154 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12936425/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
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    pmc.ncbi.nlm.nih.gov/articles/PMC12936417/
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    CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples
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    sciencedirect.com/science/article/pii/S1097276526000985
  5. Jan 2026
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    Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
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    BCLAF1 links RNA splicing to ATF4-dependent metabolic adaptation in acute myeloid leukemia
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    biorxiv.org/content/10.64898/2026.01.19.700325v1
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    Retinal determination network reactivation drives chemoresistance and blocks myeloid differentiation in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S221112472501647X
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    ΔNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2666379125006135
  10. Dec 2025
  11. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202513317
  12. Nov 2025
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    Precision prediction of venetoclax-azacitidine treatment efficacy in acute myeloid leukemia via integrative drug screening and machine learning
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    sciencedirect.com/science/article/pii/S2666379125005348
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    Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S0092867425012334
  15. Oct 2025
  16. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Chronic ER Stress Triggers Cell-Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202511573
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    Balancing Activation and Repression: CoREST-p300 Antagonism Controls Retinoic Acid-Driven Differentiation in AML
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    biorxiv.org/content/10.1101/2025.10.13.682235v1
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Jab1 promotes immune evasion and progression in acute myeloid leukemia models under oxidative stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC12520683/
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    Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation
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  20. Sep 2025
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    FLT3L-based drug conjugate effectively targets chemoresistant leukemia stem cells in acute myeloid leukemia
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  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignancies
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  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An isoform-specific RUNX1C–BTG2 axis governs AML quiescence and chemoresistance.
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405853/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ALKBH1 drives tumorigenesis and drug resistance via tRNA decoding reprogramming and codon-biased translation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12377461/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site
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    pmc.ncbi.nlm.nih.gov/articles/PMC12396291/
  26. Aug 2025
  27. www.nature.com www.nature.com
    The bispecific innate cell engager AFM28 eliminates CD123+ leukemic stem and progenitor cells in AML and MDS
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    nature.com/articles/s41467-025-63069-y
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    SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia
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  29. Jul 2025
  30. 52.53.155.43 52.53.155.43
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    CircTADA2A inhibits cell proliferation and promotes ferroptosis by sponging miR-638 in acute myeloid leukemia
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    link.springer.com/article/10.1007/s13577-025-01251-6
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nanopore direct RNA sequencing of human transcriptomes reveals the complexity of mRNA modifications and crosstalk between regulatory features
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  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer
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  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Downregulation of S6 Kinase and Hedgehog–Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation
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  35. Jun 2025
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect
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  37. May 2025
  38. www.cell.com www.cell.com
    CD97-directed CAR-T cells with enhanced persistence eradicate acute myeloid leukemia in diverse xenograft models
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  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
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  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood
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    pmc.ncbi.nlm.nih.gov/articles/PMC12082030/
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    Characterization and comparative analysis of multifunctional natural killer cell engagers during antitumor responses
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    The m5C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism
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  43. Apr 2025
  44. aacrjournals.org aacrjournals.org
    Preclinical Development of Tuspetinib for the Treatment of Acute Myeloid Leukemia
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    Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium
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  47. Mar 2025
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    Superior preclinical efficacy of co-treatment with BRG1/BRM and FLT3 inhibitor against AML cells with FLT3 mutations
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  50. Feb 2025
  51. www.sciencedirect.com www.sciencedirect.com
    PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1
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    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
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  53. aacrjournals.org aacrjournals.org
    Impact of scFv on functionality and safety of third generation CD123 CAR T cells
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    aacrjournals.org/cancerimmunolres/article/12/8/1090/746566/Impact-of-scFv-on-Functionality-and-Safety-of
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    The CDK4/6 inhibitor Palbociclib synergizes with ATRA to induce differentiation in AML
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  56. Dec 2024
  57. www.sciencedirect.com www.sciencedirect.com
    YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
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    lncRNAs maintain the functional phase state of nucleolar prion-like protein to facilitate rRNA processing
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    ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis
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  60. Oct 2024
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux
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    Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance
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  63. Sep 2024
  64. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    SJPedPanel: A pan-cancer gene panel for childhood malignancies to enhance cancer monitoring and early detection
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    Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer
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  67. Aug 2024
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    Isolation, expansion, and adoptive transfer of human ILC2s for the treatment of mice bearing liquid and solid tumors
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    SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation
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    Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells
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  71. Jul 2024
  72. www.nature.com www.nature.com
    Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
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  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vitro CAR-T cell killing: validation of the potency assay
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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
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  77. Jun 2024
  78. link.springer.com link.springer.com
    β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo
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    link.springer.com/article/10.1007/s43440-024-00614-4
  79. May 2024
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    CD37 is a safe chimeric antigen receptor target to treat acute myeloid leukemia
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  82. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    elifesciences.org/articles/90683
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  84. Apr 2024
  85. www.sciencedirect.com www.sciencedirect.com
    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    sciencedirect.com/science/article/pii/S1535610824001284
  86. Mar 2024
  87. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13638
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib
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    ncbi.nlm.nih.gov/pmc/articles/PMC10940854/
  89. Feb 2024
  90. www.sciencedirect.com www.sciencedirect.com
    Peptide-scFv antigen recognition domains effectively confer CAR T cell multiantigen specificity
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    sciencedirect.com/science/article/pii/S2666379124000454
  91. www.biorxiv.org www.biorxiv.org
    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
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    biorxiv.org/content/10.1101/2023.09.28.560054v1
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831336/
  93. Jan 2024
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10780038/
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    Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death
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    sciencedirect.com/science/article/pii/S0092867423013478
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Developing a mechanistic translational PK/PD model for a trifunctional NK cell engager to predict the first‐in‐human dose for acute myeloid leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10772472/
  97. Dec 2023
  98. www.sciencedirect.com www.sciencedirect.com
    Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18
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    sciencedirect.com/science/article/pii/S2211124723015723
  99. www.biorxiv.org www.biorxiv.org
    MYC–NFATC2 axis maintains cell cycle and mitochondrial function in AML cells
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    biorxiv.org/content/10.1101/2023.11.15.567209v1
  100. Sep 2023
  101. www.sciencedirect.com www.sciencedirect.com
    Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
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    PARP-1 improves leukemia outcomes by inducing parthanatos during chemotherapy
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates
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    ncbi.nlm.nih.gov/pmc/articles/PMC9992000/
  104. Aug 2023
  105. www.biorxiv.org www.biorxiv.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    biorxiv.org/content/10.1101/2023.07.26.550648v2
  106. Jul 2023
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical Evidence of an Allogeneic Dual CD20xCD22 CAR to Target a Broad Spectrum of Patients with B-cell Malignancies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10320475/
  108. Jun 2023
  109. www.nature.com www.nature.com
    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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    nature.com/articles/s41467-023-39241-7
  110. May 2023
  111. onlinelibrary.wiley.com onlinelibrary.wiley.com
    KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition
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    onlinelibrary.wiley.com/doi/10.1002/advs.202206098
  112. Apr 2023
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    Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1
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  115. Mar 2023
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  121. Feb 2023
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  125. Jan 2023
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  129. Dec 2022
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  131. Nov 2022
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  133. Oct 2022
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  135. Sep 2022
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  142. May 2022
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  144. Apr 2022
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  146. Mar 2022
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  151. Feb 2022
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  155. Jan 2022
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  158. Sep 2021
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  161. Aug 2021
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  165. Jul 2021
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  170. Jun 2021
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  173. May 2021
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  178. Apr 2021
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  185. Sep 2020
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  195. Aug 2020
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  197. Jan 2020
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  200. Nov 2018
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  204. Nov 2017
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