar 2024
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    Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
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  63. Feb 2024
  64. www.biorxiv.org www.biorxiv.org
    A common druggable signature of oncogenic CMYC, mutant KRAS and mutant p53 reveals functional redundancy and competition of the oncogenes in cancer
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  65. Jan 2024
  66. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FBXL16 promotes cell growth and drug resistance in lung adenocarcinomas with KRAS mutation by stabilizing IRS1 and upregulating IRS1/AKT signaling
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    Simplified Synthesis of Renieramycin T Derivatives to Target Cancer Stem Cells via β-Catenin Proteasomal Degradation in Human Lung Cancer
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  68. Dec 2023
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    G-quadruplex is critical to epigenetic activation of the lncRNA HOTAIR in cancer cells
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    ATM mutations associate with distinct co-mutational patterns and therapeutic vulnerabilities in NSCLC
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  72. Nov 2023
  73. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Fast proliferating and slowly migrating non-small cell lung cancer cells are vulnerable to decitabine and retinoic acid combinatorial treatment
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    Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers
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  76. Oct 2023
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    Pharmacological Ascorbate Elicits Anti-Cancer Activities against Non-Small Cell Lung Cancer through Hydrogen-Peroxide-Induced-DNA-Damage
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  79. Sep 2023
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    Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor
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  82. Jul 2023
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    Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
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    MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5
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  85. Jun 2023
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    Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells
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    Ectopically Expressed Meiosis-Specific Cancer Testis Antigen HORMAD1 Promotes Genomic Instability in Squamous Cell Carcinomas
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  89. Sep 2022
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    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
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    MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer
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  92. May 2022
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    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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  94. Apr 2022
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    Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes
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  96. Mar 2022
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    Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases
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  98. Nov 2021
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    HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6
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  100. Aug 2021
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    Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer
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  102. Jul 2021
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    Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers
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    Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma
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    BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis
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    Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
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    Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor
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    Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness
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  109. Jun 2021
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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  111. May 2021
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    3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis
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  113. Mar 2021
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    MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity
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  115. Sep 2020
  116. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    HSPA2 Chaperone Contributes to the Maintenance of Epithelial Phenotype of Human Bronchial Epithelial Cells but Has Non-Essential Role in Supporting Malignant Features of Non-Small Cell Lung Carcinoma, MCF7, and HeLa Cancer Cells
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    Methylation Patterns and Chromatin Accessibility in Neuroendocrine Lung Cancer
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    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
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    Structure–Activity Relationships and Molecular Docking Analysis of Mcl-1 Targeting Renieramycin T Analogues in Patient-derived Lung Cancer Cells
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    Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma
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    KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer
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  122. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Identification and Target-Modification of SL-BBI: A Novel Bowman–Birk Type Trypsin Inhibitor from Sylvirana latouchii
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  123. Jan 2020
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    Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids
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    MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network
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  127. Nov 2018
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    Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target
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    Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS
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    Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor
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    Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance
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  132. Nov 2017
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    TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells
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    O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate
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