Hypothesis

36 Matching Annotations

Oct 2025
www.sciencedirect.com www.sciencedirect.com

Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation

1
1. scibot 02 Oct 2025
  
  in Public
  
  DSMZACC 542
  
  DOI: 10.1016/j.celrep.2025.116379
  
  Resource: (RRID:CVCL_1609)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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scibot

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sciencedirect.com/science/article/pii/S2211124725011507
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

An isoform-specific RUNX1C–BTG2 axis governs AML quiescence and chemoresistance.

1
1. scibot 07 Sep 2025
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1158/2643-3230.BCD-24-0327
  
  Resource: (RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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pmc.ncbi.nlm.nih.gov/articles/PMC12405853/
Aug 2025
www.nature.com www.nature.com

The bispecific innate cell engager AFM28 eliminates CD123+ leukemic stem and progenitor cells in AML and MDS

1
1. scibot 27 Aug 2025
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1038/s41467-025-63069-y
  
  Resource: (RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

nature.com/articles/s41467-025-63069-y
May 2025
www.sciencedirect.com www.sciencedirect.com

Characterization and comparative analysis of multifunctional natural killer cell engagers during antitumor responses

1
1. scibot 16 May 2025
  
  in Public
  
  Cat# ACC 542
  
  DOI: 10.1016/j.xcrm.2025.102117
  
  Resource: (RRID:CVCL_1609)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

sciencedirect.com/science/article/pii/S2666379125001909
Feb 2025
www.sciencedirect.com www.sciencedirect.com

PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1

1
1. scibot 20 Feb 2025
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1016/j.stem.2025.01.010
  
  Resource: (RRID:CVCL_1609)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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scibot

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sciencedirect.com/science/article/pii/S1934590925000104
Dec 2024
www.sciencedirect.com www.sciencedirect.com

YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies

1
1. scibot 18 Dec 2024
  
  in Public
  
  CVCL_1609
  
  DOI: 10.1016/j.cell.2024.11.007
  
  Resource: (RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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scibot

URL

sciencedirect.com/science/article/pii/S0092867424013242
Aug 2024
www.cell.com www.cell.com

SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation

1
1. scibot 18 Aug 2024
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1016/j.celrep.2024.114536
  
  Resource: (RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

cell.com/cell-reports/fulltext/S2211-1247(24)00865-9
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling

1
1. scibot 17 Jul 2024
  
  in Public
  
  RRID: CVCL_1609
  
  DOI: 10.1016/j.xcrm.2024.101645
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @vtello
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC11293342/
Jun 2024
www.sciencedirect.com www.sciencedirect.com

A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML

1
1. scibot 06 Jun 2024
  
  in Public
  
  ACC 542
  
  DOI: 10.1016/j.xcrm.2024.101592
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @abever99
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

sciencedirect.com/science/article/pii/S2666379124002842
Nov 2023
www.sciencedirect.com www.sciencedirect.com

Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies

1
1. scibot 28 Nov 2023
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1016/j.ccell.2023.11.001
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

sciencedirect.com/science/article/pii/S1535610823003665
www.sciencedirect.com www.sciencedirect.com

Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML

1
1. scibot 22 Nov 2023
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1016/j.xcrm.2023.101290
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @olekpark
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

sciencedirect.com/science/article/pii/S2666379123004846
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Myeloid leukemia vulnerabilities embedded in long noncoding RNA locus MYNRL15

2
1. scibot 29 Sep 2023
  
  in Public
  
  CVCL_1609
  
  DOI: 10.1016/j.isci.2023.107844
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRID:CVCL_1609
2. scibot 29 Sep 2023
  
  in Public
  
  CVCL_1609
  
  DOI: 10.1016/j.isci.2023.107844
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10520325/
www.sciencedirect.com www.sciencedirect.com

Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment

1
1. scibot 16 Sep 2023
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1016/j.celrep.2023.113098
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

sciencedirect.com/science/article/pii/S2211124723011099
Jul 2023
52.53.155.43 52.53.155.43

Conditional lethality profiling reveals anticancer mechanisms of action and drug-nutrient interactions

1
1. scibot 19 Jul 2023
  
  in Public
  
  RRID:_CVCL_1609
  
  DOI: 10.1101/2023.06.04.543621
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @anisehay
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRIDCUR:Unresolved RRID:CVCL_1609
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RRID:CVCL_1609

RRIDCUR:Unresolved

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scibot

URL

52.53.155.43/402e9ae446be9d7677d004a8f8e22b2d6ac49df1/2023.06.04.543621v1.full-html.html
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells

1
1. scibot 10 Mar 2023
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1016/j.ccell.2023.02.010
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10466730/
www.sciencedirect.com www.sciencedirect.com

A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies

1
1. scibot 03 Mar 2023
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1016/j.xcrm.2023.100961
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

sciencedirect.com/science/article/pii/S2666379123000538
Jan 2023
www.sciencedirect.com www.sciencedirect.com

METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism

1
1. scibot 06 Jan 2023
  
  in Public
  
  RRID: CVCL_1609
  
  DOI: 10.1016/j.stem.2022.12.006
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

sciencedirect.com/science/article/pii/S1934590922004908
Oct 2022
www.cell.com www.cell.com

The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia

1
1. scibot 28 Oct 2022
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1016/j.ccell.2022.10.004
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

cell.com/cancer-cell/fulltext/S1535-6108(22)00495-0
Jul 2022
www.sciencedirect.com www.sciencedirect.com

Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle

1
1. scibot 30 Jul 2022
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1016/j.celrep.2022.111105
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

sciencedirect.com/science/article/pii/S221112472200907X
Jun 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Simple and Robust Single-Step Method for CAR-Vδ1 γδT Cell Expansion and Transduction for Cancer Immunotherapy

1
1. scibot 17 Jun 2022
  
  in Public
  
  CVCL_1609
  
  DOI: 10.3389/fimmu.2022.863155
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9197253/
Mar 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CDK6 Degradation Is Counteracted by p16INK4A and p18INK4C in AML

1
1. scibot 26 Mar 2022
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.3390/cancers14061554
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8946512/
Jan 2022
www.sciencedirect.com www.sciencedirect.com

SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia

1
1. scibot 12 Jan 2022
  
  in Public
  
  ACC 542
  
  DOI: 10.1016/j.celrep.2021.110233
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721017423
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

1
1. scibot 14 Aug 2021
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1016/j.ccell.2019.06.003
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

sciencedirect.com/science/article/pii/S1535610819302946
www.sciencedirect.com www.sciencedirect.com

ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency

1
1. scibot 07 Aug 2021
  
  in Public
  
  ACC-542
  
  DOI: 10.1016/j.molcel.2021.07.018
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRID:CVCL_1609 RRIDCUR:Missing
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RRID:CVCL_1609

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1097276521005876
Jul 2021
www.sciencedirect.com www.sciencedirect.com

A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia

1
1. scibot 31 Jul 2021
  
  in Public
  
  Human: NOMO1
  
  DOI: 10.1016/j.ccell.2019.11.001
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRID:CVCL_1609 RRIDCUR:Missing
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RRID:CVCL_1609

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1535610819305215
www.sciencedirect.com www.sciencedirect.com

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

1
1. scibot 29 Jul 2021
  
  in Public
  
  RRID: CVCL_1609
  
  DOI: 10.1016/j.ccell.2019.06.003
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

sciencedirect.com/science/article/pii/S1535610819302946
www.sciencedirect.com www.sciencedirect.com

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

1
1. scibot 27 Jul 2021
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1016/j.ccell.2018.05.007
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
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  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

sciencedirect.com/science/article/pii/S1535610818302216
Jun 2021
www.sciencedirect.com www.sciencedirect.com

ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia

1
1. scibot 03 Jun 2021
  
  in Public
  
  ACC542
  
  DOI: 10.1016/j.molcel.2021.05.008
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRID:CVCL_1609 RRIDCUR:Missing
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RRID:CVCL_1609

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1097276521003658
May 2021
www.sciencedirect.com www.sciencedirect.com

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

1
1. scibot 01 May 2021
  
  in Public
  
  CVCL_1609
  
  DOI: 10.1016/j.cmet.2021.02.005
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

sciencedirect.com/science/article/pii/S1550413121000619
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

1
1. scibot 17 Apr 2021
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1016/j.ccell.2020.04.017
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

sciencedirect.com/science/article/pii/S1535610820302166
Mar 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Reactive Oxygen Species Rewires Metabolic Activity in Acute Myeloid Leukemia

1
1. scibot 27 Mar 2021
  
  in Public
  
  CVCL_1609
  
  DOI: 10.3389/fonc.2021.632623
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1609
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RRID:CVCL_1609

RRIDCUR:Validated

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7993200/
Sep 2020
www.sciencedirect.com www.sciencedirect.com

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia

1
1. scibot 17 Sep 2020
  
  in Public
  
  RRID:CVCL_1609
  
  DOI: 10.1016/j.stem.2020.04.009
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRID:CVCL_1609 RRIDCUR:Validated
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RRID:CVCL_1609

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S193459092030148X
clincancerres.aacrjournals.org clincancerres.aacrjournals.org

5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.

1
1. scibot 04 Sep 2020
  
  in Public
  
  CVCL_1609
  
  DOI: 10.1158/1078-0432.CCR-19-1900
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRID:CVCL_1609
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RRID:CVCL_1609

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scibot

URL

clincancerres.aacrjournals.org/content/26/13/3371
www.sciencedirect.com www.sciencedirect.com

Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors

1
1. scibot 04 Sep 2020
  
  in Public
  
  NOMO1 (gender: female)
  
  DOI: 10.1016/j.chembiol.2020.02.003
  
  Resource: (DSMZ Cat# ACC-542, RRID:CVCL_1609)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1609
  
  What is this?
  
  RRID:CVCL_1609 RRIDCUR:Missing
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RRID:CVCL_1609

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2451945620300672
Nov 2018
www.sciencedirect.com www.sciencedirect.com

The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1097276518301084