170 Matching Annotations
  1. Last 7 days
  2. pubs.acs.org pubs.acs.org
    Hsc70-Mediated Targeting Chimeras for Targeted Protein Degradation via Chaperone-Mediated Autophagy
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    pubs.acs.org/jmcmar/article/doi/10.1021/acs.jmedchem.6c01010/5433015/Hsc70-Mediated-Targeting-Chimeras-for-Targeted
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    Mitochondrial-Mediated Apoptosis and Anti-Leukemic Effects of Tocotrienol Within the Protective Bone Marrow Microenvironment
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    tandfonline.com/doi/full/10.1080/01635581.2026.2713789
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    5-Azacytosine induces cytotoxicity via 5-methylcytosine depletion on chromatin-associated RNA in leukemia
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    sciencedirect.com/science/article/pii/S1097276526005873
  5. Sep 2026
  6. www.nature.com www.nature.com
    PTBP1 controls oncogenic transcript processing and maintenance of acute myeloid leukemia
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    nature.com/articles/s41375-026-03098-8
  7. Aug 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intracellular iron homeostasis-regulated epigenetic reprogramming contributes to −7/del(7q) leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC13482816/
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    Protocol for high-resolution mapping of RNA-associated chromatin using chromatin isolation by RNA purification-tag
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    sciencedirect.com/science/article/pii/S2666166726004028
  10. Jul 2026
  11. aacrjournals.org aacrjournals.org
    Loss of SETD8 Impairs Mitochondrial Homeostasis to Suppress Leukemia Stem Cell Function in t(8;21) Acute Myeloid Leukemia
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    aacrjournals.org/cancerres/article/85/21/4122/766740/Loss-of-SETD8-Impairs-Mitochondrial-Homeostasis-to
  12. Jun 2026
  13. www.biorxiv.org www.biorxiv.org
    Dynamic UFMylation governs cellular fitness by coordinating multi-organelle proteostasis
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    biorxiv.org/content/10.64898/2026.03.27.714830v1
  14. May 2026
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    Leukemic stem cell subtypes determine venetoclax resistance and therapeutic vulnerabilities in AML
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    PROTAC-mediated degradation of TAF1 induces apoptosis in AML cells and inhibits tumor growth in vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC12353786/
  17. Apr 2026
  18. www.science.org www.science.org
    Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity
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    science.org/doi/10.1126/science.ady5196
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC7618455/
  20. Mar 2026
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nanobody-Engineered CLL-1 CAR-T Cells: Optimizing Tumor-Specific Cytotoxicity and Minimizing Off-Tumor Toxicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012018/
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    RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response
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    sciencedirect.com/science/article/pii/S1097276526001383
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RBM15B recognizes H3K79me2 to guide selective m6A-modification of mRNA and enhance oncoprotein translation in MLL-r leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12953771/
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    FASN inactivation-induced progranulin (GRN) expression promotes lysosome-dependent cell death to suppress leukemogenesis
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  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12936425/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
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    pmc.ncbi.nlm.nih.gov/articles/PMC12936417/
  27. Feb 2026
  28. www.sciencedirect.com www.sciencedirect.com
    CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples
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  29. Jan 2026
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells
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  31. www.biorxiv.org www.biorxiv.org
    BCLAF1 links RNA splicing to ATF4-dependent metabolic adaptation in acute myeloid leukemia
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    biorxiv.org/content/10.64898/2026.01.19.700325v1
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    Retinal determination network reactivation drives chemoresistance and blocks myeloid differentiation in acute myeloid leukemia
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    ΔNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia
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  34. Dec 2025
  35. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging
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  36. Nov 2025
  37. www.sciencedirect.com www.sciencedirect.com
    Precision prediction of venetoclax-azacitidine treatment efficacy in acute myeloid leukemia via integrative drug screening and machine learning
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    Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia
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  39. Oct 2025
  40. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Chronic ER Stress Triggers Cell-Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia
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    Balancing Activation and Repression: CoREST-p300 Antagonism Controls Retinoic Acid-Driven Differentiation in AML
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    biorxiv.org/content/10.1101/2025.10.13.682235v1
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Jab1 promotes immune evasion and progression in acute myeloid leukemia models under oxidative stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC12520683/
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    Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation
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  44. Sep 2025
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    FLT3L-based drug conjugate effectively targets chemoresistant leukemia stem cells in acute myeloid leukemia
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    Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignancies
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  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An isoform-specific RUNX1C–BTG2 axis governs AML quiescence and chemoresistance.
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  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ALKBH1 drives tumorigenesis and drug resistance via tRNA decoding reprogramming and codon-biased translation
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    DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site
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    pmc.ncbi.nlm.nih.gov/articles/PMC12396291/
  50. Aug 2025
  51. www.nature.com www.nature.com
    The bispecific innate cell engager AFM28 eliminates CD123+ leukemic stem and progenitor cells in AML and MDS
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    SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia
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  53. Jul 2025
  54. 52.53.155.43 52.53.155.43
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    CircTADA2A inhibits cell proliferation and promotes ferroptosis by sponging miR-638 in acute myeloid leukemia
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    link.springer.com/article/10.1007/s13577-025-01251-6
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nanopore direct RNA sequencing of human transcriptomes reveals the complexity of mRNA modifications and crosstalk between regulatory features
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    pmc.ncbi.nlm.nih.gov/articles/PMC12230237/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer
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  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Downregulation of S6 Kinase and Hedgehog–Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12193305/
  59. Jun 2025
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect
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  61. May 2025
  62. www.cell.com www.cell.com
    CD97-directed CAR-T cells with enhanced persistence eradicate acute myeloid leukemia in diverse xenograft models
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    cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00221-6
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077275/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood
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    Characterization and comparative analysis of multifunctional natural killer cell engagers during antitumor responses
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    The m5C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism
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  67. Apr 2025
  68. aacrjournals.org aacrjournals.org
    Preclinical Development of Tuspetinib for the Treatment of Acute Myeloid Leukemia
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    Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium
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  71. Mar 2025
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    Superior preclinical efficacy of co-treatment with BRG1/BRM and FLT3 inhibitor against AML cells with FLT3 mutations
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  74. Feb 2025
  75. www.sciencedirect.com www.sciencedirect.com
    PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1
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    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
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    Impact of scFv on functionality and safety of third generation CD123 CAR T cells
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    The CDK4/6 inhibitor Palbociclib synergizes with ATRA to induce differentiation in AML
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  80. Dec 2024
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    YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
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    lncRNAs maintain the functional phase state of nucleolar prion-like protein to facilitate rRNA processing
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    ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis
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  84. Oct 2024
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux
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    Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance
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  87. Sep 2024
  88. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    SJPedPanel: A pan-cancer gene panel for childhood malignancies to enhance cancer monitoring and early detection
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    Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer
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  91. Aug 2024
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    Isolation, expansion, and adoptive transfer of human ILC2s for the treatment of mice bearing liquid and solid tumors
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    SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation
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    Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells
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  95. Jul 2024
  96. www.nature.com www.nature.com
    Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vitro CAR-T cell killing: validation of the potency assay
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  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
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  101. Jun 2024
  102. link.springer.com link.springer.com
    β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo
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    link.springer.com/article/10.1007/s43440-024-00614-4
  103. May 2024
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    CD37 is a safe chimeric antigen receptor target to treat acute myeloid leukemia
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  106. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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  108. Apr 2024
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    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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  110. Mar 2024
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  113. Feb 2024
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  117. Jan 2024
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  121. Dec 2023
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  124. Sep 2023
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  128. Aug 2023
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  130. Jul 2023
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  132. Jun 2023
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  134. May 2023
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  145. Feb 2023
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  149. Jan 2023
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  153. Dec 2022
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  155. Nov 2022
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  157. Oct 2022
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  159. Sep 2022
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  163. Jun 2022
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  166. May 2022
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  170. Mar 2022
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  175. Feb 2022
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  179. Jan 2022
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  182. Sep 2021
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  185. Aug 2021
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  189. Jul 2021
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  194. Jun 2021
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  197. May 2021
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  221. Jan 2020
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  224. Nov 2018
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    Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity
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    sciencedirect.com/science/article/pii/S1535610817305159
  228. Nov 2017
  229. www.sciencedirect.com www.sciencedirect.com
    Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia
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    sciencedirect.com/science/article/pii/S1535610817303641
  230. www.sciencedirect.com www.sciencedirect.com
    Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia
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    sciencedirect.com/science/article/pii/S0092867416316853
  231. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC7360335/