135 Matching Annotations
  1. Aug 2025
  2. www.nature.com www.nature.com
    The bispecific innate cell engager AFM28 eliminates CD123+ leukemic stem and progenitor cells in AML and MDS
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    nature.com/articles/s41467-025-63069-y
  3. www.sciencedirect.com www.sciencedirect.com
    SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2211124725009180
  4. Jul 2025
  5. 52.53.155.43 52.53.155.43
    cir-23-0692-html.html
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    52.53.155.43/1f4b1703c319970f6796ecb5a8f69e90cf12a77f/cir-23-0692-html.html
  6. link.springer.com link.springer.com
    CircTADA2A inhibits cell proliferation and promotes ferroptosis by sponging miR-638 in acute myeloid leukemia
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    link.springer.com/article/10.1007/s13577-025-01251-6
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nanopore direct RNA sequencing of human transcriptomes reveals the complexity of mRNA modifications and crosstalk between regulatory features
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    pmc.ncbi.nlm.nih.gov/articles/PMC12230237/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214875/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Downregulation of S6 Kinase and Hedgehog–Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12193305/
  10. Jun 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect
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    pmc.ncbi.nlm.nih.gov/articles/PMC12127799/
  12. May 2025
  13. www.cell.com www.cell.com
    CD97-directed CAR-T cells with enhanced persistence eradicate acute myeloid leukemia in diverse xenograft models
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    cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00221-6
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077275/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood
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    pmc.ncbi.nlm.nih.gov/articles/PMC12082030/
  16. www.sciencedirect.com www.sciencedirect.com
    Characterization and comparative analysis of multifunctional natural killer cell engagers during antitumor responses
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    sciencedirect.com/science/article/pii/S2666379125001909
  17. www.sciencedirect.com www.sciencedirect.com
    The m5C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism
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    sciencedirect.com/science/article/pii/S2211124725004322
  18. Apr 2025
  19. aacrjournals.org aacrjournals.org
    Preclinical Development of Tuspetinib for the Treatment of Acute Myeloid Leukemia
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    aacrjournals.org/cancerrescommun/article/5/1/74/751014/Preclinical-Development-of-Tuspetinib-for-the
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium
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    pmc.ncbi.nlm.nih.gov/articles/PMC11452272/
  21. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/65d1b99ed5d0f367b734e029ffde0892ad535bb6/PDF-html.html
  22. Mar 2025
  23. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/f807b69f98daf6a4cef5a05f921f601dbf8242ee/PDF-html.html
  24. www.nature.com www.nature.com
    Superior preclinical efficacy of co-treatment with BRG1/BRM and FLT3 inhibitor against AML cells with FLT3 mutations
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    nature.com/articles/s41408-025-01251-7
  25. Feb 2025
  26. www.sciencedirect.com www.sciencedirect.com
    PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1
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    sciencedirect.com/science/article/pii/S1934590925000104
  27. www.sciencedirect.com www.sciencedirect.com
    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
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    sciencedirect.com/science/article/pii/S0006497124004543
  28. aacrjournals.org aacrjournals.org
    Impact of scFv on functionality and safety of third generation CD123 CAR T cells
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    aacrjournals.org/cancerimmunolres/article/12/8/1090/746566/Impact-of-scFv-on-Functionality-and-Safety-of
  29. aacrjournals.org aacrjournals.org
    The CDK4/6 inhibitor Palbociclib synergizes with ATRA to induce differentiation in AML
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    aacrjournals.org/mct/article/23/7/961/746068/The-CDK4-6-Inhibitor-Palbociclib-Synergizes-with
  30. 52.53.155.43 52.53.155.43
    1-s2.0-S2950329925000189-main-html.html
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  31. Dec 2024
  32. www.sciencedirect.com www.sciencedirect.com
    YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
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    sciencedirect.com/science/article/pii/S0092867424013242
  33. www.sciencedirect.com www.sciencedirect.com
    lncRNAs maintain the functional phase state of nucleolar prion-like protein to facilitate rRNA processing
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    sciencedirect.com/science/article/pii/S1097276524008761
  34. www.sciencedirect.com www.sciencedirect.com
    ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis
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    sciencedirect.com/science/article/pii/S2211124724013391
  35. Oct 2024
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux
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    ncbi.nlm.nih.gov/pmc/articles/PMC11426993/
  37. www.sciencedirect.com www.sciencedirect.com
    Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance
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    sciencedirect.com/science/article/pii/S1934590924003229
  38. Sep 2024
  39. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.17245
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SJPedPanel: A pan-cancer gene panel for childhood malignancies to enhance cancer monitoring and early detection
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    ncbi.nlm.nih.gov/pmc/articles/PMC11393547/
  41. aacrjournals.org aacrjournals.org
    Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer
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    aacrjournals.org/cancerres/article/82/14/2538/706949/Chromatin-Rewiring-by-Mismatch-Repair-Protein-MSH2
  42. Aug 2024
  43. www.sciencedirect.com www.sciencedirect.com
    Isolation, expansion, and adoptive transfer of human ILC2s for the treatment of mice bearing liquid and solid tumors
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    sciencedirect.com/science/article/pii/S2666166724002612
  44. www.cell.com www.cell.com
    SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation
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    cell.com/cell-reports/fulltext/S2211-1247(24)00865-9
  45. 52.53.155.43 52.53.155.43
    Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells
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    52.53.155.43/17d9d464af1d04aab32a8e6f8ff8e2dac32e6481/Molecular Oncology - 2023 - Deng-html.html
  46. Jul 2024
  47. www.nature.com www.nature.com
    Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
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    nature.com/articles/s41375-024-02328-1
  48. 52.53.155.43 52.53.155.43
    cir-23-0692-html.html
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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11293342/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vitro CAR-T cell killing: validation of the potency assay
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    ncbi.nlm.nih.gov/pmc/articles/PMC11219661/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11217734/
  52. Jun 2024
  53. link.springer.com link.springer.com
    β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo
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    link.springer.com/article/10.1007/s43440-024-00614-4
  54. May 2024
  55. 52.53.155.43 52.53.155.43
    mct-23-0528-html.html
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    52.53.155.43/aad67d20ed53c6e2e8d83cb86f88142e832868b0/mct-23-0528-html.html
  56. www.sciencedirect.com www.sciencedirect.com
    CD37 is a safe chimeric antigen receptor target to treat acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2666379124002647
  57. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    elifesciences.org/articles/90683
  58. 52.53.155.43 52.53.155.43
    cir-23-0692-html.html
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    52.53.155.43/1f4b1703c319970f6796ecb5a8f69e90cf12a77f/cir-23-0692-html.html
  59. Apr 2024
  60. www.sciencedirect.com www.sciencedirect.com
    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    sciencedirect.com/science/article/pii/S1535610824001284
  61. Mar 2024
  62. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13638
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib
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    ncbi.nlm.nih.gov/pmc/articles/PMC10940854/
  64. Feb 2024
  65. www.sciencedirect.com www.sciencedirect.com
    Peptide-scFv antigen recognition domains effectively confer CAR T cell multiantigen specificity
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    sciencedirect.com/science/article/pii/S2666379124000454
  66. www.biorxiv.org www.biorxiv.org
    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
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    biorxiv.org/content/10.1101/2023.09.28.560054v1
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831336/
  68. Jan 2024
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10780038/
  70. www.sciencedirect.com www.sciencedirect.com
    Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death
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    sciencedirect.com/science/article/pii/S0092867423013478
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Developing a mechanistic translational PK/PD model for a trifunctional NK cell engager to predict the first‐in‐human dose for acute myeloid leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10772472/
  72. Dec 2023
  73. www.sciencedirect.com www.sciencedirect.com
    Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18
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    sciencedirect.com/science/article/pii/S2211124723015723
  74. www.biorxiv.org www.biorxiv.org
    MYC–NFATC2 axis maintains cell cycle and mitochondrial function in AML cells
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    biorxiv.org/content/10.1101/2023.11.15.567209v1
  75. Sep 2023
  76. www.sciencedirect.com www.sciencedirect.com
    Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
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    sciencedirect.com/science/article/pii/S2211124723011099
  77. www.sciencedirect.com www.sciencedirect.com
    PARP-1 improves leukemia outcomes by inducing parthanatos during chemotherapy
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    sciencedirect.com/science/article/pii/S2666379123003580
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates
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    ncbi.nlm.nih.gov/pmc/articles/PMC9992000/
  79. Aug 2023
  80. www.biorxiv.org www.biorxiv.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    biorxiv.org/content/10.1101/2023.07.26.550648v2
  81. Jul 2023
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical Evidence of an Allogeneic Dual CD20xCD22 CAR to Target a Broad Spectrum of Patients with B-cell Malignancies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10320475/
  83. Jun 2023
  84. www.nature.com www.nature.com
    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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    nature.com/articles/s41467-023-39241-7
  85. May 2023
  86. onlinelibrary.wiley.com onlinelibrary.wiley.com
    KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition
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    onlinelibrary.wiley.com/doi/10.1002/advs.202206098
  87. Apr 2023
  88. www.nature.com www.nature.com
    Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1
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    nature.com/articles/s41408-023-00826-6
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10071820/
  90. Mar 2023
  91. www.sciencedirect.com www.sciencedirect.com
    m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis
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    sciencedirect.com/science/article/pii/S109727652300151X
  92. www.sciencedirect.com www.sciencedirect.com
    Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells
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    sciencedirect.com/science/article/pii/S266637912300054X
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10466730/
  94. www.sciencedirect.com www.sciencedirect.com
    A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies
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    sciencedirect.com/science/article/pii/S2666379123000538
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical evaluation of CD70-specific CAR T cells targeting acute myeloid leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9950117/
  96. Feb 2023
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptionally imprinted glycomic signatures of acute myeloid leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9926860/
  98. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    ACC010, a novel BRD4 inhibitor, synergized with homoharringtonine in acute myeloid leukemia with FLT3-ITD
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13368
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9780084/
  100. Jan 2023
  101. www.sciencedirect.com www.sciencedirect.com
    Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance
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    sciencedirect.com/science/article/pii/S1934590922004878
  102. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Artesunate, a new antimalarial clinical drug, exhibits potent anti-AML activity by targeting the ROS/Bim and TFRC/Fe2+ pathways
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15986
  103. www.sciencedirect.com www.sciencedirect.com
    METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism
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    sciencedirect.com/science/article/pii/S1934590922004908
  104. Dec 2022
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model
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    ncbi.nlm.nih.gov/pmc/articles/PMC9765856/
  106. Nov 2022
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9645811/
  108. Oct 2022
  109. www.cell.com www.cell.com
    The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia
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    cell.com/cancer-cell/fulltext/S1535-6108(22)00495-0
  110. Sep 2022
  111. www.sciencedirect.com www.sciencedirect.com
    Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses
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    sciencedirect.com/science/article/pii/S1535610822004366
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterization of the Newly Established Homoharringtonine- (HHT-) Resistant Cell Lines and Mechanisms of Resistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC9448541/
  113. www.hindawi.com www.hindawi.com
    Characterization of the Newly Established Homoharringtonine- (HHT-) Resistant Cell Lines and Mechanisms of Resistance
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  114. Jun 2022
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    Phosphorylation of SHP2 at Tyr62 enables acquired resistance to SHP2 allosteric inhibitors in FLT3-ITD-driven AML
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  117. May 2022
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    JMJD1C-regulated lipid synthesis contributes to the maintenance of MLL-rearranged acute myeloid leukemia
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  119. Apr 2022
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    Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis
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  121. Mar 2022
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    CDK6 Degradation Is Counteracted by p16INK4A and p18INK4C in AML
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    Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases
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    The proteogenomic subtypes of acute myeloid leukemia
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    MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape
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  126. Feb 2022
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    HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia
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    Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML
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  130. Jan 2022
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    SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
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  133. Sep 2021
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    The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation
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  136. Aug 2021
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    Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity
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    The BET bromodomain inhibitor ZEN-3365 targets the Hedgehog signaling pathway in acute myeloid leukemia
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  140. Jul 2021
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    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
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  145. Jun 2021
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    MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway
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  147. jitc.bmj.com jitc.bmj.com
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  148. May 2021
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    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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    Targeting DNA damage repair functions of two histone deacetylases, HDAC8 and SIRT6, sensitizes acute myeloid leukemia to NAMPT inhibition
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  153. Apr 2021
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    Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia
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  158. Mar 2021
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    Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia
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  160. Sep 2020
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    Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone
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    Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells
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    5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.
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    Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2
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    RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia
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  170. Aug 2020
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  172. Jan 2020
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    HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice
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  175. Nov 2018
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    Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS
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    Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
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    Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity
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  179. Nov 2017
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    Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia
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    Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia
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    Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
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