143 Matching Annotations
  1. Last 7 days
  2. www.biorxiv.org www.biorxiv.org
    Balancing Activation and Repression: CoREST-p300 Antagonism Controls Retinoic Acid-Driven Differentiation in AML
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    biorxiv.org/content/10.1101/2025.10.13.682235v1
  3. Oct 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Jab1 promotes immune evasion and progression in acute myeloid leukemia models under oxidative stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC12520683/
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    Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation
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    sciencedirect.com/science/article/pii/S2211124725011507
  6. Sep 2025
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    FLT3L-based drug conjugate effectively targets chemoresistant leukemia stem cells in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2666379125004380
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignancies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12427560/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An isoform-specific RUNX1C–BTG2 axis governs AML quiescence and chemoresistance.
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405853/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ALKBH1 drives tumorigenesis and drug resistance via tRNA decoding reprogramming and codon-biased translation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12377461/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site
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    pmc.ncbi.nlm.nih.gov/articles/PMC12396291/
  12. Aug 2025
  13. www.nature.com www.nature.com
    The bispecific innate cell engager AFM28 eliminates CD123+ leukemic stem and progenitor cells in AML and MDS
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    nature.com/articles/s41467-025-63069-y
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    SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2211124725009180
  15. Jul 2025
  16. 52.53.155.43 52.53.155.43
    cir-23-0692-html.html
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  17. link.springer.com link.springer.com
    CircTADA2A inhibits cell proliferation and promotes ferroptosis by sponging miR-638 in acute myeloid leukemia
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    link.springer.com/article/10.1007/s13577-025-01251-6
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nanopore direct RNA sequencing of human transcriptomes reveals the complexity of mRNA modifications and crosstalk between regulatory features
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    pmc.ncbi.nlm.nih.gov/articles/PMC12230237/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214875/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Downregulation of S6 Kinase and Hedgehog–Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12193305/
  21. Jun 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect
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    pmc.ncbi.nlm.nih.gov/articles/PMC12127799/
  23. May 2025
  24. www.cell.com www.cell.com
    CD97-directed CAR-T cells with enhanced persistence eradicate acute myeloid leukemia in diverse xenograft models
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    cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00221-6
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077275/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood
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    pmc.ncbi.nlm.nih.gov/articles/PMC12082030/
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    Characterization and comparative analysis of multifunctional natural killer cell engagers during antitumor responses
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    sciencedirect.com/science/article/pii/S2666379125001909
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    The m5C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism
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    sciencedirect.com/science/article/pii/S2211124725004322
  29. Apr 2025
  30. aacrjournals.org aacrjournals.org
    Preclinical Development of Tuspetinib for the Treatment of Acute Myeloid Leukemia
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    aacrjournals.org/cancerrescommun/article/5/1/74/751014/Preclinical-Development-of-Tuspetinib-for-the
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium
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    pmc.ncbi.nlm.nih.gov/articles/PMC11452272/
  32. 52.53.155.43 52.53.155.43
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  33. Mar 2025
  34. 52.53.155.43 52.53.155.43
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  35. www.nature.com www.nature.com
    Superior preclinical efficacy of co-treatment with BRG1/BRM and FLT3 inhibitor against AML cells with FLT3 mutations
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    nature.com/articles/s41408-025-01251-7
  36. Feb 2025
  37. www.sciencedirect.com www.sciencedirect.com
    PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1
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    sciencedirect.com/science/article/pii/S1934590925000104
  38. www.sciencedirect.com www.sciencedirect.com
    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
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    sciencedirect.com/science/article/pii/S0006497124004543
  39. aacrjournals.org aacrjournals.org
    Impact of scFv on functionality and safety of third generation CD123 CAR T cells
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    aacrjournals.org/cancerimmunolres/article/12/8/1090/746566/Impact-of-scFv-on-Functionality-and-Safety-of
  40. aacrjournals.org aacrjournals.org
    The CDK4/6 inhibitor Palbociclib synergizes with ATRA to induce differentiation in AML
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    aacrjournals.org/mct/article/23/7/961/746068/The-CDK4-6-Inhibitor-Palbociclib-Synergizes-with
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  42. Dec 2024
  43. www.sciencedirect.com www.sciencedirect.com
    YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
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    lncRNAs maintain the functional phase state of nucleolar prion-like protein to facilitate rRNA processing
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    ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis
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    sciencedirect.com/science/article/pii/S2211124724013391
  46. Oct 2024
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux
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    ncbi.nlm.nih.gov/pmc/articles/PMC11426993/
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    Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance
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    sciencedirect.com/science/article/pii/S1934590924003229
  49. Sep 2024
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.17245
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SJPedPanel: A pan-cancer gene panel for childhood malignancies to enhance cancer monitoring and early detection
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    ncbi.nlm.nih.gov/pmc/articles/PMC11393547/
  52. aacrjournals.org aacrjournals.org
    Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer
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    aacrjournals.org/cancerres/article/82/14/2538/706949/Chromatin-Rewiring-by-Mismatch-Repair-Protein-MSH2
  53. Aug 2024
  54. www.sciencedirect.com www.sciencedirect.com
    Isolation, expansion, and adoptive transfer of human ILC2s for the treatment of mice bearing liquid and solid tumors
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    sciencedirect.com/science/article/pii/S2666166724002612
  55. www.cell.com www.cell.com
    SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation
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    cell.com/cell-reports/fulltext/S2211-1247(24)00865-9
  56. 52.53.155.43 52.53.155.43
    Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells
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    52.53.155.43/17d9d464af1d04aab32a8e6f8ff8e2dac32e6481/Molecular Oncology - 2023 - Deng-html.html
  57. Jul 2024
  58. www.nature.com www.nature.com
    Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
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    nature.com/articles/s41375-024-02328-1
  59. 52.53.155.43 52.53.155.43
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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11293342/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vitro CAR-T cell killing: validation of the potency assay
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    ncbi.nlm.nih.gov/pmc/articles/PMC11219661/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11217734/
  63. Jun 2024
  64. link.springer.com link.springer.com
    β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo
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    link.springer.com/article/10.1007/s43440-024-00614-4
  65. May 2024
  66. 52.53.155.43 52.53.155.43
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  67. www.sciencedirect.com www.sciencedirect.com
    CD37 is a safe chimeric antigen receptor target to treat acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2666379124002647
  68. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    elifesciences.org/articles/90683
  69. 52.53.155.43 52.53.155.43
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  70. Apr 2024
  71. www.sciencedirect.com www.sciencedirect.com
    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    sciencedirect.com/science/article/pii/S1535610824001284
  72. Mar 2024
  73. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13638
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib
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    ncbi.nlm.nih.gov/pmc/articles/PMC10940854/
  75. Feb 2024
  76. www.sciencedirect.com www.sciencedirect.com
    Peptide-scFv antigen recognition domains effectively confer CAR T cell multiantigen specificity
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    sciencedirect.com/science/article/pii/S2666379124000454
  77. www.biorxiv.org www.biorxiv.org
    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
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    biorxiv.org/content/10.1101/2023.09.28.560054v1
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831336/
  79. Jan 2024
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10780038/
  81. www.sciencedirect.com www.sciencedirect.com
    Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death
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    sciencedirect.com/science/article/pii/S0092867423013478
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Developing a mechanistic translational PK/PD model for a trifunctional NK cell engager to predict the first‐in‐human dose for acute myeloid leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10772472/
  83. Dec 2023
  84. www.sciencedirect.com www.sciencedirect.com
    Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18
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    sciencedirect.com/science/article/pii/S2211124723015723
  85. www.biorxiv.org www.biorxiv.org
    MYC–NFATC2 axis maintains cell cycle and mitochondrial function in AML cells
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    biorxiv.org/content/10.1101/2023.11.15.567209v1
  86. Sep 2023
  87. www.sciencedirect.com www.sciencedirect.com
    Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
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    sciencedirect.com/science/article/pii/S2211124723011099
  88. www.sciencedirect.com www.sciencedirect.com
    PARP-1 improves leukemia outcomes by inducing parthanatos during chemotherapy
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    sciencedirect.com/science/article/pii/S2666379123003580
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates
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    ncbi.nlm.nih.gov/pmc/articles/PMC9992000/
  90. Aug 2023
  91. www.biorxiv.org www.biorxiv.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    biorxiv.org/content/10.1101/2023.07.26.550648v2
  92. Jul 2023
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical Evidence of an Allogeneic Dual CD20xCD22 CAR to Target a Broad Spectrum of Patients with B-cell Malignancies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10320475/
  94. Jun 2023
  95. www.nature.com www.nature.com
    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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    nature.com/articles/s41467-023-39241-7
  96. May 2023
  97. onlinelibrary.wiley.com onlinelibrary.wiley.com
    KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition
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    onlinelibrary.wiley.com/doi/10.1002/advs.202206098
  98. Apr 2023
  99. www.nature.com www.nature.com
    Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1
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    nature.com/articles/s41408-023-00826-6
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10071820/
  101. Mar 2023
  102. www.sciencedirect.com www.sciencedirect.com
    m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis
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    Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10466730/
  105. www.sciencedirect.com www.sciencedirect.com
    A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies
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    sciencedirect.com/science/article/pii/S2666379123000538
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical evaluation of CD70-specific CAR T cells targeting acute myeloid leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9950117/
  107. Feb 2023
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptionally imprinted glycomic signatures of acute myeloid leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9926860/
  109. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    ACC010, a novel BRD4 inhibitor, synergized with homoharringtonine in acute myeloid leukemia with FLT3-ITD
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13368
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9780084/
  111. Jan 2023
  112. www.sciencedirect.com www.sciencedirect.com
    Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance
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  113. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  115. Dec 2022
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  117. Nov 2022
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  119. Oct 2022
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  121. Sep 2022
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  125. Jun 2022
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  128. May 2022
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  130. Apr 2022
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  132. Mar 2022
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  137. Feb 2022
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  141. Jan 2022
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  144. Sep 2021
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  147. Aug 2021
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  151. Jul 2021
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  156. Jun 2021
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  159. May 2021
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  164. Apr 2021
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  171. Sep 2020
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  183. Jan 2020
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  186. Nov 2018
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  190. Nov 2017
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