Hypothesis

91 Matching Annotations

Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

DNMT3A R882H Is Not Required for Disease Maintenance in Primary Human AML, but Is Associated With Increased Leukemia Stem Cell Frequency

1
1. scibot 23 Dec 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1158/2159-8290.CD-24-1604
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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pmc.ncbi.nlm.nih.gov/articles/PMC12717831/
Nov 2025
www.sciencedirect.com www.sciencedirect.com

Precision prediction of venetoclax-azacitidine treatment efficacy in acute myeloid leukemia via integrative drug screening and machine learning

1
1. scibot 22 Nov 2025
  
  in Public
  
  CVCL_1844
  
  DOI: 10.1016/j.xcrm.2025.102461
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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sciencedirect.com/science/article/pii/S2666379125005348
www.sciencedirect.com www.sciencedirect.com

Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia

1
1. scibot 22 Nov 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1016/j.cell.2025.10.028
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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sciencedirect.com/science/article/pii/S0092867425012334
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity

1
1. scibot 07 Nov 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1158/2643-3230.BCD-24-0140
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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pmc.ncbi.nlm.nih.gov/articles/PMC12050964/
Oct 2025
www.biorxiv.org www.biorxiv.org

Balancing Activation and Repression: CoREST-p300 Antagonism Controls Retinoic Acid-Driven Differentiation in AML

1
1. scibot 23 Oct 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1101/2025.10.13.682235
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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biorxiv.org/content/10.1101/2025.10.13.682235v1
www.science.org www.science.org

Small-molecule OPA1 inhibitors reverse mitochondrial adaptations to overcome therapy resistance in acute myeloid leukemia

1
1. scibot 21 Oct 2025
  
  in Public
  
  OCI-AML3
  
  DOI: 10.1126/sciadv.adx8662
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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science.org/doi/10.1126/sciadv.adx8662
Aug 2025
www.nature.com www.nature.com

Retinoic acid disrupts an NPM1c/ROS/SENP3/ARF oncogenic axis in acute myeloid leukemia

1
1. scibot 30 Aug 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1038/s41375-025-02731-2
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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nature.com/articles/s41375-025-02731-2
www.nature.com www.nature.com

The bispecific innate cell engager AFM28 eliminates CD123+ leukemic stem and progenitor cells in AML and MDS

1
1. scibot 27 Aug 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1038/s41467-025-63069-y
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
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  RRID:CVCL_1844
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nature.com/articles/s41467-025-63069-y
www.sciencedirect.com www.sciencedirect.com

A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation

1
1. scibot 26 Aug 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1016/j.molcel.2025.08.001
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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sciencedirect.com/science/article/pii/S1097276525006513
Jul 2025
aacrjournals.org aacrjournals.org

miR-196b-TLR7/8 signaling axis regulates innate immune signaling and myeloid maturation in DNMT3A-mutant AML

1
1. scibot 08 Jul 2025
  
  in Public
  
  RRID: CVCL_1844
  
  DOI: 10.1158/1078-0432.CCR-22-1598
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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aacrjournals.org/clincancerres/article/28/20/4574/709597/miR-196b-TLR7-8-Signaling-Axis-Regulates-Innate
Jun 2025
chemistry-europe.onlinelibrary.wiley.com chemistry-europe.onlinelibrary.wiley.com

Peptidomimetics Targeting the Amyloidogenicity of Nucleophosmin 1 Mutations in Acute Myeloid Leukemia

1
1. scibot 26 Jun 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1002/cbic.202500306
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cbic.202500306
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis

1
1. scibot 11 Jun 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1158/2159-8290.CD-24-0093
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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pmc.ncbi.nlm.nih.gov/articles/PMC11611684/
May 2025
www.cell.com www.cell.com

CD97-directed CAR-T cells with enhanced persistence eradicate acute myeloid leukemia in diverse xenograft models

1
1. scibot 29 May 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1016/j.xcrm.2025.102148
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00221-6
Apr 2025
www.biorxiv.org www.biorxiv.org

TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia

1
1. scibot 13 Apr 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1101/2025.04.07.647605
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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biorxiv.org/content/10.1101/2025.04.07.647605v1
Mar 2025
www.sciencedirect.com www.sciencedirect.com

A niche driven mechanism determines response and a mutation-independent therapeutic approach for myeloid malignancies

1
1. scibot 28 Mar 2025
  
  in Public
  
  RRID:CVCM_1844
  
  DOI: 10.1016/j.ccell.2025.03.007
  
  Resource: None
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRIDCUR:Unresolved RRID:CVCL_1844
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RRID:CVCL_1844

RRIDCUR:Unresolved

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sciencedirect.com/science/article/pii/S1535610825001084
www.nature.com www.nature.com

Superior preclinical efficacy of co-treatment with BRG1/BRM and FLT3 inhibitor against AML cells with FLT3 mutations

1
1. scibot 20 Mar 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1038/s41408-025-01251-7
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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nature.com/articles/s41408-025-01251-7
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

BKT300: A Novel Anti-Leukemic Small Molecule Targeting the Protein Regulator of Cytokinesis 1 (PRC1) Pathway

1
1. scibot 13 Mar 2025
  
  in Public
  
  CVCL_1844
  
  DOI: 10.21203/rs.3.rs-6017610/v1
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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pmc.ncbi.nlm.nih.gov/articles/PMC11875301/
Feb 2025
www.sciencedirect.com www.sciencedirect.com

BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor

1
1. scibot 20 Feb 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1182/blood.2023022832
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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sciencedirect.com/science/article/pii/S0006497124004543
www.sciencedirect.com www.sciencedirect.com

PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1

1
1. scibot 20 Feb 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1016/j.stem.2025.01.010
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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RRID:CVCL_1844

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sciencedirect.com/science/article/pii/S1934590925000104
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 14 Feb 2025
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1158/2643-3230.bcd-24-0140
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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52.53.155.43/b6e42261d11f7c0ae043c89c64cba240f59a1523/PDF-html.html
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

B7-H3–Targeted CAR-Vδ1T Cells Exhibit Potent Broad-Spectrum Activity against Solid Tumors

1
1. scibot 12 Dec 2024
  
  in Public
  
  CVCL_1844
  
  DOI: 10.1158/0008-5472.CAN-24-0195
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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pmc.ncbi.nlm.nih.gov/articles/PMC11609632/
Oct 2024
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

1
1. scibot 08 Oct 2024
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1002/1878-0261.13722
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13722
aacrjournals.org aacrjournals.org

Monocytic Differentiation and AHR Signaling as Primary Nodes of BET Inhibitor Response in Acute Myeloid Leukemia

1
1. scibot 02 Oct 2024
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1158/2643-3230.BCD-21-0012
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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aacrjournals.org/bloodcancerdiscov/article/2/5/518/665838/Monocytic-Differentiation-and-AHR-Signaling-as
Sep 2024
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

1
1. scibot 27 Sep 2024
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1111/febs.17263
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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febs.onlinelibrary.wiley.com/doi/10.1111/febs.17263
Aug 2024
www.cell.com www.cell.com

SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation

1
1. scibot 18 Aug 2024
  
  in Public
  
  CVCL_1844
  
  DOI: 10.1016/j.celrep.2024.114536
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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cell.com/cell-reports/fulltext/S2211-1247(24)00865-9
Jun 2024
link.springer.com link.springer.com

β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo

1
1. scibot 28 Jun 2024
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1007/s43440-024-00614-4
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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link.springer.com/article/10.1007/s43440-024-00614-4
www.sciencedirect.com www.sciencedirect.com

A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML

1
1. scibot 06 Jun 2024
  
  in Public
  
  ACC 582
  
  DOI: 10.1016/j.xcrm.2024.101592
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @abever99
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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sciencedirect.com/science/article/pii/S2666379124002842
molecular-cancer.biomedcentral.com molecular-cancer.biomedcentral.com

Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients

1
1. scibot 06 Jun 2024
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1186/s12943-024-02034-7
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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molecular-cancer.biomedcentral.com/articles/10.1186/s12943-024-02034-7
Apr 2024
www.sciencedirect.com www.sciencedirect.com

Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers

1
1. scibot 26 Apr 2024
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1016/j.ccell.2024.04.004
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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sciencedirect.com/science/article/pii/S1535610824001284
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib

1
1. scibot 19 Mar 2024
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1158/0008-5472.CAN-23-1534
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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ncbi.nlm.nih.gov/pmc/articles/PMC10940854/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

FEBS Press

1
1. scibot 15 Mar 2024
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1002/1878-0261.13630
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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ncbi.nlm.nih.gov/pmc/articles/PMC11467801/
Feb 2024
www.biorxiv.org www.biorxiv.org

BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor

1
1. scibot 04 Feb 2024
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1101/2023.09.28.560054
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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biorxiv.org/content/10.1101/2023.09.28.560054v1
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeting BET proteins downregulates miR-33a to promote synergy with PIM inhibitors in CMML

1
1. scibot 02 Feb 2024
  
  in Public
  
  CVCL_1844
  
  DOI: 10.1158/1078-0432.CCR-22-3929
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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ncbi.nlm.nih.gov/pmc/articles/PMC10524644/
Jan 2024
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

1
1. scibot 25 Jan 2024
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1002/1878-0261.13584
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13584
Dec 2023
www.biorxiv.org www.biorxiv.org

MYC–NFATC2 axis maintains cell cycle and mitochondrial function in AML cells

1
1. scibot 01 Dec 2023
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1101/2023.11.15.567209
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
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biorxiv.org/content/10.1101/2023.11.15.567209v1
Nov 2023
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Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies

1
1. scibot 28 Nov 2023
  
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  RRID:CVCL_1844
  
  DOI: 10.1016/j.ccell.2023.11.001
  
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An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

1
1. scibot 28 Nov 2023
  
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  RRID:CVCL_1844
  
  DOI: 10.1016/j.celrep.2023.113484
  
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Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML

1
1. scibot 22 Nov 2023
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1016/j.xcrm.2023.101290
  
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sciencedirect.com/science/article/pii/S2666379123004846
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Myeloid leukemia vulnerabilities embedded in long noncoding RNA locus MYNRL15

2
1. scibot 29 Sep 2023
  
  in Public
  
  CVCL_1844
  
  DOI: 10.1016/j.isci.2023.107844
  
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2. scibot 29 Sep 2023
  
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  CVCL_1844
  
  DOI: 10.1016/j.isci.2023.107844
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10520325/
52.53.155.43 52.53.155.43

Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells

1
1. scibot 29 Sep 2023
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1002/1878-0261.13521
  
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52.53.155.43/17d9d464af1d04aab32a8e6f8ff8e2dac32e6481/Molecular Oncology - 2023 - Deng-html.html
www.nature.com www.nature.com

Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia

1
1. scibot 20 Sep 2023
  
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  CVCL_1844
  
  DOI: 10.1038/s41375-022-01755-2
  
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nature.com/articles/s41375-022-01755-2
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Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment

1
1. scibot 16 Sep 2023
  
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  RRID:CVCL_1844
  
  DOI: 10.1016/j.celrep.2023.113098
  
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PARP-1 improves leukemia outcomes by inducing parthanatos during chemotherapy

1
1. scibot 08 Sep 2023
  
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  RRID:CVCL_1844
  
  DOI: 10.1016/j.xcrm.2023.101191
  
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Aug 2023
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TSC22D3 as an immune-related prognostic biomarker for acute myeloid leukemia

1
1. scibot 04 Aug 2023
  
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  RRID:CVCL_1844
  
  DOI: 10.1016/j.isci.2023.107451
  
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sciencedirect.com/science/article/pii/S2589004223015286
Apr 2023
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Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1

1
1. scibot 18 Apr 2023
  
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  RRID:CVCL_1844
  
  DOI: 10.1038/s41408-023-00826-6
  
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nature.com/articles/s41408-023-00826-6
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells

1
1. scibot 10 Mar 2023
  
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  RRID:CVCL_1844
  
  DOI: 10.1016/j.ccell.2023.02.010
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10466730/
Feb 2023
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Transcriptionally imprinted glycomic signatures of acute myeloid leukemia

1
1. scibot 17 Feb 2023
  
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  RRID:CVCL_1844
  
  DOI: 10.1186/s13578-023-00981-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9926860/
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

ACC010, a novel BRD4 inhibitor, synergized with homoharringtonine in acute myeloid leukemia with FLT3-ITD

1
1. scibot 17 Feb 2023
  
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  RRID:CVCL_1844
  
  DOI: 10.1002/1878-0261.13368
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13368
aacrjournals.org aacrjournals.org

Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling

1
1. scibot 10 Feb 2023
  
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  RRID:CVCL_1844
  
  DOI: 10.1158/0008-5472.CAN-22-1533
  
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aacrjournals.org/cancerres/article/83/2/219/715076/Plk1-Inhibitors-and-Abiraterone-Synergistically
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation

1
1. scibot 18 Nov 2022
  
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  CVCL_1844
  
  DOI: 10.7554/eLife.79940
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9645811/
Sep 2022
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Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses

1
1. scibot 30 Sep 2022
  
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  RRID:CVCL_1844
  
  DOI: 10.1016/j.ccell.2022.09.007
  
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Characterization of the Newly Established Homoharringtonine- (HHT-) Resistant Cell Lines and Mechanisms of Resistance

1
1. scibot 10 Sep 2022
  
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  CVCL_1844
  
  DOI: 10.1155/2022/2813938
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9448541/
www.hindawi.com www.hindawi.com

Characterization of the Newly Established Homoharringtonine- (HHT-) Resistant Cell Lines and Mechanisms of Resistance

1
1. scibot 07 Sep 2022
  
  in Public
  
  CVCL_1844
  
  DOI: 10.1155/2022/2813938
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
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hindawi.com/journals/jo/2022/2813938/
Aug 2022
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Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers

1
1. scibot 17 Aug 2022
  
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  RRID:CVCL_1844
  
  DOI: 10.1016/j.celrep.2022.111241
  
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A tubulin binding molecule drives differentiation of acute myeloid leukemia cells

1
1. scibot 17 Aug 2022
  
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  RRID:CVCL_1844
  
  DOI: 10.1016/j.isci.2022.104787
  
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sciencedirect.com/science/article/pii/S2589004222010598
May 2022
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Antigen presentation safeguards the integrity of the hematopoietic stem cell pool

1
1. scibot 06 May 2022
  
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  DSMZACC 582
  
  DOI: 10.1016/j.stem.2022.04.007
  
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sciencedirect.com/science/article/pii/S1934590922001606
Apr 2022
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Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis

1
1. scibot 21 Apr 2022
  
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  RRID:CVCL_1844
  
  DOI: 10.1016/j.cell.2022.03.030
  
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sciencedirect.com/science/article/pii/S0092867422003403
aacrjournals.org aacrjournals.org

Subversion of serotonin-receptor signaling in osteoblasts by kynurenine drives Acute Myeloid Leukemia

1
1. scibot 05 Apr 2022
  
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  RRID:CVCL_1844
  
  DOI: 10.1158/2159-8290.CD-21-0692
  
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aacrjournals.org/cancerdiscovery/article/12/4/1106/689604/Subversion-of-Serotonin-Receptor-Signaling-in
Mar 2022
www.sciencedirect.com www.sciencedirect.com

The proteogenomic subtypes of acute myeloid leukemia

1
1. scibot 04 Mar 2022
  
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  RRID:CVCL_1844
  
  DOI: 10.1016/j.ccell.2022.02.006
  
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sciencedirect.com/science/article/pii/S1535610822000587
Feb 2022
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HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia

1
1. scibot 18 Feb 2022
  
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  CVCL_1844
  
  DOI: 10.1016/j.molcel.2022.01.014
  
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sciencedirect.com/science/article/pii/S1097276522000570
Jan 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)

1
1. scibot 15 Jan 2022
  
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  RRID:CVCL_1844
  
  DOI: 10.1038/s41408-021-00603-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8752621/
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SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia

1
1. scibot 12 Jan 2022
  
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  ACC 582
  
  DOI: 10.1016/j.celrep.2021.110233
  
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sciencedirect.com/science/article/pii/S2211124721017423
Sep 2021
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Monocytic differentiation and AHR signaling as Primary Nodes of BET Inhibitor Response in Acute Myeloid Leukemia

1
1. scibot 28 Sep 2021
  
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  CVCL_1844
  
  DOI: 10.1158/2643-3230.bcd-21-0012
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8462123/
Aug 2021
link.springer.com link.springer.com

The BET bromodomain inhibitor ZEN-3365 targets the Hedgehog signaling pathway in acute myeloid leukemia

1
1. scibot 15 Aug 2021
  
  in Public
  
  CVCL_1844
  
  DOI: 10.1007/s00277-021-04602-z
  
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link.springer.com/article/10.1007/s00277-021-04602-z
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ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency

1
1. scibot 07 Aug 2021
  
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  ACC-582
  
  DOI: 10.1016/j.molcel.2021.07.018
  
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sciencedirect.com/science/article/pii/S1097276521005876
Jul 2021
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Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity

1
1. scibot 22 Jul 2021
  
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  RRID:CVCL_1844
  
  DOI: 10.1016/j.ccell.2021.06.016
  
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sciencedirect.com/science/article/pii/S153561082100338X
Jun 2021
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ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia

1
1. scibot 03 Jun 2021
  
  in Public
  
  ACC582
  
  DOI: 10.1016/j.molcel.2021.05.008
  
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sciencedirect.com/science/article/pii/S1097276521003658
May 2021
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A systematic analysis of signaling reactivation and drug resistance

1
1. scibot 26 May 2021
  
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  RRID:CVCL_1844
  
  DOI: 10.1016/j.celrep.2021.109157
  
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sciencedirect.com/science/article/pii/S221112472100499X
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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

1
1. scibot 18 May 2021
  
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  RRID:CVCL_1844
  
  DOI: 10.1016/j.cell.2021.04.022
  
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sciencedirect.com/science/article/pii/S009286742100502X
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Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation

1
1. scibot 12 May 2021
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1016/j.celrep.2021.109101
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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sciencedirect.com/science/article/pii/S2211124721004356
clincancerres.aacrjournals.org clincancerres.aacrjournals.org

Targeting DNA damage repair functions of two histone deacetylases, HDAC8 and SIRT6, sensitizes acute myeloid leukemia to NAMPT inhibition

1
1. scibot 10 May 2021
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1158/1078-0432.CCR-20-3724
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1844
  
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clincancerres.aacrjournals.org/content/27/8/2352
Apr 2021
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Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia

1
1. scibot 22 Apr 2021
  
  in Public
  
  ACC 582
  
  DOI: 10.1016/j.ccell.2020.10.010
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRIDCUR:Missing RRID:CVCL_1844
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sciencedirect.com/science/article/pii/S1535610820305419
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MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism

1
1. scibot 22 Apr 2021
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1016/j.ccell.2021.02.006
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRIDCUR:Validated RRID:CVCL_1844
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sciencedirect.com/science/article/pii/S1535610821001082
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Immunogenomic Landscape of Hematological Malignancies

1
1. scibot 17 Apr 2021
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1016/j.ccell.2020.06.002
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610820302750
Mar 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

1
1. scibot 02 Mar 2021
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.7554/eLife.65905
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRIDCUR:Validated RRID:CVCL_1844
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ncbi.nlm.nih.gov/pmc/articles/PMC7886351/
Feb 2021
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Abnormal dopamine receptor signaling allows selective therapeutic targeting of neoplastic progenitors in AML patients

1
1. scibot 24 Feb 2021
  
  in Public
  
  OCI-AML3
  
  DOI: 10.1016/j.xcrm.2021.100202
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRIDCUR:Missing RRID:CVCL_1844
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sciencedirect.com/science/article/pii/S2666379121000136
Jan 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation

1
1. scibot 20 Jan 2021
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1158/2643-3230.BCD-20-0155
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRIDCUR:Validated RRID:CVCL_1844
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ncbi.nlm.nih.gov/pmc/articles/PMC7116590/
Sep 2020
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Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2

1
1. scibot 16 Sep 2020
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1016/j.cell.2020.03.051
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRIDCUR:Validated RRID:CVCL_1844
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sciencedirect.com/science/article/pii/S0092867420303445
www.cell.com www.cell.com

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

1
1. scibot 04 Sep 2020
  
  in Public
  
  RRID: CVCL_1844
  
  DOI: 10.1016/j.ccell.2018.08.015
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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cell.com/cancer-cell/fulltext/S1535-6108(18)30375-1
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Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia and in Normal Bone Marrow

1
1. scibot 04 Sep 2020
  
  in Public
  
  CVCL_1844
  
  DOI: 10.1016/j.celrep.2019.12.055
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719317127
Jan 2020
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HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1016/j.ccell.2019.10.011
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610819304854
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A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

1
1. scibot 12 Jan 2020
  
  in Public
  
  RRID:CVCL_1844
  
  DOI: 10.1016/j.ccell.2018.10.004
  
  Resource: (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  Curator: @Jmenke
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610818304707
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:CVCL_1844
  
  Resource used:
  
  (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844
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sciencedirect.com/science/article/pii/S2211124718314086
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Mutant NPM1 Maintains the Leukemic State through HOX Expression

1
1. scibot 05 Nov 2018
  
  in Public
  
  ACC-582
  
  Curator: @Jmenke
  
  Resource used:
  
  (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S1535610818303593
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CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

1
1. scibot 05 Nov 2018
  
  in Public
  
  CVCL_1844
  
  Resource used:
  
  (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  SciCrunch record: RRID:CVCL_1844
  
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sciencedirect.com/science/article/pii/S1535610818302216
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Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:CVCL_1844
  
  Curator: @Jmenke
  
  Resource used:
  
  (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  SciCrunch record: RRID:CVCL_1844
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:CVCL_1844 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610818300126
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Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:CVCL_1844
  
  Resource used:
  
  (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  SciCrunch record: RRID:CVCL_1844
  
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sciencedirect.com/science/article/pii/S1535610817305020
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Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:CVCL_1844
  
  Resource used:
  
  (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  SciCrunch record: RRID:CVCL_1844
  
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sciencedirect.com/science/article/pii/S1535610817305159
Nov 2017
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Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia

1
1. scibot 08 Nov 2017
  
  in Public
  
  ACC 582
  
  Curator: @Jmenke
  
  Resource used:
  
  (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  SciCrunch record: RRID:CVCL_1844
  
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  RRID:CVCL_1844 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S1535610817303641
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Sam68 Allows Selective Targeting of Human Cancer Stem Cells

1
1. scibot 08 Nov 2017
  
  in Public
  
  OCI AML3DSMZACC 582
  
  Curator: @Jmenke
  
  Resource used:
  
  (DSMZ Cat# ACC-582, RRID:CVCL_1844)
  
  SciCrunch record: RRID:CVCL_1844
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:CVCL_1844 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S2451945617301897

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