119 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PKN2 is a dependency of the mesenchymal-like cancer cell state
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875962/
  3. Aug 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Smoking carcinogen induced inflammation promotes lung carcinogenesis via IRAK4 activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11832316/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Evaluation of DB-1419, a Novel Bifunctional and Bispecific Anti–B7-H3 × PD-L1 Antibody–Drug Conjugate
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    pmc.ncbi.nlm.nih.gov/articles/PMC12351279/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617988/
  7. www.sciencedirect.com www.sciencedirect.com
    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    sciencedirect.com/science/article/pii/S1535610825003101
  8. Jul 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Utility of CK8/18 in identifying circulating tumor cells derived from lesions in patients with non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12261347/
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    RANKL/PD-1 dual blockade demonstrates survival benefit for patients with advanced lung adenocarcinoma harboring KRAS mutations
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    sciencedirect.com/science/article/pii/S2666379125003088
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    KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S1535610825002612
  12. www.science.org www.science.org
    Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses
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    science.org/doi/10.1126/sciimmunol.adr1105
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
  14. Jun 2025
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    A first-in-class EGFR-directed KRAS G12V selective inhibitor
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    sciencedirect.com/science/article/pii/S1535610825002259
  16. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/bbb28230632658450b2bbad03fe0ee90e846e4ab/PDF-html.html
  17. May 2025
  18. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225010090-main-html.html
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  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312
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    pmc.ncbi.nlm.nih.gov/articles/PMC12076188/
  20. Apr 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S2589004225006480-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12063144/
  22. www.sciencedirect.com www.sciencedirect.com
    Combined inhibition of hexokinase 2 and pyruvate dehydrogenase surmounts SHP2 inhibitor resistance in non-small cell lung cancer with hybrid metabolic state harboring KRAS Q61H mutation
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    sciencedirect.com/science/article/pii/S0925443925002042
  23. Mar 2025
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    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S1097276525001947
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Impact of Co-mutations and Transcriptional Signatures in Non–Small Cell Lung Cancer Patients Treated with Adagrasib in the KRYSTAL-1 Trial
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    pmc.ncbi.nlm.nih.gov/articles/PMC11911804/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape
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    pmc.ncbi.nlm.nih.gov/articles/PMC11832170/
  27. Feb 2025
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oncogenic mutant KRAS inhibition through oxidation at cysteine 118
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    pmc.ncbi.nlm.nih.gov/articles/PMC11793020/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11821485/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC11795354/
  31. Jan 2025
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C–MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies
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    pmc.ncbi.nlm.nih.gov/articles/PMC11733532/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Efficacy of CBP/p300 Dual Inhibitors against De-repression of KREMEN2 in cBAF-Deficient Cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC11701801/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11668523/
  35. Dec 2024
  36. www.nature.com www.nature.com
    Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
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    nature.com/articles/s41418-024-01439-7
  37. 52.53.155.43 52.53.155.43
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  38. Oct 2024
  39. www.sciencedirect.com www.sciencedirect.com
    Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer
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    sciencedirect.com/science/article/pii/S2451945624003969
  40. Aug 2024
  41. www.pnas.org www.pnas.org
    Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer
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    pnas.org/doi/10.1073/pnas.2319429121
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic alterations predict poor efficacy, outcomes and resistance to second-line osimertinib treatment in non-small cell lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10839301/
  43. May 2024
  44. www.sciencedirect.com www.sciencedirect.com
    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    sciencedirect.com/science/article/pii/S2666379124002702
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergy of EGFR and AURKA Inhibitors in KRAS-mutated Non–small Cell Lung Cancers
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    ncbi.nlm.nih.gov/pmc/articles/PMC11078142/
  46. Apr 2024
  47. aacrjournals.org aacrjournals.org
    The immune suppressor IGSF1 as a potential target for cancer immunotherapy
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    aacrjournals.org/cancerimmunolres/article/12/4/491/741941/The-Immune-Suppressor-IGSF1-as-a-Potential-Target
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    A novel cancer-germline gene DAZL promotes progression and cisplatin resistance of non-small cell lung cancer by upregulating JAK2 and MCM8
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    sciencedirect.com/science/article/pii/S0378111924003305
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse
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    ncbi.nlm.nih.gov/pmc/articles/PMC10983104/
  50. Mar 2024
  51. www.sciencedirect.com www.sciencedirect.com
    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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    sciencedirect.com/science/article/pii/S1097276524001801
  52. Feb 2024
  53. aacrjournals.org aacrjournals.org
    First-in-Human Study with preclinical data of BCL-2/BCL-xL Inhibitor Pelcitoclax in Locally Advanced or Metastatic Solid Tumors
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    aacrjournals.org/clincancerres/article/30/3/506/733551/First-in-Human-Study-with-Preclinical-Data-of-BCL
  54. 52.53.155.43 52.53.155.43
    An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
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    52.53.155.43/d64025fcba7405c73976a9e0dc65e9989e0d835f/2023.08.23.554263v1.full-html.html
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    Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR
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    sciencedirect.com/science/article/pii/S1534580724000303
  56. Jan 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Griseofulvin Radiosensitizes Non-Small Cell Lung Cancer Cells and Activates cGAS
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    ncbi.nlm.nih.gov/pmc/articles/PMC10073282/
  58. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FBXL16 promotes cell growth and drug resistance in lung adenocarcinomas with KRAS mutation by stabilizing IRS1 and upregulating IRS1/AKT signaling
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13554
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    UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas
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    sciencedirect.com/science/article/pii/S2666379123006109
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucose Deprivation Promotes Pseudohypoxia and Dedifferentiation in Lung Adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10790128/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ modeling of acquired resistance to RTK/RAS pathway targeted therapies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10788224/
  62. www.mdpi.com www.mdpi.com
    β-Caryophyllene Inhibits Endothelial Tube Formation by Modulating the Secretome of Hypoxic Lung Cancer Cells—Possible Role of VEGF Downregulation
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    mdpi.com/1422-0067/25/2/810
  63. Dec 2023
  64. www.sciencedirect.com www.sciencedirect.com
    Phosphoprotein dynamics of interacting T cells and tumor cells by HySic
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    sciencedirect.com/science/article/pii/S2211124723016108
  65. Nov 2023
  66. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13505
  67. Oct 2023
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antiangiogenic Action of JZL184 on Endothelial Cells via Inhibition of VEGF Expression in Hypoxic Lung Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10572003/
  69. www.cell.com www.cell.com
    PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C
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    cell.com/cell-reports/fulltext/S2211-1247(23)01052-5
  70. Sep 2023
  71. www.sciencedirect.com www.sciencedirect.com
    A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants
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    sciencedirect.com/science/article/pii/S2211124723011154
  72. Jul 2023
  73. www.nature.com www.nature.com
    MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5
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    nature.com/articles/s41389-023-00478-y
  74. www.mdpi.com www.mdpi.com
    Inhibition of Monoacylglycerol Lipase Decreases Angiogenic Features of Endothelial Cells via Release of Tissue Inhibitor of Metalloproteinase-1 from Lung Cancer Cells
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    mdpi.com/2073-4409/12/13/1757
  75. Jun 2023
  76. www.sciencedirect.com www.sciencedirect.com
    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    sciencedirect.com/science/article/pii/S030438352300215X
  77. Apr 2023
  78. www.mdpi.com www.mdpi.com
    TEAD Inhibitors Sensitize KRASG12C Inhibitors via Dual Cell Cycle Arrest in KRASG12C-Mutant NSCLC
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    mdpi.com/1424-8247/16/4/553
  79. Feb 2023
  80. www.sciencedirect.com www.sciencedirect.com
    Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target
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    sciencedirect.com/science/article/pii/S2589004223001578
  81. Jan 2023
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AZD4625 is a Potent and Selective Inhibitor of KRASG12C
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    ncbi.nlm.nih.gov/pmc/articles/PMC9538594/
  83. aacrjournals.org aacrjournals.org
    Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
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    aacrjournals.org/cancerdiscovery/article/12/8/1942/707227/Enhancing-PD-L1-Degradation-by-ITCH-during-MAPK
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRC2 Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1 Targeted Therapy via Enhanced Viral Mimicry
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    ncbi.nlm.nih.gov/pmc/articles/PMC9437570/
  85. Dec 2022
  86. www.sciencedirect.com www.sciencedirect.com
    EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer
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    sciencedirect.com/science/article/pii/S2211124722017193
  87. Nov 2022
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel P53 Nanomedicine Reduces Immunosuppression and Augments Anti-PD-1 Therapy for Non-Small Cell Lung Cancer in Syngeneic Mouse Models
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    ncbi.nlm.nih.gov/pmc/articles/PMC9654894/
  89. Sep 2022
  90. www.sciencedirect.com www.sciencedirect.com
    MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer
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    sciencedirect.com/science/article/pii/S1535610822003798
  91. Aug 2022
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  93. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cancer-associated fibroblasts in nonsmall cell lung cancer: From molecular mechanisms to clinical implications
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34127
  94. Jul 2022
  95. link.springer.com link.springer.com
    Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage
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    link.springer.com/article/10.1007/s00018-022-04453-5
  96. www.sciencedirect.com www.sciencedirect.com
    FoxA1 and FoxA2 control growth and cellular identity in NKX2-1-positive lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S1534580722004580
  97. Mar 2022
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases
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    ncbi.nlm.nih.gov/pmc/articles/PMC8919295/
  99. Feb 2022
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LncRNA FENDRR-mediated tumor suppression and tumor-immune microenvironment changes in non-small cell lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8797579/
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased efficacy of gefitinib on cisplatin-resistant wild-type epidermal growth factor receptor non-small cell lung cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8798197/
  102. Jan 2022
  103. www.sciencedirect.com www.sciencedirect.com
    MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
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    sciencedirect.com/science/article/pii/S1535610821006620
  104. Dec 2021
  105. crc.aacrjournals.org crc.aacrjournals.org
    The ADAM17-directed Inhibitory Antibody MEDI3622 Antagonizes Radiotherapy-induced VEGF Release and Sensitizes Non–Small Cell Lung Cancer for RadiotherapyADAM17-mediated Radioresistance
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    crc.aacrjournals.org/cancerrescommun/article/1/3/164/665523/The-ADAM17-directed-Inhibitory-Antibody-MEDI3622
  106. Nov 2021
  107. www.sciencedirect.com www.sciencedirect.com
    HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6
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    sciencedirect.com/science/article/pii/S2589004221013146
  108. www.sciencedirect.com www.sciencedirect.com
    FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124721013759
  109. Oct 2021
  110. www.sciencedirect.com www.sciencedirect.com
    ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells
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    sciencedirect.com/science/article/pii/S2211124721013504
  111. Sep 2021
  112. www.sciencedirect.com www.sciencedirect.com
    Oncogene-dependent sloppiness in mRNA translation
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    sciencedirect.com/science/article/pii/S109727652100736X
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lentiviral-driven discovery of cancer drug resistance mutations
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    ncbi.nlm.nih.gov/pmc/articles/PMC8448967/
  114. Aug 2021
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel ETV1 mutation in small cell lung cancer transformation resistant to EGFR tyrosine kinase inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC8350694/
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8337080/
  117. www.sciencedirect.com www.sciencedirect.com
    Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy
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    sciencedirect.com/science/article/pii/S1534580721005621
  118. www.sciencedirect.com www.sciencedirect.com
    The Cancer SENESCopedia: A delineation of cancer cell senescence
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    sciencedirect.com/science/article/pii/S2211124721008585
  119. www.sciencedirect.com www.sciencedirect.com
    RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer
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    sciencedirect.com/science/article/pii/S2451945619304015
  120. Jul 2021
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