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Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R-Loop Accumulation and DNA Repair Deficiencies

1
1. scibot 11 Dec 2025
  
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  RRID:CVCL_1724
  
  DOI: 10.1002/advs.202512074
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202512074
Nov 2025
www.sciencedirect.com www.sciencedirect.com

Fosl1 is a transcriptional effector of BRAFV600E-driven intestinal tumorigenesis

1
1. scibot 13 Nov 2025
  
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  ATCCCCL-231
  
  DOI: 10.1016/j.isci.2025.113875
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @areedewitt04
  
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sciencedirect.com/science/article/pii/S2589004225021364
Oct 2025
www.sciencedirect.com www.sciencedirect.com

Purinergic Ecto-Enzyme CD73 is a Context-Dependent Tumor Suppressor in Colorectal Cancer

1
1. scibot 28 Oct 2025
  
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  RRID: CVCL_1724
  
  DOI: 10.1016/j.jbc.2025.110864
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
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sciencedirect.com/science/article/pii/S0021925825027164
Sep 2025
www.sciencedirect.com www.sciencedirect.com

Identifying an optimal perturbation to induce a desired cell state by generative deep learning

1
1. scibot 25 Sep 2025
  
  in Public
  
  ATCCCat# CCL-231
  
  DOI: 10.1016/j.cels.2025.101405
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @areedewitt04
  
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sciencedirect.com/science/article/pii/S2405471225002388
Aug 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225016359-main-html.html

1
1. scibot 15 Aug 2025
  
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  ATCC Cat# CCL-231
  
  DOI: 10.1016/j.isci.2025.113374
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
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52.53.155.43/9a2f79ff613f8a45dec149de0e30ce9da180c6ca/1-s2.0-S2589004225016359-main-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells

1
1. scibot 07 Aug 2025
  
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  RRID:CVCL_1724
  
  DOI: 10.1038/s44320-025-00099-0
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12322234/
Jun 2025
www.cell.com www.cell.com

BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival

1
1. scibot 28 Jun 2025
  
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  CCL-231
  
  DOI: 10.1016/j.molcel.2025.05.035
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @sjvitug
  
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cell.com/molecular-cell/fulltext/S1097-2765(25)00499-X
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 12 Jun 2025
  
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  RRID:CVCL_1724
  
  DOI: 10.1158/2326-6066.cir-24-0137
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
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52.53.155.43/e9fe0912dd31f8e7ff03b2811eb8d2b4310b34d6/PDF-html.html
Apr 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225006649-main-html.html

1
1. scibot 17 Apr 2025
  
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  CVCL_1724
  
  DOI: 10.1016/j.isci.2025.112403
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
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52.53.155.43/869e4b9b9322674b551e8e0015c64383b52b9e33/1-s2.0-S2589004225006649-main-html.html
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair

1
1. scibot 19 Feb 2025
  
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  RRID:CVCL_1724
  
  DOI: 10.1158/0008-5472.CAN-24-0397
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11831107/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer

1
1. scibot 21 Dec 2024
  
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  RRID:CVCL_1724
  
  DOI: 10.1101/2024.02.20.581056
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1724
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
www.sciencedirect.com www.sciencedirect.com

EGFR-directed antibodies promote HER2 ADC internalization and efficacy

1
1. scibot 19 Dec 2024
  
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  ATCCCat#CCL-231
  
  DOI: 10.1016/j.xcrm.2024.101792
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724
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sciencedirect.com/science/article/pii/S2666379124005391
www.nature.com www.nature.com

The dysadherin/MMP9 axis modifies the extracellular matrix to accelerate colorectal cancer progression

1
1. scibot 03 Dec 2024
  
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  RRID:CVCL_1724
  
  DOI: 10.1038/s41467-024-54920-9
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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nature.com/articles/s41467-024-54920-9
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells

1
1. scibot 26 Sep 2024
  
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  CVCL_1724
  
  DOI: 10.1007/s00109-024-02479-9
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11416412/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

1
1. scibot 15 Sep 2024
  
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  RRID: CVCL_1724
  
  DOI: 10.1038/s41467-024-52176-x
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724
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ncbi.nlm.nih.gov/pmc/articles/PMC11385192/
Aug 2024
www.sciencedirect.com www.sciencedirect.com

RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4

1
1. scibot 22 Aug 2024
  
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  RRID:CVCL_1724
  
  DOI: 10.1016/j.celrep.2024.114622
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724
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sciencedirect.com/science/article/pii/S2211124724009720
May 2024
www.sciencedirect.com www.sciencedirect.com

Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism

1
1. scibot 17 May 2024
  
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  RRID:CVCL_1724
  
  DOI: 10.1016/j.molcel.2024.04.014
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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sciencedirect.com/science/article/pii/S1097276524003290
52.53.155.43 52.53.155.43

Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells

2
1. scibot 10 May 2024
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1101/2024.02.18.580900
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724
2. scibot 10 May 2024
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1101/2024.02.18.580900
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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52.53.155.43/97841ca504d9556b3965877911b65905cd7f6735/2024.02.18.580900v1.full-html.html
Apr 2024
www.sciencedirect.com www.sciencedirect.com

Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases

1
1. scibot 26 Apr 2024
  
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  CVCL_1724
  
  DOI: 10.1016/j.xcrm.2024.101523
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2666379124001927
Aug 2023
www.sciencedirect.com www.sciencedirect.com

SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer

1
1. scibot 13 Aug 2023
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1016/j.ceca.2021.102384
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRIDCUR:Validated RRID:CVCL_1724
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RRIDCUR:Validated

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sciencedirect.com/science/article/pii/S0143416021000385
Jun 2023
www.sciencedirect.com www.sciencedirect.com

MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells

1
1. scibot 21 Jun 2023
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1016/j.canlet.2023.216264
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
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  RRID:CVCL_1724
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sciencedirect.com/science/article/pii/S030438352300215X
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Overexpression of synaptic vesicle protein Rab GTPase 3C promotes vesicular exocytosis and drug resistance in colorectal cancer cells

1
1. scibot 04 Mar 2023
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1002/1878-0261.13378
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9980308/
Jul 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Aberrant expression and subcellular localization of ECT2 drives colorectal cancer progression and growth

1
1. scibot 06 Jul 2022
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1158/0008-5472.CAN-20-4218
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724
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ncbi.nlm.nih.gov/pmc/articles/PMC9056178/
Jun 2022
aacrjournals.org aacrjournals.org

Liver Endothelium Promotes HER3-mediated Cell Survival in Colorectal Cancer with Wild-type and Mutant KRAS

1
1. scibot 14 Jun 2022
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1158/1541-7786.MCR-21-0633
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724
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aacrjournals.org/mcr/article/20/6/996/699064/Liver-Endothelium-Promotes-HER3-Mediated-Cell
May 2022
link.springer.com link.springer.com

Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer

1
1. scibot 10 May 2022
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1007/s00018-022-04311-4
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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link.springer.com/article/10.1007/s00018-022-04311-4
Mar 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases

1
1. scibot 18 Mar 2022
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1016/j.isci.2022.103985
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724
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ncbi.nlm.nih.gov/pmc/articles/PMC8919295/
Jan 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

AP-2α Regulates S-phase and is a Marker for Sensitivity to PI3K-inhibitor Buparlisib in Colon Cancer

1
1. scibot 05 Jan 2022
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1158/1541-7786.MCR-20-0867
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724
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ncbi.nlm.nih.gov/pmc/articles/PMC8254761/
Dec 2021
www.sciencedirect.com www.sciencedirect.com

Redox-sensitive cyclophilin A elicits chemoresistance through realigning cellular oxidative status in colorectal cancer

1
1. scibot 01 Dec 2021
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1016/j.celrep.2021.110069
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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sciencedirect.com/science/article/pii/S2211124721015552
Nov 2021
clincancerres.aacrjournals.org clincancerres.aacrjournals.org

HPV Sequencing Facilitates Ultrasensitive Detection of HPV Circulating Tumor DNA

1
1. scibot 15 Nov 2021
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1158/1078-0432.CCR-19-2384
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724
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clincancerres.aacrjournals.org/content/27/21/5857
Sep 2021
www.sciencedirect.com www.sciencedirect.com

Oncogene-dependent sloppiness in mRNA translation

1
1. scibot 25 Sep 2021
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1016/j.molcel.2021.09.002
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724
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sciencedirect.com/science/article/pii/S109727652100736X
Aug 2021
elifesciences.org elifesciences.org

Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy

1
1. scibot 02 Aug 2021
  
  in Public
  
  CVCL_1724
  
  DOI: 10.7554/eLife.27301
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724
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elifesciences.org/articles/27301
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

1
1. scibot 28 Jul 2021
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1016/j.cell.2018.09.051
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @Jmenke
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724 RRIDCUR:Unrecognized
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sciencedirect.com/science/article/pii/S0092867418312637
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Hypomorph Mutation-Directed Small-Molecule Protein-Protein Interaction Inducers to Restore Mutant SMAD4-Suppressed TGF-β Signaling

2
1. scibot 28 Apr 2021
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1016/j.chembiol.2020.11.010
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724
2. scibot 08 Apr 2021
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1016/j.chembiol.2020.11.010
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724
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sciencedirect.com/science/article/pii/S2451945620304736
www.sciencedirect.com www.sciencedirect.com

SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer

1
1. scibot 12 Apr 2021
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1016/j.ceca.2021.102384
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724
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RRID:CVCL_1724

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scibot

URL

sciencedirect.com/science/article/pii/S0143416021000385
Jan 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Membrane therapy using DHA suppresses epidermal growth factor receptor signaling by disrupting nanocluster formation

1
1. scibot 28 Jan 2021
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1016/j.jlr.2021.100026
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1724
  
  What is this?
  
  RRID:CVCL_1724 RRIDCUR:Validated
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RRID:CVCL_1724

RRIDCUR:Validated

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7933808/
jeccr.biomedcentral.com jeccr.biomedcentral.com

Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer

1
1. scibot 12 Jan 2021
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1186/s13046-020-01811-8
  
  Resource: (NCBI_Iran Cat# C480, RRID:CVCL_1724)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1724
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1724
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RRID:CVCL_1724

RRIDCUR:Validated

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scibot

URL

jeccr.biomedcentral.com/articles/10.1186/s13046-020-01811-8
Jan 2020
www.sciencedirect.com www.sciencedirect.com

VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.1016/j.cels.2019.05.009
  
  Resource: (BCRC Cat# 60311, RRID:CVCL_1724)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1724
  
  What is this?
  
  RRID:CVCL_1724 RRIDCUR:Validated
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RRID:CVCL_1724

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S2405471219301905
www.mdpi.com www.mdpi.com

N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:CVCL_1724
  
  DOI: 10.3390/cancers11101456
  
  Resource: (BCRC Cat# 60311, RRID:CVCL_1724)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1724
  
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  RRID:CVCL_1724 RRIDCUR:Validated
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RRID:CVCL_1724

RRIDCUR:Validated

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scibot

URL

mdpi.com/2072-6694/11/10/1456
Nov 2017
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

1
1. scibot 08 Nov 2017
  
  in Public
  
  CVCL_1724
  
  Curator: @gabimpine
  
  Resource used:
  
  (ATCC Cat# CCL-231, RRID:CVCL_1724)
  
  SciCrunch record: RRID:CVCL_1724
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1724 RRIDCUR:Validated
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RRID:CVCL_1724

RRIDCUR:Validated

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC5127641/